Glucose-6-Phosphate​ Dehydrogenase (G6PD) Deficiency, “aka favism”

😍🖼Animated Mnemonics (Picmonic): www.picmonic.c...
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G6PD deficiency (favism) is an x-linked recessive disorder, therefore more common in males than females.
G6PD deficiency is protective against Plasmodium falciparum malaria.
Patients may experience an acute hemolytic episode after consuming fava beans (that's why it's called "favism"). Fave beans, in this case, is an oxidative agent.
Symptoms include jaundice (yellow skin, dark urine), fatigue, pallor, drowsiness, exercise intolerance, shortness of breath, abdominal, or lumbar pain.
The most common stressor in G6PD deficiency is infections.
Reticulocyte count will be high in this case
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[@pranav6143]

Does dark urine present in haemolytic conditions,bcz dark urine is shown when,the conjugated bilirubin passing through urine in obstructive jaundice. In haemolytic anaemia ,no bilirubin is passed in the urine ,except only the light colouring urobilin is only expelled in the urine,so chances of dark color in urine is less.

[@nourshaaban9806]

كنت عطول مستغربة كيف أجنبي بيتمسخر بنص الجد وبيشرح بهضامة وبس عرفت أنك مصري ارتاح بالي 😂، بس الجد شرح أروع من رائع 👏🏻

[@MedicosisPerfectionalis]

Thank you so much 😊

[@M9_rwa]

هو جد مصري ؟

[@rnaqatawneh9399]

😍😍😍😍

[@iamgopz]

0:00 G6PD 6:47 Favism 8:16 Importance of G6PD 
 3 Functions of NADPH 9:52 Pathophysiology 11:59 Clinical Manifestation 13:50 Oxidative Stressors 16:13 Diagnosis 20:29 Management

[@ritamxx7200]

Thanks you❤️

[@mohammedyasser2688]

Iam proud an Egyptian guy has a channel like this with this super great effort . شكرا يسطا وبالتوفيق دايما 😁😆

[@omnia841]

الجمدان ده ميطلعش غير من واحد مصرى فعلا

[@jehadothman8821]

I knew this sarcasm had an Arabic tint 😂 Greattt

[@theafricanesther5795]

On the days when I'm not motivated due to the workload of med school, you should know it's your videos that keep me going. Thank you!

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@dandanthesecurityman]

This hematology series is so beyond amazing. Please let me just give you my tuition instead of my school hahaha

[@MedicosisPerfectionalis]

Haha 😂 Thank you 😊

[@Bitter_Biscuit]

Thank you so much man, great explanation BTW Didn't know you were Egyptian. Your English is pretty good :P Greetings from an Iraqi student who studies in Cairo

[@MedicosisPerfectionalis]

You’re welcome, brother 😊

[@chudapatil]

Your way of teaching is like few great teachers I had in my medical schooling days. Thanks. Your style is lucid and you make things appear so easy that one wouldn't forget

[@MedicosisPerfectionalis]

🩸 Hematology Playlist: kzbin.info/aero/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

[@Jayreed4Jesus]

This was very good. Learned way more here than any doctor I have been to. Most are clueless and only tell me to just avoid fava beans and that’s it. Thanks so much for sharing this. 😊

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@mubarakeleid6996]

الله الله ام الدنيا تنجب من افضل القنوات لتعليم الطب، احلى خبر والله!

[@user-ix1ye3sy9r]

أنا قرأت التعليقات وعرفت إنك مصرى فرحت جدا والله مكنتش مصدق أنا فى طب المنصورة وعمرى ما جربت شرح اجنبى بس سمعتك بالصدفه واستغربت إنى فهمت عشان كده قرأت التعليقات 😂😂❤️❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@lamazfarsi6843]

honestly MORE THAN INCREDIBLE !!! keep going we really need you guy

[@MedicosisPerfectionalis]

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[@wagdyabdelghaffar4756]

thank you very much for your precious hematology series , you can't imagine how much these videos were helpful for me ...go ahead

[@MedicosisPerfectionalis]

My pleasure 😇

[@rpm2day]

The most detailed information that I have ever seen on g6pd deficiency!

[@MedicosisPerfectionalis]

Thank you!

[@nadamohamed-sy2uz]

This is very simple and informative as well. I've been watching lot's of videos and this is the best channel till now!. Best of luck I'm really proud to know that you're Egyptian " another Egyptian student :D "

[@MedicosisPerfectionalis]

Thanks a lot for this complement...I am really grateful and humbled...I wish you the best of luck too! Please share if you don’t mind! Thanks a million 😃

[@TheX7mood]

والله انك فخر العرب 🇪🇬🇸🇦❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@tareqalhunaty3784]

هو عربي؟؟؟

[@MedicosisPerfectionalis]

Yes

[@asfe2245]

فخر لمصر ى دكتور والله ❤🎉 رائع 👏👏👏 اتمنى فى يوم انى اكون بهذ المستوى الراقى ، طالبة طب مصرية

[@KA-ig6qy]

So proud and happy to see a fellow Arab succeeding in life and also helping others. Thank u u have helped in many courses wish u all the best and happiness.

[@MedicosisPerfectionalis]

Thank you 🙏

[@dahmedaymn3166]

Wow how come that a genius like you is from my homeland ? 🤯🤯 this is just bog! …. All due love and respect brother ❤❤❤

[@MedicosisPerfectionalis]

Thank you 😊 I am not a genius!

[@dahmedaymn3166]

@@MedicosisPerfectionalis man enough humbleness you’re a legend… May Allah bless you and give you happiness 🤍❤️💖

[@sheir_Arabi]

ما شاء الله رائع , شرح جميل و لفظ متقن للغة الإنكليزية . من فلسطين شكرا مصر.

[@MedicosisPerfectionalis]

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[@khloudsalah6140]

Doctor you are so fuuny and i am an egytian medical student so proud of you . glad that you are an egyptian too❤❤❤❤

[@MedicosisPerfectionalis]

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[@giuliamezzapica8132]

you are a wonderful patho physiology and biochem pathway teacher: you stick to the point, explain si,ply and are interesting to listen to. I hope you become a professor.

[@MedicosisPerfectionalis]

Thank you 😊

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Really useful for my GP AKT exam - thanks! Didn't realise you were a student when you did these videos, thanks for teaching us doctors what to do, haha.

[@lisasmith1467]

Thank you so much for your medical videos! You explain everything so well, and I love your humor. I am a 58 year-old woman and work as a medical laboratory scientist in a hematology and chemistry lab. I am studying to get a hematology specialist certification, and I listen to your videos during my long commute to and from work. When I get home, I go over the slides. You have helped me so tremendously! Thanks again!

[@nazumair30]

At what levels are dangerous my hemoglobin levels are 10.7

[@hadeeljaradat363]

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[@MedicosisPerfectionalis]

Yeah! It can be funny 😁

[@rehamramadan638]

ماشاء الله بجد متوقعتش انك عربي مش مصري حتى انا قولت ده دكتور اجنبي وحبيت الطريقة جدا جدا شكرا جدا لمجهودك الرائع Keep going 💙 Greets from Egypt , we are proud of you ♥♥

[@MedicosisPerfectionalis]

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[@rozash18]

Amazing videos always! Great enthusiasm, knowledge and humour :) Thank you for helping me though the final year of my degree !

[@MedicosisPerfectionalis]

You're very welcome :)

[@razanaziz9476]

Thank you for the haematology series I don’t know how to thank you enough! i was really struggling with my lectures, hope every difficulty in your life resolve as how you resolved my difficulties in haema 😢❤️

[@MedicosisPerfectionalis]

Thank you 😊

[@spinach5204]

Hello @medicosis perfectionalis I read the opposite for G6PD-deficiency on Uptodate they wrote: "The net effect is that the deficient red cells become rigid and nondeformable, making them susceptible to stagnation and destruction by reticuloendothelial macrophages in the marrow, spleen and liver [45,46]. Although this type of hemolysis is predominantly extravascular, intravascular hemolysis also occurs, leading to hemoglobinemia and hemoglobinuria." I read in alot of sources that it is predominantly intravascular like you mentioned, but I'm no longer sure. Thank you for your incredible videos!

[@solid648]

Very well put together explanation. I love how you explain other small things that relate to the topic, a bunch of things that I forgot.

[@MedicosisPerfectionalis]

Thanks a million!

[@user-xj1lk7rj4n]

The best explanation I 've ever seen ,thanks from KSA.

[@MedicosisPerfectionalis]

Glad it was helpful!

[@MedicosisPerfectionalis]

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[@rehanarehman8683]

why this deficiency only affect rbcs not other cells?

[@molm-sry7773]

I've been following your great illustration for more than a year now and always thought you are related to Egypt due to "Om kalthom" Hint and Shesha in "Crepetations" "Go Liverpool and salah" .. it's good to know that we're from the same spot 😂❤❤❤

[@MedicosisPerfectionalis]

Thank you :)

[@sishabell8474]

To be honest Our University (HAWLER MEDICAL UNIVERSITY COLLEGE OF MEDICINE) Must reward you for Sharing these Unique and Useful videos 💯 Thank you so much

[@MedicosisPerfectionalis]

Thank you 🙏

[@te21212]

“Oky doky” how i knew you’re steins gate’s fans 🤣♥️thank you

[@mahmoudalkhamisi2127]

اقسم بالله انت برنس عااااش I addicted your channel and hope u make pharmacology series

[@MedicosisPerfectionalis]

Thank you so much 😊 I have many pharmacology courses on my website: www.medicosisperfectionalis.com/

[@kemnana8740]

ممتاز و الله انت اللي فخر مصر و العرب .. :D

[@MedicosisPerfectionalis]

😊😊😊😊😊😊😊😊😊 Thank you, dear

[@basselyasser2366]

From greatest , simplest channels i've ever seen 💙 (Your egyption student) 😅❤️❤️❤️

[@MedicosisPerfectionalis]

Greetings 😁😁😁 ...Welcome aboard!

[@basselyasser2366]

💙💙💙💙

[@MedicosisPerfectionalis]

Good luck 🍀

[@sofiaahmed3872]

Very nice thanx M medical student from Iraq and the way that U use it for explain thnings its really amazing

[@MedicosisPerfectionalis]

Thank you so much 😊

[@guzmanmed2630]

A very interesting and a well explained Video, thank you very much for the pathophysiology details, keep up the good work.

[@MedicosisPerfectionalis]

My pleasure 😇 Thank you so much

[@different3810]

واو حضرتك مصري ❤️ دا شيء فوق العظمة يعني وكون المجهود يطلع بالصورة الرائعة دي فدا شيء عظيم جدا ، كنت هكتب بالانجليزي بس لما لقيت حضرتك مصري فقلت اكتب بالعربي . 😂 ربنا يبارك لحضرتك كتير والمصريين وطلبه الطب خصوصا هنا بيدعوا كتير لحضرتك .

[@MedicosisPerfectionalis]

😃😃😃😃😃😃😃😃

[@JeliPLewis]

Living with a g6pd deficiency- information is hard to come by. This helped me understand so much more than any dr has ever taken the time to do; especially for a common deficiency. Although I don’t eat a lot of beans and avoided them my whole life; I was exposed to fava beans/falafel possibly due to the restaurant using the same oil or tools to fry the French fries as they do the falafel. I had a painful reaction afterward. It felt like the RBC’s were trying to escape through my skin or by any means possible. & now I understand why the urine is so dark afterward. Thank you for this.

[@MedicosisPerfectionalis]

Thank you 🙏 I wish you all the best!

[@zainababdulkareem7746]

Really ? U are an egyption ,wow,U are talking like native speakers , amazing .

[@MedicosisPerfectionalis]

I try my best :) Thanks a lot!

[@ellend5773]

Females are not simply carriers. They are affected and should follow the same precautions as males. Women can be fully deficient and there is also an Asian variant that is very severe....

[@jayaprakasgopalan1708]

@@MedicosisPerfectionalis Accent doesn't matter. The content matters, and that's good

[@MedicosisPerfectionalis]

Thank you so much, dear

[@malakothman-yt7wf]

You're Egyptian?? Wow, thanks from a fellow Egyptian, you make everything easier, lots of love❤

[@MedicosisPerfectionalis]

Thank you!

[@bassa193]

You are making us all proud Egyptians ❤❤

[@MedicosisPerfectionalis]

Thank you!

[@abdabdnabil6276]

Thank you for your amazing presentation You helped me in my presentation on g6pd more than any video i have watched ❤

[@Haraenul]

Wow u r Egyptian?!, ur accent is something else tho, like ur way of teaching. I like your little sarcastic comments ♥️,

[@MedicosisPerfectionalis]

Thanks 😊

[@No-gx2vu]

You’re a medical student!! I thought you’re a professor

[@hadysameh6839]

تحيا مصر ياعم فخور بيك والله

[@user-ip5lg2se8u]

بتابعك من فترة و بحب طريقتك فالشرح و بحاول اكون كرييتف زيك في أي presentation في الكلية ❤️ And try to explain it easy like you, Iam top fan for your channel, So proud of you and egyptians doctors 🤩❤️🇪🇬 فخر العرب الحقيقي 🥳🥳❤️🇪🇬🇪🇬

[@MedicosisPerfectionalis]

Thank you so much 😊

[@maymoh6157]

I can't see but the falafel 🥙 the whole lec😂 Thanks it was great ❤

[@MedicosisPerfectionalis]

I appreciate you!

[@zhiwaskalimba4096]

What a great lecture.. tbh i just needed around 10min of the video but ended up watching it whole, i wish u were in place of my boring, robotic lecturer

[@MedicosisPerfectionalis]

Thank you so much 😊

[@ahmadaljazeeri9287]

This video was so relevant to important people in my life ❤️🌹

[@MedicosisPerfectionalis]

Thank you!

[@lindav1189]

I suffer from lyonization, have Mediterranean varient. Have gone into hemolytic anemia many times.

[@teessnatchedmamas7210]

What should I look out for?? My sons been acting really sleepy.

[@wisamalshalash2235]

what a great lecture, thank you too much from Palestine

[@MedicosisPerfectionalis]

Thank you 🙏

[@livinghope8039]

100% better than Uni. Prof.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@Mblmsl]

Straight to the point! Excellent explanation,thank you!!

[@MedicosisPerfectionalis]

You’re very welcome

[@livinghope8039]

Why is after a toxic insult on the bone marrow, e.g. chemotherapy, the leukocytes are depleted before the thrombocytes and the thrombocytes are depleted before the erythrocytes. Why is that so? chose one - Susceptibility of the cell types - Susceptibility of the progenitor cells - Half-life of the cells in the periphery - Half-life of the progenitor cells in bone marrow

[@Perfect_Delusion]

فخر العرب ⁦🇪🇬⁩ Thank you very much for your work, you're a life saver

[@MedicosisPerfectionalis]

Thanks, dear 😊😊

[@Sammy.a1287]

Omg I didn't know you are Egyptian! Wow! I am Syrian, but I live in London. Love from Syria

[@MedicosisPerfectionalis]

Thank you so much, bro!

[@mwa_911]

Thank you so much, my fellow Egyptian brother :D Subscribed!!

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@michaelt9144]

Excellent. Another great video. Entertaining and easy to understand. Thanks!

[@MedicosisPerfectionalis]

Thank you so much...Happy studying!

[@nourakhaled7092]

Im very happy that you are Egyptian doctor ❤❤

[@MedicosisPerfectionalis]

Thank you 🙏

[@Only60GamesPlayed]

I HAVE SCD TRAIT AND G6PD DEFICIENT BASED ON A HEMOGLOBIN ELECTROPHORESIS. MOM HAD SCD AND BETA THALASSEMIA. SHE RECENTLY PASSED AWAY AT 78 YOA DUE TO ACUTE LIVER FAILURE! SHE WAS IN STAGE 2 KIDNEY FAILURE AS WELL! I DO MODERATE FROM CHRONE’S DISEASE AND A LOT OF STOMACH ISSUES!

[@heshamkram192]

I proud your Egyptian as me bro♥️go on your good work

[@MedicosisPerfectionalis]

Thanks 😊

[@madonna4397]

Love your channel I was surprised to know you're Egyptian . I'm from Egypt too

[@hassinayazid9286]

great explanation. you have to be proud of you. thank you

[@MedicosisPerfectionalis]

Thanks a ton!

[@MirHass]

Such sense of humour comes only from Egypt, especially with the underline sad tone when it comes to politics.. Proud of you, doctor, keep it up..

[@MedicosisPerfectionalis]

Thank you so much 😊

[@user2002n]

I am so proud of you , Egyptian 🇪🇬🇪🇬🇪🇬🇪🇬🇪🇬🤍🤍

[@MedicosisPerfectionalis]

Thank you!

[@plzp1803]

4:50 what do you mean bad luck 😂😭😭😂😂 it’s ok I’m living 🔥🫡 🧘‍♀️

[@nourieneshah3130]

Ur presentation is on point😂👍 thoroughly enjoyed and understood the class

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@datacticalsoldier]

@@MedicosisPerfectionalis also your talking to A 10 year old with G6PD

[@Tabarekoday]

Ommmgggg… why Egyptian dr always amazing in make u understand everything!!!

[@MedicosisPerfectionalis]

Thank you 🙏

[@rathodnehal2869]

hi sir i am nursing student but i have greatly understand this lacture 💪💪👍👍😊😊

[@MedicosisPerfectionalis]

Awesome 👏

[@kamal7370]

ابداع كالعادة

[@shahafsagi7257]

Thank you for your amazing teachings. I learn a lot from you. Peace from your neighbors in Israel

[@MedicosisPerfectionalis]

Thank you 🙏

[@salmamm8818]

Wowww you are Egyptian so proud

[@MedicosisPerfectionalis]

Thank you!

[@aniokeozonnia6961]

Damn, this video was so engaging and so informative. It is really, really good

[@MedicosisPerfectionalis]

Thank you so much 😊

[@lesliestrout5121]

How can you say that little Egyptian boy will be fine if he stops eating falafel? He is going to feel sad if he can't eat such a popluar dish! Seriously, thanks for such a good explanation.

[@MedicosisPerfectionalis]

You’re right 😊😊 Thank you so much 😊

[@nuhadyusuf]

Well, as a G6PD deficient Egyptian you learn that not everything you want you could have. Also, moms are awesome so mine used to make me hummus falafel not the Egyptian (Fava falafel) . Recently, we were honored by our Syrian siblings in Egypt and they eat hummus falafel and their restaurants sell it :)

[@shikhavats7898]

Once in a while I wanted to see u live on KZbin ,thnk u so much

[@MedicosisPerfectionalis]

Thank you 🙏

[@shikhavats7898]

@@MedicosisPerfectionalis You live in America right now and birth country is Egypt 🇪🇬 right?

[@thurayamohamed4319]

Greeting from alexandria 💖 you are a great teacher actually 💓

[@MedicosisPerfectionalis]

Thank you 🙏

[@rahmahraed9129]

I like the videos they're awsome thanks for making studying medicine less harder

[@MedicosisPerfectionalis]

My pleasure 😇 Please share!

[@user-ru3pw3bk2k]

Woooooow....I can't believe it sir, U are the greatest doctor,who ever Explain this ....Are u serious that u from

[@user-ru3pw3bk2k]

Egypt

[@MedicosisPerfectionalis]

ايوه يا صاحبي، انا مصري و بابا مصري 😅

[@user-ru3pw3bk2k]

وربي أنك محط فخر وعز لنا جميعا...😘😘😘....أنت متألق ،مبدع ،أسلوبك بالشرح يأخذنافي رحلة ممتعة ،وشيقه ....نسأل الله أن يجزيك عنا خيرا ...سننشر القناة بتاعك إن شاء الله ،ونعمل الذي علينا

[@MedicosisPerfectionalis]

Thank you so much 😊

[@zahidsaid2618]

Thanks sir for making me this good videos to clear my mind

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@levihoffman4161]

YOUR VIDEOS ARE CLUTCH

[@Hesham_Mohammed]

Dude I didn't know u r Egyptian, I'm Egyptian too, you helped me a lot thnx.

[@MedicosisPerfectionalis]

My pleasure 😇

[@abdelrahman893]

I am a proud Egyptian listening to your lecture 😂♥️

[@MedicosisPerfectionalis]

Thank you!

[@drahrenzy]

Thank you so much guys! Really helped with my Physio class!

[@MedicosisPerfectionalis]

You’re welcome, but I am just one guy 😅

[@drahrenzy]

Thank YOU then! 👌🏼👍🏼

[@MedicosisPerfectionalis]

My pleasure 😇

[@abonasser4777]

Yaaay, Egypt mentioned 😂🎉🎉🎉

[@sathakamara1324]

Thank you for explaining this so wonderfully 🌟🎇

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@minachlf8347]

vous etes le meilleur Dr 😀

[@AsemALNawafleh]

Man, you are great ♥ ♥ and now I'm carving to Flafel hahah !!! Greetings from jordan

[@MedicosisPerfectionalis]

Haha 😂 Thank you so much, brother!

[@nosaibashatat5003]

Urin is dark due to hemosidrin not due to bilirubin... It's intravascular hemolysis leading to indirect hyperbilirubinemia!

[@saraatef4114]

So proud of our Egyption Guy 🧠

[@MedicosisPerfectionalis]

Thank you 🙏

[@narandetagenblirtillluft1419]

Wow I’m graving falafel 🥙 now , thank you for explanation

[@MedicosisPerfectionalis]

My pleasure 😇

[@carp3tstain]

I really enjoyed that lecture. You have a great sense of humor! Great explanations I learned a lot. You have my subscription!!

[@MedicosisPerfectionalis]

Thanks a million! I truly appreciate it...It’s not common that my humor appeal to anybody! But, yeah! Thank you so much for your encouragement, and please let me know if you need any specific video. Thanks again!

[@carp3tstain]

I respect all of your guys and gals that produce these videos, anything you provide I'm grateful. Keep us posted on your website launch. I will be more than willing to donate to some of these channels that have helped me through this Master's program I'm engaging in!Edit: I just saw your pateron page below in the comments!

[@MedicosisPerfectionalis]

Yeah...You can use patreon if you wish...I would be really grateful...If you won’t, no worries, that’s ok too. Thanks a lot!

[@Mercyforthewicked]

thank you this is perfect

[@MedicosisPerfectionalis]

You're welcome!

[@magedali4081]

2Qs 1- how to treat methemoglobinemia in G6PD deficient patients? 2- was Rasputin G6PD deficient that's why resist cyanide poisoning ?