Antithrombin III | How Heparin Works!

[@MedicosisPerfectionalis]

💉 📜 50 hematology cases are waiting, LIMITED availability, go to www.patreon.com/medicosis/ 😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119 👩‍💻Sign up for Dropbox here: db.tt/IIlB8ejxWe 📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis

[@israeltommy3604]

Pro trick: watch series on InstaFlixxer. I've been using it for watching loads of movies these days.

[@kylerstanley1755]

@Israel Tommy definitely, been using instaflixxer for since november myself :)

[@salvatorealexander997]

@Israel Tommy yup, been using InstaFlixxer for years myself :D

[@jerrylachlan1163]

@Israel Tommy yea, have been using InstaFlixxer for since november myself :D

[@edytajagielska7086]

Thank you so much for all your work! I’m absolutely mesmerised by the way you explain complex physiological problems in such a friendly manner. Listening to your lectures is a great pleasure.

[@MedicosisPerfectionalis]

You're very welcome 😇

[@nargiznargiz4907]

yo are so funny and straight away and can keep talking with a serious voice....nice combination...

[@MedicosisPerfectionalis]

Haha 😂 Thank you so much ☺️

[@nargiznargiz4907]

🥰

[@dr.m6152]

The punctuation thing got me 🤣🤣

[@vaidehiupadhyay3320]

Man u r awesome 🫀🫀🫀🫀. Loved ur voice modulation and way u teach. Makes me laugh while studying which doesnt happen often. The last line was a real motivation 🤣🤣👽👽

[@MedicosisPerfectionalis]

Thank you so much 😊

[@vaidehiupadhyay3320]

Ur reply made my day👻👻👻

[@nuwodavid6625]

Wonderful, simple explanation

[@MedicosisPerfectionalis]

Thank you!

[@DjRixs]

So I am Antithrombin III deficient and it is hereditary and I am on wafarin. I was only diagnosed after second severe stroke. Didn't help that my real dad didn't play a role in my life as it is a disorder on his side of the family which I later found out. I thankful to the neurologist whom discovered my disorder but I feel I need to blame the first neurologist I was with as the diagnosis could've prevented my second stroke. Also, the second neurologist said it wasn't a common thing based on my ethnicity. I don't know, maybe you can shed some light on this?

[@gto11520]

most caucasian males/females from european descendent have what is typically genetic defect that is associated with type I antithrombin deficiency and factor V Leiden (factor V-R506Q)

[@farahkhan7718]

Amazing.... thanks for making medical students life easier🙂

[@MedicosisPerfectionalis]

My pleasure 😇

[@francescomariaraimondo3395]

"And yes, your genitalia!" destroyed me ahahahah

[@MedicosisPerfectionalis]

😁😁

[@sadibaygeldi9010]

what about TFPI?

[@ward__6782]

D. Antidote of clexan??

[@hannahrosa5485]

Thank you. Now I see why I was given a painful shot of vitamin K after I delivered my son. Thanks for your natural humor too.

[@MedicosisPerfectionalis]

You’re very welcome 😊 Thank you for your continuous encouragement! How is your health now?

[@hannahrosa5485]

@@MedicosisPerfectionalis My health, I am stable and my ankle is mending quickly. I'll be out of the air cast this week. Thank you.

[@نورالهدىعبدالأمير-ش8و]

Amazing 🎉

[@imila1295]

Awww I really enjoyed the lecture and learned.Thank you.

[@MedicosisPerfectionalis]

My pleasure 😇

[@cookingsecrets3629]

Thanks alot for the beautifuly explained video..From Pakistan

[@MedicosisPerfectionalis]

My pleasure 😇

[@ranarassam8749]

You are great man

[@MedicosisPerfectionalis]

Thanks, dear!

[@lisa5483]

This video is amazing. I'm thoroughly amused and maybe 1.25x smarter.

[@MedicosisPerfectionalis]

I am honored 😊

[@اميراحمدعبدالكاظمحسن]

Hi Dr🥺 , please can you answer me on my ,question ,is antithrombin 3 inactivate thrombin ?

[@MedicosisPerfectionalis]

Yes, But it mainly inactivates factors 9,10,11,12

[@اميراحمدعبدالكاظمحسن]

@@MedicosisPerfectionalis thank you so so so so much 🥰😇😊😍❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤

[@MedicosisPerfectionalis]

My pleasure 😇

[@ahmadabusada5998]

amazing videos

[@MedicosisPerfectionalis]

Thanks 🙏

[@pejpm]

My 6 week old son has a blood clot in the superior vena cava due to a central catheter, and is on Heparin. He is too young to do a true blood work up, but they believe he’s baseline AT3 level looks good, however when he is on continuous Heparin, he has to have injections of AT3 every couple of days as the Heparin becomes sub therapeutic when the AT3 is low. Is it typical to expect that continuous Heparin drip will cause the the AT3 level to drop?

[@MedicosisPerfectionalis]

Was he ever diagnosed with antithrombin III deficiency?

[@pejpm]

Medicosis Perfectionalis No, not so far. He is 6 weeks old and was 8 weeks premature. They say base AT3 looked good, but that it’s too early to do full blood work up to evaluate AT3 levels and that 3 months will give us a better idea of where he truly is. There was nothing flagged in genetic testing. He developed the original clot around a broviac central line which had been placed for surgery after he suffered in intestinal perforation, which was taken out and replaced with a PICC which terminated in his innonimate vein. The clot in the SVC and partly in the innonimate started to improve, but he was taken off Heparin for 48hrs for stoma reversal surgery, and the innomimate clot almost immediately became occlusive, so they suspect there could be some clotting disorder at play. Even though foreign objects can provoke clots, they say it’s unusual for it to happen so quickly. He has been in the therapeutic range (.3-.7) on Heparin for several weeks, and they’ve had to ‘top up’ his AT3 every 2-3 days so far. The PICC has been removed and they’re hoping to get through the rest of his care using PIV and switching to lovonox. They say that needing to add AT3 every few days is normal when a baby is on continuous Heparin. They aren’t saying he definitely doesn’t have an AT3 deficiency, but that requiring additional AT3 while on Heparin is expected.

[@gto11520]

did they do a lab test followup for platelet count?

[@Hartleymolly]

I’m 36, had massive ischemic when I was 1 month post partum. I have anti thrombin 3, we are a rare bleed

[@pejpm]

@ good to know! My son is now 5 and is doing great

[@nargiznargiz4907]

is it true about clot in genitalia?

[@MedicosisPerfectionalis]

What do you mean?

[@nargiznargiz4907]

Hii...you said because of warfarin use if you wont overlap it with heparin you can get clots because of factor C and S deficiency in first days...on your skin and even in genitalia....

[@nargiznargiz4907]

Probably I misunderstood...or that was just a joke .🤣...which is true ?

[@dr.noir27]

protein c inactives Va and VIIIa ! 🤔

[@MedicosisPerfectionalis]

Yes!

[@hema11901]

Nice

[@MedicosisPerfectionalis]

Thanks 🙏

[@Miskfatim]

hero ✅

[@mariamajibola7930]

wow, am in love with all your videos, the jokes are muah a woman: without her, man is nothing.

[@nargiznargiz4907]

yes he is

[@abeerana3735]

You listened to dr nagi ❤,,,🥺؟

[@MedicosisPerfectionalis]

Yes!

[@Jkawalsky1]

your videos are all over the place. your video is called how heparin works. why are you talking about PGI2?

[@btsarianagrande1956]

great

[@MedicosisPerfectionalis]

Thank you!

[@jacketpotato9857]

Actually a woman without her man is a wo

[@mohammedsalah7499]

🌹🌹🌹🌹🌹

[@MedicosisPerfectionalis]

:)

[@manarsmaan2624]

😊

[@MedicosisPerfectionalis]

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👍🏻

[@MedicosisPerfectionalis]

😊😊😊

[@sadeeparajapakshe2021]

කැරියෙක් තමයි ඉතින්... i think you can start your own university...❤ පකය

[@keithkamfwa69]

The liver is responsible for its actions, l will politicians would................LOL

[@MedicosisPerfectionalis]

Haha 😂

[@muhammadnada9433]

Don't be a simp .The man is nothing if he relies on a woman

[@nargizsafarova9989]

😠😠😠

[@nargizsafarova9989]

Terrible saying about women

[@rozepyracantha5574]

It really through me off my focus, like wtf kind of mnemonic is this?? So unnecessary

[@racheldsouza8895]

Its a joke .......don't like it, don't use it ,ignore it, come up with a better one.... Stop getting triggered

[@nargizsafarova9989]

The man without woman is nothing

[@MedicosisPerfectionalis]

Agree

[@nargizsafarova9989]

@@MedicosisPerfectionalis 🤔 is this a man who replied to me or woman?

[@samphonnetgamgee5625]

@@nargizsafarova9989 Are you a lesbian?

[@nargizsafarova9989]

@@samphonnetgamgee5625 no I am not