#39 How To Heal Leaky Gut And Improve Microbiome Diversity With Kiran Krishnan & Alex Manos

I speak with Kiran Krishnan from Microbiome Labs about 'metabolic endotoxemia' (aka leaky gut).
Kiran explains what this condition is, how it influences almost all systems in the body, and how we can recover from it by considering:
- Microbiome diversity
- Key stone species of bacteria such as Akkermansia
- Metabolic products such as short chain fatty acids
- Competitive inhibition/resilience
Kiran goes on to share dietary, lifestyle and supplement considerations that help optimise these four factors.
Our team at Healthpath help people take charge of their gut health. Visit our website to learn more: healthpath.com
Order a SIBO test: bit.ly/492BPba
Order a gut microbiome test: bit.ly/47L96GU
Visit our blog: healthpath.com/blog/
Find and work with an experienced practitioner using our directory: healthpath.com/directory
Follow us on Instagram here: / ourhealthpath
Follow Alex on Instagram here: / alexandermanos
Sign up to our new newsletter: healthpath.com/newsletter/
Recommended Reading From Amazon:
Brain Maker: geni.us/kZnR
Gut The Inside Story: geni.us/JJdjiu

[@christinagrundmann3359]

I have no words to adequately express how I am feeling, after watching this. The closest I can come to is perhaps... winning a lottery, throwing open the curtains to a sunny morning after a brutally stormy night, or simply and most profoundly... the precious "A-HAH" moment. Thank you for making all those foreign sounding words, a digestible language 😌🙏❤

[@ourhealthpath]

So happy to hear you found the episode so helpful Christina! Kiran is brilliant at breaking it all down in to easy to understand info isn’t he?

[@rimora.]

Everything said here today is absolutely wild! I had to listen to this 5 times and transcribe this talk to catch every point. This has to be listened to every month so we stay on track. A phenomenal talk!

[@ourhealthpath]

Thanks Sara! Kiran breaks down the complexity of this topic so well doesn’t he?

[@wjcroft72]

Sara, hi. Are you open to sharing or posting your transcript? Would be helpful in getting wider exposure. For example you could post a Google Drive or Dropbox link. Thanks,

[@rimora.]

@@wjcroft72 KZbin already provides a transcript for this video. If you don't see where that is in the settings, ask Google to show you where it is. But these are some timestamps for some key points: - Kiran Krishnan is a microbiologist - 3:37 the most devastating part of leaky gut is the flood of the LPS toxin from your intestines into your bloodstream that goes and affects your entire body especially your brain - 4:56 LPS is measurable. you can measure how bad your leaky gut is 3-5 hours after eating which is why many people feel bad after eating - 10:13 having toxins from bugs is normal and not problematic. your problems start when those bad things go from your intestines into your bloodstream via a holey intestine - 11:00 the reason your blood getting infected is so bad is because it makes your immune system go wild trying to stop the blood poisoning. So 1 meal can cause your immune system to try and fight a blood poisoning for the next 2 weeks. - 12:37 15 years ago it was discovered that an overactive immune system fighting chronic inflammation is responsible for our major diseases. - 13:40 only in the past 7 years has it been discovered that leaky gut/weak microbiome is the root cause of an overactive immune system. - 16:18 leaky gut is progressive. leaky gut in 1 area will cause leaky gut in the adjacent part of the intestines. - 18:00 one thing that can completely wreck your intestines is weak oral microbiome. - you're supposed to protected from a weak oral microbiome but that fails when you have things like h. pylori, low stomach acid, or bad liver/gallbladder - 20:00 low stomach acid leads to liver/gallbladder problems which leads to SIBO which leads to leaky gut which leads to constipation. LEAKY GUT IS A DIRECT CAUSE OF CONSTIPATION. constipation turns all illness into a never ending cycle. Overeating relates to low stomach acid. - 25:23 LPS can go deep into your brain and affect your memory and processing power - 30:55 an overactive immune system causes neurodegeneration! And the first symptom of Parkinson’s is chronic constipation! - 56:50 there are bugs that purposefully create neurotransmitters to go up your brain and cause panic and anxiety. so anxiety can be completely caused by just your bugs

[@raewise6345]

I agree! I am on a mission to find every podcast, presentation, discussion he is in. LoL I'm geeking out and feeling BETTER!💪👍😍

[@swyllie30]

One of the best discussions on leaky gut I’ve seen. And I’ve watched a lot of them!

[@ourhealthpath]

Wow that’s great to hear Stuart! Thank you. Kiran is brilliant at breaking things down in a systematic way isn’t he?

[@timernst8909]

Kiran ties MANY loose ends together. This talk helps to explain WHY our society is slowly suffering from SOooo many chronic diseases. Bless ya Team!!🙏

[@ourhealthpath]

He does indeed! We hope you enjoyed the episode 🙌

[@Aliciaskinsecret]

I can never get enough information from Kiran. Thank you!

[@ourhealthpath]

Our absolute pleasure! He’s back on the show next week so stay tuned!

[@diannewatts2437]

@@ourhealthpath P 🇧🇾

[@raewise6345]

I appreciate the level of conversations/podcasts I can find Kiran in!! And every time I am getting new information. Amazing 😁 You are helping SO MANY people live a more normal life. We are able to participate in daily activities again ❣️

[@ourhealthpath]

Glad you enjoyed it and love Kiran so much!

[@cathyaraya7635]

Love love love Kiran! This was an excellent video! So much great info! I love it! Everyone should see this video…thank you for having Kiran on your show!

[@ourhealthpath]

Hi Cathy! So glad you enjoyed the video! We agree! 🙌

[@LisaN-vg6sp]

He has such a great way of explaining everything. Complex but also easy to understand. 👍

[@ourhealthpath]

Yes I think it’s one of the reasons he is so popular. Hope you enjoyed the conversation!

[@marystewart3096]

Such great informative knowledge! Thanks 🙏

[@ourhealthpath]

Thanks Mary! Glad you found it so informative!

[@sonibraun4971]

I love Kiran. Thank you very much for the interview.

[@ourhealthpath]

Our pleasure soni! 🙏

[@judithlyndon4521]

Brilliant guy, I need to listen this a few times to take in all this valuable knowledge. Thank you Kiran I've got hope now.

[@ourhealthpath]

We’re so glad you found the episode helpful and that you have hope now! If we can be of any support don’t hesitate to reach out!

[@MrMadalien]

Knowledge bombs. I've heard of leaky gut, LPS in blood getting through tight junctions due to microbiome dysfunction, Steven Gundry talks about it constantly. The difference is that Kiran advocates for developing a better microbiome to deal with lectins and oxalates etc. while Gundry is similar to carnivores: remove the trigger (but still keep eating veggies)

[@ourhealthpath]

Yes it’s a much more positive approach that allows for so much more flexibility. Glad you enjoyed the episode.

[@vickia6200]

Outstanding presentation

[@ourhealthpath]

Thanks vicki! Kiran’s brilliant isn’t he?

[@dularyvarma192]

Excellent video and explanation of leaky gut Kiran!

[@ourhealthpath]

Wasn’t it just? Thanks for the comment - we’lll pass it on to Kiran.

[@chrisr9162]

Thank you both. I love listening to Kiran. He is not only a great researcher but also a fantastic teacher. He takes complex things and explains them simply and clearly. I have RA and have taken Megaspore for about five years. I would get everyone on it if I could and have recommended it to a number of people with chronic illnesses. I just wish MegaPre did not contain milk as I am gluten and dairy free to help my autoimmune disease. Thanks again.

[@ourhealthpath]

Thanks Chris. We couldn’t agree more about Kiran! Wishing you all the best on your health journey.

[@wellnessimages6976]

They have a dairy free formula.

[@chrisr9162]

@@wellnessimages6976 Thank you for letting me know. I am in the UK so I buy the products over here and I might have missed that.

[@Wavedancerone]

Love him!! Kiran for prez!

[@ourhealthpath]

You’re not alone Candice! We hope you enjoyed the episode!

[@debcambria665]

Superb

[@ourhealthpath]

We’re glad you enjoyed it! Kiran was brilliant wasn’t he?

[@DoReMiMusicSchool]

Thank you for this. Do you recommend antibiotics for H-pyorli, or do you believe that it can be eradicated naturally?

[@ourhealthpath]

Sorry but we can’t make medical recommendations over this platform. We hope you understand. Treatment of H.Pylori is very context dependent - it doesn’t always need eradicating. We recommend speaking with your health practitioner/GP.

[@BendOregonwithDerrick]

Microbiome Labs actually have a supplement for h-pyorli now.

[@cherylwilliams4245]

Is megastore biotic suitable for someone who has histamine intolerance. Thanks for reading

[@ourhealthpath]

Hi Cheryl. According to the manufacturer of the product, yes it is.

[@traceycatchpole9302]

I have SIBO also my butyrate is extremely low. I have regularly taken a supplement before every meal to increase my butyrate unfortunately my latest stool test has shown me that the butyrate supplement has not made the slightest improvement. Have you got any suggestions? I also take the spore products mentioned in this video. Thank you

[@ourhealthpath]

I can’t offer any valuable advice over a comment as it depends on so much context. I hope you understand. I’d recommend working with an experienced practitioner. You can find one using our directory: healthpath.com/directory

[@geraldinemccann7714]

that is because he is the best on this subject!

[@ourhealthpath]

Hi Geraldine! He’s brilliant isn’t he? We hope you enjoyed the episode!

[@geraldinemccann7714]

@@ourhealthpath yes I did thank you .I have subscribed look forward to more videos I usually have to rely on the Americans or Austrailians 😀 but he is my no.1 🤫

[@carolynmcnulty438]

This was the best interview with Kiran Krishna. I have seen. You did a great job with the interview. Excellent information.

[@sonibraun4971]

@@carolynmcnulty438 Then you haven't seen his other ones. Esp. the ones how SIBO gets developed are very, very good. :)

[@Seeker2400]

Does your shop ship internationally?

[@ourhealthpath]

Unfortunately not nitya.

[@lisahardeman-dunn9211]

What is the exact name of the supplement that Kiran refers to?

[@ourhealthpath]

Oh sorry I can’t remember which products he mentions in this episode. It may have been megaspore biotic or mega prebiotic? If you head to our shop on www.healthpath.com and search ‘microbiome labs’ you might recognise the product there?

[@brothercaleb]

When do u expect to have mega mucosa on your web shop?

[@ourhealthpath]

Hi there. Unfortunately we don’t have an ETA so you may need to keep an eye out on the shop.

[@health-seeking]

To think the last thing I watch was your video and the first thing was your video. 😄

[@ourhealthpath]

Glad to hear you’re enjoying them!! 😊🙌

[@TermiNader5]

Is the microbiome labs megaspore sold on Amazon legit or should it be ordered off the official website?

[@ourhealthpath]

Hi later. I can’t comment on that really but I’d recommend perhaps ordering it from the official website if you have concerns around Amazon.

[@patriciahills317]

Where can I get megaspore?

[@ourhealthpath]

Hi Patricia. It’s available from various online shops - simply Google it. Unfortunately it’s out of stock on our website at the moment.

[@santiagozambrano4865]

Take L glutamine😊

[@ourhealthpath]

Yes that’s a great consideration!

[@josephroiml]

Is this guy Hippocrates 2.0 or what?