26. Cancer 2

[@addaegyabaahemmanuel1160]

I'm thrilled by the body of knowledge Professor Martin communicates. Thanks a lot Professor Martin and MIT for this amazing lecture❤.

[@woloabel]

(On Thursday of February 9, 2023). In the Subject of Biology on the Subtopic Neoplasia (Cancer 2): 1) Tumorigenesis Regulation or Homeostasis of Growth Regulation: a) Barriers to Neoplasia Development; b) Basement Membrane (Extracellular Matrix are Proteins of Sheath Platform Function) invasion and Intercellular Adhesion Molecules Catalysis; Mesenchymal Cells or Stroma (Highly Migration because of a Lack of Adhesion Molecules) is a a connective tissue of Body Function rather than a Functional Tissue of Epithelia (90% of Malignancies Originate in this Tissue); Immune Cells (White Blood Cells) are Connective Tissue with High Migratory Ability and Immune System Mediation Function. c) Immunocompetency is the Primary Mechanism of Anti-Neoplasia (Cytotoxicity of Neoplastic Aberrant Cells; Natural Killers Lymphocytes Primarily); c) Malignancy Pathogenesis follows Logical and Definitive Steps: 1) Hyperplasia to 2) Dysplasia to 3) Malignancy and 4) Metastasis (Francoanaplasia); d) Mechanism of Dysregulated Growth and Proliferation (Oncogenic Dynamics) Aberrancy in Intercellular Cytokine Signaling, perhaps Avoiding Transcription Factors Tumor Suppressing Activity of Apoptosis (Death Signals), Independent Growth Pattern (Proto-oncogene Transformation); e) Tumor Microenvirnoment is Highly Interactive Via Cytokine Signals often recruiting other Cells and Tissue Type (i.e Angiogenesis); 1) Varied Dependency of Growth Signals but not completely Aberrant; 2) ECM is Highly Specific to Neoplasia as it seems to Mediate Growth Pathologically When Dysplasia Arises; 3) Human Epidermal Growth Factor (EGF) Receptor 2 or just HER-2 (Gene and Receptor); 4) Herceptin is an Antagonistic Antineoplastic Agent Specific to HER-2 Receptor; f) Cell-To-Cell Adhesion Binding Loss: 1) E-Cadherin are Epithelia Adhesion Proteins (Molecules Attaching Cells); 2) Epithelial to Mesenchymal Transformation (EMT) or Metaplastic Differentiation (similar to Squamo-Columnar Metaplasia a Physiologic Reaction); 3) Embryogenesis: a) Transcription Factors: 1) Twist, 2) Snail, and 3) Snug are Proteins of Migration (E-Cadherin Inhibition Mechanism); b) Migration of Development (Embryogenesis Analogous to Reverse Differentiation) is Possibly Mediated Positively by alpha-Beta Cadherin (aB-Cad); c) Breaking Out Mechanism (i.e. Neutrophil Chemotactic Function) or Motility Function Mediated by Actin (globular Polymers)/Myosin (Filamentous Structure of Protein) Cytoskeletal Mechanism induced by Molecular Signaling; d) Protrusion or Motility is a Function of Cytoskeletal Polymerization and/or Depolymerization Therein: 1) Polymerization of Actin-Filament makes forward Motility Momentum; 2) Cell Matrix Adhesion mediated by Integrin Protein Traction Functionality (Translocation Process) is Significant In Development of Embryogenesis, Homeostasis and Pathology of Neoplasia (Malignancy); PhD Adam Martin, Krankheit immer soll fahren schneller als Die Gesundheit (-Hobas). Heil!

[@sushantochakraborty4585]

Lots of thanks Sir, for imparting this wonderful lecture.

[@alexyurisimoes9704]

Another great lecture. Thanks and greetings from Brazil!

[@hugodaniel8975]

Fora Borzonaro

[@BigbaRichard]

Great lecture. Thanks to MIT

[@nadimislam5287]

Such a nice leacture

[@elpidiocastillo3342]

Thank you very much for very informative lecture.

[@abdiaden203]

Thank you very much

[@not_amanullah]

Thanks 🤍❤️

[@郑颖-m6p]

I wonder what is the signal that actin protein responding to when cell migrates?

[@not_amanullah]

This is helpful ❤️🤍

[@fei4295]

Great!

[@teresarojas7998]

46:18 xD

[@briseboy]

By this point in the class students with any mathematical background whatsoever should have pointed out the massive statistical/mathematical elephant utterly ignored by lecturers in the room: Mutations are NOT random, but highly influenced by toxic, noxious materials commonly introduced by individuals and overdensely populated human environmental products. Alcohol, nicotine, P

[@sqttttt]

you're so smart

[@Sai1ence]

If cancer is such a bad thing, then why'd they make a cancer 2?

[@matthewplays9401]

Goddamnit, u should receive an Oscar for such good joke

[@ajmod73]

the sequels are always worse

[@glenncameronjr]

Cancer is no joke. But good one.

[@Zakariah1971]

Y no mention of herpes, virology, CBD oil, and the endocannabinoid system? Major gaps in this lecture. Malpractice.