Antigen-Presenting Cells (Macrophages, Dendritic Cells and B-Cells)

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[@arusawaseem6737]

Still saving lives 5 years on...

[@MiryamHamilton]

You have a gift for teaching us hard subjects and presenting them in a very simple way. You're just amazing. The best!!!!

[@gabyfridman7475]

The nervous system, our hormones, the immune system, and our microbiome are the integrative mechanism of our incredible complex biology. Your explanations are superb. I´ve realized that integrating clinical practice, basic science, Pub Med, and incredible people like you explaining videos, are the most disruptive way of learning that I´ve found. People like you destroy the old method of teaching-learning. My most appreciated thank you. Gabriel from Buenos Aires

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Wow, you not only go in depth, but the way you talk enhances my focus. Thank you so much and bless you.

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I feel like I should give you my tuition money. I am definitely donating.

[@user-en9ox2ty3x]

that right he really deserve it

[@katmascardo1695]

You seriously have THE BEST teaching videos online. Bar none. Thank you so much for everything that you do! You have saved so many students, and still counting. What a gift! You, sir, are a true hero.

[@kwhatofit]

I don't usually comment on these type of videos, but, really great explanation.

[@AKLECTURES]

+kwhatofit thanks appreciate that

[@bryanlee1632]

Actually to be more specific, T cell receptor (TCR) and CD4 gylcoprotein are two separated components yet work closely together. TCR binds primarily to the antigen:MHC complex, but CD4, behaves as a co-stimulatory molecule binds to the side of MHC only, without any contact with the antigen. Hence, the full activation of T cells can occur.

[@jay-gu9er]

you have a great talent for explaining things, thanks so much. I'll be donating soon

[@pdiallo]

Very clear explanation. I have enjoyed listening to you because you speak so clearly and make it so much easier to understand. Thank you so much.

[@mennamotaz1101]

Patricia Vickers me too ❤️

[@BloxyFliks]

me too

[@sunsetskies14]

Thank you! You are a fantastic teacher. Learning immunology is actually fun thanks to your explanations and beautiful diagrams.

[@anastasiostresinis6899]

Immunology for dummies like me, easily understood and life-saving! Thanks big time!

[@AKM99733]

amazing as always. yet another topic that you absolutely crush

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ur incredible u saved my life!!!

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I definitely will be donating you deserve it. the best lecturer of biology. I understand more than when am in class

[@midotroubles1]

Great lectures, with incredible animated texts.. Good job

[@ndagijimanafrankaimeerodri8893]

The best instructor ever!

[@kandolaj6939]

I have a Microbiology final coming up and you SAVED MY LIFE, THANK YOU!

[@ruhidyusifov2372]

however this video is closer to immunology than microbiology I mean he focused on mostly immunological side of processes

[@kandolaj6939]

Ruhid Yusifov Oh well it was exactly what we were learning in micro!

[@hanadyhanadosha4890]

Whenever I have a topic in university that I can't understand,I come directly to your vedios.Thanks a lot

[@inesribeiro124]

Thank you so much for the video! Your explanation was outstanding!

[@edwardhaughney9665]

you hit the nail on the head. Bravo

[@TheiTzBros]

Donated my friend thank you for all of these videos

[@AndraMarrel]

Great explanation. Well done! Thank you!

[@misse2359]

Thank you so much. You help me more than my so many teachers do

[@WeddingBells1000]

This is great!! Thank you so much!!!!! You're a great teacher!

[@asmasaidd98]

your're the best , seriously THE BEST .

[@gracehutahaean3306]

Wow, It's very clear. Thank you so much for the explanation!

[@egberuarelydia1312]

all your video are very well explained,you make micrbiology very easy.Thank you so much.

[@eletro_doc9529]

Gold! Puuuuure gold. Thank you!

[@johnshim7945]

Thank you so much for this video!

[@MultiImmo]

What a great lecture from great man . God bless you sir

[@faish4191]

What a Legend this guy!

[@lubnasaqer9300]

U always get directly to my head :) thank u for ur step by step and categorizing ways of explaing things.. I have a rising question though, the difference in time of use for theses three types of antigen representing cells is where they r locted?

[@ahmadkhasawneh9693]

I like your explanation it’s awesome... I need more videos takes about DCS specifically and their characteristics I interested in it. Thanks, in advance ❤

[@sanaashahid4531]

Thanks alot ur lectures saved my life

[@cara.bella15]

Amazing video!!!

[@girlfrom__]

Thank you soooooo much. You rescue me!!!

[@gayathrig4311]

The best class on this topic😍

[@vinayakmishra2142]

Amazing lecture. Thanks a lot sir !!!

[@halashlebk897]

Oh my god you are soooooooo good ! now i finally get it ,,thank you so much

[@besherkhattab3340]

we really appreciate your clear language

[@ramaanouz1607]

Amazing ! Thank you

[@khadidja.95]

Excellent work 👏🏻

[@pharmatalksvideo7222]

Thanks a lot of explaining microphages ..

[@fatmaismail9904]

you are just AMAZING

[@areejasad1419]

Sir you are great .I really have a great respect for u becoz u make hard topics so easy to understand . Truly a great teacher 💓💓💓

[@simplytalitha9537]

Thank you. Explained very well

[@yomaru_1999]

you are the best tutor explaining the immune system

[@ridewya]

excellent lecture...as always

[@thomaspietrobelli4163]

Hello! thank you very much for the vide, very helpful. However I have a question, where do the LT and the macrophage meet?

[@hofmeister15]

ya i agree you explain this well i have seen videos that try to explain it like you do but end up confusing themselves

[@AKLECTURES]

hofmeister15 lol thanks! glad to hear that!

[@topalaluiza9647]

Thank you so much 🙏🙏🙏

[@maialaa3935]

amazing explanation thank you so much

[@sabinadukic3309]

Amazing video

[@swapnalikank9953]

thank uuu so mch😘 I was really worried about this topic of dentric cell bt now I feel its really easy 😘 thank u so mch

[@BloxyFliks]

great explanation you earn it

[@mhamadsajd2281]

Professor of all subjects

[@shaunshankar876]

this is fantastic

[@DamnMakeup]

you are the best!!!!!!!

[@ondrejcesak7625]

Thank you!

[@architavaishnav6629]

very nice lecture sir its solve all my quires

[@israshah5040]

Great!! thank U so much man

[@xiaobomao4562]

Hi Sir, thank you for the lesson! It is greatly appreciated! I have a question, MHC2 can only bind with the cleaved peptide of the pathogen, what if the pathogen is aggregated protein? Is it possible that the MHC2 can present a small aggregated motif (but not just sequence?) after the digestion of aggregated proteins?

[@xinmu5176]

CD4 is a cofactor of TCR, which binds to MHCII-Ag

[@issaalzahra4443]

thanx so much doctor

[@ahmedfayez5942]

fantastic

[@Venus-kb7ws]

thank you!

[@archonsouthpaw8690]

preciate ya stay blessed

[@ronelgallon6949]

your awesome!!!

[@jessicachan7216]

you sir are a God. UBC needs to sponsor you

[@hoangminhnguyen2191]

i have questions: How these types of cells interact with each other in innate immunity and adaptive immunity? Thank you very much ^^

[@anesumukura7312]

I love you guys

[@zackangel1710]

Dude you are the bomb

[@angelalourine1199]

Thank youuu sooo muchh

[@diyorasamadova5419]

THANK YOUU!!!!!!!!!

[@dedrg470]

I love this guy's talking pattern

[@khaldaamber2175]

awesome

[@ahmadkhasawneh9693]

We want a special lesson on DCs Thank you :)

[@hiradvl174]

i have a question. When will the macrophage or dendritic cell work with oxygen radicals and destroy themselves? when will the WBC use exocytosis after phagocytosis?

[@saya2286]

👌👏 so AmAzing

[@anahit6645]

So B lymphocytes play a role in both humoral and cell-mediated immunity no?

[@lilly-lk3mp]

can you do a video on cross presentation by MHC class I? I don't understand it at all!!

[@raanoooshh9296]

16:11 for clear picture! :) Thank you AK Lectures!!

[@menace1782]

I get it, but if they all do the same thing, what makes them differ?

[@recombinantdna6861]

You da man!

[@ThOutRider2]

0.75 playback speed makes it so much easier to follow

[@abdelazizomer2113]

Thanku

[@saadalosemi]

i have when APC engulf antigen the have to either phagocytosis them lysis them or take them to lymph node where the adaptive immunity can take care of theme Am i right ?

[@MrTRANnysaurus]

+Saad Alosemi essentially, yes!

[@birenjung]

helpful

[@dipikapatdiwala7279]

What if a helper T lymphocyte directly comes in contact of a foreign antigen ?? Will it then also undergo differentiation to form cytotoxic, helper and memory t cells ??

[@djostrichhead]

A naive t helper will not be activated by just bumping into an antigen that matches it's TCR. It need to simultaneously be co-stimulated by other proteins as well as the mhc2

[@funkman2011]

Wow a fuc**ng master!!!! Holy Cow!!!!

[@shahidashrafmalik5482]

Anybody body knows? Which book sir Ak follows?

[@twoton1991]

Do B cells activate before T cells? Or is it the other way round? Or can it depend?

[@arunbalajikrishnamurthy1850]

Ben Taylor They activated together by antigen

[@user-cy8gn7vs7o]

What about cd4 and cd8

[@gigglefeather]

Hi Andrey, what differentiates macrophages from dendritic cells?

[@alexandraforrai7390]

the form, where they are in our body and probably also some embryo stuff I am not good at :D a histology book could help you

[@gigglefeather]

In the 4 months since posting this question, I took a histology class and you're right! Dendritic cells are part of the lymphoid lineage, and macrophages are part of the myeloid lineage.

[@evagold5221]

Now i understand - antigen is your lovely word :) and you don't like patterns (

[@AKLECTURES]

+Eva Gold It is indeed Eva :-D

[@newayashine6763]

8:32 the voice crack😄

[@vineetharajendrankottai9014]

If we wash our hands again and again with sanitizer ,will our dentrtic cells get killed?

[@innoutfan]

My Nigga macrophages, got my back

[@billypchajek8439]

i keep hearing that there is almost no understanding of autoimmunity. if our protein sequences are presented as antigens would it not create autoimmunity? so it seems to me there are likely parts of cells in the interstitial fluids that get picked up by APC's or maybe a pathogen or virus takes over a cell and overwrites its ID than our immune system couldn't know the difference. we should be looking closer at these ares for autoimmunity.