23. Stem Cells

[@ao4618]

Wow, I’m amazed at how amazing her board writing is. Just beautiful!!

[@funkyblanket15]

I like the old school way of writing on the board.

[@wuvliving8083]

I however would have liked if they mentioned a bit of how stem cells are being used to cure aging. Some deep conversations happening at the healthspan discord server (discord.gg/ftSbffu) I'm just overwhelmed that aging might actually be cured soon.

[@dannyboy5967]

Me too. However it also distracts me with ASMR---making me feel sleepy.

[@TheR971]

Her kind of axiomatic approach to the topic combined with the blackboard makes it feel like a math lecture. Good stuff!

[@deinonychus5463]

Foregen wants to regenerate male foreskin with all specialized structures, if you want to know more about it : www.foregen.org

[@Emalbee]

She does too. She writes so hard to make that sound.

[@ahsanashraf4385]

The explanation is simply lovely. I can't thank the professor enough. Thanks for this excellent lecture.

[@TonySoprano55]

Damn such good teaching quality at MiT people who go there are lucky

[@awm640]

I am 18 years old and I am in the final stage of secondary school. I am not exaggerating when I say that this is the best lecture I have ever seen in my entire life. What very excellent information, experiences and explanation. Although I do not know much English, I activated the translation feature. Your teacher is wonderful and the patience is incredible. You should be grateful for having all these tools. What is exciting about This is all 10 ten years ago 😲 I wish I could study with you, Talama. I love biology very much But unfortunately he is not financially capable What is my fault? I was born from a poor family and a poor country like Iraq. I wish I had been born in a European country so that I could achieve my dreams because my passion never ends. Stay well and sincere thanks and appreciation to you❤❤

[@fragrantbloom]

Great lecture! Thank you teacher 😊 Using the blackboard was really nice. Power points are getting boring. I could understand everything! Really helpful, thanks for posting.

[@iknowtospeak]

can anyone alongwith me, take a moment to acknowledge the beauty in maam’s handwriting and presentation❤

[@Eli-too]

32:52 regulating stem cell fate by the niche (surrounding cells)

[@jesserop3207]

Great content delivery! Succintly laid out the main points with very relevant examples.

[@allenculbertson8170]

I'm a really hugh fan of MIT OPENCOURSEWARE. I find it very informative, very useful, and the professor's explain it so it's easy to understand. God bless MIT OPENCOURSEWARE and thank you for sharing 🙏

[@yaram4727]

My professors use PowerPoint and i haaaate it ! This so much better ..

[@Synflood-dot-txt]

agreed 100% can follow everything and take screen shots

[@zopa3631]

"DESPITE THE HYPE; DESPITE THE COVER OF TIME MAGAZINE;AND THE FRONT PAGE OF EVERY NEWSPAPER ACROSS THE WORLD ; STEM CELLS ARE NORMALLY FOUND IN OUR BODIES" Loved the statement......😎

[@notgeneralroblox]

Good lecture, its kind of funny how this is now counted as general knowledge and is teached at colleges when just 10 years ago this was Uni stuff

[@kevinboone2178]

Dr. Sive's a wonderful teaching biologist. To more effectively use time -- to answer student questions, for example -- I would allow students to access notes and screen images to their phones, tablets and/or laptops.

[@garyhamilton1981]

Thank you, you have just made my Christmas revision that much easier. Many thanks

[@savaninagarkar7395]

Absolutely loved every single minute of the lecture!

[@chiyoeatyourtomatoes]

The rubber ducks are a nice touch

[@Robotbeauties7777]

This seams to be from quite solid days !

[@미후루루집사]

Wow, it's a really nice video that's healing. Thank you so much for your wonderful performance

[@swadeshtaneja3512]

Very beautiful handwriting and so is the organization and explanation

[@NehadHirmiz]

Excellent Lecture. Thank you very much :).

[@BraveFox100]

Teachers at MIT must be advised to write in the board. I don’t see this often in biology classes

[@appybee]

Thank you, Professor!

[@santoshpatil2692]

Very nice explanation of topic and using all relevant examples. Improved my knowledge thanks a lot!

[@joepup8348]

I like how the school known for technology, hence Massachusetts Institute of Technology, knows when too much technology is too much. So, they shun PowerPoint in favor of good 'ol chalkboards. Now THAT is smart.

[@EatSleepSoccer4]

Great teacher, great lecture!

[@joyfullifewithjaved2820]

Hey Amelia

[@Pakistan81621]

Hhheeeeeyyyyyyy

[@Mettabeshay]

is there a difference between differentiated and committed?

[@kmk2555]

yes, differentiated cells would be the earliest stage of a stem cell; embryonic

[@davelangford2439]

No they wouldn't. A differentiated cell is at the complete other end if the process. An embryonic stem cell is totally undifferentiated, hence why it's called a totipotent stem cell.

[@sarahk6926]

An embryonic stem cell is pluripotent not totipotent, as it can't make trophectoderm/placenta

[@kemdiahdaniels6899]

Excellent lecture, I was intrigued the entire time

[@miguelalexandroolivassalci2227]

Wow what an amazing lecture! Thank you so much!

[@michaelgonzalez9058]

The 7 layers also promit On body in small intestin

[@sherianderson3065]

High dose chemo with stem cell transplant for MS at University of Michigan, AnnArbor, MI

[@jennazhang4927]

Does anyone know where I can get more courses like this about stem cells? Thanks a lot!

[@dafnielissa6727]

great lessons. thank you!

[@michaelgonzalez9058]

Body activates everytime cell processes to active forward when

[@richardcortez6538]

Great professor great teacher 😀😀

[@sibusisonyoni1666]

Beautiful lecture thank you!

[@perryreasch1209]

A VERY GOOD CLASS

[@salmanageb9069]

محاضره غنيه جدا و محتواها قيم 🌺

[@tasneemalameri8340]

100%

[@dumbask44]

All good info much appreciated

[@aboutstudies123]

Thank you very much Madam. The lecture is very helpful

[@jackpearce1728]

Would love to see a follow-up that addresses the Problems and carry's forward to today...some 3 years forward. As she says...the promise of the future that is in most cases being advanced outside of the US.

[@stemcelltreatment]

Excellent idea Jack. That is an important piece of the puzzle that doesn't get enough attention unfortunately.

[@phieriksen]

She has the most frustrating G's

[@davelangford2439]

Her G's have been winding me up for the whole lecture!

[@Wahrscheinlichkeit]

superb professor!

[@funny11744]

Regarding the stem cells from URINE obtained after urination: HOW MANY TYPE OF STEM CELLS CAN WE FIND IN THAT URINE ? We can find only USCs ( urine stem cells ) or we can find also other stem cells ? . Is there any public protocol to separate if there are many types than USCs? Thank you.

[@AsadUllah-lr2no]

Excellent lecture

[@dr.ashutoshchoudhuryveteri9143]

beautifully explained thank you ....

[@butterflyscience6043]

Tqsm mam nice explaination 🤩🥳✨🙏🙏

[@jennazhang4927]

I love her course!

[@Nurpie]

6:00 Now there are 1.960.000 hits on Google news.

[@KintaroCellsPowerInternational]

Interesting video. How do you feel about mesenchymal stem cells therapy?

[@perryreasch1209]

LOVE THIS VIDEO

[@md.shyamuddin5660]

Maam's handwriting grabs more attention than the topic...

[@theatticmonster1110]

I may have missed something here but she stated that there might be non compatibility issues with the embryonic stem cells and a none 'genetic' (wrong word I know!) match, which is understandable, but how did it work with the hairless mice? Any responses please keep as simple as possible I've just started researching this and am yet to get into full swing. Thanks!

[@AngelaWu1]

The hairless, or we call them nude mice, have been engineered so that they have an extremely defective immune system, almost no immune system at all. Therefore, they do not have any issues of rejection. Rejection of foreign materials from our bodies is based on the fact that our immune system can recognize self vs non-self (by way of antibodies and cell surface receptors - these protein molecules are like feelers that will touch all the things that enter your body, and check if they belong to you. They can signal other immune cells to mount an attack on any foreign matters, because it could be dangerous. This is why our immune system can eliminate bacteria and viral infections from our bodies most of the time). The immune system recognizes cells from another person as being foreign, because those cells will have a different genome, thus making proteins that are slightly different from our own. Therefore, if a person has an organ transplant, the recipient's immune system will try to attack the donor organ thinking it is foreign and bad. That's why transplant patients need to taken immunosuppressant drugs to keep their own immune system from destroying the donated organ - which then at the same time makes the transplant recipient more susceptible to infections and getting sick. Now you see, that nude mouse has no immune system, so there is no 'security team' to recognize foreign matter, so there is no issue of rejection. This ended up longer than I anticipated... hope it is helpful.

[@theatticmonster1110]

Oooo yes that makes sense, I didn't know about the nude mice being engineered to have a defective immune system, good to know for future ponderings and will also stop me asking silly questions. Thank you very much!

[@maxedout360]

I can't believe its available for free 😮

[@TalkinNews]

excellent teacher

[@woloabel]

(On Tuesday of January 24, 2023). In the Matter of Biology and Stem Cells (Embryologic Non-Differentiated Hematopoietic Cells, With Homeostatic Functions of Repairing and Healing. Nice, Precise and Highly Theoretical. Potency (Totipotency [Zygote], Pluripotency [Bone Marrow Cell], Multipotent (Lymphoid Progenitor) All the way to the Commitment Absolutely of a Cell); 2) Fate is the number of Possible Axes to a Cell; Determination to Total Differentiation; Stem Cells with their Self-Renewing Capacity Have the Potential of Being Therapeutic (Bone Marrow Transplantation, Skin Cell Transplantation [Burn and Repairing with a Skin Graft]); Stem Cells (SC) Assay or Technique Therein: 1) Radio isotopic Chase 2) Florescence Activated Cell Sorting (FACS) via Sorting of Cells Via Cytological Markers ((mAbs with Radio isotopic Tags), And Laser Detectors of the Tags (Apheresis) and Computer Analysis and Deflection Assortment; 3) Repopulation Assays (BMT) for Hematopoietic Stem Cells; 4) Dilution Assay; 5) In Vitro Induction Assay (For SC Potency) with Proliferation Factors (Cytokines, Growth Factors [GFs]); 6 Embryo Incorporation (With Radio Labels and In Vitro Inoculation); 7) Stem Cell Regulation and the Notion Of Niche: 1) Quiescent SC (Cytokine and Chemokine Signals) or G0 Cells (Cell Cycle Allusion); 2) Environmental Control and/or Chemical Ecology of Cell-Cell Interaction; 3) Bulge (Collection of SC for a Hair Follicle [Basal Cells of Epithelium SC Potency]) and Niche Cells (Dermal Papillae Cells) Regulation or Control Thereof SC; 4) Therapeutics involving SCs: 1) Infusion (Intravenous Inoculation or Release) of SC for Healing and Repairing Capability (Function of SC upon Full Development or Adult Stage); 2) Embryonic SC (Variation of Potency but Zygotic SC are Omnipotent/Totipotent) And Further Segregation and Culturing of Select Pluripotent SC (Embryonic Excision Modality); 3) Ethics and Moral Considerations; 4) Induced Pluripotent Stem Cells (iPSCs)or (IPS Cells) where a Reversing of Potency Via Yamanaka Factors (Transcription Factors of Four Types or Even Less); 5) (iPS) Therapeutics and The Ethical Barrier of Embryo Irreverence or Destruction for Mere Therapeutic (Single Use Disposal) is less a Matter of Consideration and shows Promising (Perhaps the Most Ever) Beneficial And Medicinal Potential; PhD Hazel Sive is an extraordinary Biologist (Geneticist). Heil!

[@perryreasch1209]

WHAT ABOUT PEOPLE THAT GET STEM CELL THERAPY TO HEAL THEIR OWN BODY

[@hosoiarchives4858]

She’s a machine with that chalk

[@MoDro281]

I need to know what she puts in her coffee, then perhaps I’ll divulge into the complexities of stem cells..

[@not_amanullah]

Thanks ❤️🤍

[@thenexus8532]

In what experiment were they artificially found. LCD chain conveyer please I got no rna cycle brain is leaking synius

[@marcusgarrett8526]

What happens when u inject the wrong sc ?

[@undefeatable-g4h]

I really like this!

[@rojanah8365]

I loved it, thank you

[@karanjoshi2662]

720i is so jarring after getting used to 720p

[@MrAzam1991]

indeed nice teacher.

[@not_amanullah]

This is helpful ❤️🤍

[@samawrite1100]

thank you so much

[@ahmadsuperlifestc3039]

For stem cells therapy, cancer, sickle cell, cataract, glycouma, diabetic,autism,infertility, click 👇👇

[@circleofsorrow4583]

Blackboards and chalk? How retro.

[@kingjoules2581]

How about HECS or mouse stem cells. Or IPs

[@itayvaknin3036]

44:20

[@eddiedann6472]

Wowwww!!! Thanks! 👏👏👏

[@dukherdohonekorunrodone6346]

just how many blackboards are there!damn!

[@ArunRatnakar-wv8jp]

Amazing lecture by amazing teacher ❤❤❤❤❤❤❤❤❤❤❤ can i get pdf please reply 😊😊😊😊😊😊😊❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤

[@mitocw]

Course materials are on MIT OpenCourseWare at: ocw.mit.edu/7-013S11. Best wishes on your studies!

[@bliss_XD]

22:43

[@BasaBoi]

Thank you!!!!!

[@MANOHARKUMAR-ym5nl]

Tnqs ma'am

[@michaelgonzalez9058]

Which is the answe is r to powas as vone morrowh

[@SavTheSlayer]

Can stem cells help adhd for 8 year od and a 15 years old

[@MariuszKulesza-i3c]

The s.c. can replace some damaged tissue. As I am aware people with ADHD have some problems with under-expression of dopaminergic neurons, so they need extra stimulation. Maybe, in the future will be possible to replace part or the whole nucleus accumbens, which is responsible for "feeling happy" and the reward system.

[@almak8785]

Why is MIT so expensive yet the university campus is the worst

[@wenaldy]

I hate math but i love bio

[@mujtabarizvi3187]

Top Notch

[@nomoyohoo5232]

I like how she writes down whole sentences on the board. I guess MIT has really low expectations of their students.

[@AliHanafiah]

Nice

[@feyzullahfazla]

perfect

[@ronturnbull2786]

Let's talk about one of the biggest advances in bio-technology ever ... but we'll use technology from 100 years ago to explain it. Why does she need to write all of this on a chalkboard? Why not a projector with slides ... or at least markers? Much easier than writing with chalk. She could cover so much more material in the allotted time if we weren't watching her write everything while she is facing the chalkboard. It should be more like a TEDtalk where she speaks to and engages the audience while the show behind her is secondary to the discussion and does not require her full attention.

[@shirinrathod8771]

thnks

[@ashishsengupta6980]

Well now I can pass my exams.

[@tranbinh2534]

Can someone answer my question: How many kinds of adult stem cells exist??

[@pasang35]

38:50

[@Iam_Seda666]

is MIT looks like ITT a for-profit technical institute ?

[@crazydudetz]

She has an accent. Where is she from?

[@lazocrinaldojr]

South Africa

[@fayssalelansari8584]

madagascar

[@mpinci]

+Avenue X at Cicero She sounds Australian

[@ruan11221]

we need to share this because i dont whant to die. and i need some green wiskers jk nice vid

[@denizak7636]

Türkçe altyazalı olsaydı yada ayarlarda Türkçe ayarı olsaydı

[@ShakespeareCafe]

Run this at 2x speed to plow through her agonizing chalking

[@swadeshtaneja3512]

🙏🙏🙏🙏🙏🙏🙏🌹🌹🌹🌹🌹🌹😊😊😊😊😊excellentl

[@AnnaPoli800]

seriously?

[@hombrepobre9646]

the lecture is interesting but too old model way of teaching which disturb her in writing on the board, can someone lend her a projector and a remote controler to save some time?

[@Daedraheart]

the sound of the chalk sucks

[@successmagnet7816]

You guys heard of whiteboards yet?