AKT/PKB Signaling Pathway | PI3k Signaling

This video will be encompass the AKT/PKB Signaling Pathway .
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B).
Initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of PI3K. Activated PI3K then phosphorylates lipids on the plasma membrane, forming second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Akt, a serine/threonine kinase, is recruited to the membrane by interaction with these phosphoinositide docking sites, so that it can be fully activated.[1] Activated Akt mediates downstream responses, including cell survival, growth, proliferation, cell migration and angiogenesis, by phosphorylating a range of intracellular proteins. The pathway is present in all cells of higher eukaryotes and is highly conserved.
There are multiple types of phosphoinositide 3-kinase but only class I are responsible for lipid phosphorylation in response to growth stimuli.
Akt resides in the cytosol in an inactive conformation, until the cell is stimulated and it translocates to the plasma membrane. The Akt PH domain has a high affinity for second messenger PI(3,4,5)P3, binding to it preferentially over other phosphoinositides.[11] Thus PI3K activity is essential for translocation of Akt to the membrane. Interaction with PI(3,4,5)P3 causes conformational changes and exposure of phosphorylation sites Thr308 in the kinase domain and Ser473 in the C-terminal domain. Akt is partially activated by phosphorylation of T308 by PDK1. Full activation requires phosphorylation of S473, which can be catalysed by multiple proteins, including phosphoinositide-dependent kinase 2 (PDK2), integrin-linked kinase (ILK)

[@yizhang4885]

Very detailed explanation, it’s very helpful, many thanks🙏

[@prabhudasnair7914]

Mind-blowing, Excellent What an explanation 👍👍👍👍👍

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@carlgustafssonwold7861]

Thank you for this amazing lecture!

[@carlgustafssonwold7861]

From three very thankful swedish med students!

[@abiodunadegbesan1668]

Thank you so much, for the well explained concept

[@AsmaaKholo-ki6qx]

Thank you for explaining it is very good video ❤

[@hussainbiology]

Thanks for appreciation....Glad it helps

[@sammolepo]

This is rather good. Thank you.

[@hussainbiology]

Thank you too!

[@priyakamboj5850]

Amazing explained 😊😊😊😊thanku so. Much bro

[@hussainbiology]

thanks for appreciation..Glad it helps

[@Kaur_2343]

Thnku sir for making this video 🙏🙏it cleared my doubts....

[@beinghuman4457]

tum yaha kya kr rhe ho.. ye toh madarasa chaap hai na ..

[@mulugetamelku4834]

Great! Thanks!!

[@subhadipdas2482]

Very good explanation 🔥

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@Lee_____________]

Thanks a lot!

[@karishmarout1038]

You are amazing 🤩

[@hussainbiology]

Thanks for appreciation

[@nishatfatima2091]

Thank you sir , 🙏

[@hussainbiology]

You are welcome ✌️

[@mohdshahwaj5454]

Thank you sir g....

[@FarheenFathima397]

Thank you for making this video sir .

[@hussainbiology]

thanks Farheen for appreciation... Glad it helps

[@dyaneshwarsontakke51]

Best videos...sir

[@peyman2965]

Ur the goat ❤

[@hussainbiology]

thanks for appreciation....lots of love

[@darkartsninja]

Thank you so much for this lecture! Which are the specific residues on p85 are phosphorylated?

[@hussainbiology]

Tyrosine 688 residue of P85 are phosphorylated

[@shwethakrishna3716]

Thanks sir ji

[@hussainbiology]

You are welcome ✌️

[@proudpalestinian3344]

thanks !

[@aryas6282]

👌

[@kanicasharma1105]

sir are these related to toll like receptors?

[@ammaramehak9473]

nice video sir plzzzzzz complete eukaryotic tranlation

[@hussainbiology]

Have completed it...Now only Processing is pending

[@biology_mcqs3037]

U should do little bit by yourself

[@hussainbiology]

boi che kale...em enus be waleth

[@biology_mcqs3037]

Wun hasa aes be panie emis jawab wana.....

[@sonyashokouhy7368]

ıt is great

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@biology_mcqs3037]

👍

[@hussainbiology]

boi...

[@rubikhan8036]

Kindly tell me plz this pathway is used in non Hodgkin's cancer plzzz bcz tomorrow is my ppt

[@hussainbiology]

Yes.. this signalling pathway is deregulated in non-Hodgkin’s lymphoma

[@adriansanchez6301]

where are the information for this video?

[@hussainbiology]

?????

[@DreadedCup]

I guess he's asking for the resources you used. The books.

[@shbangash437]

Sir I need your help from where I can get these pathways any book for this

[@hussainbiology]

hello sir.... U can't get all pathways from a single book..

[@hussainbiology]

Alberts Cell Biology Lodish Cell Biology Development Biology by Gilbert

[@shbangash437]

@@hussainbiology ok sir I am going to download these books

[@shbangash437]

@@hussainbiology Sir can I get these chapters from where you have covered all these pathways

[@hussainbiology]

@@shbangash437 these are books dear.. U can download them from Internet easily

[@shbangash437]

Hello sir

[@servandohernandezgalaviz5664]

what is a monomore? or does he just have a bad accent ?

[@peyman2965]

Monomer

[@cosmicvlog8196]

It would be better to understand if you speak in hindi it will be like a story

[@vishalkhandelwal01]

Rrre