Protein C and Protein S - Inhibitors of coagulation - Protein C Deficiency, Protein S Deficiency

[@chaikaryee9908]

Protein C : anticoagulant C-RP: acute phase reactant, an inflammatory marker C-peptide: indicator of breaking down of proinsulin to insulin

[@MedicosisPerfectionalis]

Don't forget to answer these questions for me: 1) What's the name of the enzyme that's involved in vitamin K- dependent gamma carboxylation of the coagulation factors? 2) What's the difference among: a- Protein C b- C-reactive protein (CRP) c- C-peptide. Thanks a ton! If you wanna help me make more videos, please support me at www.patreon.com/medicosis/ If you can't do that, then please share my videos with others...It really helps! Thank you :)

[@leggy12]

Protein C - Not Sure exactly, think there was something about it in this video. CRP - Acute Phase Reactant, stimulates the complement system. C-Peptide - Is the bit that gets broken off of Pro Insulin when it's converted into Insulin. It has a much longer half-life than insulin, and is, therefore, a more reliable marker and should be used instead of insulin as it will show developing problems earlier than insulin.

[@miroomalo9158]

In the algerian externa system we study hematology for 3 weeks .as a result .too much lectures without the efficient good learning thanks to you sir I'm learning passionately in the best way . Actually I'm watching your video after I passed my exam ..funny and important biiig love from algeria

[@MedicosisPerfectionalis]

❤️❤️

[@alexandraortiz9664]

The enzyme is gamma glutamyl transferase (vit K dependent). Thank you so much for your videos Medicosis

[@MedicosisPerfectionalis]

My pleasure!

[@jsabz3]

i spit out my water when he said 'if u got the question wrong maybe u have an extra chromome' what a savage i love it.

[@MedicosisPerfectionalis]

Thank you ☺️ I was just joking 🙃

[@jehadothman8821]

I don’t know whats better the high yield info or the sarcasm 😂 Highly recommend

[@MedicosisPerfectionalis]

Thanks a million 😊 Can you please help me by sharing?

[@jehadothman8821]

@@MedicosisPerfectionalis Will do

[@jehadothman8821]

I just shared you on fb. Excuse the tardiness.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@sitinabilaaimizulkefli3690]

Love how sarcastic this vid is hahahaha helps me to pay more attention in the topic being discussed. Thanks alot! Need to present this on Tuesday. Wish me luck!

[@MedicosisPerfectionalis]

Good luck 🍀

[@drhumzaashrafsial6500]

I dont knw who are u but u r just just awsome I am studying for my fcps exams and I am so depressed and I laughed so loud by watching your vedio that my mom come its amazing cleared my concepts lots of love... But my Fav line was congenital disorder when u r in womb 🤣🤣🤣👌👌

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@elizabethdavid9964]

Fantastic explanation! I love the humour and it really does make me remember better

[@jaeholeeba2853]

LOL I stopped an extra couple seconds to make sure I didn't get the questions wrong so I wouldn't get absolutely roasted... BBQ chicken

[@MedicosisPerfectionalis]

Haha 😂 You’re awesome 👏

[@sheikmohamedamanulaa3898]

MP thank u for the quality content and organising them into playlists.......love from India......u deserve a lot more subs

[@MedicosisPerfectionalis]

Thanks bro, can you please help me by sharing my videos with others...Thanks a ton!

[@sheikmohamedamanulaa3898]

@@MedicosisPerfectionalis i actually screenshot and use these comprehensive things the whole semester.......I share these screenshots with my classmates ....but I will try to share the video itself next time.....again thanx a lot bro.......

[@MedicosisPerfectionalis]

Thank you 🙏

[@kinggrooms7473]

Sheik Mohamed is there any treatment or cure

[@fatmamohammed6924]

Gamma glutamyl-carboxylase enzyme

[@MedicosisPerfectionalis]

Excellent!

[@mategido]

You are a brilliant teacher! Ty for this video!

[@MedicosisPerfectionalis]

My pleasure 😇

[@josephdamun5065]

anyone know why you require antiplatelets (clopidogrel) for arterial thrombosis and anticoagulants for venous based thrombosis cos i cant figure it out

[@suzbarak]

joseph damun i think bec in arterial thrombosis there is no trauma and no platelet adhesion to sub endothelial collagen and no aggregation and no secondary hemostasis only the platelets are causing thrombosis

[@suzbarak]

joseph damun bec Clopidogrel inhibits platelet expression of GPIIb receptor

[@MedicosisPerfectionalis]

🎁 Small gift: here are 2 FREE audiobooks from Audible amzn.to/2FQurW0 📖 Try Amazon Kindle unlimited for FREE, they have some good **MEDICAL** books that you can read for FREE. amzn.to/2UceoG2 🥰 Picture-Mnemonics www.picmonic.com/referrals/JK55NQXQQB9JLC119 ...You can thank me later 😉. 📗 Get my notes in pdf files that are downloadable at www.patreon.com/medicosis/

[@poojakarthik5040]

Medicosis Perfectionalis this video is awesome ty sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@AJ-je3pl]

So you mentioned cause the brakes don’t work and you replace the brakes or just don’t have brakes at all for this condition how would you replace the brakes take supplements of that brake type that is broken?

[@曾祐軒]

After that early publication, the efficacy and safety of drotrecogin alfa were widely debated. Drotrecogin alfa was withdrawn from the worldwide market on October 25, 2011, after analysis of the PROWESS-SHOCK clinical trial, in which the drug failed to demonstrate a statistically significant reduction in 28-day all-cause mortality in patients with severe sepsis and septic shock. [25] Trial results observed a 28-day all-cause mortality of 26.4% in patients treated with drotrecogin alfa, compared with 24.2% in the placebo group. From Medscape

[@snafu374]

What if anything is suggested in place of drotrecogin alfa

[@reachtt]

I had so much fun... Thank you!

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@ADorakadu]

C peptide is insulin Connecting molecule CRP Is.c reactive protein an inflammatory marker APC already explained by u Good job Doctor!

[@MedicosisPerfectionalis]

Thanks 🙏

[@bluehairkim1]

My father had protein as deficiency in my grandmother was never diagnosed she died of gangrene long before people were discussing this that is there anyway the gangrene killed her as a side effect from the necrosis

[@duosscriptores7836]

The enzyme is vkorc1 Vitamin k epoxide reductase

[@mimallonis]

Hello. I'm not a student. I'm a patient in need of help and information. Thank you for your video. I hope you'll read my comment and I hope my english level will be enough to explain my problem. I have a Protein S defficit. It's around 16%. My father has it also - he doesn't have Protein S at all. I have an event of thrombosis in 2017 and since then I'm taking Xarelto 20mg, now trying to swich to Eliquis but it seems like I need to high of a dose - 2 x 10mg and I've been told that there are no research for such a high dose for a long periods of time. All doses and info mentioned are after test and medical consultations, not my own interpretation. I've been adviesed to not have more children because they will have my problem. I have one kid at the age of 3 and today I have been also told that it's not common to do a therapy for a child before any event of thrombosis has occured... My father and I both almost lost our lives at around 20 because of event of thrombosis. And now at the age of 53 he has lost the ability to talk and a lot of his life quality because of a new event. So... I need a reccomendation for a specialist who would talk with me. It seems that I have seen the best ones in my country Bulgaria but I need more because... well, I just want to have a normal quality of life for me and my child. PS I'm 29, 5 foot 5, 115 lbs, very active, sporty, drinking a lot of water, non smoker etc... Just this damn protein S.

[@bluehairkim1]

Wouldn’t it be wild if protein S deficiency blood type could treat patients with hemophilia through blood donation! My family holds the gene for protein S deficiency. I think I’m the only one that didn’t get it

[@genevahsiamunyati2660]

Sending love from zambia ❤

[@PatriciaSantos-qy9dl]

this is how i imagine my teachers when they see my answers on exams

[@MedicosisPerfectionalis]

Haha 😂

[@noorhamed4690]

Amazing video.....😊 I have two question.... 1-hemostatic studies ....how the test is contain??

[@suzbarak]

Gamma Glutamyl carboxylase in the liver

[@MrZomg17]

This is my first time listening to this subject and besides the intriquit wording i understood what you were teaching

[@MedicosisPerfectionalis]

Great 👍 Thank you so much for watching!

[@noorhamed4690]

I don't understand the relation between the question and gamma glutamyl carboxylase ?? What the function of this enzyme ??

[@krileban]

Thank you 😊

[@MedicosisPerfectionalis]

My pleasure 😇

[@maryamheikal3042]

Can iask aqustion

[@mohammedsublaban8518]

I had protein C deficiency and since 2014 I'm taking warfarin 5mg ,

[@Lynxys_artsys_yashiii]

My plasma protein C is high than normal value what can be the reason ?

[@zilandizayee5579]

So what does it mean when APC V with APC/CaCl2 is prolonged?

[@markochoversus842]

I am clearly not a medical doctor... my question is: which is the relation between Protein S and Protein C with CoCoCo_vID?

[@ЮлияШеина-с4д]

Gamma-glutamyl carboxylase

[@MedicosisPerfectionalis]

Awesome 👏

[@ЮлияШеина-с4д]

@@MedicosisPerfectionalis 🤗

[@Cornbreadddd]

I love the insults, they make me smile.

[@MedicosisPerfectionalis]

:)

[@elalek4197]

Thank you.

[@MedicosisPerfectionalis]

My pleasure 😇

[@markocroatia1]

I love this guy lol! I wish I had his videos back in Med school

[@MedicosisPerfectionalis]

Thank you ☺️

[@joomahabuzaid3296]

THANK YOU so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@ahmadmusawer9392]

You're sarcasm is like Egyptians 😂

[@MedicosisPerfectionalis]

Yes, of course!

[@kinggrooms7473]

So protein k is bad ???

[@MedicosisPerfectionalis]

????

[@sagarpriyanka4504]

U really saved me by creating this video Thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@mechkourmeriem4560]

Thnx😊🥰

[@MedicosisPerfectionalis]

My pleasure 😇

[@kinggrooms7473]

Is there any cure or treatment?

[@MedicosisPerfectionalis]

For what?

[@kinggrooms7473]

Factor five

[@ibrudejude]

Dang I thought I could finnaly relate to my baby sisters passing. Slow down dude.

[@noreenmika7783]

y-glutmylcarboxylase

[@MedicosisPerfectionalis]

Excellent

[@noreenmika7783]

The question was on my exam today 😂

[@noreenmika7783]

Your videos are amazing. I love your humor

[@younghwankim7303]

expoxide reductase

[@doctormaryanne.]

Gamma glutamyl carboxylase

[@MedicosisPerfectionalis]

Excellent!

[@saifhady8514]

U great ,accept my regards

[@MedicosisPerfectionalis]

Thank you, brother!

[@rivkier7214]

Ihavvethisandiaminaahospitallandhavebeenfor22years Because of a clot in the brain injury

[@matchcapo]

Gamma-glutamyl carboxylase

[@MedicosisPerfectionalis]

Awesome 👏