A/Prof. Ken Sikaris - 'HbA1c, Insulin and CV Risk'

[@robertthompson5501]

My A1c was elevated. My MD told me to eat more meat and less carbs. A1C now lower. He knew this because he was diabetic!

[@davedunn4285]

Ken I listened to this video along with watching and comparing my own results . Thankyou for opening this amazing and informative talk . I am now a little wiser

[@jnrolf]

Ken is an amazing scientist... follow his work and you will get the very best information on the web. 10/10

[@marissavaneck1358]

What those dips in the graphs around HbA1C ~ 6 tell me is that prediabetes is the final step before several important negative feedback mechanisms in the body break down. In other words, what I'm seeing here is that HbA1C >=6 is a biomarker for a systemic level of glycation damage that represents critical failure of several endocrine and metabolic systems. It's like bouncing a heavier and heavier weight on a spring: eventually, instead of the oscillations dampening over time, the spring will simply snap.

[@rangerpretzel]

That's an apt analogy. I'm inclined to agree with you.

[@hektor6766]

This guy's my favorite. Such deep knowledge sweetened with a dry wit.

[@markiangooley]

Every type 2 diabetic I know has been told to eat SIX SMALL MEALS A DAY. Guaranteed to overwhelm the islet cells. As a type 1 diabetic, I get the same advice from many layfolk...

[@PhillipYewTree]

Thank you for this presentation. It is enormously helpful to me - as a patient - and encouraging because I now understand my risk.

[@mikehardwicke23]

What an excellent presentation- brings it all together. Thank You!

[@prashanthb6521]

This is important information. Thanks Professor Sikaris.

[@MrDavidknigge]

Wonderful. Abounding with information. Look forward to the published study.

[@adorinadorin]

Highly interesting, thank you Prof, and thank you LCDU!

[@ianbradbury3215]

Really useful. As a diagnosed T2D of 10 years, with an engineering background, it’s really useful to see all of the interactions. I like the conclusion about the value of A1C. I hadn’t realised that Insulin production typically drops off after T2D diagnosis due to Pancreas damage - but I know my own Insulin production is very low from fasting tests - so that does make sense. Maybe the rises that occur and then drop away around pre-diabetes levels of A1C are as a result of high levels of Insulin in the pre-diabetes state that then fall as you actually become diabetic. It’s the high levels of Insulin that are actually causing the initial damage, not glucose.

[@suprememasteroftheuniverse]

Or it's glucose that damage the beta cells.

[@GodzillaGoesGaga]

The correlation on the graph @15:51 is wonderful. It shows the whole picture.

[@jennyweyman3039]

Thanks Ken, fascinating as always

[@akanecortich8197]

Thanks very much. That WAS most enlightening.

[@IvorCumminsScience]

Excellent Ken, great job ! Please tell me you have ApoB/LDLp against HbA1c? ;-)

[@ellenorbjornsdottir1166]

@@thehealthychefri Apo big A is depressed by insulin resistance. Also I would doubt that you are healthy if you can't go 5 hours without food.

[@isaacsakko]

Thank God I am (Grok) healthy, ‘cause Doctors do aLot of guesswork, making it awkward for patients enough that 60%+ don’t even follow with the prescribed “love” due to fear it would make them feel worse. Amazing DATA! Recently my uncle (74yrs age) came to me worried with a high A1c reading. Told him not to “drink” his calories but to chew them preferably. And to downregulate Carbage Intake. Thanks for the talk! Eye opening! #study I am a Health Coach and MD (Musical Dietician), Real Food Promoter.

[@NariKims]

Did your uncle improve after all this time? ^^

[@suprememasteroftheuniverse]

You're a scammer.

[@lucasdeschamps1973]

Top man! Learned so much thru his YT videos.

[@MadWaloo]

Thank you very much. Very informative and useful information.

[@zambrocca]

great talk, thank you!

[@martinirving3824]

Good stuff, Ken. Very interesting.

[@nellydelcheva1068]

What if you have prediabetic HBAc1=6, but crazy low triglycerides and normal LDL and HDL.

[@rekapodor-novak2309]

Very informative presentation.

[@akanecortich8197]

my previous Dr. would probably have to google HbA1c - seriously.

[@bibingraj9743]

I can hear your heartbeat..

[@deepapurushothaman5240]

Excellnt information Thanks

[@MightyIsis]

Really good info, thank you

[@PeeedaPan]

I'm sad as a type 2 diabetec that my pancreas will never be able to produce enough insulin ever again

[@Sforzatheforcer]

Don’t eat carbs and fast and you will need very little insulin.

[@jenniferjes8524]

WOW I wish all GPs knew all this

[@songmansinatra120]

just wondering when i ate kept my a1c was 4.8 but never felt great... went back to eating carbs a1c was 5.0 not a huge difference does that mean i handle the carbs ok

[@songmansinatra120]

keto

[@erastvandoren]

I eat low fat, my HbA1c is 5%, which is equivalent to the average glucose level of 80. Carbs are NOT the enemy, it's fatty acids that block insulin receptors and also are lipotoxic for pancreatic beta cells.

[@Jefferdaughter]

@@erastvandoren - You are probably aware that there is zero dietary requirement in humans for carbohydrates. However, humans cannot live without fat (or salt). The human body readily makes all the glucose it needs, but it cannot make the spoonful of Omega 6 fatty acids is needs, or the Omega 3 fatty acids it needs: EPA and DHA -which are NOT available in plant source foods. Plant source Omega 3s are very poorly converted by the human body into the forms required, which typically leads to deficiencies in those who are not getting enough from animal-source fats. Certainly the combination of sugar and/or starch carbs with seed oils (deceptively marketed 'vegetable' oils, shortenings, and margarine) is not healthy, and highly inflammatory. Dr. Paul Mason 'Saturated Fat is Not Dangerous' (but neither are unsaturated fats, so long as they are not oxidized, and they are highly susceptible to oxidation): kzbin.info/www/bejne/hIa8kIZ6nd2Zas0 Sugar is not beneficial, and is worse when refined. Starch is simply sugar molecules linked together, that rather quickly become simply sugar after we consume them. Refined starches are worse. That pretty much leaves us with fiber carbs, structural carbohydrates from plants. Fiber is not essential to the human diet, and since we lack the anatomy to digest it effectively, and do not either regurgitate and re-chew and re-swallow it, as ruminant animals do (cattle, bison, sheep, goats, deer, etc). Or eat again the food that has already gone all the way through the digestive tract, as other true herbivores do, like rabbits and our only close relative that is a true herbivore- gorillas. (The rest of the great apes have been reclassified as omnivores.) Plants are loaded with toxins, however. Since carbs come primarily from plant sources, it pays to be aware: Dr. Paul Mason 'Are Lectins Bad for You? - and How to Avoid Them' kzbin.info/www/bejne/bpzQoGiLmKyDjtE&pbjreload=10 'Food Plant Toxins in an Evolutionary Context' Nina Tiechotz, Dr. Stephen Phinney, MD PhD, Jeff Volek, Dr. Eric Westman and many others are making information available on the safely of high fat diets.

[@ellenorbjornsdottir1166]

yes

[@ellenorbjornsdottir1166]

@@erastvandoren carbs are not the enemy for you.

[@lizakiesling1289]

If you are strict keto 20 carbs or less leafy greens for veg but A1C going higher and higher even though getting stricter. 5.9 most recently back where I started. Was originally before LCHF 5.9 went to 5.5, 5.6 now 5.9 again 2 years faithful LCHF. So disappointing. 😕

[@nelgtruth4607]

Are you watching your protein intake?

[@Sforzatheforcer]

Be thankful that you didn’t progress to diabetes.

[@naijaman6639]

@@nelgtruth4607 Many people overeat protein and if they aren't strength training, the excess turns to glucose.

[@negoodies]

Very interesting however it would be nice to know how much these numbers are manipulated by medications before the tests.

[@darrenaustralia3623]

Amazing

[@Lynt144]

I'm type one diabetic and have a Libre blood sensor on my arm that monitors my glucose 24 hours a day could be useful in this study.

[@briankelly6144]

Very informative

[@OnlyMyPOV]

Young women get rid of some blood every month. That should be the reason their biomarker for A1c does not show a correlation for the 3 months.

[@billytheweasel]

11 dislikes. How many stent and statin manufacturers are there?

[@marvinnelson5073]

Those conditions that are present when first diagnosed are more likely caused by elevated insulin which has been high for years to decades rather than glycation which has only been elevated for a much shorter time.

[@threebigfsfakenewsfakefood575]

Cool

[@kipling1957]

Yikes! Ken grew a beard!

[@johnx9318]

Was this video pitched for doctors? It was a bit too academic for me, to learn from.

[@KenSikaris]

Sorry John. I'm pleased that there are more and more doctors attending the LoCarb events, however it becomes a challenge to keep the presentation pitched for all. Appreciate your honest feedback and will try harder next time.

[@dmackle3849]

@@KenSikaris there seems to already be plenty of alternative simple takes out there for this topic. It’s a challenge to consume but I feel we need these data heavy and deep rabbit hole presentations like this one. I hope the funding barrier to making this test commonplace has improved in recent years? Otherwise it’s opportunity lost. The irreconcilable paradox I’d like to see tackled by someone with your experience is the polar opposite HCLF approach such as the rice diet experiments. Denise Minger approached it years ago at AHS. There are even comments here on this thread promoting it. And Rich Roll interviewed two proponents, both with T1D, pedalling it hard at diabetics! It’s said to offer more permanent repair of blood sugar control. Is it fraud or within your model how can this be?!?

[@ramanapsy]

Great talk, thanks.