Major Histocompatibility Complex (MHC Class I and II)

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[@raneema.2008]

I feel like you deserve a noble prize for all your videos that helps students from all over the world!! Much thanks and appreciation from Saudi Arabia.

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I was amazed when I saw your comment from Saudi Arabia

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Raneem A. Hy dear how are you

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Uujuuuuuuuuuuuu

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Raneem A. Yeaahhh I’m saudi too + I really appreciate his videos

[@rittenbrake1613]

KZbin Science Tutorials Noble Prize belongs to AK !!!!!!!!!!

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POV: you're failing your immunology class

[@dr.hugoalvaradosaldana7410]

You are going to save some of my medical students...

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Pues eso deberías hacerlo tu majete .

[@sahanavasudevan7826]

And exactly what are YOU going to Do

[@bloozism]

@@sahanavasudevan7826 That's what I was thinking. If the professor was doing his job (that he gets paid for) he wouldn't have his students going to youtube to learn.

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@Duke Jay yea, I have been using instaflixxer for years myself =)

[@hchattaway]

@@bloozism Its important to get input from MANY different sources on complicated topics like this! Each instructor can provide a different take on it and fill in areas another professor missed... One person can't explain everything! Students of anything need to listen to as many professors as possible and read as many books as they can.

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I want a shirt that says "IN JUST A MOMENT".

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idk why, but ur videos are way better than khan and university podcasts hands down.

[@AKLECTURES]

Junsu Yoo thanks! I appreciate that! :-)

[@jenniferettinger4943]

Agreed

[@angee232002]

OMG!!! God bless you, you have simplified this very complicated topic. I never understood it but now I do. I can now confidently go for my exams.

[@AlJoharahA]

Bless your soul! thank you so much for a great presentation.

[@AKLECTURES]

Jewel A. Thank you! :-)

[@SOLOHeyman]

I got a 98 on my A&P 2 test, and MHC Class 1&2 was one of the essay questions. Thanks for making a difference.

[@labpatotie]

I didn't expect I'll understand MHC for only 11 minutes. I learned more from your explanation than from my professor, you explained it so well! You're the best! Thank you for sharing your knowledge to us. God bless you! Much love from the Philippines.

[@blacktannie9284]

this is amazing!!! extremely helpful. hours of lectures condensed into a 11 minute video. thank you so much!!!

[@someone8987]

Sir....Really appreciable...Blessed be...Love from Kashmir😍😍...May Allaah SWT make it easy for all of us...

[@tativ9395]

Thank you so much! I was so stressed because I didn’t understand my professors lecture but now I completely understand! You deserve all good things 😭

[@ravshanrozyyev1206]

May Allah bless your brain and heart! Thank you! I always watch your videos

[@metodiyanev4392]

Thank you for the wonderful explanation ! I've always had a hard time understanding MHC and now it's all clear to me. :)

[@MalacoTKD]

Andrey, I'm really thankful for your videos. Much gratitude from Sweden!

[@AKLECTURES]

+Mimo Baki Thank you! I appreciate that :) Great to see I have an audience in Sweden, always wanted to visit.

[@nyahp874]

First i thought "darn too much text", but boi now i understand it completly. Thanks

[@PsVGam3R]

9:10 cytotoxic-T-cells have T-cell-receptors (not antiboides)

[@paulogigante1243]

True

[@siyabongatafadzwamnikwa8114]

I can never go wrong with AK lectures ☺️

[@paris6597]

may god bless you ...now I can go to my exam very confident. you are a star

[@alexisgjondrekaj2229]

I have never commented on a video before on youtube but I had to say, this was hands down the best video I have seen for my Immunology Exam. You really broke down over a months content for me in 11 minutes, THANK YOU KING

[@BBQYOU]

Cool video! Quick note at 9:10, T cells don't express membrane bound antibodies! CD8+ Cytotoxic T cells express clonal T Cell Antigen Receptors (TCRs) against the presented antigen.

[@kyshark1]

I'm binge watching your immunology lectures and you really are an amazing teacher. On s a side note: I thought that b2 microglobulin found in MHC I is a separate entity that comes together with the alpha chain which contains the three domains. Did I get that woung?

[@juulianaa10]

Well explained and easy to understand! Thank u so much!

[@ayahmohamed7957]

I love your videos but I am a bit confused. I thought that before maturation naive T cells have both CD4 and CD8 co-receptors and then they perfoliate and differentiate into CD4+ and CD8+ T-cells. The CD8+ gets activated to become a cytotoxin cell when an infected APC present its antigen on the MHC I receptor. However, the CD4+ gets activated to become helper T cell when a non-infected APC present its antigen on the MHC II receptor and what you are saying here is that helper T cells is what makes the cytotoxin cells?

[@WhyNot-si4pj]

Natural killer cells (NK cells) too are CD8 + granular lymphocytes that seek & destroy virally infected & neoplastic cells nonspecifically ! They belong to the (INNATE immune response) .

[@WhyNot-si4pj]

Actually there are 2 types of CD4 + T helper cells . First : T helper cells type 1 (TH1) responsible for cell mediated immunity , where it mediates the activation of CD8 + cytotoxic T cells , which in turn attacks & destroys foreign antigens presented on the MHC II of the APCs , a classic example of type IV delayed hypersensitivity reaction . Remember how the caseous necrosis in case of TB is a direct result of cytotoxic T cell attack on APCs represented as (epithelioid cell granulomas) . kzbin.info/www/bejne/n4LSimeIpdeHrtE Second : T helper cells type 2 (TH2) responsible for humoral immunity , where it mediates the activation of B-cells & transforms it to antibody secreting plasma cells . It's another form of (ADAPTIVE immune response) in which CD4+ T helper cell takes the upper hand .

[@nuinuisa1]

Thank you, this video was very helpful for my biology class in university. I'm a first-year med student :) subscribed

[@lisun1502]

Hmm, I don’t think it’s right to call a T cell receptor an antibody when talking about cytotoxic T cells.

[@khdr4165]

I feel very hopeful when i watch ur videos, just like im watching a happy movie..not a boring lecture. May god bless you sir. Regards from Syria.

[@someone8987]

U r from syria...???

[@raanoooshh9296]

@@someone8987 apparently why?

[@someone8987]

@@raanoooshh9296 Not getting u....What u wanna say??

[@raanoooshh9296]

@@someone8987 wondering why you're wondering?

[@someone8987]

@@raanoooshh9296 Sorry again...Not getting u...I love syria...thatz y I was asking...Where are u from?...Syria ,I guess😀

[@lip5739]

omg... i was so confused by textbook explanation. This is way much better. I finally understand this concept !! THANK YOU SO MUCH!

[@NK-iy6if]

Your explanation is truly very helpful, thank you so much, God bless you!

[@HelenAldrich-e8m]

I love your mind, and ability to communicate complex topics with graceful ease. ❤

[@rotor7135]

So basically Class I says "This is me" and Class II says "This is what I just ate"

[@bayansrour9283]

Please make a vedio on complement in basic immunology.

[@drdavidstr]

first time in my life i understood a lesson so great. amazingggg

[@MelomaniacEarth]

his accent of 'in just a moment' and 'in following diagram' touches me always

[@ashwathbendre1192]

Excellent video !! Understood the entire concept of MHC-1 and MHC-2 extremely well !! You are really a great teacher !!

[@sookiemohamed9821]

I would like to send my sincere gratitude to you and this channel, it helped me alot passing my Biochemistry module in my first year, thank you and may God bless you

[@richdaleaquino]

This will save my grades in immunology and serology class. Thanks!! Keep helping medical students. Love from the Philippines

[@hibaalzain5319]

Thank you so much God bless you From sudan

[@ellenbartlett7933]

Love it but please stop walking back and forth its really distracting

[@Veronica1Garcia]

You are amazing. Your explanations are so easy to understand, Thank you!!!

[@theminiaturebaker]

I was utterly confused with MHC I vs II and here I am 11 mins later understanding everything ! Thanks so much!

[@crystalamoah2802]

I am in graduate school and you are AMAZING!!! you simplify and make difficult material so easy to understand! please keep up the awesome work, you have a new subscriber:)

[@AKLECTURES]

Crystal Amoah thats wonderful to hear, thanks for the feedback and the sub! best of luck with your studies in grad school :)

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You deserve 10 M subscribers 😭😭😭😭😭

[@Pink7ification]

Thank you for this simple explanation! Greetings fron Romania :)

[@wassup589]

You are our God...you make these things even more interesting and understandable...it is fun to learn it your way Thank you! Many thanks!!! Greetings from Slovakia (Pharmacy)

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The best teacher ever!!!! I have never met somebody who explaining thinks such clearly!!! Thank u

[@eduardotetzlaff7043]

Man...you're a star. There aren't words to express how thankful I am, so I go with the usual: Thank you very very much!

[@Clarkephix]

Thank you for helping me to review 3 months of immunology course in a single day

[@whitewolf5791]

What an amazing explanation👏👏👏👏👏 This just needs subtitles, you would help more people, but damn what an amazing work, I have my test next week and this is way more undestandable than books or my teacher lecture. Best wishes for you from Ecuador 👏👏

[@Pink7ification]

Thank you for this simple explanation! Greetings fron Romania :)

[@claygeorge333]

Wow!! I watched a few different videos and animations regarding this content. This one blows them all away. So glad I found AK Lectures. Looking forward to using your lectures in the future. Thank you!

[@waleedsh8158]

You are amazing and very helpful. I have a question regarding T-lymphocyte after being activated.... does it produce only memory cells and cytotoxic cells or also new T-helper cells? Because I have been confused at min 10:00 that only memory cells and CD8+ are only produced?

[@saran6175]

you are the best teacher I have ever seen. Thanx for your video. hope you can make more biolgy videos

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Thank you for your lecture! You make it so simple yet informative!!! ❤️🤓

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You just saved the day big boss

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Thank you so much for these videos. You're saving my life in genetics and immunology rn. Really breaking things down.

[@daoduong4949]

thank you for your lecture!!!

[@monygtz3]

I hope I can learn something to ease my fears I was tested to donate blood and care back with HLA CLASS I/II don’t know what it means and some of my family members have died of cancer on their stomach or intestinal cancer. Do you know if Been positive at it means I might get cancer,??

[@absenzz]

I fricken love your lectures. So clear and concise. Hopefully I do well on my immunology midterm!

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why do u have no subtitles

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You are incredible. I understand everything you explain, it makes it really easy to study my textbook much easier after watching your videos.

[@sweet010ksa1]

Honestly, you deserve the most sincere and heart-felt Thanks. You are an awesome teacher

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Wish I found your videos towards the beginning of my apbio class! Your videos are so amazing and comprehensive - thank you so much!

[@nikolebryant7447]

5000th like! AND IM SO GLAD I WATCHED THIS VIDEO!!!!! this topic was so confusing to me and now I get it!

[@IK-fg4gw]

awesome lecture.....Thanks from Pakistan 😊

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Needed this 👍🏽👍🏽👍🏽much love from china❤️

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Thank youuu, i immediately subscribed! You're amazing! 👏 💕

[@latifabenalouane8319]

When the video was over I was like "Wow." Nice explanation, it helped alot, thanks.. Keep up with the good work .

[@wedothework4105]

I've watched maybe 6 videos on MHC I and II and read through my micro book on the subject; not until now do I understand what the hell the difference is between the two. Thanks!

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[@ShaaakAR]

What a legend

[@michaelwhite1403]

well said, excellent video .... only drawback is not mentioning the type receptor present; whether CD4 or CD8

[@malikkazimkhan3681]

Really LOVE YOU MAN !!!❤❤❤ thank you so much for being here👌👍

[@akankshasinha5063]

Your lectures are amazing sir. Thank you sir .Love from India❤

[@kaylapoujade8029]

You are absolutely amazing. Your explanation makes the upmost sense to me. You have helped me understand so many concepts for many many years. THANK YOU with all my cells

[@danielbl5857]

How does the B- and T-cells recognize the pathogenic antigen after differential caused by interleukin 2?

[@jamieryvers9147]

Hey, just a question. My Genetics textbook made it seem like the Major Histocompatibility Complex referred to a region on the short arm of chromosome 6 that contains some 200 genes which code for these different classes of HLA proteins. Is the term MHC used to refer to both the protein and the region that codes for these genes? Ref. Lewis, Ricki. Human Genetics 13th ed. 2021

[@r_x004]

To which of the following the major HC unique? A. Each cell B. Each organ C. Each species D. Each individual GUYS CAN YOU PLEASE HELP ME WITH THIS Q I CANT DETERMINE THE CORRECT ANSWER IS IT "EACH CELL" OR "EACH INDIVIDUAL"

[@ayah7056]

I thought that MHC I complex involved the presentation to T-cytotoxic cells that eventually lead to apoptosis of the cell?

[@ajiwahyuwardhana3311]

What do you mean by the Cytotoxic T Cells contains antibody on the membrane? Doesnt the T cells uses TCR to recognize the antigens?

[@lelabb4110]

My Micro professor lecture talk@ 1000 miles per hour. Thank you.

[@muhammadjanees5452]

Bro I think there is one mistake, actually the short peptides that bind with MHC are linear, they are not conformational or continues. But the antibodies are formed against the conformational peptides called epitope on the surface on an antigens. Plz clarify

[@wiwgach2076]

That is very good and clear explanation, I benefited a lot from this lecture Thanks you

[@TadanoCandy]

I think there aren't enough otakus in the comment section. My immunology exam will be fine now. Why? AK is here.

[@Farfall4Anonim4]

great explanation, but what i really can't understand is: the APC meet that kind of antigen for the first time, and so it's the first time it present its on surface, how can the t-helper cell already have the specific receptor to recognize it ?

[@JOHNNIEUSA]

what is mhc 1 involved in? only self-orientated issues such as tumors and bad protein? or what about infection by virus and bacteria and fungus,ect?

[@ramonargon5913]

Great lecture and very well explained. Just a slip of the togue at 9:10. Cytotoxic T cells do not express antibodies on their cell membranes. You were referring to the T cell receptors.

[@debstutibasu7411]

sir in nucleated cells we have MHCI thus they can be recognized as self cells but what about non nucleated cells ? how are they recognized as self cell?

[@usmanahmed3173]

third year of med school and your lectures are sill helping me with the complex material. thank you so much :)

[@stefansobaszek6487]

This is one of those topics I remember studying and answering questions about in microbio, but have no real recollection of now lol

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Thank mister AK LECTURES we love you

[@gdb8111]

I wish this video existed when I took an Immunology exam in 1999!

[@smileplease9977]

Respected Sir plz tell me about mhc class 3rd ...plz plz plz sir...

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I came looking for copper and I found gold, this guy is amazing

[@ashu587]

Very well explained. I understand it better than when the lecturer was teaching. Thanks

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upload lectures on all possible topics of biology that you can because your lectures are worthy.

[@prodigygaming6136]

can MHC1 present both self antigens and viral antigens?

[@theresacorderi]

Thank you from a nursing student in New Jersey!!!!

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thanks you so much, ur video actually helps a lot more than Khan Academy!!

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