2-Minute Neuroscience: Alzheimer's Disease

[@saraa2405]

I just love your videos so much. I love how accurate you are and how you mention the things we need to know, not just any old rubbish. Also, the fact that the videos are only 2 minutes long makes me want to watch them, as it's only 2 minutes long! :D The simplistic diagrams really help me to understand the concepts and I like how you include the transcripts in the descriptions. I use your videos for revision, a lot. Please carry on doing what you're doing - it's perfect.

[@neurochallenged]

Thanks!

[@luigisummo5131]

@@neurochallenged to have a definitive cure for Alzheimer's is it okay 60 65 years from now or would it take about longer?

[@miro1mimi]

Your videos are perfect for studying. I love how you manage to explain alot in only two minutes. I usually watch your videos before and after studying. Doing so helps me know on what to focus the most during studying and what to remember after studying❤️

[@jessicaminervini950]

This was SO SO helpful! I'm a 1st year doctorate student in clinical psychology (Psy.D) and was confused about what a plaque was. You cleared that question up and answered questions I didn't even know I had! Thank you so much!

[@sashaquarrington3729]

I love your videos so much I have just ordered your book! Although I'd love to see a video on vascular dementia!!

[@ikwonswt]

Aerobic exercise can be an effective method of treating Alzheimer's disease. It may not cure the disease but will slow down the process of degeneration. According to research, hippocampus sizes of those who engaged in aerobic exercise were bigger than those who did not. Let's all do some cardio if you don't wanna forget your mom's or son's name later in your life.

[@mistral1591]

Magnesium L Threonate crosses blood brain barrier. It improves memory in Alz pts.

[@anwar87999]

Thnx, very comprehensive summary. I was reading for two days about AD, and what you said is pretty much it.

[@lindenly22]

Beta-amyloid plaques. Tau-related neurofibrillary tangles. Microglia. Glial cells. Frontotemporal dementia. Lewy bodies. Aceytlcholine. These are the common jargon when we are dealing with Alzheimer's disease.

[@DementiaPreventionCenter]

When looking at how the brain ends up - there is a lot of damage. How do you see this different from what happens in stroke? Damage to the brain results in similar findings. Have you ever read anything that seems to confirm that the amyloid and tau are anything different than the brains result to damage? Looking back even into the 1980s - "amyloid" is not very well understood. Great videos all around you really do an awesome job compressing so much data into a few minutes!

[@neurochallenged]

Stroke can cause the death of brain tissue, but the amount of tissue that is damaged varies a great deal. It's dependent, for example, on the size of the blood vessel that is blocked to cause the stroke, how long blood flow is disrupted, etc. The deficits that result also depend a great deal on which vessel(s) are affected, and which parts of the brain they supply. So you have the potential for more localized damage, whereas the longer Alzheimer's continues the more widespread the damage becomes. As for your other question, there are many who believe these abnormal protein deposits are the response to damage. I think their true role is still uncertain and it hasn't been determined either way.

[@DementiaPreventionCenter]

Has your team ever considered damage to the brain of 10 microns- death of few capillaries (micron stroke)? Damage to a single astrocyte resulting in damage of the neuron. We often find that there is little effective information that describes damage too small to be noticed. Stroke is easy if the patient can no longer move an arm - but what happens when you loose an interneuron or an oligodendrocyte dies - these are difficult questions and thank you for hosting a discussion.

[@neurochallenged]

I'm not familiar with micron stroke. I actually couldn't find any mention of it in the scientific literature except for one paper that seems to be linked to your group. So I don't really know enough about the hypothesis to speculate on it.

[@DementiaPreventionCenter]

Yes. We struggle to find accurate explanations on the smallest amount of damage to the brain (micron in size). If the literature ever has enough content on this topic, would love to see your 2-min review!

[@lizf3857]

I really enjoy your channel! can you do a video on cerebral palsy?

[@neurochallenged]

That's a good suggestion; I'll add it to my list!

[@AC-qo8oq]

Good video

[@jamesbedukodjograham5508]

I hope I do not get Alzheimers disease because a relative of mine got the disease back In 2010, I am totally horrified by how the brain literally rots with this diseas.

[@Anonymous-df8it]

That's ableist

[@muniraddas9743]

lol lol pop😂 lol p pop😂😢😢 lol lol 😂 my hi I pop pop😅 W 😊😊y

[@spacekid9680]

EATEOT has really taken me down an actually educational rabbit hole. Seeing that thumbnail and seeing what Alzheimer's does to the brain... SHEESH! Let's hope a cure can be found soon.

[@Anonymous-df8it]

That's ableist

[@spacekid9680]

@@Anonymous-df8it no. I'm meaning it is clearly a lot of damage and the fact that so many people have to suffer through their brains doing that. It's such an awful disease.

[@Anonymous-df8it]

@@spacekid9680 Oh, I was just pointing out how silly neurodiversity rhetoric is.

[@spacekid9680]

@@Anonymous-df8it I'm neurodivergent

[@Anonymous-df8it]

@@spacekid9680 And?

[@jay-rama]

Is it correct to say “mis-folded” since APP’s are actually cut by secretases?

[@thisismylife-i5t]

How does dementia patients brain differ from drug user brain? Is there some kind of medical difference?

[@kamarbanu]

Dementia is shrinking of the brain Certain parts will get damaged Eventually leading to brain death Know more about Alzheimer's kzbin.info/www/bejne/rYm3f6xve5KfgJY

[@anetorberry1947]

Message Dr akho1 on KZbin is the best🌱🌱

[@cani5761]

Drugs affect chemical system of brain but dementia affect whole brain

[@watchmakerfs]

What about the error in the process of synaptic pruning?

[@neurochallenged]

+Watchmaker Fs there are several proposed pathophysiological processes occurring in Alzheimer's, so I only focused on the most well-known of these (I can't think of another way to approach it if you're trying to summarize AD in 2 minutes). Synaptic pruning certainly may play a role.

[@watchmakerfs]

Yes, I just mentioned because I saw an article last month that explained that this error may be one of the causes of Alzheimer's. Great channel!

[@Anonymous-df8it]

That's autism, not Alzheimer's

[@saraa2405]

This might sound silly but one thing I always wish you provided when I watch your videos are references. I suppose there is no need for you to do that, and I'm not sure whether youtubers ever even do that!

[@neurochallenged]

You're right, I should make it a habit of providing references more. I have provided them in some of my videos in the info section (see kzbin.info/www/bejne/iGG5gXeaZa-qeac for example). I have a tendency to neglect to do it because most of the information I provide in these videos is common knowledge in the field---you could find it in any neuroscience textbook. You can often get away without citing when that is the case, but really only when your audience is part of the field---and of course many people watching these videos are not neuroscientists. So I will try to remember to start adding references to the info section whenever I make a video. Thanks for the feedback!

[@nicoxoda2276]

what about amphetamines? do you think amphetamines could benefit dementia ? (if so, long term vs short term?)

[@chissstardestroyer]

How are we sure that no way can these medicines do any harm at all; even due to lack of available data and needs for the treatments; so that treatments that could do harm don't get carried out- heedless of any sorts of pressures; and that society gets completely overridden in defense of the patient against the needs of any and all leadership, while still healing the patients without available data due to the inability to experiment on the brain; so how do we know for sure, infallibly, that the treatments will work no matter what and not do any possible harm at all, as per the rules of medicine?

[@jseanbrooks1]

Milesdown

[@emi6099]

How can you get better from this?

[@500deadweasels]

There's no cure

[@BPS298]

@@rufus_wong Bruh we have a cure to so many diseases, WDYM? Edit: oops I thought you meant all disease, not just Alzheimer’s.

[@drygimangdrminjak8177]

@@BPS298 there's no cure for Alzheimer's, there's only medicine which slows it down, but it still kills you

[@BPS298]

@@drygimangdrminjak8177 did I ever say there was a cure for Alzheimer’s? Also I edited my comment

[@drygimangdrminjak8177]

@@BPS298 doesn't make a point

[@dogwoodhill777]

fight or flight and the negitive thought

[@WolfieChaz]

Alzheimer's drsea-disease 🤣 I'm not being rude or making fun of the mistake but it caught me off guard 😂

[@afifahmkmur]

Come here because of watching Limitless with Chris Hemsworth

[@stevelawson6739]

New hope Lecanemab