Age Reversal Breakthroughs, FDA Approval, and Living Forever - David Sinclair’s AMA

In this Ask Me Anything session, David and Peter discuss the latest age-reversal breakthroughs, getting approval from the FDA, and the possibility of living forever.
David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller, David has co-founded several biotech companies, a science publication called Aging, and is an inventor of 35 patents.
Read David’s book, Lifespan: Why We Age- and Why We Don’t Have To: a.co/d/85H3Mll
This episode is brought to you by Levels: real-time feedback on how diet impacts your health. levels.link/peter
Consider a journey to optimize your mind and body by visiting mylifeforce.com/peter
Read the Tech Blog: www.diamandis.com/blog
Timestamps
00:00 - 01:17 Intro
01:18 - 01:53 Why Hasn't David Been On The Podcast Scene?
01:54 - 04:07 Where Are The Breakthroughs & When Are They Coming?
04:08 - 06:45 Peter's Thoughts On The FDA & The Future Of Medicine
06:46 - 11:05 David Sinclair's Experience Dealing With The FDA
11:06 - 14:07 When Is The Right Time To Show Your Findings?
14:08 - 19:15 Are We Doing It? Are We Going To Live Forever?
19:16 - 22:19 How Are David & Peter Going To Reduce Aging?
22:20 - 23:30 Where Can You Get To Know More About David Sinclair?
23:31 - 24:37 The Human Side Of David Sinclair.
24:38 - 25:19 Outro
New to Peter?
Peter is on a mission to solve the world’s greatest problems. Named by Fortune as one of the “World’s 50 Greatest Leaders,” Peter Diamandis is a Father, Founder, Philanthropist, Humanitarian, and best-selling author. Peter has gathered over $100m to solve humanity's greatest problems. This show is Peter’s effort to share everything he knows about changing the world.
Connect with Peter:
Website: www.diamandis.com/
Instagram: / peterdiaman. .
Twitter: / peterdiamandis
LinkedIn: / peterdiamandis
Listen to Moonshots & Mindsets on:
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Apple Podcast: podcasts.apple.com/ca/podcast...
Spotify: open.spotify.com/show/5Y1NyT6...
Trailer composed and edited by @abramshaffer

[@artist5518]

Main takeaways: 1- Eat less often. 2- Avoid sugary drinks and foods. 3- Reduce meat intake for longevity. 4- Its never too late for dietary changes. 5- Find veggies that have been stressed out (organic, colorful veggies) 6-Never start a meal with sugars, if you do eat them at last. EAT LESS OFTEN -There is a genetic pathway that gets triggered by low energy. These genes (sirtuins) respond to low energy (low glucose levels-caloric restriction), high heat, low amino acids, high salt (stressors). -----They take care of the DNA repair and the stabilization of the epigenome. -When the body is hungry, the body makes NAD (fuel for the sirtuins). -Two ways to activate sirtuins synthetically: 1) Use some molecules 2) NAD booster. Longevity genes: Mtor: protein that registers amino acids. Allows the cell to build things. Not a recipe for longevity. Activates autophagy. Ampk: goes up when hungry. Makes more mitochondria (important for making energy) Sirtuins Fasting: - Metformin: mimics fasting. - Time Restricted Feeding: At least 16 hours. - Liver compensates for the lack of food. Glucose neo-genesis. It overcomes the feeling of hunger. The liver starts making glucose at a steady level. Sugar: big killer. It spikes glucose. Glucose shut down sirtuins and ampk. Defenses against diseases and aging shut down. Protein: we should avoid high protein red meat diet for longevity. It inhibits mtor. Amino acids: three important. Leucine, isoleucine, and valine: BCAAs. Are used to sense protein intake. The sensor is mtor. The mtor activates when you get them. Mtor repairs and build muscle. In the short run, this is good for building muscle etc. But in the long run, mtor is the responsible for autophagy, which is key to longevity. Plant based diets: the more vegetarian you are, the longer you live. The best, Okinawa diet, is plant base diet with fish - (probably because of Essential fatty acids)

[@morphtek]

do everything the same just cut carbon hydrates for good and eat more fat and meat only and you wont need the nad booster or whatever snake oil hes trying to trick you into buying

[@Martinoitalico]

Thank u!

[@marktapley7571]

Explain why children who are protein resticted are smaller and weaker. This was the case after WW2 in Italy and Netherlands. Plant protein is much inferior to meat and you have to eat lots more to get enough nutrients compared to a tiny bit of beef.

[@davem4131]

@@marktapley7571 I think they the advice was avoid red meat. Cod and turkey mince have the most protein per gram and are low calorie

[@TzarBomb]

Those are all nice and good, but the real answer lies in gene-editing (probably).

[@steveschooley8864]

Dr. David A. Sinclair. I’m a disabled veteran suffering from chronic fatigue, which has destroyed my life. Earlier last year I came across your research on NMN and I decided to give it a try because nothing else had helped. It changed my life. I can finally clean my house or go get groceries without extreme exhaustion. My mind isn’t in a constant fog anymore, I don’t wish for death anymore, and I finally feel like I have a little control over my own life. Yesterday I found out that your company had NMN banned by the FDA as a supplement. I am destroyed by this news and you personally have both given me hope and then ripped away any chance I had at rebuilding my life. I can’t go back to constant fatigue and a life where I constantly think about ending it. Please help Dr. Sinclair, losing NMN will be the end of my life.

[@quantumfx2677]

Stay positive as there will be loop holes and many will still get it. I just became disabled and I have terrible chronic fatigue and I will try NMN at the moment Kratom has saved my life but I don't want to be on it forever so I am now rebuilding nerve damage and bone with BPC 157 and TB 500 peptides Doctors told me I would not be walking and will need surgery down the road, Wrong they are as I now have full range of motion and getting stronger and they can't figure it out, I won't tell them I'm using peptides as they don't support alternative medicine unless they can make money well they will never get another dime from me ever again!

[@MsAtlantagal]

​@@hallenwAmazon is giving sellers until March 13 to remove NMN.

[@instanta2693]

do look into Ashgawanda and other indian supplements. I have been taken a few and energy levels have changed noticeably. Had brain fog, low drive, energy and motivation.

[@patrickday4206]

It didn't do anything for me!! Supplements are weird

[@patrickday4206]

@@quantumfx2677 kratom is wonderful did you know the DEA tried making it a schedule 1 substance one month after testing successfully a artificial derivative of kratom!!! It's in the coffee family! Use it carefully though it will mess with your digestion!!!

[@abhishekmahanta1112]

I am 22 now, if I can live till 100 completely healthy - fit and not dependent on anyone that would be enough for me ❤️🤩🙏 Dr David Sinclair is such a gem in this world 🙏.

[@bighands69]

Adapt a clean lifestyle now and you will get to 80 at the very least.

[@rounakmukherjee8807]

নিশ্চয়ই হবে দাদা।

[@GlorifiedGremlin]

In case yall didn't know, this man literally unlocked the secret to reversing the aging of ALL living cells in January. I imagine that's what he's gearing up to release in full

[@Derby08]

Wake up

[@Rafas216]

​@@Derby08 acorde você Ken...acorde

[@7296180]

Hi David, just want to let you know I have followed your videos for the past few years. When I looked back during my prime years (~ 30 yrs old), my work schedule was irregular, therefore, I only ate a maximum twice per day, sometimes even once per day. On top of that, I was an avid racket sports enthusiast. Played sports every other day, (quite intensive), and never stopped. Now, I am 50 yrs old, and still continue to play badminton (extremely intensive - advanced/pro level) every other day consistently, and only eat a maximum twice per day, most of the time eat once per day, with light snacks. All my friends and new people I met, still thinks I look around 30 yrs old. It seems like my aging halted considerably ever since I started eating less meals, and got into intensive sport when I was 30 yrs old. When I see some of my friends that are the same age as I am now, they all starting to have grey hair, and wrinkle skin, early stage conditions (weight gain, diabetes, high blood, cholesterol, etc.). Ironically, I weighed around 130 lbs when I was 30 yrs old, but now my weight has been averaging 120 lbs for the last 20 years, with an average BMI of 20.5. I notice it's a bit weird when my surroundings are aging much faster than I am. Therefore, when I saw your videos, I noticed there is a similar pattern that I have been on the right track for the last few decades.

[@mistycloud4455]

A.I and biology need to merge

[@DragonWolf2099]

We seem to be the same. I think not eating is also the answer but they have know this for decades. I wonder if you are like me in the way I don't feel hunger of thirst for the most part? I have to remind myself to drink water and eat food and it has been this way my whole life.

[@arnopienaar8111]

Moer windgat jy

[@estuchedepeluche2212]

Fewer meals, FEWER, not “less meals” your brain is regressing to a grade school level.

[@pismobiics825]

@@mistycloud4455 Nope, they don't....

[@vecci6173]

He is who I've been waiting for the world to produce. He gets it 💯 Please hurry

[@anthonyhopper7830]

Great podcast! Thank you for taking the time to put this one together.

[@bobbytheblade2550]

Nothing beats regular exercise and proper diet. That's still the best age reversal on planet earth.

[@Rafas216]

Por enquanto...

[@mlucas17]

Great update!

[@ronvictor2622]

With a global declining birth rate I believe this breakthrough would be the ultimate hedge against that not to mention Healthcare cost and Healthcare quality. This will truly be a man-made miracle for so many around the world.

[@8nakata8]

Itd be perfect for total economical collapse lol. Instead of full of 60 years old, will be full of 100 years old🤣💀

[@omittapir5986]

Waiting patiently for your podcast!

[@goodphone156]

However thank you David Sinclair I believe in science, I believe in your science.

[@xiaonanw6374]

Your "belief" and science are not quite compatible

[@marktapley7571]

You should like up immediately for your booster.

[@smkh2890]

Interesting new use of 'kicking the can down the road'! It usually means putting off a decision, leaving it for a later date. He uses it to mean the can is ageing or death, and we are extending life expectancy! Kudos.

[@savagegamingg1239]

This is my favourite video of all time

[@sinagtalamalaya5392]

love david. sinclair

[@xXIronSwanXx]

I don't care about immortality or living for 200 years, I just want to remain young. Can't wait for the breakthroughs!

[@Cookingmukti]

Meditation

[@incognitotorpedo42]

OK, so you remain young, and a long time from now you are 200 years old, but you're still young looking and you feel great. What are you going to do, shoot yourself?

[@jamiereader5147]

Two of my favourite people Much love!

[@JMSsssssss]

Excited about all of it. I wish there was more community around it, I am the only person I know who is engaging in this stuff, kind of a lonely experience. Really looking forward to the TV show.

[@bighands69]

There needs to be a developed marketplace around aging healthcare. People have got to get away from terms like age reversal because that sounds fantastical.

[@Smiley_101]

Omg this is great ! I don’t mind experience this on my first ❤️ I agreed with Peter is the idea seeing our great grand children going to mars or moon is awesome . Who don’t want to reverse their aging , tissues , organs .. im looking forward to this ❤

[@schijtaccount1]

He did just increase the price of his drug under the umbrella of safety, he disappoints me

[@Blackhearts60]

@@schijtaccount1 We dont know what the cost requirements are of something like this, it could be if he didnt make that price increase we would never get mass production of this, or maybe wouldnt get it at all.

[@incognitotorpedo42]

@@Blackhearts60 If it's NMN we're talking about, it's already mass produced and sold at a very reasonable price as a supplement. I've tried it. Unfortunately it keeps me awake at night, so I don't use it.

[@Blackhearts60]

@@incognitotorpedo42 Yeah i know ive taken it too, but i meant that it might not have gotten to the stage it is if they didnt charge a certain amount. And price increases are par for the course, things get more expensive over time and we dont know the expenses behind the scenes is what i meant

[@leed9480]

Great stuff!!

[@7296180]

Basically, long story short... EVERYTHING that David mentioned is 100% true!! Exercise, eat fewer and less per meal, intermittent fasting, watch what you eat, etc. Thanks David!!

[@marktapley7571]

We already knew all of that years ago.

[@rtothe7068]

Didn’t he have the FDA remove NMN from the supplement market by listing it as a drug?

[@knuftobor]

That's why he's grateful for them. I don't think the FDA protects the public.

[@billkipper3264]

The company that he is a cofounder of, Metro Biotech, is currently lobbying the FDA to classify NMN as a drug. That has not happened yet and there is speculation in the longevity community that it won't be and will remain available in the same manner that NAC is. I believe there will be a huge battle between the FDA and longevity supplement companies and longevity advocate groups if the FDA moves to ban it. Certainly, Dr. Sinclair is in the doghouse over all this and the letter he wrote as a response didn't help him. No matter the outcome, we must remember that he is the main one who got us this far and without him we might not even be having this discussion. Personally, I'm torn between hating him for this mess and admiring him for what he has done to advance the science of longevity.

[@squamish4244]

He tried.

[@pastryshack551]

@@knuftobor take these guys with a grain of salt, I wonder when their drugs will be approve for the poor public. They both look like con artist to me. Bill gates want to dim the sun too, so it means we will be buying vitamin D for the rest of our lives. I am 77, no medication at all so I don't need to listen to these Guys. They are phony in my mind both taking metaforfing yet, did not say they were diabets I knave to get off yt for 23

[@Dawn8022]

He did this to make big bucks. Just a con in my opinion

[@Victoria-sk2zs]

YouLOOK GREAT DAVID!!! 150 YEAH. LETS GO FOR IT. THANK YOU. LOOK FORWARD TO YOUR NEW DISCOVERIES.

[@claudiafernandez3548]

I love David Sinclair! I really love him because his work

[@ironmaidenfitness654]

Me too, no one would be freaking out about having NMN ‘taken’ from them if it hadn’t been for David educating us about NAD pre curser benefits 🙄

[@sinagtalamalaya5392]

love dr sinclair

[@peterdavila3045]

Great video, thank you. I'm one of those taking Metformin, even though I don't have diabetes. My cardiologist was asking me why I'm taking it. I had to explain to him the longevity research behind Metformin. Why should I have to explain this kind of health information to a physician? Isn't their job to know what could possibly make their patient healthier? In addition to Metformin, I'm taking Apigenin, CA-AKG, Fisetin. I have felt my Testosterone levels increase since Apigenin. Since I started Metformin, over a 6 month period, my A1c went from 5.4 to 5.3. Glucose went from 97 to 87. My albumin is 4.4. I do feel pretty good for a 67.5 year old. I have been doing intermittent and long term multi day water fasting for at least 20 years now. My diet is pretty good. Sardines, salmon, organic vegetables, berries, nuts, beans, green tea, organic dark chocolate (85% cacao). Daily drink of organic garlic in water and extra virgin olive oil. I love life. I want to continue to live a healthy life for as long as humanly possible. Give another 100 years, at least. "Live long enough to live forever".

[@fidelogos7098]

From my experience with doctors, they either don't have the time or don't take the time to keep up with research in areas outside their purview. My primary care doctor asked me what NMN and caAKG was and why was I taking it. Even though he didn't advise against it, it was clear he disapproved my taking medication a doctor hadn't prescribed.

[@hiamp1000]

metformin longevity study was a fail

[@Bllackdog]

To demand a doctor knows everything about new research is inappropriate. I do understand the frustration about that but it's clearly not possible. Dozens of new research papers are getting released every day with a huge variety of topics. And on top of that a doctor based in a town or a village has to support his patients all day long. Especially during this time with covid and other stuff, they got plenty to do. At some point a doctor also needs some rest. They are human. I do think that there should be something like a trainee-program for doctors in new research fields and the state should support that. In a jungle full with regulations, new patients, pharma-companies that contact you to get you into their selling - program etc., something like an anchor is needed, on which a doctor can orientate himself without checking dozens of papers. You also may not forget that Sincere just like other researcher on KZbin are not medical doctors, they are researchers. It's their journey to find such things, they have the time for that, because it's their all day long business. And I also want to mention that nowadays almost everyone knows about bad nutrition like sugar that harms your health. The internet is full with advice about food and nutrition and still are a lot of people overweight or have bad nutrition. How many doctors are out there that give advice to their patients to eat better or change their lifestyle and yet they keep up their bad habits. A doctor is not the best practice to change life and live healthier. First of all its the own will to be able to enjoy a longer life.

[@peterdavila3045]

@@hiamp1000 Too soon to tell. The reason I decided on Metformin is because Diabetes runs rampant in my family. I was seeing my A1c creep up every year to reach a peak of 5.4. Glucose getting up to 97. That 97 number is way too high. I was finding myself routinely falling asleep after eating. It was more like passing out. I was very close to pre-diabetic. The Metformin has taken my glucose down to 87. I'm trying to get it down to below 80. My A1c is down to 5.3. A little lower would be more desirable. But, I just don't take Metformin. I do intermittent fasting every day where I eat all my calories within a 4 hour period, from 2 pm to 6 pm. This allows my body to lower the blood insulin level for those 20 hours without food. So even though Metformin may be making it easier to the cells to absorb sugar, there is none in the blood. I'll report back in about 2 months with updated glucose numbers when I get my latest blood work.

[@TV-ob1if]

@@Bllackdog no. actually it's not inappropriate. Unrealistic maybe, but not inappropriate. They have our lives in their hands

[@Montie-Adkins]

I'm 51. If I'm going to live potentially another century the technology will get better and better in that century and I would fully expect to life spans to become what we want rather than what we have to accept.

[@marktapley7571]

Living on fantasy Island, huh Mon?

[@globaljobs1855]

Nice hopes

[@ironmaidenfitness654]

LOVE David and totally believe that he is doing everything possible to bring longevity to the masses. You go Professor.

[@masoncnc]

Don't connonize a guy that sells faked research projects to big pharma.

[@steves6016]

His company is advocating and petitioning fda to ban nmn without prescription. Think again..

[@ironmaidenfitness654]

@@steves6016 I don’t care what everyone is saying, I’m still Team David because he had impacted my life in a positive way.

[@ironmaidenfitness654]

@@masoncnc first of all your statement is not factual and second, I love David as he has impacted my life in a positive way. If it wasn’t for him I would not be this healthy and have hope of scientific breakthroughs associated with longevity being imminent. I choose to be positive and kind, not spread misinformation and negativity.

[@masoncnc]

@@ironmaidenfitness654 Google it. I'm factual.

[@TripleVR]

This was amazing. Why on earth is this so short? This should be 1-2 hours at least.

[@aolcb]

David please do a podcast of all supplements we can take or purchase to help extend our lifespan!

[@grantburris]

I like David Sinclair. I try to follow him wherever I find him. He has a huge message.

[@unreactive]

Awesome!

[@udonloews1301]

To be healthy and young -live productivity -be mindful 🌹

[@godiz6773]

Glorify Bless

[@MrJpchi]

Frozen? Oh yeah, that’s what they did to Captain America!! Lol. 🙌🏽 Honestly I’m the biggest fan of David Sinclair for the last five years and will continue on his exceptional knowledge and work.

[@RLReagan]

I saw Peter walking in the road in Culver City and almost jumped out of the car to meet him. I love how he thinks and speaks.

[@wg8561]

You should have told him to use the sidewalk you'll live longer 😜

[@amarsinghhembram4379]

@@wg8561 😜

[@Rafas216]

​@@amarsinghhembram4379 😜

[@drsriram167]

I am very much interested to try david's medicine

[@user-bd1ge2fd4f]

Dr Pius Ozigbe is Always on time. compassionate. Empathetic. easy to take to and relates exceptionally well. Hands down the most effective and efficient doctor I recommend him. thank you doctor!!!!!

[@paulman1970]

Imagine what we would have if all military spending had been spent on medical/biotech research.

[@rjwearelindfors904]

We would've been a radioactive suburb of Roosha; no lie. Go study some actual history.🌅

[@phillthorpe2643]

That would be the end of the USA

[@Life-Inspired-Healing]

It's easy if you try 🙏☺️

[@joshgroft5682]

Your point is well taken because that is alot of money that might seem misdirected in comparison to life giving research. But it also highlights an even greater need for military research and protection to identify and protect against bioweapons and biogenetic weapons that might spring from it. Anything that counters aging and cause deaging might be reverse bioengineered to cause accelerated or rapid and potentially irreversible aging. Where longevity research focuses on advancing life, it will be the military's job to identify how this new technology might become a threat. They will take measures to prevent that from happening or prepare for it's possibility with antidotes and counter tech. It"s also possible the military might already have this type of knowledge but keeps it under wraps based on the defensive consideration of risks above benefits. When we want to live longer their may be opponents who don't want us to live at all. And as wonderful as the results of this research can and will likely be, it's essential to keep the potential for harm in mind, primarily concerning an advancement of this magnitude.

[@erseshe]

​@@rjwearelindfors904 How would Russia have any weaponry if all military spending had been spent on medical research?

[@stevenwelp7165]

The Warriors.

[@Kaitrader]

People do not really want to live for ever - they just want to be "younger" for longer - so if we could live to 100 but remain "youthful" for the first 80 or so years that would be great enough. So working on how to substantially slow the aging process is certainly the right perspective.

[@luismiguelmartinezsanchez4069]

Tampoco es obligatorio vivir eternamente

[@ChrisBear1989]

I think people would rather chose when to go, staying young(20s) at their behest.

[@Live-Forever-Club]

Interesting to get an update on the Longevity X-Prize - that should raise awareness of rejuvenation and encourage even more scientists and companies to get involved

[@bighands69]

Scientists are not were it needs to happen. What needs to happen is a developed market place with the public keen on it. That will create incentives never seen before. There is no reason why aging healthcare cannot be as popular as iphones or the latest fashion trend.

[@christriseninteractivechur2192]

Thx

[@yannlang4849]

Greetings Doctor I am waiting for you to discuss

[@healthdecodedwithaltaf3647]

Great show, I am doing this the natural way so far I am happy with the results 💥

[@Life-Inspired-Healing]

Natural ways are tried and true 😉 mind-body healing, exercise, nutrition, anti stress activity and lifestyle 🙏 this industry is interesting though.

[@Dreamaster2012]

The humor is welcomed ☺ Not too much of course, but life is worth it because it's funny as much as anything else.

[@Life-Inspired-Healing]

Laughing benefits our circulation and eases muscular tension 😄

[@mossycreek]

What I learned from this video is that people may live longer some time in the future.

[@orangesunlabs]

There is a way to get clarity of safety that is more effective than mechanical instruments/testing, but that will require that scientist recognize and employ the value of intuition. I foresee a future where the most sensitive and trained instruments on earth (certain type of humans) and scientists work together in harmony to make great and highly valued strides.

[@marktapley7571]

It’s called the 4th industrial revolution, where you will own nothing. Kind of a repackaging of Marx’ (Moses Mordecai Levy) communist manifesto.

[@conniegreenamyer6636]

The most important is to get old and continue to be independent Love ❤️

[@SkipYearSix]

Where do we order these supplements?

[@freemarketswork]

I sure hope they add Vascular Health to the age reversal X prize. “A man is as old as his arteries.”-Sydenham Happy New Year!!!

[@marktapley7571]

The main thing they're adding is more research dollars into their pocket. Eat low carb and get off the seed (vegetable) oils.

[@kathleenking47]

Use vitamin K2 or eat natto It keeps arteries clean and lowers blood pressure. However you need to get over the taste/smell

[@incognitotorpedo42]

@@kathleenking47 I use K2 in gelcaps and there's no smell at all. I guess you're talking about natto.

[@MyFirstHandle]

I'm looking forward if he'll ever continue working to discover ways to for a slower aging than NMN. 20% longer isn't my ideal living. I want my cells to stay with me longer or forever without abandoning me behind, leaving me dead regardless how healthy my lifestyle was.

[@Life-Inspired-Healing]

The game changer for you will be when they isolate the aging genes and deactivate them. Personal suspicion: more progress has been made here than what's been published.

[@VenturaIT]

@@Life-Inspired-Healing yes, they have it but they are hording it for "themselves", hence the great reset

[@Life-Inspired-Healing]

About ten years ago a genetic research group announced they had isolated the aging genes. It was news for a week then radio silence - subject has barely surfaced since. Interesting is all ...

[@VenturaIT]

@@Life-Inspired-Healing They know, we are a reset civilization... we've just been figuring out old tech for a while.

[@VenturaIT]

@@Life-Inspired-Healing It's just like with robotics, I was into robotics in 1982 and you really don't see much difference in robotics since then except companies like Boston Dynamics... the LED tech got better but other than that it's still at the same basic level as in 1982... which means they have super advanced stuff in secret that nobody knows about.

[@Life-Inspired-Healing]

I can't help but feel it's only a matter of time before the age reversal industry feels strong push back in terms of regulation which centralises the power, profits and control of distribution. A population living half again as long (as David himself alludes to in 'Lifespan') brings with it a ton of socio-economic challenges and complexities. For now, let's leverage the early opportunity presented 🙏 great work

[@ChrisBear1989]

It'll be the opposite I think. People will be desired to be less weak and fragile as aged people ar. It will be incentive(So they can continue working longer). Reversing aging process to not being an issue is a massive boon.

[@Life-Inspired-Healing]

@@ChrisBear1989 I hope so - and also that it is available to every one , and not just a wealthy few.

[@ChrisBear1989]

Understandable but I don't think it will go that way, not to mention I can see people outright refusing it due to religious reasons and such.

[@konradponiewierski7907]

Yes. Some technologies are available now. Non drug is a bonus.

[@2xc4u67]

9 years to go!

[@ligiasommers]

Love the work of you both ! 2023 of happiness, health , youth and peace 🙏🏻✨🥂🌹🙏🏻

[@Birhanu.A]

Same to u dear 😊

[@thanosvibes]

Very insightful podcast!

[@bighands69]

One way of getting better PR on it is to rebrand it has aging healthcare rather than calling it a cure or age reversal. Aging healthcare sounds better and it is something that many would get behind especially if it is focused around muscle health, brain health, organ health, blood health and so on.

[@lutaayam]

I have a feeling this will just suddenly hit us the way AI is doing now

[@swozzares]

so overhyped and overrated then

[@MrDarre86]

why I get the feeling if we follow this guy we will live shorter and shorter...

[@mohammadkooheji1286]

@@MrDarre86 why

[@joshgroft5682]

@@mohammadkooheji1286 I ask why as well. I think it's wrong when people try to discredit David Sinclair. He is a credible pioneer in Longevity research and genuine in his efforts to increase life span and health span for people. He loves his job and is doing all he can to help humanity and increase quality of life and survivability.

[@Rafas216]

​@@MrDarre86 porque você é um pessimista 😜

[@myagent21]

Where can we invest in this medical breakthrough?

[@mikolajnwrski4648]

Good morning! I am contacting with you because I am very much interested in the topic of sirtuin activation and general antiaging. I have been following various studies for years and have a strong interest in this subject. I have been wondering for a long time about the properties of astaxanthin (specifically, whether it works antiaging or also activates sirtuins). Have you ever done any research on astaxanthin? Is our any information on this subject you could share with me? Thank you very much in advance for your help! Kind regards, Mikolaj Niewirowski

[@ciaranryan7303]

The FDA have put a ban on NMN inresponse to David's company filing for a form of it as a drug. So far you can still by NMN but its future is uncertain. As it has already been sold as a supplement it may end up contested in court. While I appreciate David's research, I don't think he should get to own NMN as it occurs naturally in the body and in certain foods we eat.

[@stephencarlsbad]

@7:16 "The FDA was surprisingly receptive..." Yeah, I bet after you offered hefty kickbacks!

[@faisal-ca]

Very well said.

[@pastryshack551]

@@faisal-ca he wants to milk the public, that's what. Another phony scientist.

[@robburnett9053]

Are you involved in potential ban for NMM?

[@tonyeden8381]

How long were covid vaccines/drugs tested for?

[@jsikes4435]

Sign me up. I’d love to feel and look to be in my 20 years again.

[@someblokereckons]

The success of this is inevitable, but i wonder how closely held it will be.

[@alexegus71]

Who in their right mind wants to extend their lives to 150yrs when you can have eternity pain-free up above

[@marcusiA-immortalistMarcus]

I love the nad plus pills. I believe on physical immortality

[@f1rstprinciple]

Simple question, how do anyone it works?

[@jensenachilles2766]

I'm 27 and already take rapamycin and metformin. Get on top of it early guys, the younger you start, the better.

[@MHG796]

I'm 20, should i start?

[@johnhess5104]

How did you get rapamycin?

[@NTMihaila]

"It runs in my family." XD

[@hackingthehumantimemachine9360]

We need progress. One way of getting important information quickly to guide later human trials is to perform experiments on Primates. What we would need is to reverse the age of an aged Primate such as an old Chimpanzee. What does the Chimpanzee have to lose? We should be able to get primate trials done much earlier so that we can use this information to help to de-risk the human trials and thus to get them approved earlier.

[@nothingmanofgod.6288]

Awsome thats is better than the end 👽🙉

[@autisticautumn7379]

Does metformin have more of an effect in older people ie 50 when inflmmageing kicks in .Been told its not effect in younger people.

[@coder8515]

Senectus ipsa est morbus (Old age itself is a disease) - Terenzio Afro (160 BC)

[@ivaluska]

Age reversal is HERE!!! .... In the lab. Unfortunately, anyone 30 years and older will be long dead before any of the stuff talked about here becomes a bonafide treatment for aging. I appreciate the detail of breakthroughs - they are astounding - but let's face it, from initial trials with mice to working therapies on humans is one or two generations away. Maybe my grandson will be able to use this?

[@fannyvalentino.1951]

What is the effect of resveratrol,MNM,to someone? Im taking now 500 mg/ day and Im experiencing LBM.

[@arxmechanica-robotics]

When the guy working on longevity research looks younger than the last time I saw him, he might be sipping on the soup he's cooking.

[@manjunathaa.m9242]

I've been taking NMN (1g) and trans-resveratrol (500mg) supplements for 6 months, and I've noticed increased hair loss. My hair is thinning, and my scalp is showing. If I stop taking these supplements, I notice that the hair fall halts. Has anyone experienced this? Any advice?

[@MrChristiangraham]

Is the NAD booster Sinclair's company is working on simply NMN?

[@ironmaidenfitness654]

It’s a different form of NMN

[@artievipperla2635]

What about no-carb intermittent fasting? As best as I can tell as a psychic energy healer the benefits of eliminating insulin resistance with wholesome nutrition surpass the promise of inventing some bio-manipulative intervention.

[@sandtowalk]

What's david's take on Resveratrol ?

[@mrodino3544]

1g and must be white in colour and always with fat. cocosoil is good, olive oil is even better. About one table spoon

[@ArkeOpen-kb2us]

We can't get it medicine in Nepal when arrive it madisine in Nepal and qatar

[@denaaustinmiller1331]

Please tell me that this means me/ I can become pregnant and birth a health baby or babies at 52 or older. So grateful to have birthed two healthy sons, my happy sons now 21 and 23. I would love to have that life again. Age reversal for me means being able to do Mom life all over again.

[@UncompressedWAVmusic]

David thanks for mentioning your list of supplement you take daily as mentioned on page 304 of your book Lifespan. I just googled it found it and taking the list to the health store. Thanks for your great work to benefit mankind. It's amazing that you have been listed by TIME as one of the “100 Most Influential People in the World,”.

[@faizalpatel6050]

What are the supplements he takes in page 304?

[@UncompressedWAVmusic]

@@faizalpatel6050 Google His name and the first name of his book and page 304 supplements and it shows up.

[@marktapley7571]

The supplement manufactures thank you very much!

[@UncompressedWAVmusic]

@@marktapley7571 I appreciate the supplements adn the many benefits they give me and many people who don't believe in supplements end up with the many side effects of the prescription drugs their doctor gives them.

[@marktapley7571]

@@UncompressedWAVmusic I think that lots of the stuff Sinclair recommends is marginal at best. Eat a good diet, get sufficient exercise, plenty of sleep. None of the oldest people that I have looked at took very many supplements if any. Remember too that Sinclair has started marketing supplements.

[@Wreklessink]

the show sounds interesting

[@royalaurastudios3339]

If we can ever regenerate energy cells in the body for reverse aging we may be able to reverse and even repair bad or damaged brain cells in people who have memory loss. we may be able to revers it in our main DNA base codes I hope that can become a reality.

[@marktapley7571]

Hope in one hand, s**t in the other and see which one fills up first.

[@incognitotorpedo42]

@@marktapley7571 LoL. Eventually we are going to have some real anti-aging technology. I don't know when, but probably sooner than a lot of people think.

[@r8bior]

Question: In staving off death, are we foregoing time that could be spent in the afterlife?

[@joshgroft5682]

There's no way to know that without dying.

[@ScarlettM]

I don't think it matters to God if you meet him a couple of thousands/millions of years later than planed. He is eternal.

[@TrueLife..]

Have at it hoss

[@yourlogicalnightmare1014]

Time doesn't exist in that realm

[@nyx211]

Yes. Just like how we stave off death by not jumping off cliffs or running into traffic.

[@svenoscarhansen8847]

Wow. This is a bit materialistic in it’s scope. Many of live a life where the soul is also a daily experience. And where it’s not simply about extending the material experiences of life. This perspective should be part of the discussion.

[@arthurcallahan4735]

With red meat does that take into account grass fed redmeat or just processed factory meat?

[@dongrey8975]

Solve the Hayflick Limit ?

[@foxfox-xx3zk]

Yinfeng has priced itself at the top of the market alongside Alcor, which charges $200,000 to handle a whole body and $80,000 for a neuro. Alcor has the largest number of people who have committed to paying its fees. Cryogenics

[@davidderidder2667]

Excellent dialogue. My sincere appreciations gentlemen, this is for sure the kind professional and balanced tone and manner of dialogue that will motivate good folks to rally around the topic. Can you organise a movement? Or can I and we help you to organise the movement better? Please advise or brainstorm with me / us.

[@AC-vz9cz]

David, Just call the treatment for aging a Booster AMA and if we don't we could die sooner then should :)

[@philodox7599]

Hi David. Just wondering why your company lobbied politicians to ban NMN in the non proprietary versions and why did your company AT THE SAME TIME have a proprietary version of NMN developed that you could sell for 50x the price of the off brand NMN that your company just helped get banned?

[@JacksExoticReptiles]

Yeah he’s not gonna be on Rogan anymore doing this type of stuff and if he is he will be talking like Zuckerberg 😂

[@curiouskittycat5977]

Because money. I am super disappointed that nmn is a drug!! As if it cam hurt anyone. Really awful... so only desirable people will get to live (longer) and the rest can get cheap vaccine against new flu.. and perhaps they don't reproduce as much.

[@TheDailyGrindChannel-Sam]

Anyone think it would be boring to live forever I know this will never happen but suppose it’s cool to speculate I guess us humans just have the will to survive and not lose everything we’ve accumulated

[@ovidio722]

Unless you have billion's of dollars it will mean you'll have to work forever.

[@TheDailyGrindChannel-Sam]

@@ovidio722 yeah true or you’d need a crazy retirement package😂I suppose you’d need to work to keep yourself occupied if you lived super long though but when people say death gives life meaning I’m not sure I agree with this maybe it’s cause I’m only 29 so just not figured it all out yet

[@SeeAndDreamify]

I suspect it would contain a lot of every emotion, including boredom. Maybe at some point it'd become unbearable, but I suspect that would have more to do with random happenstance than directly based on how long you live. If you live longer the probability of a rough patch would increase just because it has more opportunities to occur, but if you get through it there should be good times again.

[@TheDailyGrindChannel-Sam]

@@SeeAndDreamify yeah I definitely get what you mean I’m 29 and I’ve had so much pain and heartache already just imagine been with your wife let’s say 300 years and she leaves you wtf would that feel like or after you’ve lost a lot of the people you love, but it would definitely be cool to double our lifespans if possible

[@TheDailyGrindChannel-Sam]

@@SeeAndDreamify but I do think existing for a super long time or indefinitely would be better than the alternative but who knows what the future holds

[@sudeepgorhe]

i know some ayurvedic anti ageing herbs but no evidence i can produce one such is jivanti tree powder.

[@cosminxyz2004]

Aging it's a build in feature of life. This is by design like when you make a car. You don't want a machine which will run forever. But to really know that, first you should know the driver - know yourself as life.

[@patrickanderson4680]

Question........ Why do we age? What changes in our bodies to cause us to age? So....do we fix the root of the problem or do we stick with tradition and focus on the systems.

[@Edovic13]

Our cells fail to replicate as they once did when we were young lads and lasses. But using the Yamanaka factors, our cells can “remember” what we once were. Fingers crossed here!

[@ScarlettM]

To stop aging we would have to fight entropy itself, systems slipping into chaos, a universal constant. It's easier to just "reset" the cells every couple of decades.