Treating Brain Cancer with a $50 Antidepressant? Drug Repurposing in Glioblastoma

[@totalsynthesis]

Hey there - thanks for watching! Let me know how you liked the video and if you have any questions or suggestions. Thanks to all my channel supporters! www.patreon.com/totalsynthesis | instagram.com/totalsynthesis_official/

[@squareacid]

So Temozolomide is gone be the next Explosion & Fire vid? i guess

[@bushhawk5460]

Call it "Fighting cancer with explosives" or something like that.

[@chemistryofquestionablequa6252]

This is possibly the ONLY reason I'd take Prozac after reading the trials that got it approved. I occasionally infuriate doctors by refusing "off label" prescribing. I'd much rather have a medication for it's intended purpose than for it's interesting side effects. Mostly excited to discover a new energetic here!

[@pocpic]

you're missing out.

[@chemistryofquestionablequa6252]

@@pocpic nah, I've tried a lot of the common "off label" Rx meds and antidepressants.

[@timecode37]

@@chemistryofquestionablequa6252 why do you refuse them? do the off-label medications just not work as well or do they work but the side effects aren't tolerable?

[@-bamks]

Off label is made up tbh. It does the same stuff for everyone.

[@danaveye3977]

@@chemistryofquestionablequa6252 SSRIs are neurotoxic. End of story

[@MandrakeFernflower]

Chlorpromazin and trifluoperazin has shown promise in various brain infections Might be worth makng a video on?

[@chemistrycapital]

I saw this paper and thought it was super interesting. I think we will see lots more examples of this, especially with the machine learning and "AI" methods being developed.

[@dariusszablowski5474]

Great video. Super interesting papers and underlying mechanism. Thank you for the great video. ☺

[@totalsynthesis]

Why mixed up?

[@martinperales3531]

Love the coverage of the biology aspects, great

[@totalsynthesis]

Glad you liked it!

[@OsmioIridio-og8cn]

Excellent content

[@totalsynthesis]

Thanks Giga Chad!

[@TheBackyardChemist]

16:10 I wonder what happened to the sertindole results. Most of the drugs on the ass end of this spectrum had relatively weak activity, but sertindole appears to have some sort of subgroup-selective conflicting effect. On a few patient samples and all three cell lines, it is as effective as VORT, but it makes things worse often and badly enough to be the second worst drug on the list, on average. I wonder if this is just noise, or there is some difference in gene expression that decides if sertindole harms or helps the cancer cells.

[@abs0lute-zer061]

I actually got this one on time!

[@totalsynthesis]

Yasss

[@jhonbus]

0:40 "We've only recently realised it's explosive" Jesus, really!? That much nitrogen in one place automatically puts this in the "probably explody" category for me!

[@totalsynthesis]

1000%

[@andreasholmqvist4422]

A missed opportunity to highlight the pivotal role of thalidomide in the discovery and development of PROTACs.

[@totalsynthesis]

I go into degraders at the end of my thalidomide video!

[@isa-manuelaalbrecht2951]

It seems Methadon ist very effectful in case of brain tumors..😊

[@Psychx_]

Antidepressants increase BDNF signalling and through that excert neuroprotective effects towards glia cells and neurons. Inflammation gets downregulated, the capability to buffer and withstand oxidative stress increases. BDNF is closely related to actual nerve growth factors/hormones, which could prove as a double edged sword, since it could actually promote the growth of an existing tumor, make it more resilient against treatment and improve its capability of immune system evasion.

[@geekswithfeet9137]

I don’t know how chemist doesn’t realise that is an explosive just by looking at it

[@totalsynthesis]

Never feel too safe around that many nitrogens

[@sofiyaaaaaaaaaa]

There’s a problem with with the mechanism at 7:38 ain’t it?

[@totalsynthesis]

Why?

[@danaveye3977]

The neurotoxicity of flourine should be enough to make anyone stop taking SSRIs. Yet here we are trying to repurpose that toxicity. What a time to be alive.

[@enacherobert1068]

what are you talking about?