12. Pharmacokinetics: Excretion (Part-1): General Pharmacology Lecture

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : / clinical.learning
Pharmacokinetics: Excretion -
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Pharmacokinetics - Excretion (Part-1) focuses on the elimination of drugs and their metabolites from the body, a critical step in terminating drug action 💊. Excretion primarily occurs through the kidneys 🩺, where drugs are filtered at the glomerulus, secreted by the renal tubules, or reabsorbed before elimination via urine. Other routes include the liver (via bile and feces), lungs (for volatile drugs like anesthetics 🌬️), skin (through sweat 💧), and minor pathways like saliva and breast milk 🍼. The rate of excretion depends on factors such as drug solubility, ionization, and plasma protein binding. Hydrophilic drugs are excreted more efficiently by the kidneys, while lipophilic drugs often require metabolism into polar forms for effective elimination. This process is vital to avoid drug accumulation and toxicity, ensuring therapeutic safety and efficacy. Understanding excretion pathways aids in optimizing drug dosing and management in patients with renal or hepatic impairment 🚑.
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[@amolkelkar7231]

Nice video

[@medschoolsimplified007]

Thank u