5 Scientists Who Experimented on Themselves | Human Guinea Pigs

[@SciShow]

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[@hansolowe19]

The "de" in de Hevesy is part of the name, he wasn't "Hevesy" he was "de Hevesy" 👍

[@LeoAngora]

Yes, more videos with good sponsors please.

[@YouTubePurgetheblackplague]

I want to know your explanation for why I see the moon during the day?

[@hansolowe19]

@@KZbinPurgetheblackplague it happens sometimes. The moon can be visible during the day. I've seen it many times.

[@MariaMartinez-researcher]

7:19. Huge pronunciation mistake there. The surname Carrión is NOT to be pronounced in English, but in Spanish, same as you pronounced German and French names more or less according to the original pronunciations. So that name DOESN'T sound like "carrion" decaying flesh, but like "carry on" with the stress in the "on" part. If you manage to pronounce the "rr" like the "r" in "rose" that would be the closest way to get the name right. PLEASE...

[@purplealice]

Marie Curie left samples of radium in vials all over her lab, because she liked the way they glowed in the dark. She kept a vial of radium salts in her skirt pocket. Between that, and the fumes she inhaled while boiling down mineral solutions to find new elements, she died of aplastic anemia, probably resulting from all the radiation she'd been exposed to.

[@mrjoe332]

But didn't we figure radiation can kill a person just after it killed Curie? Still yeah, that's a bummer

[@Ewr42]

I thought it was leukemia

[@user-yv6vx]

@@Ewr42 both conditions destroy the bodies ability to create new blood cells, so perhaps that's how the two got confused.

[@Ewr42]

@@user-yv6vx where exactly is the confusion tho? Which was it? does it even make a difference at all? How can we know for sure and how much do we actually know about her case? For all I know she got her life force slowly sucked out of her by magical green dust and if all we had to work on was she being too pale and weak that'd be a hypothesis as valid as any other, maybe not reasonable or coherent with reality, but it'd still be a valid interpretation without knowing more than that So what do we know and what about what we know tells us it was one and not the other?

[@mimisezlol]

@@Ewr42 people were able to record information about diseases and conditions at that point. She was killed by aplastic anemia, which may have been caused by her use of unshielded X-ray equipment during world War I

[@ConstantChaos1]

For anyone wondering the way/reason heavy water kills you is that it is slower to react so it slows metabolic processes which we all know are literally what keeps us alive

[@idontwantahandlethough]

I WAS wondering that, thank you :)

[@Paul-A01]

Sounds like you'd have to drink nothing but heavy water until it made up a significant portion of your body mass.

[@ConstantChaos1]

@@idontwantahandlethough extra tidbits: Heavy water is slightly sweet And There are actually even heavier waters that aren't radioactive that involve O¹⁷ and O¹⁸

[@ConstantChaos1]

@@Paul-A01 unfortunately it is not that easy, especially since the more heavy water you consume the more of heavier waters you would consume (there are 9 non-radioactive forms of water on earth from normal H2O to single deuterium water to deuterium oxide with oxygen 18)

[@Sapphire3759]

@@ConstantChaos1 "the more heavy water you consume the more of heavier waters you would consume" Does this mean they combine to create different variations of heavy water?

[@borttorbbq2556]

I mean when you consider it's one of the few ways around ethical legalities

[@borttorbbq2556]

But I'm not saying it is a complete bypass to ethics but it is typically not something that'll get you in prison for testing something on yourself to my knowledge

[@borttorbbq2556]

By the way if I remember correctly you have to replace something like 14% of the water in your body with heavy water before it actually starts impacting basic functions because tap water contains deuterium so your body does have the ability to use it it just isn't as good as standard hydrogen

[@shreyasbhatt7112]

@@borttorbbq2556 did you just reply to yourself twice?

[@borttorbbq2556]

@@shreyasbhatt7112 yes it just keeps things compact it's a habit from certain types of videos I watch so I just tend to respond within my own comment to put everything I have to say in one spot so you don't have to go searching for other things I've said

[@borttorbbq2556]

@@shreyasbhatt7112 so I watch a lot of young Earth creationism and Flat Earth and other pseudoscience debunking quite often and when I respond to those or I watch you know a person's response to it how often put all of my personal arguments that I would respond with in the single comment it is also partially for bookkeeping for myself as I can just find my things in people's comment sections and just find everything I talked about there in any references I may have used for bookkeeping and the future when I start creating my current videos I just haven't decided to do it yet. Also I want to get a decent gaming headset so I can have a good mic and good return sounds noise canceling all the additional features of that stuff has

[@jeffreybernath6627]

I was hoping this video would contain a chapter on Barry Marshall. He and Robin Warren believed that a specific bacteria, H. Pylori, could cause stomach ulcers in humans. They were unable to convince their colleagues, who thought ulcers were caused by stress, and that bacteria could not survive in the acidic environment of the stomach. So Marshall drank some H. Pylori, and within days he had severe ulcers, and H. Pylori living in his stomach. This was how he convinced his colleagues of the link between H. Pylori and ulcers.

[@francistaylor1822]

I think this was a glaring omission as well.

[@General12th]

I'm not sure this list was supposed to be comprehensive.

[@scriptureSolace-13354]

Came here to say this. This is one of the foremost examples for scientists experimenting on themselves.

[@General12th]

I looked it up and it turns out SciShow already did an episode on Barry Marshall back in 2017. The video title is "The Man Who Tried to Give Himself an Ulcer... For Science". You could argue Stefan should have mentioned him again, but they've certainly already covered him before.

[@AnteBrkic]

Surely their colleagues should have been the ones who are drinking Pylori since they didn't believe it is harmful? 😁

[@melodyszadkowski5256]

Landsteiner also co-discovered the rh factor in 1940. My mother suffered 3 miscarriages due to rh incompatibility in the late 1940s so glad they eventually got the word out.

[@jessicaharris1608]

I'm grateful for the knowledge about the Rh factor since my mother is -O and my dad is +O. I'm the first born and I'm +O so I wouldn't have been affected by her Rh negative blood but without the treatment she got after my birth, my brother also with +O would never have made it. I wonder how many miscarriages occurred in past centuries were due to Rh factor incompatibility.

[@brentgroen3204]

"Now onto another person who liked to consume things from the lab: Carl Wilhelm Scheele, who worked with cyanide and arsenic." When he said this you just know hes gonna die

[@ninjakiwigames5418]

Yup

[@smokeduv]

I'd add Barry Marshall to the list by discovering H. pylori and linking it to gastritis and peptic ulcer disease by ingesting a vial with the bacteria to prove it and be awarded a Nobel Prize for it

[@seratheeducatedfeline4227]

Dude threw back a bacterial culture like a uni student doing shots on a night out.

[@janetf23]

My favorite unsung scientist was the US Air Force doctor at Travis AFB who cured my ulcer, (due to Helicobacter pylori bacteria) in 1971 with an antibiotic; long before Marshall (experimenting on himself) and Warren were recognized for their Nobel prize winning work with H. pylori. Thanks, doc, whoever and wherever you are!💖

[@NewtonMD]

You mean helicopter 😏

[@NewtonMD]

In just 50years, medicine is a different thing. I wonder what will be different in the next 20years

[@rukbat3]

I kind of thought this video might talk about Donald Unger, who only cracked the knuckles on one hand for 60 years to find out whether it caused arthritis or Justin Schmidt, who deliberately lets bees and other insects sting him on different parts of his body so he can rank how painful it is. But the ones it does talk about are fascinating, and it just goes to show that there must be plenty of other examples. Maybe enough for a Part 2 sometime?

[@vangu2918]

I second that.

[@Master_Therion]

Yes, Daniel Carrión, who was a medical student at the time, died from giving himself Oroya fever. Obviously he didn't win a Nobel Prize but he did get several degrees.

[@js66613]

Should I feel bad because this got a chuckle out of me?

[@redjsaceda9264]

Hi dad

[@phyllo8958]

Oof

[@dwaynewilliams3077]

😂 I see what you did there!

[@saumitrachakravarty]

6:53 Although biology textbooks cannot get over the enthusiasm of the concept of universal donor and recipient, the current practice in medicine only ever allows the transfusion of AB or O group based on that "universal" concept under very special and/or emergency situations. The standard practice is to match the group EXACTLY, no matter what group it may be. Also there is Rh typing and tests for minor antigens as well as cross-matching. You cannot be too careful with transfusion because any slight mismatch might result in death every once in a while. It is time science communicators and school textbooks rectify this dangerous relic of information.

[@Ewr42]

Isn't there like a significant amount of people in India or smth that have a weird blood type?

[@saumitrachakravarty]

@@Ewr42 I could give you specific answer if you ask specific question

[@Hayden-rc1ru]

Yeah, I used to date someone who was a lab tech, and he'd handle blood tests for emergency and non-emergency transfusions, and he told me the same. That there's much more to it than A, B, O and Rh- and Rh+, and that you can't just match a O- bag to someone even if the situation is fairly urgent. Once, he got yelled at by a freaking _doctor_ because he insisted the blood needed to be tested and that no he wasn't just gonna send O- and risk killing the patient.

[@Migul011]

6:40 so between Landsteiner and 5 other colleagues they accidentally discovered that they had three different blood types (A, B and O)? Quite a lucky sampling, especially considering that type B is quite uncommon in Germany/Europe

[@goodguycarl]

Luck and fate in life is funny innit

[@juliaspoonie3627]

I don’t know if I would consider it rare here in Austria, 41% have type A, 37% type O, 15% type B and 7% have AB. I agree that they were lucky to detect all 3 at once but they had a decent chance.

[@fvckyoutubescensorshipandt2718]

Reminds me of how the artificial sweetener sucralose was invented. Supposedly the lab was actually trying to find a new more effective insecticide with less environmental collateral damage and the head scientist told an assistant to "test these samples". The assistant mis-heard him and thought he said "taste the samples" (??? Taste something that supposed to be a bug killer? Umm ok). So he did and noted on how it was so sweet it also had a burning sensation (200x sucrose/common sugar). Thankfully no poisonous effects were noted at the tested/tasted dose. And this was in the mid-1970's when you'd think things like that didn't happen anymore.

[@mackdog3270]

This is a very interesting subject. I was reading a medicolegal book from the 18th century and in one section they were discussing carbonic acid (carbon dioxide/monoxide) and nitrogen and what effects they had on people: those who survived exposure and those who didn't. It was mentioned that the author got his information from scientists who had inhaled the various gasses. It was a neat thing to read, you could tell that they were very nearly there in their understanding, but not quite. They understood that there are asphyxiants and gasses that act differently, but not the mechanisms.

[@birdwatching_u_back]

Other excellent examples, imo, would include anybody involved in psychedelics research in their very early development. Albert Hoffman first took LSD completely unsuspecting of the wild experiences about to ensue, for instance. Later on, Alexander Shulgin synthesized, consumed, and pharmacologically documented hundreds of novel psychedelic compounds. Lots of stories like this are out there...I’d highly recommend Hamilton Morris’s journalism for more info on these wild scientific escapades for more info :)

[@Ewr42]

Check out recent comments for my story on how I tried to find out if Psychotria trichophora had DMT and/or MAOIs by self experimentation I didn't say it in my original comment, but I did feel the slightest ayahuasca-like trip with them Not the one you get from an ego-killer dose, but from "micro"dosing Ayahuasca, stronger than any LSA trips I've had/tried to have. Even if it does have DMT/MAOIs, it's by no means a safe plant and it almost killed me for trying to smoke it. And I didn't find out exactly if it really does have them bc my attempts at thin layer chromatography failed spectacularly and I didn't try again yet

[@csn583]

Came down here to say this list is ridiculously incomplete without Shulgin, who made and personally tested more tryptamines and phenethylamines than anyone ever has or ever will. Many hundreds! He also had a test group of friends, and his wife, who were offered any that passed his "phase 1 trials". "Phenethylamines I Have Known and Loved" (PiHKaL) is a great autobiography of his life and Wild West psychedelic science.

[@piggythepimp]

Wish John Stapp had made this list. He strapped himself to a rocket sled to study the effects of deceleration. After initial tests with many participants he went on to be the only test subject and on his final run experienced 46g's of force, also breaking the land speed record at 632mph. But beyond that he saw the importance of seat belts in cars at a time you had to buy them ffrom an auto parts store. He lobbied with companies and politicians to get seat belts included in every cart. Today I found out has a great story on him which also details Murphys law funny enough

[@vgman94]

Scientists who go this far for science deserve the highest respect. Moreso than anyone else IMO.

[@NobleWolf33]

Agree

[@mrjoe332]

While it is true that their sacrifice did great impacts and helped advance their scientific field. I think it's on the best interest of everyone to not encourage that kind of self destructive behaviour. A scientist that lives to make 10 small discoveries is just as good as one that kills themself to make a big one.

[@jamesburgess2k]

I disagree. While there were instances where they didn't fully understand the risks they were putting themselves/others at due to the limited scientific knowledge at the time, you still shouldn't get credit for endangering your life or someone else's in the "name of science". At worst, you're causing the death of a great scientific mind and at best, you're cutting short the life of a great scientific mind just for a few experiments (that with more safety precautions, could've been solved a few years later).

[@huldu]

I agree with this. These are people that are determined to find a solution to a problem - without necessarily risking the lives of other people. They'll go to great length to prove something. Obviously this is a *very* treacherous road to walk but sometimes it pays out in one way or another. Personally if I had a choice I'd rather live a short meaningful life than a long pointless one. Most people are the latter.

[@pierreabbat6157]

Jack Barnes tried touching jellyfish to find out which one causes Irukandji syndrome. The one he found is called Carukia barnesi for him. (Other species in the order Carybdeida can also cause Irukandji syndrome.)

[@nathaliedesrosiers2104]

Alexander (and Ann) Shulgin comes to mind for me. And the scientists/authors to who take novel psychoactive drugs to report on the effects or to collect samples for metabolic determination.

[@Ewr42]

How about the ones who almost die from doing that? I didn't publish anything more than KZbin comments, but I've found Psychotria trichophora's berries to be mildly dissociative, probably highly rich in DMT and/or MAOIs, but I also almost died bc I tried to smoke its leaves/flowers No replications whatsoever or plans to do so and my tlc attempts failed spectacularly, but I did have my blood drawn the morning after getting deathly sick, I'm just not sure anything will have shown up bc I asked about if they could detect the sodium monofluoroacetate but the nurse and the receptionist didn't even understand what I was talking about, so I'll probably just have my levels of c reactive protein and other blood/pee data Anyway, full comment on "recent comments"(if it didn't get obscured by thousands of other comments already)

[@TW-lt1vr]

Y'all should do a video on "the golden blood type." Rh-null

[@krista2216]

They have, I just can't remember the title. Look back, it was a couple of years ago. Something about a dangerous blood type.

[@AnnoyingNewslettersPage6]

Moral of the story, if you suspect lead exposure to your garden, don't eat potatoes or other tubers.

[@rehnahvah]

An expansion of the first story would be a good video for SciShow Pee. It's been a while since there's been a video on that channel.

[@avaboaudione]

"Until he died in his lab from a unrelated heart attack." Yeah right, unrelated my ass!

[@kitchengun1175]

oh wow, I caught a fresh episode of scishow

[@sunny_muffins]

You forgot to mention how Dr. Curtis "Curt" Connors experiment went wrong and turned him into *The Lizard*

[@kelbygassett1389]

1984, Barry James Marshall, drank a cultured sample from a patient's endoscopy. Discovering the bacteria H.pylori and its role in gastric ulcers, by developing the same ulcers the patient was experiencing.

[@jonathanbalagtas848]

Respect and be grateful of what we have now because of scientist like them. 🙏

[@vimalkapur1]

We owe gratitude to many unsung heroes for the progress made possible in different disciplines.

[@calindiaconu6866]

I've just been to a screening of "The Fly" and this video is in the feed :)

[@FearlessP4P1]

God bless these dudes. We wouldn’t be here without the giants before us and it’s not acknowledged as often as it should be.

[@Leo_Lionhart]

Every person in Jackass series deserves a Nobel Prize. They are all pinnacles of human self-experimentation, without them, we will never know EVERY painful experience they have gone through and how to scale those SCIENTIFICALLY. Please GIVE them a Nobel Prize and HONOR them humanely.

[@lucettacole4617]

Soooo....i have a question. Is oygen actually odorless/tasteless or are we so desensitized to the taste/smell that our brains ignore it?

[@Ewr42]

Higher concentrations would be stronger, if we're desensitized at birth, we can't ever smell it and if we don't smell it it ain't got a smell Bc nothing does, actually, smells are hallucinations just like colors, not properties of objects, but our brain's interpretation of something that appears to be correlated to that object We'll never know, because if you could live without inhaling oxygen, and then you did, it'd be like opening your eyes to a flashlight after an accident, too intense of an experience to even process with reliability The fact is, as it exists in the atmosphere, perceived by human brains through respiration, it either has absolutely no smell, or is a huge part of what we define as "no smell" in the first place. My point is that your question is too deep for science, it actually fits better as a philosophical question in the shape of "Can we even know at all if oxygen is odorless?" And if you ask me, anything besides "I think therefore I am" is pure speculation based on made up axioms, assumptions and other logical cheats. We don't _Know_ anything at all, never. We explain stuff based on what we think we know(because it seems to keep being) and it works amazing up until the point where you question the true nature of something Then it's when I apply Heisenberg's uncertainty principle to the quantum information that exists about something and the ways we as humans can extract it from the fundamental levels of energy, through what we perceive as being the material world, and because quantum information can't be duplicated perfectly, you'll either destroy what you try to measure or you won't be able to fully measure it. Uncertainty is inherent to any and everything that manifests itself through the material world, certainty is but the queen of all illusions, it is precisely what defines delusions and it's only *_defined_* to be correct through consensus. So in short, I don't know. But they who say they do know, know even less than I. If you accept the common assumptions tho, you can try to invent an experiment to see if smells change in other gasses or something other to determine whether or not there is something humans can perceptually measure about oxygen besides our parasympathetic physiological reactions to low levels of it, I've heard that pure oxygen makes you dizzy and lightheaded or something like that

[@PrestoJacobson]

@@Ewr42 “so in short, i don’t know. But they who say they do know know even less than i.” lol🤣

[@ConstantChaos1]

The 4th one sounds like Syphilitic hepatitis which was also native to those regions Edit: to clarify I am remarking on the fact that they share a superficial pathology and are from the same place and I think that's neat

[@ConstantChaos1]

@@AndrewTBP oh yes I know it just sounds similar, im well aware they're different (or at least I would hope I knew that, im a healthcare provider lol) I was just remarking on how it's interesting that 2 diseases from the same region had similar pathology

[@STONEDay]

High like learning [reading] about scientists who experimented on themselves with plants n such back in the day.

[@elliott614]

Alexander Shulgin is the first to come to mind given the video title. I skipped through and it appears he was left out???

[@gaillewis5472]

I was hoping to hear about h pylori and how some ulcers are caused by bacteria. Part 2?

[@supersophisticated9943]

Hey. I just wanted to say I'm one of these kinds of people. When you're a serious enough scientist, you simply accept that your death (or worse) will be something you have to risk. I work in the field of drug research, so there is a lot that can go wrong, especially with the specific type I focus on. I could be risking heart problems, liver damage, dementia, serious seizures or strokes, and tons more things. So far, all I have is psychosis, what seems like either anterograde or dissociative amnesia, and some light HPPD. However, those things were all caused by *unrelated accidents which were actually what INSPIRED me to do the work that I do.* So there you go. I don't think my name will show up anytime soon alongside these, since my work is more in the shadows and likely not cared about by most, but I am glad to risk loss of myself for science, just as they did.

[@jeremiasrobinson]

Alexander Shulgin comes to mind when I think of questionable self experimentation.

[@jeremiasrobinson]

@Censored Opinions Luckily, science exists for more reasons than just to indulge your personal desires.

[@MountbattenMusicVideos]

Isn’t it gravity (10N) that helps the plant for any heavy material to remain in the roots, while only lighter material travels higher up into the plant?

[@saumitrachakravarty]

I was expecting an entry of Dr. Barry Marshall for ingesting H. pylori bacteria to establish it as a causative agent of peptic ulcer disease. He and his colleague got Nobel prize for the discovery. The therapy and diagnostics based on their discovery has saved millions from untimely death and lifelong misery. So it was not too much to ask! Maybe you can dedicate a whole episode to this.

[@Ewr42]

After so many comments, I'm sure they will

[@mayaenglish5424]

They already have a video on that very case! It has it's very own special video like you suggest lol. They did it in 2017. kzbin.info/www/bejne/foGZi5lnm8tqidk

[@LucyRoseLuna]

now I know that my blood type isn´t the number before 1, but the first letter of ohne

[@eduardobarros6562]

Here's one thing I didnt get with blood types: If type O coagulates when in contact with A or B, how can someone with O type donate to someone else? Wouldnt their blood coagulate inside the reciever? What is done to prevent this?

[@azuradawn5683]

@@samarnadra This was incredibly helpful! Thanks for taking the time to break it down like that!!

[@margaretdonahue9284]

@@samarnadra your " over-simplified" explanation 🤯. Some times simple is better 😂☮️❤️🕯️😎

[@eduardobarros6562]

I understood that part, but what doesn't make sense to me is about the donator blood attacking the reciever blood. Since, I dont think there is a way for the blood cells to know if they're outside of their original body or simpli recieving blood from another body, what is there to stop the O type, with anti A and anti B, to attack the reciever with A type and antigen A. The antibodies dont just die all of a sudden.

[@kenneth7894]

@@samarnadra best explanation ever

[@MerkhVision]

I can’t believe he said “1, 2, Pee” with a straight face hahaha

[@AwesomeIan135]

I mean the third guy sounds fine (assuming sterilization procedures were done when collecting the samples) then the only criticism I would have for him is that he should have had a larger sample size.

[@telotawa]

albert hoffman and alexander shulgin are interesting self-experimenters :)

[@TheLottus]

They called it type O, short for “oh no” hahah

[@lyven9872]

I think blood O was actually type zero, but it was wrongly read as O, and it stuck

[@bobmcclure8069]

'Easy as One, Two, Pee...' HA!!!!!

[@marcuspradas1037]

Isaac Newton pierced his own eyes while researching the nature of light

[@dominic.h.3363]

Props for the actual effort that went into pronouncing the names well enough that they were recognizable by natives of the mentioned gentlemens' respective birth countries, without having to follow the accompanying text. An actual, acclaimed youtuber (still nowhere near your subscriber count) made the argument that he deliberately mispronounces names according how Americans would EXPECT these names to sound like, so it would be easier for them to recognize a name they have probably (mis)heard before. An utterly ridiculous notion in my opinion. (Same guy doesn't send his questions to non-native interwevees ahead of time, and doesn't put subtitles under their arduously improvised answers, so yea...)

[@tru7hhimself]

do you think so? scheele is pronounced "as americans would expect" in this video.

[@dominic.h.3363]

​@@tru7hhimself Yes, I think so. Scheel or scheile make no difference whatsoever, while Carl is pronounced at least 3 different ways even between German speakers, take it from someone who has spoken German essentially all his life. This deviation is to be absolutely expected even between different German/Austrian dialects. Try to speak to anyone in Salzburg with an education that makes you fluent in standard Hochdeutsch and you will be in for a hell of a surprise, you'd have more luck with understanding Dutch or Afrikaans. Hungarian however has absolutely no dialects to speak of in the sense English or German would have, there is so little deviation from the standard, that there is no such thing as one Hungarian not understanding any other Hungarian on the planet, and Hevesi was the clearest pronunciation of a non-English name from an English speaker I've ever heard (Hungarian "e" is not the same as any other "e", quite sneaky) and as a translator of transnational projects for 15 ongoing years, I've been accustomed to hearing all sorts of non-native speakers speak all sorts of languages. He nailed it...

[@outofcontrol4499]

Might I suggest we fast forward a bit to Colonel John Stapp? The original rocketman.

[@angelitabecerra]

"Easy as one, two, pee" 🤣

[@scarletletter4900]

And this is just a list of some of the tamer examples. Some of these guys into full WTF-101 territory in thier pursuit of knowledge.

[@cassieoz1702]

Heavy water is still used to calculate energy expenditure in test humans

[@erdnalickeroftoads2143]

I want to study the brain, psychology and toxicology. To be frank what I am testing rn is just what any physician would do plus some theories I come up with sometimes but it's still all over the place and so far has produced nothing really... I know my goal, I know how to set up everything, I simply need to acquire the necessary monetary resources and I will soon be ready to start my self study. I shall keep you updated.

[@rugvedkulkarni1593]

The segments for parts 2 and 3 are combined in the scroll bar menu.

[@timclark7507]

I thought for sure Barry Marshal would get mentioned.

[@mayaenglish5424]

kzbin.info/www/bejne/foGZi5lnm8tqidk

[@danparish1344]

I’m surprised the x-ray lady wasn’t on here.

[@Ewr42]

I consider myself a scientist that's experimented on themself as well (I think i didn't die tho, but I'm pretty sure I should be dead now) Tl;Dr: I'm so stupid I almost died bc of it You know Psychotria trichophora? I'd be surprised if you did, because it has no common name at all and is mislabeled in most of the internet alongside pictures of p. Hoffmanssegiana, and also, there's literally only 5 "papers" on it, two barely even mention its existence at all(flukes), two are the exact same one about the seed formation morphology, and the last one is half a page long and looks like a HS project, like, it had less information than the draft one makes in their own head before writing a full paper. It has bright-blue purplish berries that come in a bundle of 5-8 fruits iirc, 2 seeds per fruit, they're white on the inside and taste better than grapes, they're not as sweet but for a completely wild berry I think they're amazing. The most defining characteristic of the species is the hairs that cover it(thus *tricho* -phora) on the stems and leaves, making it have an angelical aura when looked at against the light. After testing the berries in my skin, then chewing them up and spitting, then eating a couple ones; and having felt no side effects whatsoever besides diuresis after many hours, I concluded that the berries are probably safe to eat.(further research is needed but unless I'm the only one immune, eating a couple ones is ok) But I'm also stupid and after a couple days I decided to smoke(yup, that kind of stupid) the leaves and flowers for no reason besides being stupid. Well, about 20hrs later I came up with an unbearable headache that just wouldn't go away with meds nor by sleeping it off, then I started to vomit profusely until there was nothing left, then I went through green bile, yellow bile, red ~bi..~ blood.... At that point I was sure I would die right there and then, bc after 4hrs of vomiting basically non-stop, not being able to keep any water down whatsoever and just feeling the worst sickness ever, I still didn't show any signs of getting any better, so I went to bed anyway and just thought "if I have to vomit again I'll do it on the floor, and if I have to die I'll die lying down comfortably, at least(and fully aware of the risk of both happening simultaneously)" Then I woke up feeling a bit better, ate half an apple, drank a lot of water with hydration packs diluted in it and went to the doctor to get 500ml of IV saline and a list of medical exams to take, which I did as soon as possible (the saline solution and doctor visit and all were all free, but the exam results aren't and I can't pay them yet, but it's been 4 months and I'm alive(I think) so I don't even expect much, I took them mostly out of curiosity) After a LOT (pretty much exhaustive, I'd say) of research, I've narrowed it down to a toxin present in other plants which name's sometimes appear with the right photo of p. Trichophora wrongfully mislabeling it with a name that's never used to describe it anywhere else at all. Which is Sodium monofluoroacetate and from what I gathered, it kills cows that eat its leaves and I assume that the toxin is concentrated in the trichomes, hence the lack of a reaction from eating the berries, and why after consuming the leaves/flowers which have them I had an intoxication precisely within the textbook-set "time for symptoms after consumption " window for sodium monofluoroacetate. So if anyone ever wondered what'd be stupider than eating an unidentified berry that's a shade of blue so beautiful that it screams "toxic", smoking it is stupider. --------------------------------------------- If you ever do, for a miracle, find this plant, sodium monofluoroacetate is water soluble, so if you want to be less stupid than me, at least consider washing and boiling it a couple times, throwing the contaminated water away and putting fresh water in, before eating it at all, as a Jam. I also tried to do tlc with it against Ayahuasca, DMT (p. Viridis crude extract, fresh), and MAOIs(crude b. Caapi extract, fresh), and I had coffee(brewed) as a control, but by now you should've ~somehow~ realized that I have no idea what I'm doing and I just pretend like I do, so unsurprisingly after putting them in acetone to develop it and leaving them in a bag after dry, for weeks(till I had an uv light), I put them under uv and didn't see anything(not even the MAOIs which should fluoresce).. I think that literally everything, at every single step, was flawed in my attempt to do tlc with it tho Anyway, I have much more data about it if any toxicologist wants a case study and I have easy access to dozens of individual plants if any biologists(from AP bio to post-doc) wants easy papers on a plant that's not yet truly known to science just yet

[@adricortesia]

When you said at the beginning that people won Nobel prizes with those experiments I automatically assumed Barry Marshall comes up on this list. He experimented on himself with helicobacter pylori the culprit of gastritis.

[@lohphat]

I wonder how the kidneys deal with deuterium in the osmotic process of extracting water and waste from blood.

[@stephss]

If we had a "society" that would trust science and practice better Informed Consent; non-humans animals wouldn't be (as) exploited.

[@JackClayton123]

I’m surprised you didn’t discuss H. Pylori

[@Theoryofcatsndogs]

We all owe these guys a beer.

[@mothra24]

Aww, no Albert Hofmann? :(

[@tailsofpearls]

I though y'all we going to mention the dude who ran a wire from his arm to his heart during a PRESENTATION to prove it was safe

[@josephpacchetti5997]

Interesting Video. 👍 Thanks For Posting. 🇮🇹 🇺🇸

[@aaronnester5132]

It doesn't "have" deuterium, it IS deuterium.

[@samuelowens000]

Water is h2o. To make heavy water the hydrogen is replaced with deuterium, meaning heavy water is d2o. Heavy water isn't deuterium, it's a molecule with deuterium in it.

[@elinope4745]

heavy water is mildly radioactive, you are simply factually incorrect. The tritium in heavy water is radioactive. It's very difficult to get deuterium only heavy water and that specific kind wouldn't be radioactive, but it can be under the right/wrong conditions.

[@nathanandsugar5252]

If popular media is any guide consuming lab test gives you superpowers. Don’t try this at home unless background music appears out of the ether.

[@yaragorm]

Can’t believe they forgot about Michael Morbius. 😏

[@lukeadams1708]

Barry Marshall and helicobacter Pylori

[@mayaenglish5424]

They already did that one: kzbin.info/www/bejne/foGZi5lnm8tqidk

[@mojosbigsticks]

Fascinating

[@General12th]

Hi Stefan!

[@RobertTLongway]

I was expecting the guy who experimented with g forces to be on the list

[@n1k0n_]

Don't forget the greatest of all test tasters... Alexander "Sasha" Shulgin. 🤯

[@jcspider7259]

Imagine, for just a moment, the atrocities of 2022 that science will look back on in another 100, 200, 300 years...........

[@paige1925]

This is the 300th list show!!

[@UGNAvalon]

“Lemme just inject myself with this harmless disease so I can document its progression…” “Umm, boss? You’re expressing symptoms of a fatal disease..” “…crap. Um, ‘for science’, right? 😅😓😫”

[@leecrawford6560]

oh, dang this was pretty cool

[@ahuman217]

You missed the perfect Darwin award joke in the intro when you were talking about ones who lived and the ones that died.

[@YoJesusMorales]

What? Only 5, the dude that won the latest ig nobel for, I think it was history or anthropology, was doing enemas in the 80s(? because the Mayans did them for medicinal and ritualistic purposes.

[@IIARROWS]

If the second experiment wasn't a failure, it would have created the Flash.

[@mastod0n1]

3:58 how does one taste a gas?

[@evelynlamoy8483]

welp. time to do some garage science on myself and get Xmen powers.

[@TagetesAlkesta]

My favorite will always be Albert Hofmann

[@FedJimSmith]

Passion outweighs Safetiness

[@SteventheGrey]

No love for Albert Hoffman?

[@pattarleonard5397]

wheres shulgin at

[@southernflatland]

You forgot where Isaac Newton stuck a needle into his own brain to study vision...

[@chillgates9892]

You forgot Norman Osborn

[@D1GItAL_CVTS]

Not including Sasha Shulgin on this list is a crime against humanity.

[@jeremygalloway1348]

I experimented on myself with drugs as a teen. Lot of fun...gained alot of knowledge and resources research was mostly fun

[@Thnielsen85]

Great and interesting video :) But Niels Finsen died age 43, not 44 ;) dec.15 1860 - sep 24 1904

[@poorboybmx2511]

Enjoyed your video although was bemused at the statement on Wilhelm Scheele's death at 43 was a possible cause of his experiments when the average lifespan in the 1700's was 35.

[@RedXiongmao]

That number is skewed by the fact that 1/3 to 1/2 of people back then died before the age of 5

[@itsdonaldo]

That poor scientist who tested Preparation A through G.

[@jonatanromanowski9519]

Go Go Sci Show

[@chearoth5093]

not try this at home! So that mean try this at school or park or restaurant ect is okay?

[@rsk6929]

What about the chemist who made lsd!