Human Skin Rejuvenation: Li Li, PhD

[@conqueragingordietrying123]

Timestamps: 0:00 Introduction 0:38 Presentation, Skin Rejuvenation Via mRNA Q&A: 24:44 Does rejuvenating skin improve systemic health? 26:30 Is ATF3 downregulated in skin because of systemic viral burden? 29:03 Using metabolites instead of mRNA to rejuvenate skin? 32:02 Does skin rejuvenation impact skin pH or the skin microbiome? 35:18 Why is ATF3 downregulated in aged skin? 37:35 Are there systemic biomarkers of decreased ATF3 expression in skin? 43:12 Are human clinical trials or patenting the technology coming soon? 45:50 Are there ways without the mRNA technology to upregulate skin ATF3, to help keep it young?

[@chrisgiles5653]

As I understand it, skin aging is not just about the cells, it's about degradation of the Extra-Cellular Matrix (ECM). This area gets very little coverage or research.

[@whatthefunction9140]

You are on a roll with great interviews

[@conqueragingordietrying123]

Thanks @whatthefunction9140, 3 more are scheduled for January, too!

[@chris-lk4ml]

This is very interesting - I really appreciate her presentation. But what made me laught out loud was the interesting transcription factor "AI". Seeing cappuccino site and some other stuff in my skin made my day. Kerathinocytes may be hard to translate for a robot. Illinois 6 and Illinois 8 instead of IL6 was also too good to be true. Anyway, thx!

[@peterz53]

Thanks for bringing the science. On your "what can we now?" question, it seems the incentive in many labs is against investigating natural compounds or lifestyle habits which regulate the same pathways in favor of making a patentable product. A side benefit, though, is clarifying the biological processes/[pathways which can be looked at by others. A quick AI search for natural compounds which promote ATF3 expression came up with 3, but I did not read the papers to see if relevant for skin.

[@conqueragingordietrying123]

Thanks @peterz53. I came across a paper, too, which showed that DHA can increase ATF3 expression, but in microglia-did you find papers for increasing ATF3 in skin?

[@peterz53]

@conqueragingordietrying123 I'll check the papers to see if the tissue involved was skin. Compounds in gink biloba and bloodroot were mentioned. Probably worth checking if exercise modulates Atf3. And what UV and infrared do, if known.

[@ChessMasterNate]

Resistance training is also supposed to improve skin somehow. I have been using a humidifier when I sleep. That seems to improve the appearance of skin aging, but probably not actual skin aging. I think hyaluronic acid works similarly. No genuine improvement. If you stop using it, everything is back the way it was. Perhaps the resistance training is more real. Red light is also supposed to help. HBOT claims virtually everything, including facial aging. There are also some things that are supposed to help remove scar tissue. And we each have more than it appears. I think it was nattokinase and something that sounds similar from silk worms.

[@shane8695]

whar removes scar tissue?

[@ChessMasterNate]

@@shane8695 Purportedly, nattokinase and serrapeptase help remove scar tissue throughout the body, often termed fibrosis when in the body and just scar tissue when on the skin. Infections, toxins, injury, and other things can kill enough cells that the body responds in a way that is fast but sloppy, and we get scar tissue rather than the same kind of tissue that was there prior to the damage. This is presumed to be a survival mechanism. Better not to bleed to death, or die of infection, while slow repairs are made, even if fast is a mess. It would be nice to shut that system down as we have modern medicine and sterilization and such now, but it is what it is. There is a Scottish woman, Jo Cameron, who both feels no pain and also heals without scaring. A useful combination. Though, I think, pain is a good thing, on balance. Though, I would surely change my mind if I got arthritis. Scaring often happens in heart attacks, in lung damage and larger skin injuries that break the skin, of course, but also many other tissues. I have been experimenting with these. Honestly, it makes me feel less well, so I am only taking it intermittently. I am hoping it is slowly removing scar tissue and then appropriate tissues are replacing the scar tissue. But, I have not seen anything that suggests it works yet. I probably need to take pictures of my scars, so I have a more objective data point to compare to later. Okay, I took pictures of the 5 scars I remember. I am guessing, if it does work, it probably will take a year or more. Mostly I don't care about the scars, though there is one between my eyes my glasses cover up, that would be nice, gone. I am not holding my breath, as I have had that since I was 6, or so. If I had had a few stitches, it probably would not be there, but my parents did not care, and were directly responsible for the injury as well. They may not have wanted to explain that. The other scars were my own stupidity. An Exacto knife when I was 12, a sharp chisel about 10 years ago, a cut on my knee, from a grinder maybe 8 years ago, and a simple but long scratch on my arm that did not even draw blood. Not sure why that one did not heal normal. No different than the other 1,000 scratches in my life. It feels the same as the skin around it, but it does not have pigmentation. I am pretty light, so it is not that noticeable. Everyone has their own story their scars remind them of. But it is nice if they are smaller and less obvious. But more seriously, I know I inhaled a lot of concrete dust that likely did damage my lungs somewhat. And I lived in heavy smog for a couple decades before we cleaned up the air. It was orange most of the time and if I breathed deeply by lungs would cough that stuff out before I could fill them. If you are under 30, you just have no idea how crummy the air was in the 1970s, and 1980s in the major US cities.

[@invertage]

Living an optimal healthy skin conscious life will get us most of the way there. I'm an avid faster and focusing on ridding of senescent cells which I assume would be a factor in the skin too. Giving the skin all the nutrients it needs including aminos and collagen peptides will help with skin aging. Using moisturizer. Sun damage prevention of course. I'm 60 in 3 months and have been improving my skin last couple years, but have decades of ignoring it. I've been going heavy on blood circulation, L-Arginine, and inversion, maybe niacin helping too "skin flushing effect?" Getting increased blood flow particularly to the face can help. Its always elevated, even on pillow . >>>INVERSION

[@alexno007]

very interesting, great topic as always! If atf3 gets modulated by the Immunsystem, probably this is modulating the aging in all of our cells, does it make sense to improve skin cells probably on the cost of other cells? Shouldn't we look to improve Immunology and trying to keep inflamation low when we age? Isn't HRV a great marker for the strength of our Immunsystem which is still underestimated?

[@conqueragingordietrying123]

Thanks @alexno007. In a separate paper, ATF3 activation induced viral reactivation, so systemically shutting it down may be a strategy to limit viral burden, at the cost of aging: pubmed.ncbi.nlm.nih.gov/39543280/

[@johnvanderpol2]

Is it not that the immune response we have now is perfectly balanced to get a homosapiens to reproductive age. Now we finally can take control and even up this immune system, and prevent it even from being needed. Great times ahead.

[@mannmstorm]

Thanks! What is your take on molecular hydrogen for inhalation and flow to mask that covers the face for skin health. In drinking water?

[@conqueragingordietrying123]

Got some links to share?

[@stellarblur]

Aren't lipids like soap to cells?

[@conqueragingordietrying123]

Cell membranes are made of lipids-the lipid nanoparticle allows for the treatment to enter the cell

[@rredding]

Interesting, m-RNA research! I will now be extremely cautious with untested therapies, whatever the happy producer has to say about it. I would be really really surprised if these researchers knew what the vitamin D serum levels were in the subjects, Magnesium intracellular levels, omega 6:3 ratios etc. These are factors heavily impacting photoaging. In design of experiments uncontrolled factors are called Noise, and as such it is very important to think of those factors before even setting up the experiment. One step further: experimenters can control these factors by supplementation. Now they are control factors, making for a more powerful experiment. Not your standard clinical trial, but a bit more advanced. Probably this kind of experiments is financed by an industry that needs patents and good PR, not sharing knowledge about proper nutrition and healthy levels of micronnutrients..

[@conqueragingordietrying123]

ATF3 expression is down in aged skin, and they used mRNA (not a viral protein, i.e. the spike) to restore ATF3 expression, which rejuvenated skin. Totally different situation vs the vax "L.L. and G.M.C. are listed as inventors on a patent application related to the work in this article"

[@stellarblur]

I've never seen people taking all the stuff, stay young

[@AP-nj1mr]

You lost me at mRNA

[@conqueragingordietrying123]

It's not a viral mRNA, totally diffrent situation

[@joemoya9743]

​@@conqueragingordietrying123Unfortunately, there is a large amount of misunderstanding and belief based ignorance about mRNA.

[@usernwn7qe]

Did anyone notice most female "researchers" specialize in aging & esthetics, what a coincidence.

[@conqueragingordietrying123]

This work is from George Church's lab. Are there any official stats for most women (vs men) specializing in esthetics research?