'Age-reversing' supplements: What NMN, TMG and berberine did for us

[@nicholablakely2832]

I’ve been taking nmn 450mg for a month and I noticed a spike in my energy straight away, work outs are much more enjoyable, deep sleep and dreams, skin is noticeably softer (I am 54)… went to a function with friends and family recently and two people asked what I was doing as I look younger! So I am hooked, I believe incorporating daily exercise and good nutrition is part of this as they help to generate the effects even more. The Pulse is a good Chanel to follow on this subject.

[@thehonestchannel]

Thanks so much for sharing this. It’s great to hear. I’ll follow The Pulse.

[@nicholablakely2832]

Oh and thanks so much, I enjoy your channel and find the info you provide really helpful ☺️

[@snowyowl6892]

Do you also take TMG with your NMN ?

[@BlackMamba-lt8oe]

@@nicholablakely2832 is ur 🐈🐈🐈🐈 tighter with nmn

[@peteh6063]

Absolutely bang on with exercise and healthy diet we have to remember that the benefit to our gut and body health is through fermented foods. Has been the Asian way for centuries

[@drehoward9670]

I like supplements, but EVERYONE should read "Fast and grow young". Our bodies are incredible miraculous creations with the ability to heal itself! All of todays "Dis-eases" are created by our diet. Our food lacks the nutrition it once had, and even 'organic food' has toxins from the soil. Fasting has long been doen throughout many cultures, and even animals instinctively 'fast' when they're sick. The book is fabulous and very eye opening.

[@thehonestchannel]

Thanks for the tip.

[@elsygarcia2831]

Pppppppppppp

[@bigzachful]

100% Amen. God tells us to Fast

[@PierreDybman]

Tell that to a potent virus…

[@drehoward9670]

@@PierreDybman ANY disease! You’re trying to open a whole other discussion. But yes, our bodies are designed to fight any ailment. Any signs of infection, such as runny nose, fever, cough, etc - they’re all SYMPTOMS of our bodies fight. The problem today is that most people will run to the drugstore to get whatever remedy they can, instead of realizing that our body NEEDS the fever, it needs the getting rid of phlegm! If dogs or cats, or any other animals get sick, they don’t eat! The body is naturally designed to go into fasting mode, so it can use all its resources to fight whatever disease. Digestion takes up the most energy, so if we constantly feed our bodies, it takes away resources from this fight. I referenced a book in my original response that I feel everyone should read. There is so much research and information on this subject … one only has to want to learn. God bless 🙏🏼

[@Oliviawww164]

In March 2022, I decided that I was sick of being 16st. I did these things 1. Cut out sugar 2. Cut out carbs 3. Began a carnivore OMAD LIFESTYLE!!!!!! This is not a diet it is a life choice. I am now a healthy 10st. ( Though BMI said I should be 7.5st. Ermmmm no way I would look terrible🥹) I take NMN and TMG as-well as other supplements. At 60 I feel better than I did at 30. I have energy confidence and a new zest for life. PS Love the channel ❤

[@snowyowl6892]

Is NMN beneficial on its own ? ie without the TMG ?

[@Oliviawww164]

@@snowyowl6892 Great question. TBH I do not know if TMG makes a difference . It’s my understanding that the NMN will eventually work but TMG activates it and specs up the process. I definitely look and feel better, but how much if this do I contribute to NMN or living a different lifestyle????? It’s the same with all supplements I think. Only if we stop will we know if they did any good. Hope this helps.

[@C2C.]

@@snowyowl6892 Taking TMG/betaine along with NMN (or NR) helps with healthy methylation in the body -- it replenishes the methyl groups, since boosting NAD+ drains methyl groups, which can affect various biological functions. Studies also suggest that TMG may help reduce higher levels of homocysteine that can harden arteries, help manage fatty liver, help with insulin resistance, and with managing symptoms of anxiety and depression. The recommendation is to take equal parts TMG and NMN/NR.

[@snowyowl6892]

@@C2C. thanks .. appreciated 🤗

[@Gismotronics]

I was in bad health and overweight about 6 years ago. Sleep Apnoea and Acid Reflux. I was about 58 then. I felt consistently terrible. After some research, I changed to a Keto lifestyle. I shed the excess weight easily and never felt hungry on one meal a day. Sleep Apnoea and Acid Reflux gone. However, I think those things caused damage that I will have live with. I would urge everyone to adopt a healthy Keto lifestyle. Don't wait to get overweight and sick (insulin resistance). Prevention is best.

[@MISSIONCAT11]

This regimen sounds great ! I am on a low budget so I use Nicotinic acid instead of NMN. Dr. Stanfield says that NMN and NR are quickly converted to Nicotinic acid after ingestion, so Dr. Stanfield uses 51mg Nicotinic acid instead of NMN. Exercise I do now - (To Raise Blood Oxygen, drop blood sugar, strengthen legs, arms and back) : One or Two Minute Exercise Every Hour. Sit on side of bed holding a small 5# weight in each hand at head level. Stand, pushing weights up and inhaling through nose. Sit down, dropping weights back to original position. While moving down, with mouth closed, blow hard and release air on way down. The back pressure on the way down increases oxygen transfer to blood. VO5 will increase. Continue exercise set for 2 minutes. Do one set per hour. This has been shown to drop blood sugar spike so do extra sets after eating carbohydrates. Varation: Hold weights down. While standing up, pull weights up under arm pits to tone biceps.

[@thehonestchannel]

Thanks for sharing your experience!

[@blythemajors9193]

The tiredness is exactly how you are supposed to feel at night. It means that your circadian rhythm has been reset. Awake during the day and sleepy and ready for bed come night time. I had a similar experience going fully carnivore. Great sleeps and fully awake as soon as my alarm went off and I was ready to go for the day.

[@raduneo]

Exactly!!! I was just going to post about this! People need to get realigned with our bodies and with nature. Also screen time before bedtime that she describes is terrible practice. It is SO important to take sleep seriously for health.

[@megret1808]

During the lockdowns I fasted, went paleo and rapidly lost 22 kg going from hypertensive pre diabetes to perfect. A daily one hour walk to and from the gym was also helpful

[@MostAlpha]

Congrats.

[@wildflower-web]

This video caught my attention because these are 3 out of the 4 supplements I take. The fourth is Cod Liver Oil.

[@thehonestchannel]

Omega 3 is really important so that's a smart choice. I try to eat a lot of fish and also eat flaxseed daily.

[@noutram1000]

I also take a low dose multivitamin/mineral tablet for the water solubles and Omega3 for the fat solubles.

[@stefcat5331]

I add AKG and creatine as well. At 70, the berberine is better for me with breakfast and dinner, but your supplement regime is sound and gets desired results.

[@tjf7101]

NMN and NR are one phosphate molecule away from being identical. They’re both good folks

[@HelloNil]

I have had bought Berberine and lost since then I taking them a few pounds ! Very pleased about it ! Thank you :)👍👍🌹🌹

[@anjaxtv]

Oh dear...I've been taking nmn for a about a month now during dinner 😳😳 I've been confused as to why I can't sleep at night. Literally an hour ago my friend asked me how my sleep has been and i said i have to take sleeping pills to even sleep a few hours. Ive always slept 9 hours a night. THANK YOU for this interview ❤️💛💕!!

[@thehonestchannel]

Glad it helped!

[@noutram1000]

Take it before breakfast or lunch at the latest. I treat it like caffeine in that respect.

[@anjaxtv]

@noutram1000 thank you ❣️❣️ I will :)))

[@margaretfoley1247]

I’ve been keto/ carnivore for ten years. Now 60 yrs young I feel fantastic. So much energy and cleared ALL my health issues . Stopped menopausal symptoms within months x

[@sandragittleson9750]

Margaret, can yo tell me any more details I am turning 60 this year and I started on a menopause patch .. I does help fight hot flashes. But I'd rather not be on them

[@marcjames3487]

Thanks for introducing Dr Seranova, she has a wonderful ability to explain things precisely and clearly. I know NMN works because at first I took it at night and had the worst sleeps with a hyperactive mind ! Although at the same time my ability to absorb information dramatically increased. Now it's the first thing to take when I wake up before I exercise. The mind does remain clearer and more grounded. I've slowly come to regard carbs as the enemy, in some ways a poison, and here is confirmation that Keto with a lot of low carb veg is the way ahead. Cycling is a good idea, I have found the effects diminishing although maybe I'm just getting used to it.

[@thehonestchannel]

Thanks for sharing your experience!

[@C2C.]

I really wish this channel would feature guests who don't have a commercial motive. I take NMN/NR, but I get my information from credentialed sources (reputable MDs and PhDs) who aren't selling the supplements. Same with cosmetic products and devices. It's just more credible to rely on evidence-based research and get information from people who aren't promoting their products.

[@inthemystery8297]

So if you use otc brand which do you use?

[@C2C.]

​@@inthemystery8297 ProHealth Longevity. It's one of the few that have been tested to show that it actually contains the amount of NMN claimed on the label. If you can, get on their mailing list to get discounts. I usually by mine in bulk when they have their big annual sale. I've also taken NR from Renue by Science.

[@C2C.]

@@PolishPocahontass ProHealth Longevity. It's one of the few that have been tested to show that it actually contains the amount of NMN claimed on the label. If you can, get on their mailing list to get discounts. I usually by mine in bulk when they have their big annual sale. I've also taken NR from Renue by Science.

[@nigelcrits]

@@PolishPocahontass i use nootropics supply depot, the dose is low but perhaps the coating makes it more efficient.

[@Mariellemusique]

My thoughts exactly! I was trying to wrap my head around what bothered me about the video. More like a very carefully placed out, disguised ' informercial.

[@melelle25]

Thanks for the info! I've recently come across Pycnogenol and am starting to take it. I've read some amazing benefits, like it increases hyaluronic acid levels in the skin up to 40%! It also helps with blood circulation. Keeping the blood vessels on the face healthy and living is important to aging gracefully.

[@pineapple365]

What brand do you take?🥺

[@thehonestchannel]

Interesting! Thanks for sharing this.

[@melelle25]

@@pineapple365 I've been taking the Now brand 100 mgs once a day, it also contains AMLA. I take it with arginine and ornithine upon awakening. A&O seem to burn fat for me. I'm on day 3. No side effects and I can tolerate taking it on an empty stomach.

[@pineapple365]

@@melelle25 😇

[@melelle25]

@@pineapple365 BTW, The Ordinary has a 5% Pycnogenol topical. I've been using it for a couple of days. I don't really like how it feels on my face but I shall persevere.

[@lq4657]

She is riding on the coattails of Sinclair while selling the supplements he recommends. Berberine is a non script alternative to Sinclair's darling, metformin.

[@StellarNomad42]

How is what she's doing riding on Sinclair's coat-tails? It's a free market.

[@sjb2105]

I’ve been taking NMN for about three weeks and the first week was terrible. No energy, tired, sluggish- week three it’s finally got better! I feel rested in the morning, got energy during the day and im not wiped out after the day at night. It’s not the big burst I keep hearing about more a steady and consistent energy.

[@thehonestchannel]

That's really interesting because I felt tired for the first few weeks too and that's resolved. I do think I have more energy overall - just as well as I really need it right now!

[@thehonestchannel]

@@ranghashalatr142 NMN Bio and others ship internationally

[@snowyowl6892]

@@thehonestchannel HERXHEIMER reaction ✅

[@revealanation7778]

​@@snowyowl6892... are you sure it's a reaction because I'm about to send my NMN back to the company, I feel horrible taking it for about a week now at 150 mgs?

[@amperage8032]

I took NMN for almost a year waiting for an effect and felt nothing but more fatigue. I’m a healthy person so maybe it isn’t necessary.

[@user-xm8ye5ti5f]

I just started watching. I have taken all 3 of these supplements for 6 months and to be ownest with you i noticed no difference. That's why i stopped. Have a great evening!!

[@thehonestchannel]

That's interesting to hear your experience. It's funny how these things affect people so differently.

[@user-xm8ye5ti5f]

@@thehonestchannel i have to add that i follow a ketogenic diet and i'm 42. Thank you for these very interesting interviews!!!

[@thehonestchannel]

@@user-xm8ye5ti5f You're already turbo-charged then 😄

[@TheDulce82]

I have taken nmn supplements , TMG and berbrine ( which is also found in cinnamon if you drink cinnamon with hot water ) for a year . I noticed not much of a difference . HOWEVER when I took NAD plus via IV drip , that had a turbo affect on me , killed my sugar cravings , I have a sharper focus , better quality of sleep and decreased my anxiety substantially. And also I recover so fast from my work outs . I highly recommend taking the drips , they have a higher dose and goes through ur blood stream . Having said that I still take the supplements and I also take multi vitamins and probiotics developed by a neuroscientist . I also have a Celluma infra red panel that I am addicted too . 😅😊😊😂😂😂

[@ginar51]

Why not just take NAD supplements?

[@santanacaipirinha9536]

I tried this for a few years, different doses, premium quality products. No results whatsoever. It was worth a try, but a hit to my bank account.

[@thehonestchannel]

Thanks for sharing your experience

[@kmjdebay]

I'm curious about your age. From what I've seen, the younger you are, the less of a difference. Another viewer mentioned Brad Stanfield, who is in his 30s, and some of his choices for his own supplements are based on his age. He has said he will do things differently after 40, 50, and more.

[@santanacaipirinha9536]

@@kmjdebay I was in my early 40s when I took NMN, mid 40s now. I follow Dr. Stanfield as well and he's actually stopped taking NMN and plans to start taking NR once he reaches his mid 40s. He's just not convinced about the research so far. It's hard navigating all these supplements as you always seem to have to take all kinds of different ones together . Once you start taking one, you need to take two other ones to counteract some effects of the first one. Then after you've done that for a while one of the people you follow in the field will come out with a video on why they stopped taking it. At least if it did something for me it would be worth the time, effort and money. Same with all the beauty products and devices. You start out very committed, but it just becomes too frustrating at some point. I'm on a cavewoman break for the time being, watching it all unfold from the sidelines.

[@heidikamrath1951]

Clare, with all this talk about blood glucose levels, have you considered wearing a continuous glucose monitor for a few weeks to *actually* track it? There are several on the market. Levels comes to mind. Zoe offers one as well if you agree to be in their study/ies. I just think, rather than say you “feel” like your blood glucose is this or that, it would be more convincing if you *know.*

[@thehonestchannel]

Yes, that’s a good shout

[@anngray9171]

One very strange thing re NMN is eyesight.... February cataracts, July cararacts both eye, looking through fog. Mid August up to mid October taking NMN. Vague idea that i could see things, less fog ++. Ran out of MNM . Went to hospital specialist. Eyes are good! Now 6 days without MNM can't read small print, fog descends. There is no other explanation that i can imagine. Why aren't i taking MNM? Can't get hold of it. I have a supply in the EU customs and they aren't releasing it. Banned substance in EU. The long reach of big Phama.

[@thehonestchannel]

That's so frustrating for you Ann. Thanks for sharing this and I hope customs release your order soon!

[@sansabh]

I watch the other channels too, and I think you're the most articulate 🙏

[@thehonestchannel]

That's kind of you to say, thanks.

[@olilumgbalu5653]

What do you think about glutathione? Glutathione is supposed to have anti-aging effects and it is composed of three amino acids: 1) NAC (n-acetyl cysteine) which is also supposed to be anti-aging, likely because it is a precursor to glutathione 2) glycine which is also anti-aging for the same reason as NAC and 3) glutamine which is good for gut health.

[@claudiaglows]

Another great interview! Thank you Clare

[@manuelojeda9144]

I've been taking almost all those products for 6 months or more by ProHealth Longevity from California USA.

[@rosiefoster713]

Maybe you could ask someone to give their option that does not aim to make a financial gain from selling their own product, an unbiased review .

[@lisellesloan3191]

This is all based on anti-aging pioneer, Harvard's David Sinclair's protocol, which has proven results. I advise going easy on the berberine if you have stomach and digestion issues, as it caused terrible cramping in my intestines. I recommend Metformin (off-label) for blood sugar control for those that have similar issues.

[@bigguy130]

What about the more absorbable form of berberine called dihydroberberine? Supposedly one can take a lower dose with less concern about side effects.

[@vee8633]

Berberine can also cause constipation.

[@charlessavoie2367]

I'm reading about taurine, carnosine and jiaogulan for anti aging!

[@eileenbrown3805]

Very useful information especially when there are so many doctors promoting their supplements & diets! Hard to know which is best & right for one or what may be just hype. Thank you for investigative reporting! PS. Maybe your father may want to try the red light therapy on his feet for his arthritis to see if it may help as well?

[@thehonestchannel]

Thanks Eileen. There is a lot of conflicting information out there at the moment, that's for sure! That's why I usually position myself somewhere in the middle of it all!!

[@liveagaincoachingministry1319]

Moringa is a godsend for treating arthritis.

[@juliusctw]

Please run an nad test as soon as possible. Ideally you would run the test before the supplements, but you should do it soon to keep track of the progress. At your age your nad level should be at half of a teenager, so if you take the test now you can compare against that. I would be very interested i hearing your results. Also, you want to consider taking a biological age test, your biological age should decrease as you take NMN and TMG. If you take that test also please share your results.

[@juliusctw]

@-TheHonestChannel ok thanks, acknowledged?

[@brookeb7994]

​@@juliusctw where can you get those tests? What are they called?

[@juliusctw]

I just got my tested and it was very low, he appears. That NAD boosters I was taking were not effective.

[@SuperDflower]

How do you test NAD? Where did you get tested?

[@deanervik]

I take 500mg of NMN (based on human trials results) on Wednesday and Saturday mornings hours before eating my first meal at noon. Also I take resveratrol after dinner on Wednesday and Sundays, especially if there’s oils or fats in the meal. I was 56 when I started 4 years ago, feeling great so far, hair seems to have stopped greying 🤞 (To be precise I take 250mg in the morning on an empty stomach then the other 250mg in the afternoon between or before a meal)

[@thehonestchannel]

Thanks for sharing this. It’s a really interesting approach and one I’ll speak to my mum and dad about. I’d rather not take NMN every day without breaks.

[@theo5261]

Hi ! Is there a reason for you to cycle NMN only on Wednesday and Saturday mornings ?

[@blythemajors9193]

@@thehonestchannel you could take the weekends off if concerned about long term use with no breaks.

[@drunvert]

Resveratrol isn't all that. A lot of the studies have been debunked

[@deanervik]

@@theo5261 Too much of anything isn’t a good thing and I’m the same with vitamins I think of them as stains that permeate the body, just as it gets cleared from the body a few days later, then there’s another hit to top it up. Moderation seems prudent and in the long run there should still be benefits.

[@HeartFeltGesture]

Berberine, Niacinamide, TMG, Psyllium Husk, Cider Vinegar.

[@masiiharwood6082]

Thanks very much for this wonderful information ❤❤❤

[@joannsmith9]

I feel much better, don’t need an Afternoon nap any more, more stamina but I do notice that I’m NOT sleeping as well and I’m only taking 250 mgs

[@mihaelafrincu8732]

Very good presentation, keep it up!

[@thehonestchannel]

Thank you!

[@megret1808]

I tell people to shop the perimeter of the supermarket where the coolers of fresh food is kept. I also love my bulletproof coffee with grass fed butter

[@usadaily135]

Same here.

[@raduneo]

Tiredness at night is NOT a downside. We are supposed to feel tired at night as our bodies tells us that WE SHOULD BE SLEEPING EARLY. If we do not, you will get much less production of the 4 hormones that heal you, help you with cognition, help you memorize, and help you rest properly. Watch the emphasis Dr Huberman gives on sleep. (and any serious holistic health practitioner really)

[@jacklan4103]

Carbs are not entirely bad. Refined carbs are bad but complex carbs are good and can be found in fruits and vegetables. This is why the Blue Zones are known to be the most healthiest places to live because their diet is high carbs, low protein, and low fat.

[@susymay7831]

Your timestamps really accentuate your nice videos! 👍

[@TheWBWoman]

25:24 - She actually reports her experience in taking NMN.

[@creightonfreeman8059]

In 1982 Pearson & Shaw in "Life Extension, A practical scientific approach" suggested caution in abruptly stopping megadoses of water soluble vitamins because of the potential of causing symptoms of vitamin deficiency if cells and tissues acclimated to high levels of vitamins are suddenly deprived of them. For this reason I doubt that "cycling" a water soluble co-enzyme like NMN is a good idea, at least not without a gradual taper off the dosage over a period of two or three weeks. For the same reasons Dr. Seranova recommends ramping up dosage when starting a new supplement, when quitting I think it advisable to ramp down the dosage over time as well. Cells seek to maintain Homeostasis, and abrupt changes mess with that.

[@coralinenorman5149]

Thank you for this fascinating and informative video! :) I'm wondering if you take a B vitamins complex, in addition to NMN? Is it fine to take niacin in addition to NMN? I have been taking Seeking Health's B-Minus Complex which contains 50 mg niacin but I don't know if that's compatible with NMN. All best wishes from Brighton ^_^

[@Cozmicsuga]

Thanks you for sharing all this info.

[@nickchristopherson6162]

If you can exercise u do not need to take berberine..in fact it attenuates the stress it puts on u and lessens your vo2 max...plus it was just found out that when NMN goes through the liver porthole it is changed to nicotinic acid..you are better using nicotinic acid that is a fraction of the cost and it does support the nad salvage pathway

[@thehonestchannel]

Hi Nick. Do you have a link to the nicotinic acid study you mentioned so I can take a look? Thanks!

[@markroeder2491]

@@thehonestchannel Crickets?

[@Dggttaj]

Could you pleases interview Dr William Li EatTo Beat disease

[@safffff1000]

This sugar, insulin problem is recent. I think the biggest factor is the destruction of the gut biom from the onslaught of desiccants, pesticides used in growing food and the 100's of additives to food and antibiotics. I think the gut was to preprocess the sugars before being absorbed into the body.

[@Philly1958]

Doesn’t berberrine inhibit lean mass muscle development

[@susanbornhoft955]

If you had breast cancer is it NOT recommended to take NMN . Thank you

[@sadiqakhan3498]

Thanks for doing this video dear.

[@elizabethk3238]

What makes you 🤔 no it's okay to refer to these women as 'dear.' NOT OKAY! Especially for a Muslim man!

[@holli918]

Great video (as always) are you still on the supplements? An update would be fantastic!!

[@thehonestchannel]

I still take NMN and am working towards doing an update in October. I dropped the TMG and berberine but then reintroduced TMG recently. Sorry for the delay in doing an update. We have had a couple of health setbacks - nothing major but we wanted to get the conditions right for testing our NAD levels properly.

[@momozenzo4975]

I do respect very much this expert's opinion. However, on anti aging diet, I would check Dr. Valter Longo and David Sinclair (both PhD too) which are the most importante experts in life style for anti aging purposes and their work is mainly scientific.

[@cathrynanderson9524]

Please clarify, the Doctor stated the study about NMN and cancer patients, and she said the study was actually using NR - she repeated that cancer patients should not take vitamin B, so is she saying it's safe to take NMN or not? ❤ I am a cancer survivor undergoing testing for a possible recurrence, and I've been taking NMN for almost 5 months ... Thank you!!

[@anngray9171]

I'm following Dr. David Sinclair. He has years of experience in research. Interesting regarding Resveratrol, low dose to lengthen life. If you're older, perhaps the shadow of tumors in the background, high dose of Resveratrol ....seeks out and destroys possible tumours situation. So one product 2 different purposes. Check out the man. Damning thing..NMN banned in EU from this year. Why? Perhaps Big Pharma feels threatened?

[@bernadettebecher4689]

DrBeen did a recent podcast on Berberine- very in-depth.

[@markusantonious8192]

I've long taken a whack of supplements - including berberine et al - but it would be rather more convincing here if the guest speaker wasn't peddling these supplements. Moreover, no mention is made of the simplest, cheapest and likely most effective way to reduce / eliminate insulin resistance, i.e., by intermittent fasting and time-restricted feeding (I eat mostly only within a 6 hr. window; so 18 hours fasting per day). These regimens also reduce carbs and result in caloric restriction (since you are simply eating only one to two meals a day). There is also the question of the bioavailability of NMN...and, naturally, the expense.

[@slaveamanahilova3802]

great video! good point! Thank you!

[@marthanguyen2533]

I love your videos! Can you talk about "Nira PRO laser" only sold in England. And "AMIRO" skin device. Thanks!

[@lr6606]

The answer to the question about these supplements feeding cancer did not address the actual problem. Of course, doctors will not give these supplements to someone diagnosed with cancer. The issue is, taking these supplements BEFORE knowing of cancer diagnosis and unknowingly feeding cancer by taking these supplements. Would be ideal to have this addressed.

[@blancabenet290]

That is precisely my worry , why I stopped taking NMN

[@AMcD-fp1yf]

There are so many supplements on the market so it can be quite confusing to know the ones that actually work. My friend was on supplements, a liquid to be precise, from a company called Fountain. I remember that it was quite expensive but looking at her I could actually see that it was making her skin glow. I believe that once you start on it you may have to continue in order to maintain the youthful skin.

[@thehonestchannel]

There seems to be a new wonder supplement on the market with each passing day!

[@KenDanielMurphy]

Berberine does reduce blood sugar, so if yours isn't going very high due to diet restrictions or diabetes medications, then your blood sugar may dip too low causing tiredness as well

[@thehonestchannel]

Interesting theory!

[@edenposh1890]

then before taking NMN I have to check myself for cancer???

[@raloufen4292]

Yes.

[@andybowen5814]

OK where to start,,having been seriously ill for nearly 6 years I had nothing better to do than go down the rabbit hole that is anti-ageing and all that is connected with the subject,,I decided to give nmn a try it was not apparent over night that there was any improvement in any aspect of my illness but within 8 weeks my family and friends noted that I was more active and happy to interact with others around me I did myself note that there was an definet improvement overall but put it out of my head with the thoughts that it might not last or it was somehow a placebo,,,roll on to present I am able to complete a hole day at work and go to my bed later rather than come in go to bed routine that had become the normal,,,hopefully I can continue to improve so I can get my life back on track

[@thehonestchannel]

I'm so glad to hear you're feeling well again!

[@andrewward7042]

Since I started taking NMN I do seem to get up more frequently during the night (67 years old). It could be my imagination.

[@deanervik]

Take your NMN in the morning not in the evening or late afternoon as it can act as a mild stimulant. Also don’t drink much water (wine, beer, tea or coffee) in the evenings, I have a 1/3 glass of lite milk after dinner instead of tea or coffee and ever since I’ve never had to wake up to pee in the wee hours. The calcium in the milk also helps modulate the acid in my stomach so haven’t had any heart burn in bed either.

[@deanervik]

Take your NMN in the morning not in the evening or late afternoon as it can act as a mild stimulant. Also don’t drink much water (wine, beer, tea or coffee) in the evenings, I have a 1/3 glass of lite milk after dinner instead of tea or coffee and ever since I’ve never had to wake up to pee in the wee hours. The calcium in the milk also helps modulate the acid in my stomach so haven’t had any heart burn in bed either.

[@deanervik]

Take your NMN in the morning not in the evening or late afternoon as it can act as a mild stimulant. Also don’t drink much water (wine, beer, tea or coffee) in the evenings, I have a 1/3 glass of lite milk after dinner instead of tea or coffee and ever since I’ve never had to wake up to pee in the wee hours. The calcium in the milk also helps modulate the acid in my stomach so haven’t had any heart burn in bed either.

[@leximohamed9532]

@@deanervik thank u

[@lindajoy23]

Thank you Clare for your investigative interviews. My understanding is to take resveratrol with NMN, this is the advice I have heard from scientists studying the area of epigenetics without direct monetary gain from marketing their own supplements. Do you have any info or thoughts on this?

[@thehonestchannel]

I see quite a few scientists recommending resveratrol, and my husband takes it along with NR. I eat a lot of plant foods rich in polyphenols so haven't prioritized resveratrol - but it's on my radar and I promise to take a closer look at it on the channel.

[@jjtopp99]

@@thehonestchannel There is a medical doctor from New Zealand (his name escapes me at the moment, Stanfield perhaps?) who studies supplements that purportedly promote anti-aging. After reviewing multiple scientiific studies on resveratrol, he has concluded that most of what we are reading and hearing is just hype, unsubstantiated promo, if you will, and more scientific research is needed to confirm or dismiss it as an effective contributor to our anti-aging protocols. He is here on You Tube. Also, David Sinclair refuses to engage in a discussion with him regarding his findings. I take resveratrol daily by the way. I would really like to know if I am wasting my money on a largely ineffective supplement?! It is fairly expensive.

[@thehonestchannel]

@@jjtopp99 Dr Brad Stanfield? I've watched a few of his videos. Unfortunately with conflicting studies it's hard to give people definitives around supplements. I also think it depends on your lifestyle and what you eat too. If you already eat a lot of polyphenol-rich foods then you may not need to supplement. Or you could hedge your bets and cycle supplements so you're not taking them all the time but for periods of time.

[@eightfigs3508]

@@thehonestchannel what is NR?

[@margaretsmith9637]

NR is similar to NMN , Nicotinamide ribosode, I think.

[@Chiroman527]

Frankly, I'm on INFO Overload. I have Spinal Arthritis which generates daily Chronic pains and Terrible stiffness affecting my entire Body and Psyche. I take far too many supplements ....the list is long but does include Berberine, Turmeric, Ginger, Cinnamon, Bromelian, Zinc, Ds, Cs, Es, Mgs, K2s (with D3s). Wish I could say there is improvement. No Can do. Just had 3 recent MRIs done (Cervical, Thoracic, and Lumbar), the arthritis, the Disc Degeneration, sites of stenosis continue to increase. These conditions have been experienced for decades having started in the Lumbar Spine /Hips/SI joints and Transgressed up the spine to the top of my head. So, I seek "MAGIC" (there is no Surgery to help me per 6 surgical Consults). Like BIG PHARMA, I am increasingly leary to puruse even more Supplements (They are expensive too). I'd love to see what this doctor recommends. THX for your time to make this video.

[@deanervik]

I’ve heard that arthritis is a form of autoimmune disease, the K2 and D3 will help but will take time, my wife has similar symptoms but she won’t try any of those. I read something about T cell immunology techniques about 2 years ago that sounded promising but I haven’t followed it up in recent times, worth checking out.

[@deanervik]

I’ve heard that arthritis is a form of autoimmune disease, the K2 and D3 will definitely help but will take time, my wife has similar symptoms but she won’t try any of those. I read something about T cell immunology techniques to combat arthritis inflammation about 2 years ago that sounded promising but I haven’t followed it up in recent times, worth checking out now I’d guess.

[@cori1302]

Do you take a highly absorbable form of calcium Bis-glycinate or get it from food? K1/K2 and D3 work off that. Magnesium Glycinate is a highly absorbable form, and is used in many body processes. Glucosamine/Chondroitin with MSM (sulfur) help coat the ends of joints with cartilage. (MSM helps stop inflammation). Can be bovine (cow) or shellfish based. Also need trace minerals, they're not in the soil anymore. I got Fulvic Minerals by Solaray. Can also drink BLK water from a grocery, or mineral water. Trace minerals help you stay hydrated. Water alone may flush you out too much. Use Celtic sea salt or Redmond's Real salt. I also uso NeoCell liquid hyaluronic acid berry flavor. To hydrate skin and joints. *Just a half a shot in a glass of water, and you will notice a difference in 20 minutes. Regular minerals like potassium, copper, selenium and zinc. **30 to 50 mg or less, as the body turns off zinc when it gets too much. Niacin is important too. You may want to consider a simple heavy metal detox like Cilantro drops (or eat some) Parsley is good too. Don't eat too many greens everyday or you may build up Oxalates, which also cause inflammation, gout, and imitates arthritis. Methyl Folates are absorbable. Folic acid is artificial. Avocados, broccoli, cabbage, cucumbers, are a natural source of NMN... And Vitamin C is needed for many body processes. Found also in berries, not just oranges. Liposomal Vitamin C is absorbable. Ascorbic acid is an incomplete form So - not everything every day. Moderation. On/Off. And eat real foods. For energy/antioxidants I use: Ashwaganda (Yogi Tea Vanilla Spice Perfect Energy) SOD (sodium dismutase) NAC (N-acetyl-Cysteine) with Glycine ***There is also Carnosine, and Carnitine...good stuff, but different Convo. And Collagen in some beverage... Start 3+ days in a row then back off to every other day. See what feels right for you. ***Use filtered water, not Tap.

[@taylorfausett177]

Red light therapy is good for arthritis pain as well.

[@Phoenixrises89]

Look up Orvel Douglas fruitarian… he does monthly challenges on only eating high water fruits and the testimonials have been astounding!!! It’s €15 to participate. My joints, inflammation & arthritis improved so much it was life changing. ❤❤❤

[@edenposh1890]

thank you for another interesting video:)

[@thehonestchannel]

Thanks for watching!

[@camwells9726]

I lead a very healthy lifestyle, early 60s, exercise nut and on a paleo type diet , tried lots of different diets over the years , One thing that was frustrating, my blood pressure while not dangerously high , was always higher than you would expect from my lifestyle, low 130s/low 80s When I went on tmg it dropped almost instantly, around 120/79 , I suspect now I must’ve had high homocysteine, If I was someone else who wasn’t so healthy in lifestyle I suspect it would’ve been dangerously high and a conventional doctor would’ve put me on blood pressure medication that would not have solved the cause

[@galain]

With so much talk about ketogenic and especially carnivore diets, I'm curious how this impacts the microbiome. I can't imagine one getting much resistant starch from a meat heavy diet but I'd love to hear an expert opinion on this.

[@creatuitiveguru]

I feel like potatoes shouldn't be a problem. But there are a lot of GMO potatoes, and with all the big farms and year round growing, the soil may no longer have the nutrients. And even organic potatoes, people peel them! I always leave the peel on mine.

[@LisannNatoli]

I subscribed. I’m 10 yrs post menopausal and wondering if these supplements would be beneficial to bone density health?

[@thehonestchannel]

Thanks for subscribing! This is a good question. I don’t have an answer but I will return to this subject on the channel and try to find out

[@lisafalanga8457]

Is it just the USA where you cannot purchase NMN anymore? I heard that our FDA is banning it…OTC or otherwise..Thinking this is the case..🤓

[@lisafalanga8457]

And, THANK YOU CLARE😍Fantastic Piece, here🌟🌟🌟🌟🌟🌟

[@andrewward7042]

It is still available, they haven't stopped retailers yet.

[@lisafalanga8457]

Thank you, FRIENDS☀️

[@rustyrules4264]

Amazon

[@wendymccleary1465]

My understanding is that it is soon to be banned here in the US thanks to David Sinclair himself, who has, with his company filed the petition to ban it in the US without a prescription.

[@generaldamage3282]

Feels like such a Wild West with these supplements. You hope that at least they don’t cause damage, and will be of benefit to the body, but the reported effects can easily be placebo, or are negligible compared to eating well, getting excercise and good sleep. Measurements of biomarkers do show what we think is beneficial, but how these small changes in some biomarker value actually relates to overall wellness and quality of life as well as reduction in mortality, etc, is not known. It’s a very interesting topic and because of that there’s a lot of business opportunity for ppl selling a magic pill , it all feels like a bit of a fad belief with not much objective evidence so far.

[@thehonestchannel]

I hear you and I do agree that lifestyle - a good diet and plenty of exercise go a long, long way. My dad is adamant the NMN is making a difference to his arthritis and prostate condition. Very hard to judge though. We're going to keep going for a couple more months then take a break to see what difference it makes, if any, coming off it.

[@nigelcrits]

Actually bud your more in the wild west with any big pharma product these days XD. Simply read about the company before you purchase. Take some and you'll easily see... seems like you have FOMO snd this is cope.

[@m.fazlurrahman5854]

Age Revising Supplements: there is a group of people who believes if one bathe in the “fountain of youth” regularly then eternal beauty may be attain, however, this external tanning of skin is futile if internal temperatures falls in the face of real youth. Probably Energy Drinks May Help!!

[@mihaelafrincu8732]

Please ask dr Helena what are the 20 supplements she takes daily, thank you

[@v8rockz]

But who can afford alll this supps specially at the moment were prices are to the roof? I would spend so much money each month only with the NMN, TMG and Berberine. And there are still all the other supps like Vitamin D, Omega 3, ALA, NAC, 5HTP etc. Even if you don't have to buy it each month it's getting very expensive. I've got a good job, so no problem for me, but it seems anti aging is only for people with cash...

[@thehonestchannel]

I do agree that it can become very pricey which is a shame.

[@generalbystander1631]

The good doctor doesn’t seem to know too much

[@feeltheillinois]

i wonder if there is also an element of a placebo effect on yourself and your parents. drug studies often report something like 30% improvement of symptoms in placebo groups (versus maybe like 70-80% improvement of whatever the actual drug is)

[@thehonestchannel]

Yes, true, although my mum has seen no improvement so far.

[@monag.769]

That would be a cheap solution

[@ThriveCollective1188]

I’ve tried berberine and it made me horribly nauseous. After stopping it I developed the most ravenous Hunger like ghrelin went into overdrive. Really threw my usual intermittent fasting regime right off. I’m reluctant to try again

[@thehonestchannel]

Yes, I can imagine. Sounds like it's not the right supplement for you.

[@chardibinx]

If you’re fasting you probably don’t need the insulin benefits of berberine

[@slaveamanahilova3802]

What happens to the body when we take NMN for a month or two and then stop taking it? Would we feel the absence of the supplement?

[@jimbob4456]

That’s my question too. What happens if you stop.

[@genevityplus]

It should be taken at least 6 months to restore the broken DNA. It will gradually raise NAD+ levels in our body only after a few weeks, but ideally, to see results on a cellular level, it should be taken for at least 6 months.

[@marsery]

Interesting subject..was reading about some advanced research and for instance "when M-Tor suppression+ Insulin pathway were modified simultaneously, lifespan was increased by 500 %: an impressive fivefold difference".[6] Dr. Jarod Rollins. However , I would disagree that a Ketogenic diet is better than eating carbs "too much fat and proteins " is not good for longevity and it is proven partly because of what they call the "protein mess" which is one of the identified ageing process

[@thehonestchannel]

Definitely an ongoing debate!

[@marsery]

@@thehonestchannel indeed 🙂

[@marthanguyen2533]

Super Oxido of Dismutase tablets Is true works like anti-aging?

[@01maggie]

It is an anti ager but not to the strength of NMN.

[@MattMick]

Interesting that no mention is made of Professor David Sinclair who pioneered all this research

[@thehonestchannel]

She talked about him in our first interview - this was a follow-up

[@chasingshangrila]

Nmn 1g for 3 months with no increase in energy. Everyone is different is just not for me. When I’m done with this 6 months I’m done with it. You guess what lol try again when I’m older. I use TMG in conjunction with it as well.

[@tinkymcginnis]

What is she talking about when she says NR ??? Might help to explain what it stands for

[@thehonestchannel]

This is a follow-up to my first interview with her the previous week when we talked through that in detail. NR is nicotinamide riboside - another form of vit B3 and thought to boost NAD.

[@riddlescom]

Before taking any supplements. Get out of your of bed. Throw away all your twinkies . And get to gym and do cardio and resistance training 4 hours every morning fasted . And eat clean food restricting your calories. Then if you want take a pill after 30 days . Go ahead. But don't lay in bed with a bag of cheetos and your remote control and pill bottle of m&m s and think your going to live forever.

[@fosse04]

You should take trans-Resveratrol with the nmn.

[@C2C.]

There is no evidence to support this.

[@didiermaes6258]

You had me at vivid dreams

[@manuelojeda9144]

I already started taking all NMN , TMG, CaAKG, RN I stopped for a while Berberine. Quercetin and Fisetin as well.

[@BK-dy8jk]

RN is what???

[@manuelojeda9144]

NR I meant, sorry

[@bigthingshappenin]

Would love any updates on your NMN journey!

[@thehonestchannel]

I was planning to do something on my supplement stack in the summer so I’ll be sure to update. I’ve done a blood test to measure my current NAD levels and will do another after three months to see if taking NMN has increased it.

[@bigthingshappenin]

@@thehonestchannel Thanks for getting back to me Clare! I actually just today sent off my blood work for my NAD levels and can't wait to see what it says, I'm not sure what brand I will go with for NMN once I find out. I see the brand that you use but was also looking at DO NOT AGE which is where I got my kit from.

[@thehonestchannel]

@@bigthingshappenin I started using DoNotAge NMN powder recently because they sent me a sample. So far so good.

[@bigthingshappenin]

@@thehonestchannel good to know! Thanks!

[@joncross4537]

I want to contact your guests basically see if help stroke recovery with supplements

[@Psalm91-1]

Some people experience hair loss with Berberine

[@tonidesconocido3983]

Is it recommended to start taking mnm in your early 40ths? And how much is it recommended to take per day?

[@masonryjoe]

I subbed, you asked great questions. Thank you !

[@thehonestchannel]

Welcome - and thank you!

[@TSlowdive]

Are there any vitamins or supplements that cannot be combined with NMN, TMG and berberine? Would you know?

[@thehonestchannel]

No, and that is a bit of an issue with vitamins and supplements, as recently flagged by Dr Brad Stanfield, on this channel. We don't know a huge amount about what happens when we combine multiple supplements.

[@schalazeal07]

What time should you take Berberine?

[@gloriagolemboski4515]

What do with do with vitamins we take for other reasons. Like D3, K2/m7, magnesium, zinc, Q10,fish oil, B vitamin etc. B1 also.

[@thehonestchannel]

I take several of those vitamins myself. I'm not aware of any issues taking them alongside NMN but you may want to talk to your physician about it.

[@pticman]

All anecdotal. Please post citations on a human RCT to validate your claim.

[@campbellpaul]

Where does TMG naturally come from inside the body? Is it a hormone produced by the pancreas?

[@sgill4833]

If your taking Betaine and getting Gycine, shouldn't you take NAC as well.

[@rosscopeeco69]

Hello, have you looked into Gary Brecka and the 10x genetics testing??

[@tounechareunsouk1085]

People said take NMN first thing in the morning, empty stomach. But I have to take my thyroid pills, first thing in the morning too. So can you suggest, which one I should take first? Thanks! (I'm in the process of ordering what you suggested. Hope it really work!) 🎉

[@thehonestchannel]

It would be worth reaching out to NMN Bio and seeking their advice on this one. I'm not an expert by any means. My mum has a thyroid condition and takes her medication first thing and then takes her supplements a couple of hours later but she usually doesn't eat until late morning.

[@drbethtx]

Take Nmn in the morning per David Sinclair.

[@Merzui-kg8ds]

Sugar cravings disappear with berberine? Not so much. That is way outside the realm of what is known about berberine. And, for that reason, I'm out.