A debate between Vadim Gladyshev and Aubrey de Grey

Is comprehensive damage repair feasible? A debate at Undoing Aging 2019 between Vadim Gladyshev, Harvard Medical School and Aubrey de Grey, SENS Research Foundation
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[@mikecottrill9789]

Wow, if only political debates were as respectful to the other person as this debate.

[@josephbach1]

in politic they always forget that they all sit in the same boat and have the same goals.

[@kral3046]

Aged like sleepy Joe

[@JBPVFL]

Gladyshev could be right, but I personally do not like all of the “not possible” coming from him in a science that is very young. The words not possible or impossible shouldn’t be mentioned. Great debate gentlemen!

[@BattousaiHBr]

true, but in the context of a topic as prone to wishful thinking as this, maybe a bit more down-to-earth attitude is also good.

[@slightlygruff]

Then there's Musk. He never says impossible

[@slightlygruff]

Nobody wants to believe Vadim is right)

[@SebastianNiemann]

Live Long Enough to Live Forever 😉

[@professorscambuster3063]

That's the ultimate goal. :)

[@mikewazzupski]

@Adrian 19 here :D

[@mikewazzupski]

Adrian i saw another cool video about this kind of stuff check out David Sinclair if youre interested he has done a podcast with Joe rogan also if you like that. We certainly live in amazing times

[@user-cr3db7cb8n]

I’m 20 I have faith I’ll at least live to 120

[@AG-qo5vt]

I'm 25 but tbh I don't know if I'll make it

[@lawrencegatley6157]

Thanks for uploading these videos for those of us who couldn't make it. Looking forward to the next one. Excellent to see robust debate over solutions.

[@nozhki-busha]

I watched this on the day and it was very interesting, it is good to see it again. I agree with Vadim that repair and reprogramming approaches both have merit.

[@professorscambuster3063]

It's nice to see a friendly debate consisting of technical arguments. I'm sick of people using ad hominems. I have legitimately read comments from people saying that effective medicine for the elderly can't happen because Aubrey's ex-wife has bad teeth. On a related note, I'm sure you can't be specific with the details, and that's fine, but will there soon be another LEAF-sponsored mainstream KZbin video? I'm thankful the big KZbinrs who make videos in support of rejuvenation biotechnology get a mostly positive reaction. Hopefully those same channels start treating cryonics with the same level of respect soon.

[@ildisiri]

@@professorscambuster3063 my favourite is "If anti-aging is so good why does he look (make himself look) so old?" cracks me up EVERY time.

[@professorscambuster3063]

@@ildisiri Oh, you're right, that's a classic. My response to that is "how can anyone benefit from medicine before it's created?" - those pessimistic people looking for reasons to whine never have an answer for that. :)

[@AndyNyle]

Gladyshev is one of the most creative, forward thinkers in aging I have come across.

[@professorscambuster3063]

Great video and I'm looking forward to LEAF's Ending Age-Related Diseases conference as well as the next Undoing Aging event. :)

[@anthony1003]

If you're a professor, especially in any biological fields, then I would appreciate it if you could direct me to the kind of undergraduate major/path and later PhD that would lead to researching aging?

[@fourthz4460]

havent even watched the video and i already gave it thumbs up xd been wating for this vid for like a month now

[@josepbru5402]

Great debate!! The first debate I see about the most important issue in the world! How can it be?

[@SilverFan21k]

Hello thank you very much for posting this for the public to view.

[@fourthz4460]

I like vadim. He is very skeptic about the sens approach (which is fine, he's got a point) but he doesnt have to be insulting like that oxford professor Blakemore. In my opinion that Blakemore guy was disgusting in his debate with Aubrey (its just my opinion)

[@LuigiZhou]

I was very interested to hear the other questions at the end of the debate. Is there any link to the continuation?

[@MEgmbh]

So am I, if I remember correctly at the conference there were quite a few more interesting questions asked.

[@ildisiri]

I'm interested in that too, questions are on point.

[@slightlygruff]

Probably those questions put Aubrey in even worse light

[@gymguy1765]

@@slightlygruff lol

[@snorttroll4379]

Point on the doll where aubrey touched you

[@user-wz9lk4sp2x]

nice more of this plz :>

[@Dan-jo8py]

interesting, but ultimately think gladyshev misses things, perhaps because he's always been in a single field, that aubrey doesn't. nanobots will be able to deal, eventually, with things like protein folding, and intracellular waste generally, as an example, has a threshold. below the threshold it doesn't really matter, so you don't need a physically perfect system, you need a tolerably engineered system, which is what aubrey understands better.

[@ZaqZiemba]

Lmao whaaat. Please show me currently the work on such a nanotechnology-based strategy. I seriously doubt any significant research on this idea has been done

[@gymguy1765]

@@ZaqZiemba what

[@farshm.7400]

Why the hell do we have to debate this?! Of course living longer, healthier lives is better. Everybody just focus on making this happen.

[@snorttroll4379]

How?

[@asturner19]

It would be nice to understand why Vadim is pessimistic and Aubrey is more optimistic about rejuvenation and Longevity Escape Velocity (I don't understand their scientific back-and-fourth).

[@professorscambuster3063]

I think it's about timeframes. There are scientists who think longevity escape velocity will be maintained indefinitely when all of the rejuvenation therapies needed to achieve robust human rejuvenation are created, but they expect the research will go slower than Aubrey and others think it might and they expect those rejuvenation therapies are nowhere near completion.

[@asturner19]

@@professorscambuster3063 I mean besides that. I don't understand the details of why Vadim is pessimistic and Aubrey more optimistic about LEV.

[@VincentDraw]

@@professorscambuster3063 So far the research goes slower and the actual implementation of therapies is even more slower.

[@professorscambuster3063]

Dokuganryu9 The research goes slower than what? From my understanding, it's faster than ever.

[@VincentDraw]

@@professorscambuster3063 It must be going slower hence why would be Vadim Gladyshev so decisive in his predictions. For example, relocating mitochondria to nucleus would be useful and is being worked on,but to do it in humans...I am not really sure about it.

[@NomenNominandum]

The mentioned "hallmarks of aging" paper contains 3 epigenetics related items whereas Aubrey's list contains none. I therefore don't understand why Aubrey is always claiming that his list has stood the test of time.

[@gymguy1765]

Because those are metabolic processes

[@NomenNominandum]

@@gymguy1765 So what?

[@gymguy1765]

@@NomenNominandum they aren't damages

[@gymguy1765]

@@NomenNominandum They produce damage

[@NomenNominandum]

@@gymguy1765 They produce chaos, so you want to fix it. Fixing the damage downstream is hopeless.

[@snorttroll4379]

About the list. Categoriws might be exhaustive, but maybe things in the categories can be more numerable

[@christophsteck531]

David Sinclair and his lab showed that cellular reprogramming works for neurons

[@WorthlessWinner]

I think he's downplaying how ineffective geroprotectors are. Humans are already one of the most protected species on the planet so I'm not sure we could do more than raise average lifespan with it, i doubt they'd raise max lifespan. We should take both paths, though I think eliminating ALL damage is unfeasable we could at least eliminate some which could have benefit. Removing AGE crosslinks for instance, seems like a thing we could do that would have many benefits.

[@snorttroll4379]

Remove senescent xells t8o

[@schalazeal07]

Damn.. i sure do hope that Aubrey is right.

[@dhiahassen9414]

He is much more right than others , at least put that way ... he is right enough and that's enough

[@nocon6684]

He Looks like Elon Musk :D

[@raysonlogin]

The world needs more Elon Musks!

[@royzlatanestevez9843]

Thanks for uploading these videos for us. They are going to be of historical interest, reveal to future generations the folly of yet another foolish attempt to cure aging, which has failed throughout millennia... 4 years later and we still do not have a cure of aging... still aging... slim hips rounding out with visceral fat, foreheads expand as hairlines retreat...

[@snorttroll4379]

Did you do any medical experiments to bring the field fprward? Did you pony up cash tp say the bick institute, lev foundation or sens?

[@joebradley3502]

live long & prosper. v

[@saulsavelis575]

more and more warriors on our side is gathering

[@jiasenghe008]

Why is no one talking about Li Qingyun who lived for over 250 years? (1678-1933) A recent and documented case of a Taoist adept who conquered aging with herbs and exercises including Neidan. He proves by his longevity that the answer to aging is not to be found in the laboratory or scientific studies. He practiced what can be referred to as "the yoga of reversal". (one description). The yoga of reversal (Neidan) depends on stimulating and activating the glands in the brain and creating new brain cells by chanelling base energies in the pelvis into more refined energies that are circulated throughout the body.

[@theextractionpros8276]

lol i love Aubrey but I wish he would find a less obnoxious way to toot his own horn lol

[@MarcoAntonio-zi1nl]

Péssima filmagem

[@sensorganization2535]

Aubrey for PM! Trust Mr Trump's watched this, seeing as he's interested in preserving life.

[@harrisongalvin]

So what honestly would be a realistic time line, because if we can all live as long as we’d like, the world would progress much faster and everyone will eventually see every point of view of world issues and racism homophobia and issues with religions and conflicts will slowly disappear

[@cineblock224]

Those questions are the needles that pop the over inflated optimism balloon, of reversing aging soon.

[@nozhki-busha]

Over-optimism is a problem in the community for sure but we should also not fall into the trap of becoming too pessimistic either. There are therapies in development and human trials now which could potentially buy us more time and that means more time to solve these problems. I am optimistic we will make progress in the next decade or two.

[@sensorganization2535]

@@nozhki-busha me too, but I want it to be quicker to save my folks. Anyway, it's not a destructive goal to have, is it, cine block? You can make the treatment arrive more quickly by lobbying your government … !

[@vickybiagini8623]

Roses are red, violets are blue. I made Professor Scumbuster mad, boo, hoo, hoo. I hope age reversal works for everyone, it doesn't matter for me anymore. Ten years ago it would have. Something about losing loved ones takes away life's joy. I hope you live till 1000

[@professorscambuster3063]

I'm not mad. I've noticed a spilt personality shtick you've got going on, though. Sometimes you say something nice like you have in this comment about wanting everyone to be healthy, then other times it seems like you take the view of a religious fundamentalist. I hope you really do want everyone to benefit from advanced medicine, and if you truly do, then you and I agree on something.

[@professorscambuster3063]

Also, why the poetry? I'm not mad, I'm just curious.

[@cineblock224]

Vicky how do you dare to disagree with Scambusted? How do you dare to have free opinion and stand between Scambusted and his escape orbital velocity? He will cross over you with his high speed vessel made from stacks of peer reviewed papers and glue? Now silence you piece of unproven existence because that Scam want's to live forever, you hear me?

[@professorscambuster3063]

@@cineblock224 Your terrible grammar is present even after editing your comment. You can't debate using technical arguments, so you embrace brain dead sarcasm. Nothing you've said has given any actual evidence for your debunked nonsense. All you're doing is showing how uneducated you truly are.

[@cineblock224]

@@shootingholes2388 That link is the needle that pops the over inflated certainty of the professor. He is brain dead after just one argument. Scam Busted.