DNA Replication (Updated)

[@AmoebaSisters]

UPDATE: We have videos dubbed in Spanish and Portuguese using an artificial voice via aloud.area120.google.com to increase accessibility. See our Amoeba Sisters en Español channel kzbin.info/door/1Njo3LBy53cOPngz6ArV8Q and Amoeba Sisters em Português kzbin.info/door/YTQPX2X_mXe0ZMPi0fXxbg Want to help translate our subtitles in any language? Learn more here www.amoebasisters.com/pinkys-ed-tech-favorites/community-contributed-subtitles We hope you like our newly updated DNA replication vid! So what's different? You will find the script to be almost the same, except with a little more detail: we included topoisomerase activity and better explained leading and lagging strands. (Again, remember, there is still much detail to explore beyond this video!) Our art has also improved as we continue to practice and no MS Paint this time ha! You can see our milestones here: www.amoebasisters.com/milestones.html Also, no worries, we try to not delete old videos. The old DNA replication video, if you prefer it, is still here: kzbin.info/www/bejne/a6K2o6Cbnrymq8U

[@fran.2780]

Cool i watch you guys like 2016-2017

[@mayakays8208]

So informative video keep it up

[@far_oppositeflow3652]

We love your every single updated or old videos ❤️ This amazing science universe needs more subscribers .. Love from India

[@q_likes_bugs]

I'm so happy!!!! This is my favorite video!!!!

[@Moshpitti]

The originals actually helped my wife make it to the university of applied sciences this summer! We had other material too, but having it explained in more layman terms and breaking it all down was absolutely the key for us to really crack into the subject. The Amoeba Sisters are our heroes!

[@warwick802]

Me in Middle School- Laughing at these videos. Me in High School - Appreciating these videos for saving my life to prepare for exams. Me in College: Literally thanking these videos for saving my entire degree.

[@reemaal-koubaytari8907]

FELT

[@---oliviasan-9943]

i felt that- ;-;

[@user-bv5sq9dy7w]

Me in college: lowkey laughing at the videos 👁👄👁

[@gaeullver]

@@user-bv5sq9dy7w Lmao😭🤚

[@seandonohue1056]

Me in medical school reviewing this before reviewing biochemistry..

[@davet4335]

Me, 82 year-old, high school grad, fascinated, self-educated, life-long learner...loving you for your amazing work.

[@Ahmad_Salameh]

You are my role model. Keep it up king

[@shreenithi.n9500]

Oh I wish to be like you but I'm already too lazy for my teenage. Sometimes I wonder why I'm not curious at all. Please help me

[@ronaldmorgan7632]

Almost 65 here. I'm just here because the way that a cell works like a factory completely blows my mind.

[@user-cs8pt4zf8u]

@@ronaldmorgan7632 I think it is really cool how cell structure is so fascinating it can interest people of all ages. I'm a teenager and it blows my mind too.

[@Burgerman8664]

@v I'm 13 and also very interested in biology

[@ashleygrey7986]

The fact you made a 11 minute video to explain what my teacher explained in 2 hours....

[@santiago-ve2oq]

Amanda Grey video is 8 minutes

[@1_-Uzi-_1]

Lol

[@ariwang8613]

Ikr, and it's explained better

[@patrickthornton5053]

Facts

[@Michyramos29]

Mine took two classes (three hours)😂

[@ameedalzndani4051]

As a medical student, I love this woman, always saving my life with these amazing videos. THANK YOU

[@mafranciscacorreia8852]

sameeee

[@remedyhope7352]

Hey​@@mafranciscacorreia8852

[@juliusbaltazar8773]

me tooo all the time😂😂

[@xDjiki]

I wish I’d watched this before I got a C on my biology exam… which I today gotta correct to an A. The fact you were able to explain this whole process in 8 minutes and my teacher couldn’t in literal HOURS of lessons is just amazing. Props to you!

[@studywme8293]

RIGHT ? I have just finished a four hours lectures about the DNA replication and i couldnt understand a thing.

[@jonatanroland]

u problem

[@alnimri]

I remember my 9th-grade biology class using these videos to teach us. Currently reviewing for a DNA test in a college Microbiology class. Still just as useful as ever!

[@anutararara]

I'm watching this for my microbiology class as well! 😚

[@leenhaidari7959]

Me to

[@sarahurtado6985]

same

[@tyladacreator]

Same haha

[@alnimri]

@@tyladacreator haha looks like I'm not alone. For an update, it worked. It actually helped quite a bit on the exam!

[@dunebuggy3262]

learned more from this than from my teacher with a PhD

[@sciencetrainee3583]

There are some good teachers and bad teachers. And people who have titles but have zero experience or interest in teaching... Honestly, it is HARD to be a good teacher. So, so hard. Being in the same time expert, a good educator and a human being who will give life advice.

[@jasminex6661]

same

[@LlghtShlne]

It's not the teacher's fault. Watching a video showing the whole process is way more effective than a boring lecture of 5 hours

[@joshualklein]

relatable just a teacher without a PhD

[@zakiahmed6655]

guys what vids do you suggest for post grad (im an under grad btw just wanna prepare)

[@kennethng7922]

That moment when realize you're already in gradschool and still watching this to prepare for exams

[@supremechris4437]

got a test tomorrow worth 50% of grade.... mum says if i dont pass ¨bad things will happen¨

[@graceteague4058]

@@supremechris4437 hope it went ok!!

[@coolcatproductions6804]

hahaha same

[@Vonnie-zq2nt]

Bro I felt that

[@MathMith]

dude, really there's no shame in this. I'm actually half my PhD, watching this to refresh some basis before my PhD exam. Keep it up!

[@amsd5780]

I just love how the audience is growing up with the videos, a few years ago we were all doing either IB or AP and now we're coming back to this in college. Thank you for raising us amoebas! :D

[@diyasenthilkumar4015]

and then freshman me just realizing how dependent im gonna be on these vids

[@farizasiddique4790]

This comment made me laugh hahah.

[@seungseungminji]

I'm an IB kid, and I already live off of these videos. Can't wait for college!

[@justsomeone5660]

​@@seungseungminji same 😭 I'm doing A levels and these videos are ❤

[@starsuperville6863]

Yhup!!

[@kristinaquilindo2318]

i study a bachelor in biology and personally think these videos give me a better understanding then the professors do, thank you for helping me through this mess

[@vish850]

This really helped me with the whole lagging strand thing.

[@shyamgovani262]

Same here! which of course is why I came here in the first place lol

[@sehlaw5311]

Sameeee I was confused about that

[@isaacsamuel9520]

Same with me!! my book sucks at explaining them!!!

[@KCaviness3]

yes! I literally came here because after 2 hours and an open lab i did not undertstand the concept and now i'm solid after 8 mins lol

[@georgelkelley]

same!! i was so confused about it for the longest time

[@chrstinejoyrocks]

LITERALLY GOT A MICROBIOLOGY EXAM TOMORROW AND WATCHED THESE IN HIGH SCHOOL BUT STILL HANDY IN COLLEGE

[@MohammadDaniel]

meee too DUDE

[@dr.thunder1567]

Same

[@anime-rx]

My microbio exam is today 😂

[@harvey4892]

Lmao I’m in med school and still watching

[@lizardwaffles]

Watching this for MB too lol

[@2StacksT]

How you guys decided to update this 2 days ago when my test is tomorrow is beyond me! God bless y’all for being on your A game lol💕

[@JohnJones-sq5jb]

who has a test during summer break?

[@Duttywhinequeen]

People who take summer classes

[@Sam-bt5cj]

You've been had John

[@arshiavora2966]

How was the test?

[@DJTT-d9h]

Did you pass your test?

[@alleycat1217]

Right now, I’m a 9th grader studying for an honors bio unit exam, but I have a feeling I’ll be coming back to these videos in college! Your videos are always super helpful, especially for me since I’m a visual learner and struggle to understand concepts without pictures and graphics. Please keep doing what you’re doing! Update: I got a 98 on my exam! Thanks so much Amoeba Sisters!

[@Dyna07]

Same ❤

[@dymene]

I'm in my first year of college finishing up my bio class. Trust me you'll need this video as a refresher

[@alissasonnenberg4108]

@@dymenei’m in my second year, trying to study for my molecular biology exam lol

[@Selenanina19]

It's the way that I'm finished with my first semester of uni and my professor never explained why and how DNA polymerase only goes in a 5 prime to 3 prime direction. I learned an entire semester of biology in this one video and I'm beyond grateful or else I would have failed my exams. ㅠㅠ Thanks so much for the awsome video!!

[@FabyArtz]

That's honestly crazy how do you only do this in one semester and miss something so crucical? What was here is like 15 pages explained very well of the 500 I got for this semester's Biochemistry. Sorry if it sounds like an attack, it's not, I'm just genuinely curious. What specialization is that?

[@byuchu454]

Amoeba sisters: exist My science teacher: Y. E S

[@junothedragon5341]

Thank you for your input Toko

[@ahl3cks]

toko you're weird.

[@michaelbrantley8783]

Same

[@Spurrr]

My entire Micro class was confused from a professor who cant speak english well. This taught more more in 8 minutes than she could in an hour and a half. Thank you

[@cosmiccaravan9408]

who the heck are those 448 people who disliked this video? this is an amazing and extremely helpful video that gives the chance to get a general and very clear image of a topic (like every single one video of the amoeba sisters!). Thank you so much! thanks to you i learned to love biology and now i'm studying it at the university. your videos saved my life!! thank you so much for that! you are amazing and i look forward to your next videos! Lots of hugs from italy!

[@elizabethholmes4933]

@@cor3495 ???

[@tracy3252]

Co-ask

[@tonytherussianlol9299]

Its wrong

[@natashaesquice4846]

This video literally helped me out for a test I have tomorrow. I didn't get a thing the teacher said while I was in class and yet I paid attention. The simplicity and clarity that this video had, made me forget that this test was going to be hard. It literally took all my stress out just seeing that it's that simple (I know it's more complex but I got it). Props to the ones who created and edited this video. You made my day. Keep it up :)

[@firefoxx6185]

POV: you're in university and still watching these videos from grade school to prepare for finals because they make more sense than your professor...

[@choco1322]

You did not-😭😭😭

[@PaidaMaposa]

The struggle is real😢

[@katrinhodgins3717]

I can not tell you how grateful i am for your videos. After being a stay at home mom for most of my days, i am now back in college and i am so overwhelmed with all this information. Your videos help me sooooo much! Thank you!!!!!

[@ericaphelps2369]

You were the first person to help me actually understand why the lagging strand has to build in fragments. BECAUSE the strand is being constantly UNWINDED from the fork. Makes so much more sense now. Thank you.

[@jedimario8860]

I'm currently taking an entry level bio course with a very bad professor, and you explained 5' and 3' better than she did in less than a minute. Props to you for understanding the material so well and being able to present it so clearly.

[@Just_different132]

I swear took me minutes to understand the lagging strand from this video, takes me an hour to understand from a lecture. Thank you.

[@tkurthyt]

why am i paying a university to test me on this when you can watch it on youtube for free....

[@kadenrodriguez21]

Thomas Kurth lmao

[@michellemontes384]

!!!

[@rainydaze1502]

Unless the Amoeba sisters can give me a degree lmao.

[@aztec9651]

Because it doesn’t give you a degree

[@sh31422]

No better source for accessible knowledge about genetics. Literally everyone from middle schoolers, to grad students, to people learning for the sake of expanding their worldview can appreciate these (I'm currently in college, a science major, and I need review, haha). Thank you so much for being our reliable science companions.

[@georgelkelley]

the way this video explained these concepts so much clearer and i actually understood everything in less than 10 mins vs. my college professor…

[@charlottedesia7847]

Three years later and this animation is still saving college student's lives Thank you !

[@DrReginaldFinleySr]

Sukei! This is single-handedly the best video I have seen explaining in common-sense terms and simple graphics how and why the lagging strand must have Okazaki fragments inserted due to the directionality of helicase and the unwinding of the strands. My students and I are much appreciative of having a visual representation that breaks this down simply. You guys are amazing!

[@Pearl226]

Didn't give these vids enough credit back in the day, I'm in high school now and these are absolute lifesavers.

[@freshtasharifi7926]

I love the way she uses these little game characters to explain it. Really helps. ❤

[@takemetothesky1888]

I can't believe I've been struggling with lagging strands for months.... finally a visual study which surely helped me a lot🥺 ty amoeba sisters

[@amaan7028]

I started seeing your videos for my Pre Med School and I am not exxagerating when i am saying that you guys are the best in explaining these important concept in complete,relaxed and perfect way!! Please keep up the good work.'

[@CoolittleProductions]

I’m about to graduate college and the lagging strand has always been sooooo confusing. THANK YOU Amoeba Sisters for making this make sense!

[@ThatoGee]

You guys have literally just saved my life because I have a final genetics exam in 5 days and I did not understand anything that was said during the lectures. This 8-minute video just succinctly covered and explained what was taught during a four lecture period! That's just amazing! 💕

[@yz4wg]

I don't think I ever came across any other yt channel, referencing their sources in the description and even giving further research suggestions. And that on top of a great explanation a n d a great visualization. for free. your whole channel is really a high quality life saver so thanks a lot

[@redheadredemption3]

Better than any college class, graduate or otherwise-Amoeba Sisters you are paving the way for future scientists everywhere!!!❤Much love and appreciation for you both!!

[@mia.delahunt]

I've just started my university degree and my genetics lectures have made me feel like my brain is going to physically implode, so thank you so much for this! I'll no longer spend sleepless nights crying into my textbook absolutely baffled about what any of this means, you're a real lifesaver :)

[@jenntran9727]

I spent 6 hours trying to study DNA replication for my university course and this video really just summarizes it. Honestly wished I found this sooner. Keep up the great work!

[@Benjamin7534]

Love it when a 9 min video explains what my textbook cant over an entire chapter clearly. Thank you so much!

[@michellemontes384]

I have an exam in a couple of days and my professor covered this rather quickly. This video really helped me understand the bigger picture, so now I can study the specifics! Great vid! Been watching since I was in high school :)

[@hadii_alhaj]

I am now studing for my exam in uni, and your video is AMAZING, it explains everything with a such simple way ,absolutely without getting bored, but with entertaiment. THANK YOU SO MUCH!!!

[@abigailpeterson3276]

This video made more sense than any lecture in my current college biology course. This video deserves an oscar, thank you so much.

[@amw1901]

Anyone else having to teach themselves A-level biology bc of quarantine???

[@oliviageorge1768]

me lol didn't even learn this properly in college. i'm doing ocr btw

[@patrickthornton5053]

How do you think this video got a million views

[@zakiahmed6655]

@@oliviageorge1768 did you do your ucas exam I have it tommorow

[@ariannakraljic6237]

yes...my Human Genetics Prof is a nightmare

[@sanjanadalsaniya3741]

FRRRRR

[@in7minutesorless]

The 4 horsemen of DNA replication: -Dna polymerase -Helicase -Primase -Ligase

[@billiethebluebird]

🤍🤍

[@JD-fn3ni]

Great video, just one quick thing though. Before the Ligase glues the segments together, a different DNA polymerase (DNA Polymerase I) degrades the RNA primers that are left in the segments as the RNA primers itself isn't part of the DNA base pair and replace the segments of RNA primers with DNA segments instead, after this process, the ligase will then glue all the DNA segments in the lagging strand together when they are fully packed with only newly formed DNA segments.

[@paulaguaste]

I'm a PhD student and I'm still coming back to your videos to fill in gaps from my undergrad. Thank you!!

[@gauribanayat7873]

Love the fact she never fails us to tell that there is a lot going on....study the details aswell its just a intro for that 😀

[@amiya7488]

you guys are my saviors

[@ericanevin9332]

THANK YOU FOR UPDATING THIS A WEEK BEFORE MY FINAL. BLESS YOUR SOULS I LOVE YOU SISTERS

[@violetteb4946]

I'm a first year french medical student and I just want to say thank you ! You make it so easy to understand whereas my teacher just stammered for a whole hour haha.

[@sarahmikati5869]

Please don’t ever stop doing these KZbin videos cuz u explain and put an image in our heads even the teacher couldn’t

[@jynnxx3d]

I remember i used to watch your channel 6 years ago in my Algebra 1 class back in 8th grade. And now I’m watching your biology videos for my Bio final for my first semester of college 😭 time went by so fast you have helped me so much throughout the years

[@katd349]

"I can only do 5 - 3" I died.

[@AshThumbsUp]

Lol

[@sanjanatummuri3645]

yes skssksksks

[@linostoe]

rip

[@carolinaalejandra4454]

I just want to say one thing... I'm in college

[@アイかねき]

Me too, and still watching this all over again.

[@Aligatorxx3]

same xD this is really helpful lol

[@majdoulinebouroua6981]

That hit me so hard 😭

[@maryambeeto3322]

Couldn’t relate more to this

[@mariandelgado4294]

sameeee

[@laurieflems]

amoeba sisters: *exists* me: happy learning noises

[@oliverpetrovic3689]

Are you ok?

[@cheyennehammonds2331]

One thing I love about the Amoeba Sisters is that, not only are they easy to understand and clear in their examples, but they also include the relevance and importance of this information. So so so great to share.

[@amonh3765]

25-year-old MD me: studying molecular biology from these videos for usmle exam. thank you for saving my burnt out brain.

[@LiveWellwithNicola]

Been trying to understand this since A level biology (I got an A* btw) and now studying a science degree at a top London uni, can honestly say this was the first time my brain has fully grasped it. Who knew your 8 minute cartoon could be superior to years of teaching! Thanks for everything you do!

[@NoahSidney]

Me in 7th grade: laughing at video Me in college: Pulling all nighters with Amina sisters so I don’t fail my exams

[@iivector8994]

@Cameron LOL roblox is starting to attract people of older ages now too... but half the time people like this lie so idrk

[@fluctuatingfanby]

Okay I find biology class extremely dull and did NOT want to trudge through my textbook's explanation, but y'all explained it in such an engaging way, and this is actually really interesting! This video made a lot of ideas click together in my brain, and I think I've been convinced to try giving my textbook another chance :)

[@charlesgovea4399]

studying for my uni midterm tomorrow. This video just summed up 3 pages of my notes in 8 minutes.

[@samaeeso3947]

I just want to say thank you this is the first time in my whole life where i feel smart and fast learner. from now and on i will watch ur vids after my 2 hours and half classroom which i understand nothing in. THANK YOU

[@KatherineCallaghan-hf5de]

Your videos are so so so helpful! I've been using them since freshman year in high school and I still uses these videos in college. You do an amazing job breaking down complicated concepts while also making biology interesting! Keep up the good work!

[@crystalclear3123]

This is the best video on DNA replication I have ever seen😍.. This makes my concept crystal clear just like my name😅

[@marylynnelamantia2798]

As usual, your videos are AWESOME! I teach college biology and continuously use these videos to supplement my lectures! The only thing I would add would be the separate DNA polymerase that removes the RNA primers and fills in the gaps before ligase glues the Okazaki fragments together. Other than that, FANTASTIC!!

[@mahshadarj1583]

OMG! You are AMAZING In 4 days I am going to have an important exam and I am thankful for your videos because you helped me to summarize biology very well You are the best.

[@juansebastianortizperez]

You are awesome!, I´m writing form Colombia and I understood more to you in English than to my biology teacher in Spanish, both of you make a great job

[@kandacenoire]

love this. You (and Hank Green and studying) are the reason I have a 96 and 92 so far on my AP exams.

[@stinafalnes7647]

This has helped me so much! Are you guys planning on making longer, more detailed videoes on these subjects? Because I know I would LOVE that💕🥳

[@emilygiannotta1093]

I learned more and made more sense of this than what my AP Biology teacher taught me!! Thank you so much!!

[@oliviasnow4029]

The amount of times this channel has saved my life

[@KadenceEdwards]

Watching this day of my summative, didn’t understand a thing, now feeling confident in the process. Thanks a ton for your videos 🫶

[@thanosasscheeks]

I am taking AP biology and this genuinely is so helpful. Thank you so much!!

[@ingridespinosamarquez2517]

i for real thought there was a 'what type of polimerase are you' quiz and was willing to drop studying to take it:(

[@nadael-mahdy9602]

I looked for it in the description HAHHA

[@wholemealblousey2641]

Imma make one haha

[@jaelyncarpenter9316]

Same :(

[@Mai-Chang]

Underrated comment right here. XD

[@elhaamkazemi7863]

Bio Professor: we have an exam Me: I hope Amoeba Sisters has a video on this or else RIP me

[@beenieeee]

So I’m german, but until last year I had bilingual lessons, which means I had for example biology in English, that’s when I first watched a amoeba sisters video. This year I have biology in German, but i love your videos so much, and think that they are so helpful and entertaining at the same time, I still watch your videos and just translate the vocabulary for my exams. I really love your videos and hope you’re not gonna stop in a long long time

[@17vrobert]

As an educator, this video might just be perfection. As a learner taking the world's worst-taught microbiology class ever, this definitely is perfection!! Thank you!!

[@msrottencandy3650]

You make these subjects SO easy to understand. Thank you!

[@alyciamunoz6818]

Any other college students here ??? :)

[@Djdnnwiz]

Here bro

[@there_is_someone_here]

High school 😭

[@subhangibag4102]

yep

[@vaghelanaval634]

Yes microbiology student

[@hayamurrad]

Bro college.??? I'm learning this in 6th grade

[@phoebeyan9962]

Watching your video is like taking a break from studying while learning. Amazing!! Thanks again!

[@civicstestandn-400applicat3]

Thank you, amoeba sisters. I am in the first year in college and your videos made me love biology and ended up with an A in general biology 2. I appreciate all the help you offer and I hope you can expand your biology topics to genetics and evolution.

[@arantzac5972]

I love you this saved my life for my bio exam tomorrow

[@mrsgiraffey]

You guys are awesome. I can't wait to have kids someday so that I can teach them about DNA replication from your videos, haha 😂

[@deadlybrownie4318]

why would you do that to your kids

[@emmanoelle6551]

Deadlybrownie You’re not the only one thinking that 😂😂

[@goodnessoverloaded1078]

Please don't subject them to the tortures of science .

[@kr2346]

Wow! This is the best way to teach those kids lol

[@ching2098]

Still watchin in 2025 for my pre-med entrance exam😭♥️

[@MindMeld_Media9]

We low key study tg

[@Ido84ba]

Simple, fun, accurate. Awesome job! I know it's a lot of work but I'd love to see videos like this one that go into more depth! (show and explain the different DNA polymerases, differences between eukaryotes and prokaryotes DNA replication). You're really amazing, thank you for these fun videos!

[@Art_hub66]

It helped me a lot... Every time before I learn theory I came here for a recap ❤❤

[@areyousirius4243]

Gah! You are a godsend! I'm struggling really bad with my 10th grade biology, and I couldn't really understand a single word our teacher tried to explain to us. This helps a lot. Thank you for existing!

[@tarunsingh7235]

Hy .....i am from india ....i am watching this video because like your voice...and you clear any topic very essily 🙂🙂🙂...

[@m_imran8823]

I'm also from India 🇮🇳

[@surbhijariya7440]

Hey, i am tooo

[@chiku6488]

I am also from india

[@malaybal1068]

Me too

[@itstoasty7089]

aidni

[@mariakhan5685]

Well. I knew all enzymes but was confused about it. Thank you for explaining it so beautifully.☺️

[@daxtar6659]

BRuh this vid teaching me more then my bio 9 teacher

[@Valorclight]

My teacher wasted three periods trying to teach this cuz he didn't even get it himself, and u explained it perfectly in less than 10 minutes thank you!!!!

[@artemis1708]

Wow I finally managed to understand the difference between leading strand and lagging strand 2 weeks before my final exam. Thank you!❤️

[@rebecaaldaba24]

THANK YOU SO MUCH! i have a bio test tomorrow that will determine if i finish the semester with an A or C and i didn’t get the whole 3’ to 5’ thing

[@aditianup8032]

okay you guys are amazing! PROBABLY THE BEST DNA REPLICATION VIDEO OUT THERE! Subscribed!!!!

[@MeMyself-ni3fo]

3:36 Primase add a piece of RNA and leaves, Dna polymerase then continues to add nucleotides. This is a major point. Which needed to be clear. 😉😉

[@carlisytt]

Ugh thank you so much for clarifying. They did a great job explaining everything but this part was kind of confusing to me.

[@MeMyself-ni3fo]

@carlisytt it was confusing for me too.

[@joselinamador3757]

oh my god, finallyyyyyyyy.... something that makes sense, this is so comical, the fact that the simplest video out there (not discrediting your hard work) can explain the hardest concept I am dealing with. thank you

[@ryannne]

i would pay a million dollars for an mcat playlist with these videos, they explain it in english and make it funny while all the other books make it sound so muddled. thank you amoeba sisters!

[@Joqu1nn]

Stressing over exam here but that D&D reference made me crack a smile 5:06

[@nobodyinparticular1116]

My god, me too brother me too.