Thank you for your question :) I think the answer is yes, only because relaxation means the movement of molecules, and crystallisation requires the movement of molecules - hence they must go together.

Thank you - I hope it was useful

Thank you - that's very good to hear

Thank you for your kind words. Nicotine and cocaine are both called drugs because they are the chemical species that elicit a response in the body. If formulated they would be medicines. I think the confusion is that some drugs are subject to legal restrictions; for instance, controlled drugs, such as morphine, or illegal drugs such as cocaine. But to the general public the word 'drug' is often used only for illegal substances.

Thank you - that's very nice of you to say and also good to hear!

Thank you :) I do indeed, so please throw any suggestions my way. I'll probably look at TGA and DVS next, as they're in my lab!

Thank you for your very kind words and I'm glad you found the material understandable :)

Yes, that is a tricky question. I guess the answer depends on whether you get enough bioavailability for your active. If not then a metastable form is an option but I think most companies would go with the stable form and use an alternative solubilisation strategy (eg milling, salt formation or mixing in an amorphous polymer).

@@PharmaDrama : Thank you for response. Your channel was very helpful in brushing up my pharmaceutical crystallization knowledge.

T15

Yes! You're right :)