a nice introduction for newbies in bio-optimization :)
@MarsSixty25 минут бұрын
I am surprised that you even bother with LDL... There are numerous arguments and facts that explain why it is Not important... However the one that is most convincing is the observational study (Sweden or Norway) where they followed a large cohort of participants (believe 400k) for 30yrs....the most surprising data was that every one that reached 100 had high LDL also all of them had low blood iron levels... I am a bit vague, but it's been at least a year ago I watched it. Also regular blood donations will lead to smaller (younger) red blood cells as well as lowered iron levels. To increase your lymphocytes, you can look at supplementing with Rutin and Devil's Claw, or an even better alternative, do the TRIIM protocol... I would change metformin for Berberine, and add 4g of Glynac and 1g of Taurine. Adding Alpha-Lipoic acid to your supplement stack would further reduce ROS within the Mitochondria as well in lipids... I would like to see exactly which blood tests you do. I live in SA, and it is pretty expensive to test here, especially anything to do with genetics.
@oibal6054 минут бұрын
Thanks again. Live long and, yep, prosper.
@MasoudJohnAziziСағат бұрын
Excellent 👍
@christiancrafoordСағат бұрын
this feel lika school setting, reminds me of my own uni... do u teach? can i become ur student 😌? i and ur viewers here are more involved!!!
@conqueragingordietrying123Сағат бұрын
Definitely @christiancrafoord. I do occasionally teach grad students (last week, for ex), but sometimes joke that my channel is the equivalent of "Lustgarten University" I offer client consults, which may be of interest...
@christiancrafoordСағат бұрын
@@conqueragingordietrying123 i just imagined a cool situation walking to uni and discussing potential biohacking/longevity strategies - that would be cool af 😁
@peterz532 сағат бұрын
Michael, you touched on parabiosis which is an interest of mine as there was work from the Conboy lab in 2020 which showed that some level of tissue rejuvenation occurs by simply removing old plasma from test animals without using young animal plasma - "Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin" Conboys were involved in some of the early parabiosis experiments in the Rando lab. In any case, they concluded that removal (dilution) of old factors also resulted in shifting gene expression to a younger phenotype. Effect duration is unknown but appears to last at least a month. They also collected human data (2022 paper) from TPE work and showed a number of biomarkers (DNA damage, immune cells) moved towards younger profile. Also unknown is volume exchange needed to effect changes, although they did a one time 50% plasma exchange in lab animals. How this might be immediately applicable to humans is that we can donate plasma every 4 weeks at our local blood banks, which is what I've started doing shifting from my whole blood donation. Volume is 800 mls or about 25% of my plasma volume. I haven't done enough blood work yet to assess effects but will using some of the parameters in their 2022 paper to assess my blood. I believe RetroBiosciences is trying to build on this process and better assess biological effects but have already shown positive effects on the brain.
@adamd94182 сағат бұрын
Fantastic video Dr. Lustgraten - keep em coming!
@conqueragingordietrying1232 сағат бұрын
Thanks @adamd9418, videos will be posted for the next 3 days, too!
@adamd94182 сағат бұрын
The risk of death increasing by age - should it be exponential instead of linear?
@conqueragingordietrying1232 сағат бұрын
I'm not sure-if there is published data showing an exponential increase, please post it!
@maumbeot2 сағат бұрын
hey!
@conqueragingordietrying1232 сағат бұрын
yes
@Liface2 сағат бұрын
Would still love a video on how you store your data and do your correlations!
@conqueragingordietrying1232 сағат бұрын
Hi @Liface, some of that approach is on Patreon, but I can definitely do that for YT, possibly sooner vs later...
@SV88123 сағат бұрын
Thanks for sharing. I understand you probably have a limited time for your presentation and you want to fit in as much data as possible, nevertheless I would suggest to slow down a bit to let listeners "breathe".
@conqueragingordietrying1232 сағат бұрын
Yep, thanks @SV8812, I did rush it a bit.
@johntaylor79523 сағат бұрын
Hi Michael! John Taylor here....great presentation!! I hope you know you are doing great, unique work in a field full of not so ethical people! I admire you. I did have a question...have you thought about a way to rank, in order, the most to least important bio markers? It is overwhelming. Tx again, jt
@allehelgen2 сағат бұрын
You can rank them using the coefficients that are applied in the phenoage algorithm for example
@conqueragingordietrying123Сағат бұрын
Hi John, and thanks! I prefer not to rank them, as I've seen a lot of blood tests where parts of the data look youthful, and others, aged. If I ranked them within that context, I might mistakenly thing the whole picture was youthful. Instead, I look at biomarker groupings, and assess whether each organ and/or systemic function is youthful and associated with lowest risk for all-cause mortality. For ex., creatinine, BUN, uric acid as kidney markers, glucose + lipoproteins, TGs for metabolic health, immune markers (WBCs and their differentials).
@estudioguti112 сағат бұрын
The best video on the importance of sunlight I have seen 🙌🙌🙌🙌
@NespoliLeonardo18 сағат бұрын
Hi have you ever find what are the optimal level of vitamin d in ng/ml in the blood? thanks
@kellio808721 сағат бұрын
Also cold weather cause vasoconstriction which can cause higher blood pressure, blood clots, heart attacks. Also, dehydration because people drink less water during the winter.
@cmb11921 сағат бұрын
Thank you for this important information.
@jackbuaer3828Күн бұрын
Perhpas Dr. Seheult can provide us with some names of low cost legitimate home devices. I know he says to just go outside in the morning. However, that's not practical i in the cold weather. i have been exercise outside in the morning and my skin on my face is taking a beating (perhaps from the cold or allergies to sunscreen). I have not had this issue in the warmer weather and when I went without sunscreen.
@GaiasFleasКүн бұрын
There are LED bulbs that give the red spectrum offered by Phillips, we use them here in EU.
@conqueragingordietrying123Күн бұрын
Thanks @GaiasFleas. I recently bought a 670 nm red light, but one that includes 670 and beyond (near-infrared) is tough to find (not sold out) in the US...
@samplay4626Күн бұрын
An incredibly informative and easily understood video. Great and thank you !
@conqueragingordietrying123Күн бұрын
Thanks @samplay4626!
@1aliveandwellКүн бұрын
Found your vid when looking up rdw-cv(12.1) compared to rdw-SD(48.8 hi) Is 1 "better " than the other. Thanks for your pictures as helps to understand what rdw means. My MCV is in 90's, so wondered if low iron and B12 can cause labs to even out. .
@arthurcgusmaoКүн бұрын
Amazing.
@GaiasFleas2 күн бұрын
Does Covid19 virus survive sunlight? This could be another reason why Covid mortality was lower in countries with more direct sunlight. Maybe you have less viral burden in general when you're in sunlight, due to sunlight killing it off or at least reducing viral numbers?
@spgp2732 күн бұрын
Thanks for an interesting interview! While I too am in midlife with these thoughts, unfortunately I also think a systemic collapse is coming, and I'm not sure I even want to live much beyond it.
@arthurcard11522 күн бұрын
2000 units D three. Way to low. What’s your D 3 levels? I take between 5 and 10 for decades. My levels are between 80 and 100. Sick once in a Decade. I live in the sun all year round here in Philly. Except half the time it’s covered with Chemtrails. 🤦🏻♂️. Age 60. Health Guru.
@StevenLewis-u1j2 күн бұрын
Humans generate infrared radiation. It’s not merely reflected, but emitted by all objects based on their temperature. Since human bodies are typically around 98.6°F (37°C), we naturally emit infrared radiation related to our body heat. This is why infrared cameras can detect people in the dark by picking up their infrared radiation.
@rogertrygg54853 күн бұрын
Africans around the equator should live longer than those in the Nordics? No, No! Again
@conqueragingordietrying1233 күн бұрын
Good point-lots of factors besides sun exposure are clearly involved.
@spgp2732 күн бұрын
Melanin differences. Sunlight exposure still important everywhere. Of course, Nordics not proven to live longer than Mediterranean people, opposite in fact.
@rogertrygg54852 күн бұрын
@@spgp273 Oh Yes! Who died like flies in Covid! The Italians! Lowest mortality! Finland, Denmark and Norway
@rogertrygg54853 күн бұрын
No sun in Finland. They had one of the world's lowest infection rates. Italy! Strong sun all day. Massive Covid infection.
@SarahLiebowitz-h4v3 күн бұрын
I really appreciate your efforts! Just a quick off-topic question: My OKX wallet holds some USDT, and I have the seed phrase. (alarm fetch churn bridge exercise tape speak race clerk couch crater letter). How should I go about transferring them to Binance?
@spgp2732 күн бұрын
Screw off.
@tmcmiz10053 күн бұрын
Would this apply to niacinamidr as well or only nicotinic acid?
@conqueragingordietrying1233 күн бұрын
The only way to know is to measure NAD...I haven't done that experiment yet, outside of NMN
@auricauric81503 күн бұрын
Sol’s out, swoles out!
@whatthefunction91403 күн бұрын
Move to hawaii
@whatthefunction91403 күн бұрын
I watch med cram. He often mixes up uv and ir light...
@whatthefunction91403 күн бұрын
This guy loves correlation
@Franky2A33 күн бұрын
We shouldn't wear sunglasses outside? BTW I don't.
@whatthefunction91403 күн бұрын
I have a lot of relatives who have recurring skin cancer. How does one get sun and not get sun damage?
@davidkeating13793 күн бұрын
Wear long sleeves and a broad brim hat. As shown in the presentation, near infrared light, easily penetrate clothing, but UV light does not.
@monnoo82213 күн бұрын
there are at least 2 effects of NIR: triggering melatonin and activation of cytochrome C oxidase. The responsive synthesis of Melatonin requires healthy mitochondria, at least half-way healthy, kind of. If CytC does not do its job, the electron transport chain (ETC) starts leaking and produces ROS. Since a working ETC is the sine qua non for everything, that effect of NIR might be much more important than the induction of melatonin. Yet, even on the level of the ETC, prevention is better than correction... IMHO PQQ is the missing key in many approaches and perspectives about mitochondrial health, so also regarding melatonin. It effectively prevents ROS formation in the first place, as it can work as a joker shuttle for the electrons. I think you should make a video about PQQ and is richness of effects and importance, also in relation to other energy production processes.
@sooooooooDark3 күн бұрын
questions: 1. does sunscreen lotion repel these particular beneficial rays or just uva/b? how about mineral based sunscreens? 2. how much infrared is around in colder months (when the suns angle to the atmosphere is less optimal)? how much during overcast? compared to sunny/non-cloudy days
@conqueragingordietrying1233 күн бұрын
I think sunscreen only blocks UV light For #2, I'm not sure...
@elenaortega54593 күн бұрын
Americans are not trying to make incandescent lightbulbs illegal. The corrupt Biden regime is. We want America healthy again.
@jackbuaer38283 күн бұрын
I just ran around my house lifting up all of the solar shades. Dr. Seheult will now have direct responsibility for the expediting of the furniture / rug color fade.
@conqueragingordietrying1233 күн бұрын
Is there a way to have windows or shades that block UV, while allowing longer wavelengths to enter (red, near infrared, etc)? Probably a higher electricity bill, too
@jackbuaer38283 күн бұрын
@@conqueragingordietrying123 My newer large windows have low-e coatings which minimize the amount of ultraviolet and infrared light that can pass through glass. This was required by the local government to get the permit to add them to the house. I believe they are required to be energy efficient due to being oversized. My old windows probably let everything in. Window manufacturers claim that low-e saves on both heating and cooling costs. I believe the speaker stated that they only save on cooling costs. He may be wrong on that.
@drlorishemekКүн бұрын
😂
@23952AAB3 күн бұрын
Thank you so much! I was just supplementing Vitamin D and actively avoiding sunlight with the intention to prevent risk from UV damage. This has greatly made me decide in adding sunlight to my routine. This seems to be a high impact information and has the potential to improve many lives! Thank you so much, Michael and Roger!! :)
@conqueragingordietrying1233 күн бұрын
I agree, and thanks @23952AAB!
@AwesomeFDO7893 күн бұрын
Why would incandescent bulbs be better than red light leds. Especially when they can produce Near infrared light which is much better at penetration past skin.
@conqueragingordietrying1233 күн бұрын
Good question-have you found a red light that combines near-infrared wavelengths, too, and that isn't crazy expensive? I found a 670 nm red light for $30, but have yet to find a relatively affordable light that combines both red and near-infrared.
@kiramiftari94863 күн бұрын
Great report! :) When you say CACAO BEAN intake - what form are you eating them in? Cacao powder, or whole bean chocolate 🍫 bars? Thnx!
@conqueragingordietrying1233 күн бұрын
Hi @kiramiftari9486 and thanks! Whole raw cacao beans, mixed with Medjool dates in a food processor
@kiramiftari94863 күн бұрын
@@conqueragingordietrying123 Sounds delicious 😋 I never tried whole cacao beans - what is your preferred source for these, for reference?
@AndrewOudin3 күн бұрын
I became aware of the importance of sun exposure around autumn of 2019 and I experienced major health/wellness improvements after beginning to sunbathe. My personal dose guide is sunburn; I get as much light as I can without getting any burn whatsoever. (Not rationalizing minor burns; I'm talking zero.) The benefits seem to last at least three or four days. If I can only get exposure once a week I'm limping along.
@conqueragingordietrying1233 күн бұрын
I know the feeling in terms of limited sun exposure on not feeling great. In terms of the dose, I'm not sure that the maximal, non-burn dose is optimal. In my case, I used to sunbathe for an 1 hr/session, without burning, but my skin started to show signs of skin damage (sunspots), so I cut back to at most, half of that duration.
@AndrewOudin3 күн бұрын
@@conqueragingordietrying123 Good point. Its true that I rarely actually get as much as I can without burning, I'm probably around half that myself. I just have been operating with little guide other than not burning. I may indeed suffer skin aging consequences as a result of my approach. Thank you for putting this great content out there! And for your dose-response sanity.
@Maple5973 күн бұрын
Fabulous presentation and discussion! Thanks!
@conqueragingordietrying1233 күн бұрын
Thanks @Maple597!
@wagonsports14 күн бұрын
This is great! We’ve been following MedCram for a while. You have an Excellent channel.
@conqueragingordietrying1234 күн бұрын
Thanks @wagonsports1!
@KenDBerryMD4 күн бұрын
Excellent info here!
@conqueragingordietrying1234 күн бұрын
Thanks @KenDBerryMD!
@Battery-kf4vu4 күн бұрын
Most blue zones are at lower latitudes, so one can wonder if sun exposure is not a confounder. The nordic diet, with contains whole grains, fish, nuts, fermented foods sounds really healthy, perhaps it would give nordic countries a blue zone status if they had more sunlight.
@conqueragingordietrying1234 күн бұрын
Good point!
@Battery-kf4vu3 күн бұрын
@@conqueragingordietrying123 Also in northern countries perhaps because of the climate people don't go out as much so exercise less and socialize less. That could perhaps also be more risk factors.
@lmyers9999Күн бұрын
Food should be local/ seasonal to the local environment
@lmyers9999Күн бұрын
Yes sunlight is the primary factor and they eat local
@RXP91Күн бұрын
I wondered that after spending time in Grasse, south of France. Everyone there seems to have beautifully designed houses that let light enter, they always eat outdoors on their balcony even poor folks.
@silviahayakawa66554 күн бұрын
Any sunlight protocols you have or are changing?
@conqueragingordietrying1234 күн бұрын
I bought a 670nm red light, currently using it daily Sooner vs later I'll move to a warmer climate (currently in Boston), and get sunlight daily, all year round...
@silviahayakawa66553 күн бұрын
@ Thanks! Do you have the one you’re using linked somewhere?
@conqueragingordietrying123Күн бұрын
@@silviahayakawa6655 Nope, but here it is! Not affiliated or sponsored... www.amazon.com/dp/B0D8RHHXYC?ref=ppx_yo2ov_dt_b_fed_asin_title
@gastropodahimsa4 күн бұрын
This guy's speech is incoherent.
@conqueragingordietrying1234 күн бұрын
Sorry to hear that, I just checked on mobile, it sounds good to me
@jackbuaer38283 күн бұрын
@@conqueragingordietrying123 I think the above comment was directed at as to whether the subject matter was explained in an understandable manner. In any event, I thought the speaker was clear, well-spoken, and well-organized. I appreciate his passion and the information that he provided.
@destinyotoibhi92933 күн бұрын
@@jackbuaer3828I thought he was a skilled communicator and presenter as well!