Applied Pharmacology 1, Systemic Drug Administration

[@fatmaelzahraael-zahraa2224]

Thanks! I appreciate your efforts.

[@kellyinthemood1848]

very clear and easy to follow. thank u!

[@catirerubio]

So why not take most pill form drugs sublingual or via buccal? Faster absorption and less work for the liver. Right? I look forward to a answer. Thanks.

[@goldon5909]

Thanks a lot very well explained👍👍

[@sandrasampsondunn436]

This was very helpful! Thanks for making this :)

[@ashmonks7926]

Great video, thanks John !

[@geojor]

thanks dr John ...

[@adadinmaagubueze]

Thank you sir. You videos help a lot

[@AssadNizam]

I’ve been having an argument with a family member: she was given diazepam tablets (normal 10mg diazepam the same as given PO) - with instructions to use them “internally” as a vaginal suppository. I was always taught that diazepam is a systemic CNS depressant and simply absorbs via the mucosal membranes of the uterus and vagina, albeit with a low bioavailability, and is absorbed into the blood and metabolized in the liver, however her “specialist” swears that used vaginally it is only effective locally. Now, I’m not an MD, I’m just a mere lowly EMT, however every MD and RN I’ve spoken to agrees with me that diazepam cannot act locally, and the md who told my (non hcw) family member to use it for “local spasms” is simply a a crank and that my family member is simply taking the advice she wants to hear and disregarding anything contrary. Several other family members who are registered nurses and medical doctors all agree with me. The family member in question also has a history of hypochondriasis and, I suspect, Münchausen syndrome. I’m extremely concerned that this specialist has prescribed high dose diazepam, hydrocodone and flexeril for years now, the former two are prescribed PO at regular intervals, with no warning what so ever of possible chemical dependence or addiction potential, to say nothing of contraindications from drug interactions with other supplements, medications and various “homeopathic” remedies. This person also uses “essential oils” internally in capsules as well as topically/ transdermal and will not listen to me or heed my advice. Thoughts?

[@violettiger21]

Hi, I love your videos! I do have a question though- if enteral means via the intestinal tract, how are buccal, sublingual and rectal considered enteral methods, if they are absorbed straight into the bloodstream, and do not pass through the gut and liver? Thanks.

[@Studypharmaa]

Nice explanation 👍

[@chef_mamanpaz22]

ممنونم از حمایتت عزیزم.. خوش اومدی به کانال آشپزی مامان پز🥰🥰🥰🥰🌹🌹🌹🌹🙏🙏🙏🙏🙏

[@GinaEcheverryMontes]

Greetings from Colombia Here a Med student

[@PreetKaur-fk3ds]

thanks for the video.

[@aymiskawtame512]

Very brief explanation

[@hadidarvishikhezri814]

❤❤

[@nicknick1215]

thanks

[@junczhang]

thanks