ASCP | MLS | MLT | Hematology | Anemias Caused by Defects of DNA Metabolism

👉ASCP Short Notes in Hematology: www.amazon.com...
Have you ever wondered what a defect in DNA can cause? In this video, we'll explore the fascinating link between DNA and macrocytic anemia, megaloblastic anemia, and pernicious anemia. We'll discuss the relationships among these anemias, and teach you how to classify them appropriately within their categories. You'll discover the essential roles of folate and vitamin B12 in DNA production and the general metabolic pathways in which they act. We'll also dive into the absorption and distribution of vitamin B12, including carrier proteins and the biologic activity of various vitamin-carrier complexes. You'll learn the biochemical basis for the development of anemia with deficiencies of vitamin B12 and folate, and understand the cause of the accompanying megaloblastosis. We'll help you recognize individuals at risk for megaloblastic anemia by virtue of age, dietary habits, or physiologic circumstances such as pregnancy, drug regimens, or pathologic conditions. We'll also teach you how to recognize complete blood count, reticulocyte count, red and white blood cell morphologies, and bone marrow findings consistent with megaloblastic anemia. You'll learn how to determine the likely cause of a patient’s deficiency, given the results of tests measuring levels of serum vitamin B12, serum methylmalonic acid, serum folate, plasma or serum homocysteine, and antibodies to intrinsic factor. Lastly, we'll explain why the test values for bilirubin and lactate dehydrogenase are elevated in megaloblastic anemia. This video is a must-watch for anyone interested in DNA and the fascinating ways it can affect our health. Don't miss out on this informative and educational video!