All about the ACE2 receptor the coronavirus uses to enter our bodies

#PureScience #ACE2 #COVID19 #Coronavirus #ThePrintScience
The ACE2 enzyme is the receptor for the SARS-CoV-2 virus, and is found in the cells of our noses, mouth, lungs, and in many other organs. ThePrint’s Sandhya Ramesh explains why this receptor exists and drugs are being developed around it.
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[@mandarbopardikar9135]

Being myself a research scholar in Biochemistry at a premier research institute in the country I would like to say that I have never seen such a fantastic explanation of any branch of science from Indian media!!! In fact, I learnt new science from you that ACE2 levels are higher in males than females. Sandhya this is really good stuff. I think you have a strong science background. With this way of communicating science or any other field you could revolutionize the way Indian media operates. I salute your spirit!!!

[@kiberenigestsebez6633]

But there is confusion enzyme has substrate not receptor. Then ace2 how come it got receptor

[@lone-wolf2098]

I am into IT but learning medicine and biology is among my hobbies. I give thumbs up to you that you easily explained some good things.

[@headfullofmusic422]

how can one upregulate their ace2 after damage by covid and vaccine?

[@justtheblues7412]

You have to remember that it's not the ACE enzyme that is the problem. ACE creates angiotensin-2 (AT-2), which is the one with all the deleterious effects if too much AT-2 is created. ACE-2 is a counterbalancing enzyme to ACE. ACE-2 grabs some of the AT-2 and converts it to Angiotensin-1-7 (AT-1-7), which has all the good effects ( opposite of AT-2), such as lowering blood pressure, in decreasing thrombogenesis ( blood clotting). AT-1-7 binds to a receptor called MAS to deliver its good effects; whereas, AT-2 binds to the AT-2 receptor to deliver its - not so good effects. BTW, I'm a professor of Cardiovascular and pulmonary pathology-- that's why I know this stuff.

[@thebeanymac]

Doesn't nicotine occupy ACE2?

[@willmcallister8464]

Would insulin resistance or full blown diabetes increases the levels of Ace2 receptors ?

[@eleanorclub]

@@willmcallister8464 There's a link to plentiful ACE 2 receptors on adipose tissue, likely because of increased production of angiotensin2 by fat cells. Some heful YT videos on the to9ic.

[@royalfamily3076]

@@headfullofmusic422what helped you to support ace 2?

[@kf2606]

I am impressed! Great video! You ‘Aced’ it!

[@ajithkannan4818]

Research of mam's work amazing and very keen to see your next work and presentation is brilliant.

[@aravinthadhii296]

Missed ur video for about a week....and now❤️🤓 ,, seriously a lot to learn from u mam🤩

[@mukeshastik]

excellent explanation... I was reading abt it but this video explained by the Lady made my understanding very clear. Thank you.

[@bishnuprasadsahoo5153]

I was searching for scientific explanation of the gender bias... Thankfully got some light on the issue. Beautiful presentation of scientific facts and research works mam. Many of us were worried if the show was cancelled thankfully u r back mam. Keep going mam good luck.

[@subhasisganguly265]

Madam there is a little mix up between ACE1 and ACE2. I am not a doctor but a diabetic patient of long duration. I believe correction and consistency are required.

[@vidarbhiasacademy-sagarsir]

Excellent

[@maharudradarade1055]

UPSC Pre 2021 pickup question from the Print video😂😂

[@hareshhariani8553]

Think u had taken a few days off Back with a bang great as always

[@bhanuprakashprakash7255]

Thank you madam

[@charmertech8805]

Informative

[@pavanKumar-bk9ll]

soo GUDD

[@kirstenbrogan5958]

1. If smoking causes the creation of more ACE2 receptors, would that correlate to smoking being a risk factor for covid? I thought I heard early on that is wasn't considered a risk factor. Also, I wonder if this increase receptors in lungs only? 2. It makes sense to find these receptors in the nose and mouth, because this is the initial place where one fights off a virus via the innate immune system. So I wonder if bypassing this initial response reduces the body's ability to fight off the infection? It could be like trying to drive a car before it's warmed up. The innate system can sometimes even stop it from progressing all together, giving the body much needed time to prepare in case it does progress.

[@anonymousisbest.5253]

Love you mam.

[@sriram10593]

Would be helpful if print publishes a story on feluda test , rt lamp test and their current status ?

[@akashchandra2779]

Does ACE2 inhibitors drugsbsuch as Ramipil Work against COVID 19 virous

[@anupriyakhare3556]

Please update ..this is not in sync with latest findings of 2021

[@komalthecoolk]

I feel like Gupti Ji had discussed this stuff a few weeks ago in another video

[@nitinkumarverma44]

Excellent explaination

[@drsaravanakumar]

NITIN KUMAR VERMA google doctor with many doctors in KZbin on same subject.all she did was steal.

[@oneplustwo5t441]

Aloo bukhara 👌👌👌💖

[@aryabhatt2198]

What arr the effects of charge on the ace 2 ?

[@puggleski6097]

Maybe, a correlation exists between decreased lung volumes and capacities (not tidal v alone, i.e) due to chronic lack of exercise, pollution, sedentary activity & increased mortality due to covid ?

[@symonsmith3497]

Vitamin D3 and K2 Helps.

[@goutampodder5354]

👍

[@jondicsre3056]

Two questions. You mention that it is a Zinc containing enzyme. If Zinc helps it bind, how is it that Zinc helps stop replication of the virus? Does A2 milk have anything to do with Ace2?

[@jondicsre3056]

Or am I getting that wrong and the Zink is resisting?

[@JtheOneMan]

So what happens if the body is flooded with protein spikes that latchss on to the ACE2 receptor?

[@anneblubaugh58]

Cytokine storm.and anaphylactic shock

[@Baxvel]

Чому тут не можна субтитри увімкнути?!

[@chuteboxegod]

I started on Lisinopril and all of my covid symptoms came back after being symptom free for 5 weeks. Now a month after trying lisinopril which I am no longer taking I can barely get out of bed for more than 30 min. Im dizzy, light headed, brain fogged, weak and lethargic. Anxiety is really bad as well. They are saying its long haul covid, but I was fine till I tried lisinopril. Not sure what to do, something is wrong with me.

[@thebeanymac]

Sorry to hear. Might be side-effects?

[@ialamkharkongor5550]

You are so smart and pretty 😭😭😭

[@AM-te1ff]

🤣

[@shikharsingh8930]

SIMP

[@gitmoholliday5764]

so.. maybe smoking can activate more ACE2 receptors in the nose and mouth ? this would help a virus to latch on to ACE2 inside the nose sooner, before entering the lungs ? wouldn't that be a novel way of vaccinating people also, not the smoking, but firing up the immune system starting with a nose spray or mouthwash with cov19 spikes ?

[@johneroagos7151]

What could be taken to regulate ACE 2?

[@misteareous]

One step in finding out the cure is finding out of to fix the symptoms until they are all gone, I want to know how to counteract the binding of cov-19 to Ace2 receptor.

[@tejateja6920]

New haircut me cute dikh rhi ma'am 😍😍

[@westfield90]

The receptor and the enzyme are two different distinct things. I don’t think journalists should try and explain science.

[@drsaravanakumar]

Everyone is a doctor these days.leave it to the specialist.horrible state of affairs.even doctors don’t know it’s beneficial or detrimental.PRINT seems to be obsessed with Covid.medical fraternity will find a solution soon.

[@kiberenigestsebez6633]

Every video i saw no 1 explain my questions. So still i am in confusion. 1-if Ace2 is an enzyme then , enzyme dont have receptor but a substrate. 2- ACE2 being an enzyme , what is its substrate and its product

[@taibaimam7811]

@kiberenigest sebez So I'll speak from my personal knowledge, do counter check my answer. 1. Physiologically speaking Ace2 is is an enzyme that converts Angiotensin 2 to Angiotensin(1-7) in our body countering the effects of Angiotensin 2 and hence lowering blood pressure. So physiologically it is an enzyme, substrate of this enzyme is Angiotensin 2 and product if angiotensin(1-7). Now talking about the ACE2, its essentially an anzyme but it ACTS as a receptor for the sars cov 2. Now what happens is since sars cov 2 is keeping ACE 2 busy by bindig with it, its original physiological substrate cannot bind with it (original substrate- angiotensin 2) and does not get converted to Angiotensin(1-7) Hence Angiotensin 2 level are high leading to high blood pressure and increased inflammation. I hope this clears up your doubt :)

[@taibaimam7811]

Product is** Angiotensin(1-7)

[@ankitmehta2794]

12 out of 17 comments are for "franship" ...hahahaa

[@sumitpawar7373]

who else think that the anchor looks alike tokyo from money heist ???

[@puggleski6097]

Nope. That's sandhya all right. Or The Print's "La reina del sur" if you prefer..

[@abhinavbansal7106]

NO! Also- Pay focus on what she is teaching, not her looks.

[@Raaj913]

Meanwhile kuch bhi samajh nahi aaya

[@ajaysisodia1086]

Samaj kuch nahi aaya

[@manojsundar5719]

you hear her english, how she puts those words since is in front of camera and imagine how she would speak (if in hindi) after the video!! ?? Why are girls always faking an english accent?? thinking that is an accent!!

[@ashu0583]

I not very accurate