2-Deoxy-2-D-Glucose (2-DG) | Molecular basis of new anti-covid therapeutic | INMAS & Dr Reddy's Lab

[@aditipaul701]

A burning topic....vry nicely explained...👍

[@naseermuhammad3921]

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[@shailyaverma3883]

Very nicely and precisely explained. Good job :)

[@deepthipram]

Grateful for the initiative. Thank you Dr

[@BiprojitNath]

Thanks a lot

[@ze5737]

I DONT know what will u think of me guys ,but I have a foolish question to ask . The explanation in this video was so good ,that urge me to raise such question . If co- virus did it job in glycolysis in the host cell - Can we take more glucose in any form then during the time of suffering in order to compensate the glucose that have been broken down by the virus ??

[@amanpratapsingh8829]

first read pathogenesis of COV-19 you will get the ans

[@BiprojitNath]

HI Zenyorika! No question is a foolish question! Coming back to your question. 2-DG is a glucose analog and not glucose. 2-DG inhibits glycolysis. So, if you intake more glucose once you are infected, you are serving the infected cells with more glucose and hence the rate of glycolysis and glycosylation will increase! and hence the infectivity and reproducibility of the virus! 2-DG inhibits this by blocking increased glycolysis of the infected cells.

[@ze5737]

@@BiprojitNath alright ,thank you soo much 🙏.

[@কৌশিককুন্ডু-ঝ১ত]

so, good and polished explanation...😊

[@BiprojitNath]

Thanks a lot 😊

[@healthyandfitness4836]

Great. Well, explained.

[@SAURABHYADAV-pm9cp]

To explain it in 10 min needs a good background understanding. Nice one bro 🤜

[@BiprojitNath]

True 👍 ✔

[@vigneshM2000]

What happened to normal cell.....? May they prone to starve of glucose

[@nishantdash24]

Very well explained...

[@BiprojitNath]

Glad you liked it

[@boris2512]

Can u explain how this 2DG selectively targets the virus infected cells not the uninfected cells?

[@BiprojitNath]

Hi @boris 25! 2-DG is basically an analogue of glucose! targeting infected cells is based on the fact that infected cells are highly glycolytic in nature! so the uptake of glucose in the infected cells will be high! But, again 2-DG does not have "DRUG LIKE PROPERTY" so it is not highly specific to infected cells, rather cells that are highly glycolytic will also take up 2-DG, for example, a tumor (its highly glycolytic, and hence will take up 2-DG. I don't have enough data from INMAS Work to appropriately tell you what modification has been done on 2-DG to make it highly specific for covid infected cells! Hope it helps!

[@boris2512]

@@BiprojitNath thanks

[@ambipillai3081]

Beautifully explained.. Very useful.

[@BiprojitNath]

Thank you sir 🙏☺

[@gurkiratsinghnizer9153]

Very informative and well explained 👏

[@BiprojitNath]

Thanks bro

[@vishalkhartade7399]

What if normal cells uptake the 2DG, is there any side effects for that if not then why its only affecting infectious cell and not normal

[@boris2512]

I heard this 2DG selectively targets the virus infected cells ..If normal cells takes it up it will be very serious since it will stop the glycolysis in those cells thereby stopping further pathways like tca cycle and electron transport chain

[@BiprojitNath]

Hi Vishal! 2-DG is basically an analog of glucose! targeting infected cells is based on the fact that infected cells are highly glycolytic in nature! so the uptake of glucose in the infected cells will be high! But, again 2-DG does not have "DRUG LIKE PROPERTY" so it is not highly specific to infected cells, rather cells that are highly glycolytic will also take up 2-DG, for example, a tumor (its highly glycolytic, and hence will take up 2-DG. I don't have enough data from INMAS Work to appropriately tell you what modification has been done on 2-DG to make it highly specific for covid infected cells! Normal cells will also take up 2-DG, but that will be a basal uptake and not high uptake as in infected cells. Hope it helps!

[@vishalkhartade7399]

@@BiprojitNath thanks for the reply I appreciate good info

[@vishalkhartade7399]

@@boris2512 my question was how? because its just analog for the glucose

[@shrankhalasinha979]

very well explained bhaiya

[@suruchijain3418]

very good , and early explanation

[@BiprojitNath]

Thank you mam 🙏 ☺

[@shivashankar4016]

Really a good video.

[@sayanmukherjee7748]

Very informative presentation

[@BiprojitNath]

Thanks sayon

[@999361465]

Very well i think this drug are effective in any variant of this virus

[@dr.anuradha5803]

Please tell how it selectively targets virus infected cells

[@BiprojitNath]

Hi Dr Anuradha! 2-DG is basically an analogue of glucose! targeting infected cells is based on the fact that infected cells are highly glycolytic in nature! so the uptake of glucose in the infected cells will be high! But, again 2-DG does not have "DRUG LIKE PROPERTY" so it is not highly specific to infected cells, rather cells that are highly glycolytic will also take up 2-DG, for example, a tumor (its highly glycolytic, and hence will take up 2-DG. I don't have enough data from INMAS Work to appropriately tell you what modification has been done on 2-DG to make it highly specific for covid infected cells! Hope it helps!

[@dr.anuradha5803]

@@BiprojitNath tq😊

[@raviteja131]

Well explained bipro👍

[@BiprojitNath]

Thanks ravi sir

[@pallabinath6097]

Excellent explanation 😁

[@BiprojitNath]

Thanks! 😃

[@aireenzaraabsal5346]

Nicely explained

[@BiprojitNath]

Thank you 😊

[@prabhatattri7442]

👍

[@cassy610]

Pls improve your COMMUNICATION Skills . Otherwise good video presentation .

[@BiprojitNath]

thank you for ur advice! will surely work on that!

[@biswajitnath7498]

we'll explained

[@BiprojitNath]

Thanks biswajit