2018 2019HBV & HDV 1

[@WhyNot-si4pj]

At 24:47 you mentioned that the presence of both HBeAg & HBsAg is an indicator of an unresolved or chronic hepatitis B infection ! Can you explain that in more details ?

[@xDomglmao]

Both can be seen as markers of ongoing replication but in order to Dg chr hep B you'll need also some AB values (antiHBsAB & antiHBeAB negative while IgG positive); Ninja Nerd made a good vid about this :)

[@WhyNot-si4pj]

@@xDomglmao Thank you for your explanation ! Do you mean by " while IgG positive " Anti HBc IgG ?

[@xDomglmao]

@@WhyNot-si4pj You're very welcome! I know how it feels like if one has a question that needs to be answered in order to fully grasp a concept. Yes, antiHBcAB is of two types, one is IgM, the other IgG

[@WhyNot-si4pj]

@@xDomglmao So in case of chronic hepatitis B infection , i.e : > 6 months . +ve HBs Ag. +ve HBe Ag. +ve anti HBc IgG .

[@xDomglmao]

@@WhyNot-si4pj Yes, but keep in mind there is a "chronic replicating" and a "chronic non-replicating" form, precisely: Chr. non-replicating = HBsAG+ HBeAg- HBV DNA- antiHBsAB- antiHBeAB+ antiHBcAB: IgG+ Chr. replicating = what you described = all Ag+ antiHBsAB- antiHBeAB- antiHBcAB: IgG+ And then you can classify the chr. forms even further but this is a bit too much (I won't be learning this, too).

[@xDomglmao]

Thank you! :) Would you please explain the signal-to-noise ratio? I don't quite get it (signal = IgM but what's the noise? Otherwise I don't understand how they calculate the ratio which helps to DD btw reactivated hepa and acute hepa) :/