15y Younger Biological Age (Blood Test #7 in 2024; Test #36 Since 2018)

[@NicholasDunbar]

You should write a book that puts all your research and learning together

[@conqueragingordietrying123]

Definitely, but royalties are small (~10-25%) If I put all that into videos, it's a better business model-at some point I may start making longer videos, 1-2h, like a movie, but charging for it...

[@bigstrongguy91]

@@conqueragingordietrying123why not do both? 😁 book & videos

[@conqueragingordietrying123]

​@@bigstrongguy91That's definitely possible-1st will be a video series with ~25 biomarkers, but will be posted exclusively on Patreon. I'm aiming to do that in the 2nd half of 2025 Then, focusing on a book could be the plan...

[@HH36055]

I went out and got all 9 biomarkers tested this morning to establish my baseline. only 4.6y (11%) reduction. Only spent 12 USD for these tests done in Vietnam.

[@pursuingtruth13]

Great video & thanks for sharing the spreadsheet 👍

[@conqueragingordietrying123]

Thanks @pursuingtruth13!

[@johntaylor7952]

Congratulations Michael! Great video. jt

[@conqueragingordietrying123]

Thanks @johntaylor7952!

[@jimdres7000]

Glad you followed my previous advice to add the essential GGT liver enzyme as a proven longevity biomarker within your future lab tests.

[@conqueragingordietrying123]

Which paper(s) are you using to suggest GGT as a proven longevity marker? It's easier to interpret relative to AST and ALT, which is why I'm including it.

[@jamesgilmore8192]

@@conqueragingordietrying123 GGT (in addition to AST and ALT) is standard on the panel where I am, and I've always found it easier to interpret. I've also been able to reduce it. Although its not tissue specific which is its downside like AST and ALT. Using biomarkers that are tissue specific and monotonic for HR/ACM etc should be the reach aim.

[@jimdres7000]

@ Here you go Mike . It was published by Geroscience. link.springer.com/content/pdf/10.1007/s11357-023-00936-w.pdf

[@espinosalexis]

Thanks a lot Michael. You are the most transparent age researcher out there! Idea for an interview: It would be fantastic if you could convince Matt Kaeberlein to measure a decent set of the things you measure for yourself and have a constructive discussion about biological clocks and his and your results. So far his comments (together with Peter Attia's) have been very biased and totally against the use of clocks. In one of his latest videos he presented ome measures an almost laugh on camera about them (I guess you saw that!). A question: What about Levine's et al. new clock that uses measures related to many organs functions. Have you tested on that one? Do you have a spreadsheet for that one too? It would be nice if you could share.

[@conqueragingordietrying123]

Thanks @espinosalexis. I don't disagree with Matt's criticisms of epigenetic clocks... I do have data for Morgan's latest clock, but it's epigenetic, too. I'm finding the most value from tracking the actual biomarkers, not their epigenetic estimation.

[@espinosalexis]

@conqueragingordietrying123 Ok. Thanks a lot. But this sounds a bit inconsistent with your continuation on posting biological clocks results. If you were in complete agreement with Matt, then I guess you would drop the posting or give a clear disclaimer at the beginning together with some tests similar to Matt's that prove his point and your agreement. In regards to the biomarkers you are following, do you have a clear list of those posted somewhere?

[@invertage]

Keeping it real with the sirens 😸 Have you retested for pace to see any improvement there?

[@conqueragingordietrying123]

Ha, noisy Boston! Yep, on the same day as this test, waiting for results, which should be in within the next 2 weeks

[@Seeker_of_sense]

The question is how well does phenoage predict life expectancy?

[@conqueragingordietrying123]

An older PhenoAge is associated with an increased risk of death for all causes. I'll include that data in the next video in this series, next month...

[@Brant-Footwear]

Can you add a link to the specific lab test ordered, rather than just their website?

[@conqueragingordietrying123]

Here's the foundation for what I usually get: C-Reactive Protein (hs-CRP) and Homocysteine Chemistry Panel (CMP) & Complete Blood Count (CBC) Lipid Panel Uric Acid I then add-on other tests. For example, for December': DHEA Sulfate, Immunoassay Free T3 and Free T4 Blood Test Panel Gamma Glutamyl Transferase (GGT) Candida Albicans Ab (IgG,Iga,IgM) Lipoprotein (a)

[@jeremycloud]

Which Ulta Lab test panel do you use? They have so many...

[@conqueragingordietrying123]

Here's the foundation for what I usually get: C-Reactive Protein (hs-CRP) and Homocysteine Chemistry Panel (CMP) & Complete Blood Count (CBC) Lipid Panel Uric Acid I then add-on other tests. For example, for December': DHEA Sulfate, Immunoassay Free T3 and Free T4 Blood Test Panel Gamma Glutamyl Transferase (GGT) Candida Albicans Ab (IgG,Iga,IgM) Lipoprotein (a)

[@wallexx-rl9nj]

You meant liver health when talking about GGT being a better marker? (U said kidney health)

[@conqueragingordietrying123]

Ah, yes, apologies @wallexx-rl9nj, and good catch!

[@Brant-Footwear]

I'm at Ulta Labs. Which test do i order? CMP?

[@conqueragingordietrying123]

Here's the foundation for what I usually get: C-Reactive Protein (hs-CRP) and Homocysteine Chemistry Panel (CMP) & Complete Blood Count (CBC) Lipid Panel Uric Acid I then add-on other tests. For example, for December': DHEA Sulfate, Immunoassay Free T3 and Free T4 Blood Test Panel Gamma Glutamyl Transferase (GGT) Candida Albicans Ab (IgG,Iga,IgM) Lipoprotein (a)

[@Brant-Footwear]

So there are 6 total tests I need to get to use the pheno calculator?

[@conqueragingordietrying123]

@@Brant-Footwear Nope, just 2: C-Reactive Protein (hs-CRP) Chemistry Panel (CMP) & Complete Blood Count

[@joeextraknow2854]

Lots of tests though. How much would cost for these tests? Or just 9 tests for the age calculator? Thanks

[@conqueragingordietrying123]

For the biomarkers on the calculator, it's around $80 USD Including DHEA-S and uric acid brings the total cost to $130. I also included other biomarkers, which further increased the price, though (Candida IgG, Lp(a)), ApoB, ApoA1).

[@joeextraknow2854]

@ this sounds reasonable. I may start to track my biological age. Thanks.

[@ddutton4716]

Uric acid-Healthy aboriginals on their native diets have UA in the 3-4 range.

[@conqueragingordietrying123]

Thanks for the insight @ddutton4716, are there published papers that you can share?

[@michael-qp9xd]

Hi Michael - great videos as always and thanks for all valuable information. Like you i use cronometer for food tracking. With breakdown on this site i see i am deficient in a few micro and macro areas - one is biotin or vitamin b7. A bit surprising as eat much variety but only unprocessed so fish , meats , veggies, nuts , some dairy and fruits. So probably I’m now to supplement for few items. Wondering if u find same using cronometer and then you too take a few vitamin and mineral supplements to make up for cronometer items found low per RDA values?

[@conqueragingordietrying123]

Hi @michael-qp9xd, and thanks. Cronometer's biotin database may not include all foods, so it's a tough nutrient to track. As we'll see in the next video, I'm covering the RDA for all vitamins and minerals, and purposefully going higher based on correlations with ~25 blood biomarkers.

[@robinsonpp010]

I just did my test this morning with the 9 biomarkers. I have been on the longevity pathway for 6 months. Chronological age-51, Pheno age-40. But my cholesterol ratio is not good. Actually it should be incorporated in the calculation right? Any opinion? Anyway thanks for the spreadsheet

[@conqueragingordietrying123]

Hi @robinsonpp010, 11y younger is good news! PhenoAge didn't arbitrarily pick the 9 biomarkers-they let the stats determine the best predictive model, which didn't include cholesterol. That said, I still track cholesterol and ApoA1, and ApoB, which could be more informative.

[@monnoo8221]

almonds, without the bown skin, which contains most of the oxalates, and TRF raised my HDL. Besides that, chol ratio is not indicative for anything,, because LDL level is a poor predictor. Much more relevant is triglycerides/HDL.

[@GeorgiosAndreasIoannou]

Wow brother, that was a good analytical video, I love your biological age decrease from your tests, great progress I need to do more tests myself, I would love to see your next video where you will go through your diet and supplements that contribute to your biological age decrease. Say healthy us immortalist heros will help and love another for the goal of living forever. ♾️❤️ (I am from r/immortalists)

[@conqueragingordietrying123]

Yes, hi @GeorgiosAndreasIoannou, and thanks again!

[@GeorgiosAndreasIoannou]

​@conqueragingordietrying123 I am trying to get you more traffic, you definitely need it, your content is great, maybe working on your titles and thumbnail to be a little more click baiting in a good sense

[@conqueragingordietrying123]

@@GeorgiosAndreasIoannou In the YT longevity space on YT, it's not about thumbnails, but content For ex., people are interested in red light therapy-that video has recently gone viral on the channel. Less people care about blood testing (for now), and most want to focus on supplements (which is a minor component of the approach for now) When I first started on YT, far, far less people cared about self-testing, but that's been growing every year!

[@OneManStartup]

This creatinine should be replaced to Cystatin C or similar newer better marker at some point.

[@conqueragingordietrying123]

Yep, definitely-other clocks include it, but require additional biomarkers: www.longevity-tools.com/humanitys-bortz-blood-age

[@monnoo8221]

yes, yet phenoage is as it is. I can not measure creatinine for eGFR because i supplement with creatin. ... what i do is to measure cystatin C, then using the eGFR Calculator of the national kidney foundation in order to determine a surrogate value for creatinine. The calculator accepts creatinine and cystatine C. So, I then determine the Creatinine value that would return the same value for eGFR as provided through cystatin C

[@pablofarias8902]

​@monnoo8221 can you share more info? I also use creatine and it obviously pushed creatinine up and hence my phenoage calc

[@jamesgilmore8192]

@@monnoo8221 I think you are better off just ignoring the creatinine contribution in phenoage in this case. The problem with this approach is cystatin C has one of the highest associations with ACM of all biomarkers, and its monotonic unlike creatinine. This means all the coefficients in phenoage would need to be remodelled because of the correlations.

[@jamesgilmore8192]

@@conqueragingordietrying123 I put my numbers into this calculator and it suggests to raise my Vit D to 175 nmol/L. Umm thats very high...

[@troychristensen8016]

How many hours did you fast before test?

[@conqueragingordietrying123]

17-18h, which is the standard for each test

[@MasoudJohnAzizi]

Does reduction of biological age, as gauged by your assays, read out as improved healthspan?

[@conqueragingordietrying123]

I'd modify this to, *a consistent reduction for biological age* over a long period of time In terms of an improved healthspan (and lifespan), we'll see

[@MasoudJohnAzizi]

@conqueragingordietrying123 👍. Sometimes I wonder if non-physical forces are mediating our healthspan...

[@MasoudJohnAzizi]

@@conqueragingordietrying123 Does a "consistent long-term reduction in measures of biological age" translate into increased lifespan and healthspan in pre-clinical studies?

[@conqueragingordietrying123]

@@MasoudJohnAzizi afaik, that approach hasn't been published

[@MasoudJohnAzizi]

@@conqueragingordietrying123 Thanks for sharing 👍

[@lv1985aa]

I don’t think you’ll be able to get that Free T3 (highly doubt you have nutrient deficiencies) or DHEA-S higher without supplementing with T3 and DHEA.

[@conqueragingordietrying123]

You could be right, but we'll see!

[@monnoo8221]

there is a whole stack of reasons, though in Michael's case those risk factors seem to be all excluded, except fructose, maybe

[@troychristensen8016]

Dr Lustig advocates for a Triglyceride/HDL ratio < 1.5 but yours is < 1 which breaks the glass ceiling. Your results show a chol/hdl ratio as well which is similar? Which Quest CPT code is that ?