Alcohol Effects and Neurotransmitters: The GABA and Glutamate Balance

[@BackAgainize]

as an alcoholic, this video has helped me realize my disease. Thank you!

[@chernandez121593]

I truly enjoyed your presentation. After spending a few hours on an article, ridden with terminology, I decided to search for clear, concise explanations detailing the roles of GABA and Glutamate, I found your video. This article finally makes sense. Thank you!

[@serious-cyrusnoelan8127]

L Theanine is a good natural alternative… Kava is as well. However, it may be harmful on the liver and is quite controversial… Exercise and healthy eating are essential (coming from someone who has been through GABA/glutamate imbalance). Been off Valium for a few months now and it’s worth it. Most importantly, GOD! May God bless all of you on your journey!!!

[@astrarai-thesobercoder]

This explains why over time, even if I drank less, I'd experience extreme withdrawal symptoms even though I was drinking significantly less. Thank you for this data/ video.

[@BackAgainize]

Not enough is said in rehabs and AA even about the CHEMISTRY aspect of alcoholism!!

[@silentumexcubitor6747]

Only ignorant, egotistical, blowhard assholes think AA is a "cult"....

[@tactics-mnk6084]

silentum excubitor Give yourself to higher power and all that. I’m not even from the US, but isn’t that you “should” believe in AA? That’s a cult.

[@silentumexcubitor6747]

@@tactics-mnk6084 You must allow for both linguistic misunderstandings, and translation errors, but NO!, AA does NOT say "give yourself" to a higher power. It say's believe that a Higher Power can and will help you, especially so if you ask. Your higher power can be almost *ANYTHING*/body/person/god/etc..... And, you are free to get rid of your higher power, if that higher power isn't working for you. Atheists have gotten sober in AA. That's hardly a "cult", is it?.... The roots of AA are very well documented in various AA publications. To continue in ignorance is YOUR choice.....

[@tactics-mnk6084]

silentum excubitor You are right, maybe I was too quick to judge. Believe is a powerful thing and creates. It was just the thinking that they push God onto you, that kicked me in the bullocks. I don’t know actually, never been to AA.

[@Koopa213]

Thanks Doc! Easily understandable and to follow. Learned quite a bit! Hope those going through withdrawals are fighting. Health is wealth!

[@EvanLevow]

What an excellent presentation of alcohol's effect on GABA. This, together with the dehydration that occurs, can make a drinker feel rough after consuming too much alcohol.

[@checkandbalance2903]

Actually its fundamentally incorrect on many levels. Alcohol does not raise GABA levels, it just stimulates the GABA receptor. Topomax does not raise GABA levels either. Wrong WRONG WRONG. Don't take my word for it, just look it up yourself.

[@tactics-mnk6084]

Simulates not stimulates. Don’t be wise please. Your brain thinks: well we are getting enough of this. We don’t have to help these receptors anymore.

[@lifelieswaiting]

Jonathan, for some of us, it can take a long time to heal from benzo withdrawal. Cold turkey increases the likelihood of this since the body wasn't given the time to adjust to the missing drug that weaning would've provided. The best cure for what you're feeling now is simply time. The farther away you get from the drug, the better and better you'll feel. Speaking from experience here.

[@tactics-mnk6084]

lifelieswaiting well said. Went cold turkey on alcohol and went on a health trip. Cleaning my system way too quickly. Then after two days, voices and music. Fucking poison.

[@Ajbaker2019]

Can Monosodium Glutamate (MSG) also play a part in destabilizing the GABA/Glutamate balance in the brain?

[@RandyVidz]

simply putting things in perspective is the key to learning. i love it

[@einrand]

Very nice presentation Dr. von Stieff. Clear concise and easily understood. Why have the cheap and affordable supplements GABA and Taurine been virtually ignored as an alternative therapy for those finding themselves unable to drink in moderation (i.e. one or two drinks per day)? In conjunction with AVRT, could such therapy be effective for alcoholism?

[@furaka1]

I really enjoy your teaching style. Particularly how you link it into the real world makes it very easy to understand. I'll be studying Cog Neuro next year I've subscribed!

[@anjdah]

Could you please tell me the name of the two drugs for restoring the gaba-glutamate balance? I am a medical student and found it very interesting as how it relates to alcoholism, so I wanted to do some further research on this. :-)

[@poleag]

Topamax and Campral.

[@vincivedivicilextalionas4036]

@@andrewheppner8809 youre replying to a 6 year old comment lmfao

[@vincivedivicilextalionas4036]

@@andrewheppner8809 You got hope. I like that.

[@vincivedivicilextalionas4036]

@@andrewheppner8809 My man.

[@cyphi1]

I just took a 500mg GABA + B6 supplement ...feeling pretty relaxed.

[@Nitroblast]

Placebo effect lmao. GABA taken as a supplement cannot cross the blood brain barrier, hence it does nothing in your brain.

[@Hyper-Linkman]

@@Nitroblast that's why people need to challenge the FDA on their decision to ban Picamilon in supplements. Picamilon has been used in Russia since the late 60's to treat a variety of issues, including alcoholism, brain injuries, anxiety, etc. It's simply GABA combined with niacin, since niacin is able to cross the blood brain barrier. If you look into the reasons why it was banned, you may soon come to realize that there are many similar supplements which should have been banned as well following their logic. Picamilon is officially classed as an experimental nootropic, however you may be convinced of its safety after reading this quote. “FDA has run amok when it comes to Picamilon and their logic is extremely flawed. Picamilon is derived from two natural compounds: nicotinic acid (niacin) and gamma-aminobutyric acid (GABA). There is a prodrug of GABA called picamilon - which, once crosses the BBB, is converted into GABA and niacin via hydrolysis, and will work as endogenous GABA. FDA’s logic is that Picamilon is a drug although it is only comprised of niacin and GABA (two completely DSHEA compliant products). If FDA’s logic on Picamilon were to be followed throughout the supplement industry the following would be banned: Calcium Citrate (calcium and citric acid combined to help absorption); L-Arginine Alpha Ketoglutarate (A combination of Arginine and AKG); Citrulline malate (a combination of Citrulline and malic acid); and Magnesium amino acid chelate (called magnesium aspartate) would also be banned. Magnesium aspartate is a mineral amino acid chelate containing magnesium bound to the amino acid known as aspartate or aspartic acid. Almost all vitamins and minerals are bound to some salt or compound for stability of the molecule and usually for better bioavailability. To ban Picamilon for the same actions that have been going on in our industry ever since DSHEA was created in 1994 shows this to be a witch hunt against Picamilon initiated by Pieter A. Cohen.” - Jared Wheat, Hi-Tech Pharmaceuticals blog.priceplow.com/supplement-news/picamilon-fda Currently struggling to find Picamilon from a reputable and fast-shipping retailer, because it's difficult to find being in the US where it's effectively banned, even though it's GRAS (generally recognized as safe) in basically all respects. Funny, because Ivermectin for example is being touted by many health experts (Paul Marick, Kory Pierre, FLCCC, America's Frontline Doctors, etc.) as a "miracle drug" for its effectiveness in fighting and preventing covid (it's part of a prophylaxis treatment protocol), but it's in FDA limbo, regardless of how urgently these treatments/meds are needed. Also regardless of how safe it is if used responsibly.

[@mr.elastomeric1787]

@@Hyper-Linkman Any luck?

[@Hyper-Linkman]

@@mr.elastomeric1787 do you mean in terms to finding picamilon for purchase? I found it some time ago from a Russian website that was tricky to locate, and I'm not sure if they still have it in stock. I can rummage through my emails if you're curious to look.

[@mr.elastomeric1787]

@@Hyper-Linkman Yes please; love to read any literature you deem worthy. Some of the sites look kinda skeptical for purchase. Thank you for responding

[@FredVonStieff]

I'm sure you'll agree, linking neuroscience to the real world is an important step to helping a lot of people.

[@silentumexcubitor6747]

Hush with that "neuroscience" nonsense. You'll scare all the quack psychiatrists....

[@furaka1]

Most definitely! I was wondering what your view is regarding the legality of substances? And what are your thoughts regarding MDMA? Thanks.

[@katanphetamine]

Thank you...so much. My professor is all over the place, and I don't recall a word she ever says. Thank you actually teaching.

[@checkandbalance2903]

See my other comments. Your professor will rightfully fail you if you listen to this. Its incorrect

[@mr.elastomeric1787]

@@checkandbalance2903 Question if I'm trying to quit vodka; on day 4 have Campral and Valium is there a certain window where I could have a seizure. Taking 4 Campral spaced out every 4-6 hours with 2.5 mg of Valium. Start Day 5 tomorrow no shakes just rough(really rough sleeping) Thank you.

[@echo1434]

GABA does in fact cross the blood-brain barrier, but just barely. I have tried a very large amount before and it certainly had an effect (unless having a crazy scrambled brain for a few hours afterwards was just a placebo). Indeed, Picamilon is another story with the BBB and worth serious consideration as a GABA supplement.

[@doseofdanni]

SO helpful! explained in a way thats easy to understand. thank you.

[@ushilives3]

hi there. have you any recommendations/supplements for anxiety or sleep maintenance insomnia? if i wake up in the night it can take me hours to get back to sleep.

[@emmaohrwall]

Thank you so much for your videos!!! Will buy your book.

[@FredVonStieff]

I'd have to talk to you more to make a betterinformed decision. My office is in Concord CA. If that's too far, I suggest reading all the findings in my book that relate to your case, as well as the drug index in the back and then sharing the info with your doctor so that the two of you can explore your options more successfully.

[@rosesantos9311]

Fred 3 uygg Von Stieff - Brain In Balance I h

[@silentumexcubitor6747]

>madinamerica.combeyondmeds.com

[@xmxe4486]

What was the name of the Drug what lifts ub GABA? Campl?

[@moy2010]

Good evening, Dr. I have one question. Does the gaba levels go down or the gaba receptors become less sensitive due to a down regulation response? Thanks in advance.

[@tactics-mnk6084]

Moises Garcia Marquez You never got a response, too bad.

[@nivniv23]

I read mangese toxicty is associed with gaba and glutamate

[@richipitchi92]

Somebody knows the drug "abilify" and if there are some more progressive drugs on the market right now? I think abilify is ca 4 years old and i heard about glutamat and gaba already in an explanation of prof dr gerhard gründer, so, my question. is there maybe something better on the market than abilify? i should take 30mg a day in the next weeks. but i feel very fatigue, tired, free of energy and so on. but maybe these are Minus Symptoms of schizophrenia? I do not know if my health status is caused by the side effects or the illness, schizophrenia. in german, hebephrenie or hebephrene schizophrenie. i have to listen to your presentation a 2nd time. maybe someone has an advice or annotation to my thoughts.. greets from middle germany

[@silentumexcubitor6747]

Please visit >madinamerica.combeyondmeds.com

[@silentumexcubitor6747]

@Adrienne Gurge Well, Adrienne, I don't know WHY YOU are telling the LIE that I was "telling someone with (so-called) schizophrenia not to take their medication". That's bullshit, Adrienne. Psych drugs are neuro-toxins, which is also what Dr. Peter Breggin calls them. See: "Toxic Psychiatry" By Dr. Breggin. He's written many more books besides. Japan, Korea, Taiwan, are among the countries which no longer use the word "schizophrenia". Psychiatry and psych drugs have done, and continue to do, FAR MORE HARM than good. Why do YOU use the fraudulent and deceptive euphemism "meds", when what you really mean are PRIVATE, FOR-PROFIT DRUGS? If so-called "psych drugs" are so good, then why aren't they a PUBLIC, NON-PROFIT public good? Actually, your statement that "most psyche drugs are not addictive" is false, and not supported by science. Why do you think psychs typically tell their drug zombies that they will need the drugs "for life"? To cover up how addicting they are! Duh! The so-called "side effects" of most so-called "anti-depressants" include "suicidal and homicidal ideation and behavior", as quoted fro the package insert. In other words, Science KNOWS that psych drugs CAN, and DO cause persons to commit suicide and mass-murder. The FDA-mandated "black box" warning has appeared on SSRI's since the 1990's. ****vaccines don't cause autism, alcohol doesn't cause alcoholism, heroin and fentanyl don't cause drug addiction, and depression does not cause suicide. You do believe that that's all TRUE, don't you, Adrienne....????....

[@silentumexcubitor6747]

@Adrienne Gurge Are being deliberately obtuse, or are you simply stupid? So-called "schizophrenia" was invented over 100 years ago. It reflects the relative level of medical and scientific ignorance at the time, compared to today. It's a misunderstanding of how the CNS works, and an ignorance of the sequelae of ACE's.... Why is it that the SAME DRUG, is prescribed for a wide variety of different "diagnoses"? And WHY is any given "diagnosis" dosed with a WIDE variety of different drugs? If psychiatry and psych drugs were even 1/2 as legit as they claim, there'd be a more 1-to-1 relationship between drugs and diagnoses. But there's not. Because psychiatry is a pseudoscience drug racket, and means of social control. And you suggest that the drugs "get taken up too fast"? tell me about "pharmaco-genetics", Adrienne.... You can't, can you? All you can do is ARGUE, LIE about me, and spout the same brainwash propaganda psychobabble and gobbledygook you've been spoon-fed for $$$$ by QUACKS!....

[@tactics-mnk6084]

So while in hard withdrawal, like close to hearing music and voices again, take Gaba? Because I have some but am worried to take it while being drunk. Shit

[@Hyper-Linkman]

Research Picamilon. Far more effective at raising GABA levels than GABA alone. GABA struggles to cross the BBB (blood brain barrier) when taken alone in supplement form.

[@checkandbalance2903]

Correction: topomax does effect the GABA receptor to some extent so I retract partially my comment regarding topomax, though it does not really raise GABA I will state that it has some effect on the receptor

[@ushilives3]

what if you take gaba and niacin together? would you get a similar effect? I have anxiety and sleep maintenance insomnia, sleep being the thing that zaps me of my energy. This video has made sense to me because if i drink heavily, the next day my anxiety and sleep is worse.

[@Hyper-Linkman]

7 years later, but yes! Picamilon. You were on the right track with that thought. I posted an in-depth reply to a comment talking specifically about this. Picamilon is GABA combined with niacin. Developed in 1969 in Russia, interestingly enough.

[@ushilives3]

@@Hyper-Linkman thanks for 7 year later comment lol.

[@Hyper-Linkman]

@@ushilives3 always fun to open up a time capsule now and then lol

[@ushilives3]

@@Hyper-Linkman seen on your profile you've got 4 comments so I'll check them out for more picamilon info

[@snomad2248]

If you try to quit drinking without taking a GABA supplement (pure is best) then your glutamate will go haywire and you’ll become irritable, have insomnia and become prone to seizures.

[@Hyper-Linkman]

Picamilon, Picamilon, Picamilon. I'm responding to a lot of comments on here about it, because it's highly overlooked and effectively banned in the US due to FDA regulations. Look for my reply to the user Feral Cypher if you're curious.

[@korndog87]

really impressive video thanks dr

[@taylorcassidy9283]

This helped so much. Thanks so much.

[@juhmoedah3237]

If u have any questions about the way an alcoholic or drug addict experiences sobrierty, near death experience and mental illness, please ask me. I've experienced it all several times. If u have any questions to do your research i'm happy to help and i can write a book about it, i might will anyway.

[@okiown2]

i was on lorazapam for 7 months , i was always calm , always sociable , always happy or high , then suddenly my doctor took me off of it without weaning me off the drug , now I am anxious , depressed, and stressed all the time. Do you have any suggestions on how i can balance my levels without creating a craving for benzos .

[@silentumexcubitor6747]

>madinamerica.combeyondmeds.combenzobuddies.com

[@tactics-mnk6084]

Adrienne Gurge You just gave a beautiful description of the power of belief. All what is, do not resist, accept even death, and you are free. Makes me think of Jesus what I said there, I’m not even religious. Sorry if I come across as a smartass.

[@justin7468]

I have been taking clonazapam for about a month and I just recently come to the conclusion that it's having a really bad effect on my sychy I only take .5mg at night I skipped a night and I felt like myself again has my gaba been in balanced since I only been on this for 30 days?

[@lodelode4951]

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[@alsalibramiento5709]

Too late probably, but most likely no, you dont have a dependence. Unless you started increasing dosage, .5mg of clonazepam isn't prone to cause a dependence within just a month or so of daily consumption. However benzodiacepenes are not used over long periods of time because they do have a risk of psychological dependence and a bigger one on physiological dependence. What should help if you stop taking it, is not to stop from one day to another (known coloquially as going 'cold turkey') but rather decrease the dose gradually (ej. start taking half pill instead of one, then decrease to a quarter, etc.) This relies on the assumption that a health professional prescribed it to you.

[@silentumexcubitor6747]

Sorry, "alsa", but you're full of shit. Dependence on benzos *CAN* occur in a month of clonazepam, even at .5mgs. Try >benzobuddies.combeyondmeds.commadinamerica.com

[@lupaman100]

Thank you sir

[@HafizahHoshni]

Thanks for this awesome video. great info !

[@piseseven6666]

Ethyl alcohol is by far the most toxic and dangerous of all commonly used recreational drugs. Except for perhaps MDMA (in terms of toxicity); despite the fact that heroin and methamp users are the poster children for drug abuse. I can't help but wonder if this was some form of compromise by the rulemakers here: IE no drugs allowed buuuut you can have at'er if you're likely to hate it. Thus, ethyl alcohol. Lookin' across the pond over at the Brits here....

[@lyndsieannette957]

Brilliant!

[@germanshepherdmom1143]

My friend died 15 years ago - he was an alcoholic.

[@FredVonStieff]

Happy to help!

[@roberthigham8924]

blimey you're a walking talking medical text book, had everything and more ,been there, read the book, got the t-shirt

[@jflmf]

Me tooo!!!

[@The_Primary_Axiom]

Phenibut phenibut is disgusting.

[@7within]

"Only GABA!'' not Yaba