Calcium and Calmodulin

[@sitins07]

100 nanoMolar (not nanometers):)

[@Ethan-un1ot]

Your lectures are great. Keep them coming pleased.

[@aoifewest]

Love how deep you Analyse. Thank your for your help!

[@BaderAlharbi]

What a great explanation!! I really understood that for the first time, papers are way to condense and technical if you wanna learn something for the first time the right way

[@moristhetiger]

Thanks a lot great lesson.. i want to say that Calcium also binds tightly because of smaller ionic radiac as it is divalent cation so loss of two electrons has made it small. the smaller size translates into interaction becoming stronger like black hole.

[@medizzyie]

u make everything make sense and i mean EVERYTHING

[@Alexander-xd8dd]

Straight to the point… Thank you!

[@kszoology3684]

very good and easy to understand

[@TaylorChristoffel]

This is amazing, thank you. Would you mind expanding on CaMKII and it's phosphorylation stages in another video? Especially at the microtubule "lattice" sites that Craddock, Hammeroff, and Tuszynski talk about.

[@danmainville1918]

Love your style. Great lectures.

[@kartikyevarshney1754]

You mentioned calcium binding to proteins in cytosol and making them insoluble. ER lumen also contains a lot of protein molecules due to presence of ribosomes (Rough ER). Wouldn't the calcium store in lumen precipitate them too?

[@LongenWhatNot]

+Kartikye Varshney there is a pathway in the ER consisting of an enzyme that adds glucose groups to new proteins, and another enzyme that uses the glucose tag to "check" the folding of the protein, cleaving it off in the process. if the protein is not folded correctly (or has a calcium stuck to it) it is returned to a chaperone to be refolded with a new tag. i might have the two enzymes backwards but i hope that makes sense! source: cshperspectives.cshlp.org/content/5/5/a013201.full.pdf+html

[@RandomPadestrian]

your lectures are so concise... Thank you.

[@AriJeru]

You are the best! These lectures are so thorough!

[@olabodeomotoso9518]

thank you for this AkLecture

[@bernardochamun]

Coming back here 4 years after the first time i've watched, but this time as a medical student.

[@jakabrzin7553]

I like your presentation, but I wish there were no obvious errors. Because of this, it is hard to rely on the data presented. While you can detect errors on things that you are familiar with, you cannot do so on topics you wish to learn about.

[@moristhetiger]

4:10 What I think is that the presence of Calcium in the cytoplasm would active proteins that are only to be activated at some points in time not always so maybe that is just another reason why we would want less of Calcium ions most of the times.

[@abelincolnparth]

I assume you mean nanomolar ond not nanometers. Good lecture.

[@iraklitsomaia124]

Great lecture. Thanks!

[@catarinadebettencourteavil7703]

Thank you so much for this!

[@하와이대대저택]

You are perfect

[@HenriFaust]

2:58 That is nanomolar not nanometer. It should be written "nᴍ" (small capital m) or "nM" (capitol m).

[@SarahMMorsy]

thank you so much, very useful

[@keurinrin16]

Thank you veery much🥰🥰🥰

[@musclelogic]

nanomolar (nM) not nanometers (nm)

[@xhuljanoshehu4399]

Great video!

[@gurralamohankumar5838]

Thank u so muchhhh sir very helpful 🙂♥️

[@VasilProfirov]

@AK LECTURES What steps(direct, indirect and the levels between) can be taken in order for one to be able to influence these processes, aimed at modulating his state as to continuously increase performance?

[@dr.jackauty4415]

nanomolar* (not nanometer)

[@باسلتمر]

You r the best of the best :-)

[@tawkinhedz]

Really cool!

[@hussainmuhammadthoha4287]

Video quality improving vastly, keep it up (y)

[@jawiga_cusub_ee_waxbarashada]

Regulation in rise of cytosolic calcium ions causes them to restore and return back to the smooth ER. Is that the only solution that these rise in cytosoljc Calcium ions can be regulated ?

[@hkgs_knight4216]

Thankyou!!!!

[@mirnachavski7227]

You are mega awesome>:)) Thank you

[@sitins07]

Great!

[@skaterpro142]

the concentration ist not nanometers it is nanomol right? o.O

[@lostSempaiWissame]

The way he said look it up on google 🤣🤣🤣🤣🤣🤣🤣🤣

[@johnlinneman2779]

Nonometers will probably get you partial credit on an exam lol

[@Alan_is_here]

lmao

[@YaN-gm1qj]

👏👏👏👏

[@patient3841]

K

[@patient3841]

U

[@patient3841]

A

[@patient3841]

Y

[@patient3841]

N

[@patient3841]

O

[@patient3841]

T

[@daphnehao8724]

nanometers lmao

[@patient3841]

H

[@mari0xDD]

you always say endoplasmiticulum is that kind of a dialect or laziness?

[@foz-xm4fv]

what about the content of the video? does that even matter?

[@patient3841]

K

[@patient3841]

A