Autophagy Lecture

Рет қаралды 25,276

Күн бұрын

Пікірлер: 30

@josephmeeuwsen5411 7 жыл бұрын

Fantastic video for people like me at the grad student level. Clear, exhaustive, and well-paced. Just what I needed to start dissecting the autophagy literature. I'll be checking out your other videos soon!

@AJKeefe 7 жыл бұрын

Thank you! Glad you enjoyed!

@rachelhale6717 7 жыл бұрын

Hey AJ! Super great video and very informative!! Thank you so much you're the best!

@brookstorm9789 3 жыл бұрын

Thank you. I wonder what you think all the supplements and senolytics that interfere in these delicate processes to theoretically gain longevity or healthspan.

@davidnimby 3 жыл бұрын

Congratulations, this is a really world-class presentation on a new and exciting subject. You've done a remarkable job of explaining to my mind so many important aspects that I had found very difficult to grasp prior to viewing this very well done presentation, thank you so much

@giorgiobozzoni8681 4 жыл бұрын

hello from italy, thank you for your videos. i dont understand one thing about autophagt. why do fasting increase autophagy? i dont understand the logic of this. i can understand that during fasting the cell has less amminoacids so that the cell since needs them for proper function,it starts to break down protein, ages inside the cell to get the amminoacids. But during fasting the cell should not go into starvation mode, because glucagon, cortisol, gh increase the break down of fatty acids in the adipose tissue, and help to bring energy to the cells. So in theory during stravation cell should have energy from adipose tissue and the level of atp in the cell should be normal. But because we are no eating protein, the cell is lacking of ammino. So during fasting what really trigger autophagy? only the lack of amminoacids? thank you for your help

@blaisemariner 4 жыл бұрын

Check out the mTOR pathway. This may help you out.

@anonymous672 6 жыл бұрын

Great video. Well explained, I am researching about sirt6 and autophagy.

@AnGela-fe8rk 6 жыл бұрын

Thanks a lot for this great video. A really good review of the complex autophagy pathway.

@Carlos_Costa 2 жыл бұрын

In the complete absence of amino-acids, nutrients, nutritional protein and glycogen depletion (as in fasting), how long time does it take for the autophagy process to get rolling-on in a meaningful way? thank you!

@iot3136 3 жыл бұрын

Hi AJ, Thank you for this comprehensive video. Really helpful. Could you help me to understand; 1. How these names were given to Autophagy proteins ATG1, ATG2, ATG3 ...... are they all similar to each other? 2. Also I saw some proteins have ATG4 isoforms (ATG4A to ATG4D) what does this mean?

@דוריתנחושתן 5 жыл бұрын

Aj thanks a lot great review I am a physician and this was an extensive useful review

@kevinlam6997 7 жыл бұрын

Hey AJ, awesome video! I was just wondering where you obtained your back round information from. Was it from a textbook or from other articles that were found online? I'm investigating the aspects of autophagy and the development of the ATG12/5/16 complex, and i wanted more information on the basics of autophagy.

@AJKeefe 7 жыл бұрын

I mainly gathered my information from review articles on autophagy. If you would like I could send you a few resources. Just email me at AJ.Keefe10@gmail.com

@afiaayub7092 3 жыл бұрын

Can I know which sources you used to sum up this presentation? I am now working on the kind of same topic, and your video is quite helpful and it would be more helpful if you share your study/information sources like books/articles..