What is GLP-1, What Does It Do, and Where Does It Come From? with Dr. Ben Bikman

In today's episode of The Metabolic Classroom, Dr. Ben Bikman delves into the fascinating topic of GLP-1, a hormone of significant interest in metabolic research. Dr. Bikman sets the stage by expanding the discussion beyond GLP-1 to include other incretions, defining them as a class of hormones produced by the small intestine. These hormones play crucial roles in nutrient metabolism, satiety, and hunger regulation.
The discovery of incretions stemmed from observations following gastric bypass surgeries, where elevated levels of these hormones were found in the bloodstream, leading to improvements in diabetes. Dr. Bikman highlights GLP-1's well-known effect on insulin secretion and glucagon suppression, which contribute to its ability to rapidly correct high glucose levels and improve diabetes. However, he notes the ongoing debate regarding GLP-1's direct insulin secretagogue effect in humans, contrasting findings from cell culture and animal models with recent human studies.
Moving beyond GLP-1, Dr. Bikman discusses other incretions like GIP, PYY, and cholecystokinin, outlining their roles in glucose regulation, appetite control, and digestion. He explores the pharmacological applications of GLP-1 agonists in managing diabetes and obesity, detailing various drugs and their mechanisms of action. Furthermore, he touches upon natural methods to enhance GLP-1 secretion, including dietary factors like protein, fat, and sugars. The session concludes with insights into the live Q&A session, emphasizing the dynamic interaction between science and audience participation in The Metabolic Classroom.
Learn more at: www.insuliniq.com
#insulin #insulinresistance #type1diabetes #type2diabetes #type2diabetestreatment #type2diabetesawareness #metabolichealth #metabolicsyndrome #metabolicflexibility #metabolicbalance #weightloss #weightlossdiet #weightlossdrugs #fasting #intermittantfasting #insulincontrol #timerestrictedeating #intermitentfasting #intermittentfasting

[@LuzGarciaMSNAGNP-C]

Nurse practitioner here doing medical weight loss and primary care. I have become extremely interested in metabolic syndrome and insulin resistance merely because of the high number of people that come in to see me and are pre diabetic or diabetic and have no idea. I have watched many of your videos to get a good understanding. My passion is to help people reverse insulin resistance and get them healthy. Thank you for your videos and wealth of knowledge.

[@insuliniq]

Thanks for watching and for your kind comment. I hope we can keep helping you. If you haven’t already, be sure to go to our website and create a free Basic Membership so we can stay better connected. www.insuliniq.com

[@ssky9244]

You are my most trusted scientist on all the internet. Your research and application to common metabolic problems is astounding. These lectures are even better than when you do interviews! Thank you for your dedication, enthusiasm and caring for the metabolic health of people.

[@insuliniq]

You’re kind. Thank you for your nice comment. I appreciate it.

[@meatdog]

I am totally immersed in your lectures. Thank you. I practiced family medicine for 50 years, so I'm dialed into education amd enjoy listening.

[@insuliniq]

Wow, thank you!

[@gregferguson2170]

Me too. I'm a retired nurse age 64. Trying to get off 2 meds and get healthy. Dr Bikman is a genius.

[@nurjimenez7401]

❤More I listen to these geniuses the more I tell myself I should have studied science because sometimes it’s over my head but it doesn’t stop me from listening and keep learning. Thank you Doc!!❤

[@lucyburr5516]

@@gregferguson2170Hi, Greg, I am a retired RN myself. Dr. Bikman is a genius-right-but he is also very skilled in making complicated information easy to understand.

[@mae8861]

Good for you. My doctors tell me not to listen to KZbin. They are threatened by how finally, we can take charge of our own health and knock them down from their God pedestal

[@floatingmoon5778]

I took the minimum dose of Mounjaro for 5 months. During that time, my blood sugar was excellent, but I saw my thyroid numbers go crazy (have been on Synthroid and Cytomel for years), developed granuloma annulare, and yes, experienced all the gastric and digestive problems. Stopped taking Mounjaro in May 2023. My thyroid function has improved, but not yet quite back where it was previously. The granuloma annulare is almost gone, but the gastric and digestive issues are still not resolved, 9 months later. I will never use any GLP-1 drugs again! I appreciate all your videos and concise information.

[@insuliniq]

Thanks for watching and commenting. Best of luck in your journey. Sounds like you are trying to stay on top of it.

[@mariamunguia8863]

@floatingmoon5778 how much weight did you loose? Just wondering because I took mounjaro for approximately three months, and I did see some weight loss last total of 20 pounds doing keto and working out. I still have 40 to go but I stopped using the medicine because it scared me after I saw that lady that passed away in Australia, was such a sad story.😢

[@floatingmoon5778]

@@mariamunguia8863 I wasn’t taking it for weight loss. I had an A1c of 5.6, but was using small amounts of insulin, even while eating ketogenic, because I was not getting the lower blood sugar readings I wanted with the dietary changes and exercise. I wanted off the insulin train. I achieved it with the Mounjaro, but my health tanked. I think I lost 5 pounds? I’m still trying to lose 20 pounds, but I doubt it will happen until I lose the insulin.

[@angelatakano6072]

Conclusion: don’t take drugs if not absolutely necessary

[@kennettle]

tell that to all the doctors

[@chyla1]

Thank you for spending this time to educate us all. Very grateful 🙏🏾💗

[@insuliniq]

Thank YOU for watching!

[@Snapkrackpop]

These lectures are priceless. Thank you so much for the clear and concise info. It’s come in very handy to help a friend understand better why his metabolic health or rather dysfunction is what it is

[@insuliniq]

I am glad it is helping you. By the way, when you visit with friends, you can tell them to look at my introductory course, “Raising Your Insulin IQ for Improved Metabolic Health” that’s part of a free Basic Membership on my website: www.insuliniq.com

[@NoPronoun224]

Thanks for rebroadcasting the live Q&A.

[@titasama3655]

This was fabulous--thank you so much. I'm sharing this with my primary care provider.

[@simonwiltshire7089]

Superb. Thank you, Ben

[@bernadettebecher4689]

Thank you. Have learnt so much again today.

[@iainneilson1453]

Спасибо большое, Доктор Бикман! This series is so enlightening and your presentation style is brilliant.

[@pamelaiverson9045]

Everyone says it makes your cravings go away because you're nauseous. It's more than that. It makes the food noise in your head go quiet. If you dont have food noise you cant even relate. Its similar to the overall noise on your head go quiet with ADHD medication. ther cravings diminish. Discussion on reddit among Ozempic users include less cravings for cigarettes, alcohol, nail biting, and drug addiction. This isn't because you're full or nauseous! Docs are missing the mark on this. 😢

[@daisiesushitam984]

Great info. Thanks!

[@ianhowe1449]

Such an effective educator.

[@carolr.556]

Thank you for all this free vital health information!

[@insuliniq]

Thank YOU for watching and spreading the good word!

[@CoyoteWindRanch]

Missed it live again! 😳 Awesome information.

[@insuliniq]

Thanks.

[@user-xu1df3cy8r]

Your lessons so interesting I can not stop to listen to you! Best regards from Saint-Petersburg 😊❤

[@insuliniq]

Thank you! 😃

[@monicamcandrews5431]

I love this series!

[@insuliniq]

Thanks for your comment, Monica.

[@monicasarmiento5984]

Thank you for all your generosity and for sharing your knowledge. It means the world to me and you're the most trastuwordy doctor in my opinion. Thank you sooo much 🤩🤩🤩

[@insuliniq]

You’re kind, Monica. Thank you.

[@williamberliant8145]

Fantastic video!!!! Professor Bikman gets an A++

[@NoTrashInHeaven]

Married to a T1D, so always particularly interested for the both of us. Thank you!

[@insuliniq]

Thanks for listening. And thanks for commenting. If you ever have questions-even about your spouse’s T1D, always feel free to go to our website and ask my team: www.insuliniq.com

[@heavychevy4616]

thank u sir

[@cccalifornia7206]

Excellent informative video on ("insulin resistance")!!! Thank you so much!!!👍😉🇺🇸🇺🇸🇺🇸

[@marynone8681]

Love love love all your info. Helped me understand "hangry". How long in hours do people need to fast for a fasting insulin test?

[@venkvelaga]

They recomend 8-10 hrs but no less than 8 and more than 16. I do 14 hours. So if test is 9am finish eating before 7pm.

[@great-garden-watch]

Information you can trust, and because it’s explained on a deeper level than usual, you can see for yourself that it all makes sense. In other words, Dr Bikman backs up his statements with hard science.

[@AliceFarmer-bg4dw]

Dr can you cover the Randle Cycle? We can not get a good straight answer.

[@TomSmith-cv8hk]

GLP-1's action on insulin secretion is of interest. I've always had high normal FBG, got insulin tested at the same time recently, FBG was higher than usual but Insulin was only 4 mlU/L. All the talk about insulin resistance had me worried.

[@Ronlawhouston]

Please keep talking about glucagon because I really don't think clinicians understand the role it plays in diabetes. I am a 63 year old diabetic who has lived a low carb lifestyle for about 7 years now. Low carb never totally normalized my blood sugars. This really puzzled me but it was clear that my liver was a glucose making machine. Ozempic has stopped that. (When I can get it, these drugs are now in very short supply.) My question is whether there is an easily available glucagon test. Thanks for reading my comment.

[@insuliniq]

Thanks for your question. You may want to go to out website and ask my team: www.insuliniq.com

[@olderandwiser127]

Try zero carb carnivore; sometimes low car is not enough.

[@jenjabba6210]

Too bad there is a ton of semeglutide peptide in China. Did you try carnivore?

[@leandrobecker123]

Ben. I am a cardiologist and live in south of Brazil. Here erva mate is quite common. Many people take it every morning with hot water. I would like to know if you could write me the study about glp1. And also the one's regard glp1 tesponse with different fats as we also produce and consume olive oil here.

[@mikeb4555]

Love these videos, but wasn’t clear of your position on GLP1’s. Are they good or bad? Should one avoid them in lieu of “natural “ solutions? IMHO, only heard low-carb

[@DG-ky4qk]

So, glp-1 is a glucagon antagonist, slows food transit time through the digestive tract and sends satiety signals to the brain. The primary contributor to weight loss appears to be that of satiety. Is that correct?

[@vsnrao36]

Great information from a great scientist as always - just did not get the name clearly, of the second natural substance that helps with GLP-1 production that is native to South America - allulose was the first one you mentioned.

[@insuliniq]

Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com

[@user-yx9lj4zo7f]

Ilex paraguariensis, also known as yerba mate tea

[@vsnrao36]

@@user-yx9lj4zo7fThanks a lot - very unusual name, so could not get it😀

[@curiouskitten]

Sometime ago I read there were side effects to consuming Yerba matte tea... I tossed my stash to trash.

[@HuyLe-up3mx]

Do you have any study on thyroid c-cell tumor in human? Thought that was from animal studies.

[@francinelally5296]

31 Amino Acids Ozempic 39 Amino Acids Mounjaro Mounjaro (tirzepatide) is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life.

[@TheKingdomWeigh]

Are these LIVE’s every Thursday, what time?

[@insuliniq]

Wednesdays at noon, mountain time.

[@danlhart]

Thank you !

[@samueln714]

Please help... just watched Dr Rob Cywes claim that GLP1 has more of an effect dealing with the sugar you eat than insulin. He stated that insulin has a very small uptake to control sugar. Seems opposite of everything I have learned from you. Can you clarify as I'm getting confused. Thanks.

[@sailingsam3815]

Semaglutide gave me severe constipation and messed up my digestive system.😢

[@simev500]

1:57 It sounds plausible that the diabetes condition disappeared along with the removal of the excess number of the dysfunctional stomach lining cells when the patient had the gastric by bypass.

[@quisge]

I'm confused. If a GLP-1 agonist causes people to eat less (slowed gastric emptying and increased satiety signaling) but insulin is not necessarily suppressed, doesn't the metabolism adapt to this caloric reduction and thus inhibit fat loss? Or is insulin reduced as a result of the slowed gastric emptying and reduced appetite, thus allowing for lipolysis to occur?

[@elenaquinn1915]

Where does the gut microbiome fit into this discussion? I am reading about Akkermansia and other probiotics that promote GLP-1. Is this more or less effective than allulose or yerba-mate? Would taking both be beneficial? There are studies that show that certain probiotics are effective in treating T2D as well, which I assume is from the promotion of GLP-1.

[@insuliniq]

Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com

[@tusker4954]

Thank you @ben_bikman this series is so helpful at filling in the many gaps I have 🙏

[@insuliniq]

Thanks for commenting. We all have “gaps”, so I am glad it is helping you.

[@mikerudd4943]

Hello Dr. Bikman. I have been on lanreotide for 5 yrs plus. 8+ months ago I began a 98% carnivore diet. I lost 65 lbs (220 to 155) STAGE 4 NET. I reversed my NAFDL and type 2 diabetes. The Lano is said to have possible effects on holding back tumor growth or even shrinking. My last scan was about 3 months in and it showed 5cm reduction of the largest tumor. They say it was likely a error. My question. Can I do anything else chemically/biological to my body to decrease glucose (I monitor with a cgm now) and or glutamine as the tumor can feed on glutamine. The lano is said to increase glucose? I am producing ketones 24/7 and blood test the other day was at 27. My urine tests are always 40. Thank you

[@insuliniq]

Thanks for your comment, and for reaching out. Because your specifics are fairly complex, you may want to consider doing an online consultation with our Medical Metabolic Health Director, Lindsay Venn. You can learn more about doing that here: www.insuliniq.com/medical-consultations

[@janetmcburney4582]

??? How to join live

[@insuliniq]

You can participate LIVE by becoming an Insulin IQ Community Member: www.insuliniq.com/insulin-iq-community-membership-signup

[@iss8504]

Ben, smoked yerba mate or unsmoked?

[@carrieyund862]

I don’t know if it’s just your opinion that popping a pill is more convenient than doing an injection, but I much prefer the injection convenience-wise because it’s once a week.

[@alisonholmes2409]

My understanding….taking GLP1 as a medication reduces lean mass and bone mass (as well as fat mass) Question….does having allulose or Yerba mate also refuse lean mass and bone mass?

[@insuliniq]

Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com

[@miggonzr1998]

How is GLP-1 manufactured? Is this created in a lab or does it carry any human cells for development and production?

[@anonymoususer7606]

I’m curious how these hormones interact with hypoglycemia. Non-diabetic , either reactive or non-reactive hypoglycemia.

[@JasonBuckman]

Reactive hypoglycemia is a diabetic construct. If not diabetes, it's either pre-diabetes, or pre-pre-diabetes.

[@anonymoususer7606]

@@JasonBuckman perhaps you are correct. But I can’t help but wonder if something else is possible. 10 days before my period I suffer from hypoglycemia. I can even faint because of it. My A1c is 4.9. I think I have intestinal permeability.

[@JasonBuckman]

@@anonymoususer7606 I was speaking of reactive hypoglycemia.

[@johnschlesinger2009]

Digestion doesn't start in the stomach: it starts in the mouth: there is amylase in saliva, and breakdown of carbohydrate starts in the mouth.

[@Karen3263]

❤

[@jeffrey4577]

💯👍‼️❤️🙏

[@insuliniq]

Thanks, Jeffrey.

[@MichaelBDotHelp]

Years ago I noticed yerba mate was not good for me. I named it anger mate

[@insuliniq]

Hmmmmm...

[@SamShank175]

Interesting, another strike against seed oils.

[@micro2159]

do glp1 regenerate beta cell ?

[@zanna660]

i wonder if drinking no coffein coffee is better then ordinary coffee ? when i drink ordinary coffee my blodsuger rise i guess indirectly coz of stresshormones

[@joefiganootz2425]

Unimate? Wow! It's hard to hide money!

[@marianne1959]

Lean mass unlikely to return after age 60? So wt. training will not do anything? Age 65 here

[@insuliniq]

Talk to my team, Marianne. They will have some good ideas for you: www.insuliniq.com

[@foodmonsterweightloss5886]

Look into the book "Body by Science" by Dr. McGuff. The research behind the book is based in older women recovering from serious sacripenia and bone loss.

[@marianne1959]

@@insuliniq wish I could but $$ are so tight in this awful economy. My budget spent on quality meat and eggs. But thanks...I'll keep exploring and watching your videos. You've been instrumental in reversing my t2 diabetes and improving my health ❤️

[@petebowen9031]

Wonderful lecture: you make the “Eat Less/Move More weight loss approach sound like a Neanderthal’s approach to health.

[@OrasSelection]

I feel like I am the ONLY thin Diabetic. Looking into Glucagon now. To help my Pancreas that is still hanging on to start making Insulin. I could be wrong but I think I can motivate my Pancreas to start making more Inulin. I think I am on the right tract. Have to RESEARCH RESEARCH RESEARCH to help myself because these flipping Western Dr.s are not helping. I don't need to loose weight. Wouldn't hurt me to gain a few pounds. I will win this battle.🙏

[@upriver7047]

You may want to try searching the terms: integrative medicine doctors and also metabolic health doctors for your area. Tgat was a helpful way to search for me. Then U called and interviewed the reception person to learn more about how the doctor works. You could also ask to speak with one of nurses in the office. You may have to travel to see a doctor you can work with but it will be worth it in the long run in my opinion.

[@anatomain1057]

After gall bladder operation how can some person eat more animal fats without any GI problems? I am daily witnessing that in my wife

[@insuliniq]

Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com

[@janetmcburney4582]

If more fat cells are made then if person goes off diet and drug and eats crap wont they get fatter than ever since they have more cells to store fat

[@insuliniq]

Thanks for your question. You may want to go to out website and ask my team: www.insuliniq.com

[@jobrown8146]

I think I've heard this mentioned before by a reputable YT channel. Sorry I can't remember which one; I've listened to a lot of them.

[@janetmcburney4582]

Not even considering taking drug. I am ketovore 19mos and IF. I am not in favor of taking something that screws with you system. Gi e your body what it needs and it will take care of you

[@upriver7047]

​@@janetmcburney4582 Not always. We are all a little bit different. I am 7 years

[@jeffreyfitzgerald4673]

😁 "Promo sm"

[@stellat2405]

what an amazing video on GLP1 agonists! But how increase of insulin production and of glycogen in the liver guarantee weight loss after treatment is over, just with appetite suppression when the CAUSE of weight gain, the insulinogenic diet, comes back? Does this duo makes it faster to rebound weight? Oh my! Why on earth should I take Ozempic (incl SIBO it creates) when with Low Carb/Keto I get all the incretins I want to lose weight and maintain it for ever with LC? Really the world has gone mad. @InsulinIQ however, slow gut motility is a SIBO cause, a definite one, so your recommendation on LC and small dose of GLP1 only for diabetics to facilitate fat burning adaptation, really does the thing