Ask Me Anything about MitoSENS - Dr. Amutha Boominathan and Michael Rae

Michael Rae (Science Writer for SENS Research Foundation) asks Dr. Amutha Boominathan (Group Lead, MitoSENS for SENS Research Foundation) about her MitoSENS area of research. This video is part of our End of Year Campaign 2022 | Week 2: MitoSENS | www.sens.org/eoy2022

[@neilchristensen538]

This work is so important! Thanks!

[@tintin_999]

yes loving it guys

[@InquilineKea]

Is mitophagy inhibited when ALL mitochondria are subfunctional?

[@SENSRF]

Thanks for asking! Please send us your question to our [e-mail] inbox!

[@SENSRF]

To be clear, it's not that defective mitochondria actually inhibit mitophagy. It's that the main mechanisms whereby the mitophagy selects individual mitochondria for culling are short-circuited when mitochondria's energy-producing potential is greatly inhibited. So it's a mitochondrion-specific effect, whether one mitochondrion is defective or all of them are.