Almost All Achievements in

The only achievements I missed were Ascend 10, Ascend 20, and My Lucky Day (win a Daily Climb). These achievements were skipped because either they are incomparable across attempts (My Lucky Day) or they take too long (Ascend 10, Ascend 20).
The card duplication glitch was abused rather extensively to play certain cards multiple times, though I could definitely use it more often or more efficiently to shave off even more time. The only other glitch I abuse is the Neow reward glitch, which gives you a Neow reward if you quit and reload the game twice. My fastest glitchless achievement run is somewhere between 4 and 5 hours, by comparison. With good luck, the glitches don't actually save that much time.
RNG on this attempt was quite good. It only took me one Ironclad run to get a Feed, and only took one Defect run to get Meteor Strike + Creative AI. Unfortunately, Silent was much less smooth, and Catalyst refused to drop for a long time. Play was rather slow throughout, but I might still struggle to beat this time (about 4.2 minutes per achievement from file creation to the last achievement picked up).

[@probe1765]

I find something inexplicably amusing about The Silent waking up in front of Neow, then immediately dropping dead at the start of the run. Poor dear died of fright.

[@lautarosaucedo871]

2:22:43 DESTROY DESTROY DESTROY good luck with that buddy

[@RadekCarda]

never seen the shiv glitch before :-O 48:00

[@totalineptitude9165]

god that claw turnaround at the end of the first run was insaane

[@tailspikes]

Any reason for instantly viewing the draw pile every time you got dazed? Is it an exploit?

[@ForgottenArbiter]

It skips the animation to add statuses to your deck, slightly reducing the time to draw your next hand of cards.

[@manstie]

now for ascension 20 achievement

[@junny6624]

sad to see the last achievement was a glitch exploit.. was curious to see a real deck of 5 Well done for the others

[@baltazargabka340]

Did you use a seed for "Ooh Donut"?

[@anon.8971]

They did not.

[@raketenrocko]

Nice job man!

[@Asttnn]

Szz

[@ShtraddaG]

i love you

[@nickbarlow4270]

God this video is pointless without commentary.

[@Azurelius]

48:10 bug? Cheater

[@VeilsideTofu]

Since when are Bugs considered cheats