Yoshinori Ohsumi: What is autophagy? A dynamic cellular recycling process

Nobel laureate Yoshinori Ohsumi's lecture at the Molecular Frontiers Symposium at the Tokyo Institute of Technology, Japan, Oct 2017. The topic of the symposium was "Science for Tomorrow". Check our KZbin channel for more exciting science videos! For more information, visit www.molecularfrontiers.org

[@lovepeacebliss]

Hilarious how mostly everyone is complaining about his presentation. He won nobel prize for his discovery, not his speaking nor english skills.

[@markothwriter]

Those people are not looking at the slides. He's presenting the science as diagramed on the slides, not trying to sell someone verbally which is what everyone is used to.

[@aureliamukian1259]

He is still human being which means we do certain things excellent and some things we are not skilled at all. That’s normal ! No?

[@jaxnaturals]

Most of the people complaining can't even speak one language properly let alone 2

[@KenLongTortoise]

his english > my japanese

[@theodoros_iosifidis]

Watching him for 2 minutes was painful but you are right... i came for the facts not for some fancy presentation.

[@silencenhikes6692]

Countless stories about autophagy helping people with cancer. Thanks for studying this and not being competitive.

[@gmo4772]

Finally a Nobel prize that went to someone who truly wants to help people bravo!

[@__-bc4bs]

Screw the prize, celebrate Autophagy. 👌👌👌

[@lorrains.robinson1404]

I think mike mew deserves a nobel prize too

[@jezzdogg6857]

@paisleyyama true right you are. Obama was a peice of shit shill

[@AntonySimkin]

Sure, but... his studies have nothing to do with human bodies. He studied fasting on non-human cells and he clearly said I DON'T RECOMMEND RELATING MY STUDIES WITH ANY HUMAN DIET. How "infodemy" is spreading lies... damnit...

[@the_good_citizen]

The last slide appears to be important. But is difficult to understand. Can someone correct the language please so that we can get the meaning?

[@jeannettestuckelschwaiger5071]

An outstanding scientist who didn't speaks english easily. He is highly educated and profoundly human. He has nothing to sell to anyone. May God bless him.

[@thyagtubes]

This groundbreaking, life-changing research on autophagy is being explained by the man himself, and all we have is random nobodys from the internet telling he needs to work on his speaking skills.

[@shaaddhillon3819]

Seriously! Hes a Japanese speaking perfectly understandable English. Wonder how many of these complained can speak Japanese?!

[@lexasamuel5097]

Thk you it’s like the saying goes ...you can take the horse to the water but you can’t make him drink...their ignorance is deafening

[@jamesnguyen7069]

Sapir-Whorf hypothesis

[@annemarioherd]

I am not a native English speaker and for me his presentation is quite understandable

[@marylou2663]

@@annemarioherd His command of English is beyond that of those who criticize.

[@soupysails1373]

We are all watching a current day Einstein who’s research will heal and save many generations to come.

[@sagarshetty3175]

Er this thing was discovered a long time ago in vedas. Wonder why he gets a nobel for rediscovering it

[@Arabiscuits1]

IcarUs uploads I think lots of traditions have fasting not just vedas

[@sagarshetty3175]

@@Arabiscuits1 yes

[@peterwellington7338]

@@Arabiscuits1 Yes, literally every culture/religion has fasting as a ritual. This guy's work is still valuable because he explains how it works to benefit humans in the future.

[@damidee7818]

@@sagarshetty3175 Well, he was talking about cells, specifically Yeat cells, not human bodies, not animals, not even animal cells, and those are drastically different. Yes, nowadays researches try to investigate this possibility as well, however, as you can clearly see, he mentions nothing about IF or that people should restrain from eating during certain periods of time. Albeit I wish he invented such a "magical pill", but, alas.

[@altchang]

The difference between knowing and understanding is huge. What a great quote by him.

[@karenalmeria7598]

Sir, for me your study of Autophagy is already a free medicine for many people and thus it became so popular and being quoted by many doctors as well. You are doing excellent and thank you so much we had a person like you in our generation. May God bless you more with longevity.

[@livedz3121]

We Muslims have been obligated to fast 14 centuries ago because of its benefits to the body. The hadith can also be understood in the sense that fasting protects a person from desires and mental and physical illnesses that may afflict him, and makes him get rid of bad things that may affect him negatively.

[@icekacangfactory]

Alhamdulilah...this month is Ramadhan,fasting month for Muslim than i found this video...watching this made me more to practice fasting properly...tq Profesor...

[@edwardh.banksy9633]

Just one complaint. 46 minutes of him is just too short. I want more!

[@Kobe29261]

We should be ashamed of ourselves - plants and forests are the most resilient things in nature and from year to year they VISIBLY display autophagy - it took this beautiful Japanese man to point all humanity to the obvious. Survival depends, indeed requires long periods of deprivation. Everything* in nature is necessary!

[@initnotofit]

Perfect point.

[@rickstokes2239]

A true researcher that started with a simple curiosity of those things not many people were interested in and now may be unlocking many fields of health and medicine with far reaching implications. Bravo Professor

[@frankfromupstateny3796]

Yoshinori sir,....thanks for your dedication,.....extremely hard work....discipline and sticktoitiveness. May God continue to bless you whilst on the "Path"...

[@dreamingrightnow1174]

Not sure what god has to do with it, but okay.

[@anwarnayani5849]

@@dreamingrightnow1174 ?????

[@Democracyfrw]

Dude he won't see your msg here xD

[@AmaratMamu]

I can not believe that the camera person took about 5 min to realized that there was also a presentation with added information helpful to the presentation. We can hear him and being able to see the slides is a great complement to his talk.

[@averma175]

This research will change the medical word...this research deserve minimum 10 Nobel prizes

[@rdstobbart]

Thank you dear sir for your hard work and dedication to help your fellow man. As a cancer patient you give people like me hope when modern medicine says that they can't do anything more for us. Your research has helped many stage 3 and stage 4 patients heal without toxins. You voice sounds like my father's, gentle and kind. Yes God has given us nature to heal us. Congratulations on your Nobel Prize, it is well deserved.

[@lifelemonswhenlifegivesule9209]

O am deeply honored to have even watched this video of a remarkable man and his discovery. I don't mind how he communicates. I'm just in awe!

[@peterlampropoulos3505]

He changed my life in a week and just getting better

[@geniataub7705]

Where can I find his protocols

[@peterlampropoulos3505]

Bluezones.com

[@benjaminfowler3532]

Congrats for such fantastic research and your contributions to medicine. Fasting has changed my life.

[@artkapustka3703]

Fasting is great. I’m doing 42 days water fast. Today is my 22nd day today. God bless you!

[@filadelfiagraw4363]

Please be careful with the re feeding.Hope you can post your results.Take care.

[@saraswathis4538]

Pl check thoroughly & do take care. All the best

[@MaximusUndecimus]

Please report results . I could not pass 21 days . I lost 25 pound , regain 8 and now stabilized. I thought I was going to die after day two ):.):):). Now I do not take any high blood pressure medicine, nor take any pills to sleep, diabetes, and heart, I am having intercourse 2 times a day and I am 62 Year. young. Basically I am cure after losing a total of 40 pounds via fasting ( and other special secret diets) in 9 months total.

[@richardlawson6787]

That's astounding....fasting takes incredible discipline...my record stands at three full days no calories....I'm gonna try a four day fast soon...

[@antoniomanuelvale3755]

So humble and so brilliant presentation. Greetings and special thanks from a portuguese admirer.

[@ani5cal]

Please accept our heartiest congratulations on your Nobel prize and our happiness at your winning it. My happiness and gratitude from National Taiwan University, Life Sciences, when I had the great chance of getting a seminar class lecture from you Sir. You spoke in detail for an hour about the discovery of the role of Atg molecules in cellular autophagy. Thank you, ba anni.

[@Hebasanch]

This is a great and useful discovery, thank you very much Yoshinori! Thanks a lot for sharing, MoleCluesTV!

[@babuddha]

Thanks. Nothing like getting your information straight from the horse's mouth... even if one must continue learning to fully appreciate what one has been offered.

[@stefpap0310]

Pr Ohsumi is so touching when speaking. The time flew while listening to him and his messages are profound, thank you Professor and the cameraman also

[@NoBody-nu6kx]

Love his message at the end. Very pleasant man, and pleasant presentation

[@parboneedey7192]

His little contribution has brought a great change in our understanding. It was li'l difficult for me to understand his work previously, but now, since I did, I thank him for his contribution in biological science. I'm one of his fans now and will tend to figure out if it can further help humanity to fight diseases.

[@ryanvacation7319]

Thank you for sharing with us your wisdom and knowledge

[@shambunampoothiri8112]

My grandfather used to have food at 11.30 and 6.30 ( yes IF ), had healthy life till he passed away at 103, yup couldn't back with science till and we never got into that food life style , Now am doing IF , and water fasting upto 3 days ....

[@dl-iy8jf]

U mean 16.30? Or 18.30?

[@shambunampoothiri8112]

@@dl-iy8jf 18.30 , morning 11.30 to evening 6 30

[@MOBU76]

Thats my time too :)

[@falconx7921]

@@MOBU76 Are you near 103 😂?

[@63oma]

I concluded we do not need to eat so frequently checking my eating childhood habits. People used to be slim having just three meals a day. Suddenly, there was a fridge and we were advised to eat five meals a day! I am going back to my childhood eating habits and fasting. I feel better without eating so frequently.

[@paf9533]

Sir, thank you for sharing your knowledge and expertise on this field. Congratulations for having won a Nobel prize.

[@fernandomina8921]

Thank You very much doctor for the dedication made to come with this. Wonderful reasearch that would lengthen lives for those who understand the deeper meaning of it.

[@jayaprakashrao7535]

Exceptional, dedicated Scientist...truly worked for good health of mankind...A great blessing for humanity....This world certainly requires the likes of you, Sir...

[@King0fHArtford]

i love this dude, incredible work. thank you mr Ohsumi.

[@zhiweiqin5849]

What an amazing discovery by this professor

[@g.annasmith9834]

Brilliant doctor 👏 Million thanks and massive congratulations Sir Ohsumi 👏

[@annegallagher8284]

Thank you. Great lecture. I've been intermittent fasting only 2-weeks. Good to hear the science behind it. The graph 24, 36, ... 72 hours was informative.

[@evolutionxWife]

I hope more people including doctors start actually looking more into this as another form of helping people!!

[@rainmaker8655]

I appreciate your lecture, great information and discovery, yes, you deserved that Nobel prize!!!

[@saraswathis4538]

Excellent research 👏👏👏👍hats off Sir ...Congratulations 💐you deserve many more awards...GOD bless you 🙏

[@sanderg6346]

Great contribution to humanity. Thanks for your valuable research and discovery. May God always guide you

[@lickantrollico6929]

Thank You, Sir...You solve a big part of the 'big puzzle'. Thank You. All the best.

[@janettept6379]

Just be thankful that he speaks english. Majority of Japanese highly educated, founders and CEOs do not speak english because they love their language. More than that, be thankful for his discovery because it might be key for life’s longevity for all of us.

[@geetanair879]

Arigato Yoshinori san....Your contibution to the world outstanding....Every nick and corner of the world trying to using this method.......once again thank you.

[@ligayaannawi4779]

Thank you so much Sir for your hard work. You are saving a lot of people.

[@babup8986]

Language is not a barrier when the intention to communicate is great. Happy to have got an entrance to such a great mind. Fasting is known as a cleansing process , to ancient societies .But what he has done has brought new generations to fasting vigorously. It's iffect is revorborating all over the glob. It's really celebrated everywhere. Great .

[@urosnemec8632]

Last 6 monts I am eating at most time from 12 to 18 am. I am eating almost everithing healty foods than before, less shugar and much more litlle fishes in between lunch and dinner. I have been lost a lot of fat, and 7-8kg. I am feeling much much better than before, have more energy and mind is cleaner. Workout/training with my bodyweight is now 25-35min 4x in week. Before this 18/6 ritual i have been in fitnes for 4x ca 1,5hours weekly and almost never have so good results as now. Thank you sir to beeing, many times is so simple, but the industy/marketing told us that we should eat whole day 5-6x bla bla.

[@rabbitexpert]

Hi there, Would you be able to posting your sample diet and routine during the one week, I'm in depression and would like to follow the Dr. recommendation

[@jeffharmed1616]

Wonderful research and a deserved Nobel prize.

[@LemyAng]

Thanks for upload this video

[@sonomasyrah]

Great Talk. Love the information.

[@derhansl7666]

Just put on captions people, let this wonderful man speak about what we need to hear!

[@esdraswordlyupdates7081]

I sense the spirit of humor and kindness in his voice.

[@Tikyo11]

oftentimes people say its not ok to fast because you’re just going to starve yourself..well finally now i know that fasting is the best a human body can heal itself without any meds whatsoever/diet supplement. im preparing myself for fasting next week.i am 60kg.. and i’ll be back after 7days fasting(autophagy) . Thank you!

[@savaionut1989]

xyzabc hi! How is it going on? Do you think fasting for long periods of time can increase self healing activity in human body? Do you think there is also some kind of mental healing as well going on while one is fasting for long period of time?

[@Tikyo11]

Liberty Ro Mania 7 days i lost 5kg.. my stomach is not bloated anymore.. before its hard for me to breathe now i feel better because im lighter.. my hair is shinier.. my skin is smoother not dry.. but i have not been back for MRI for the tumor in my head but i can say i dont feel headache anymore and i sleep better 😊

[@jonnybodrog1705]

@@Tikyo11 thanks for letting us know, I pray for you to get full recovery and all sickness to go away. :*

[@ramyshahwan6157]

I think he was talking about the entermitten fast , for good result , When I listen for his assistance , in other videos they talked that too autophagy may give negative result . do u heared about that ??

[@dreamingrightnow1174]

@@ramyshahwan6157 I don't think it's too much autophagy, but too little nutrition, especially protein. If you eat well in the eating window, you will be okay. For some people it means they have to have a bigger eating window. Some do Alternate Day Fasting with maybe 10 or 12 hours of eating every other day.

[@JB25956]

God bless you such a great gift to all of humanity. Thank you for your generosity in sharing your work. I will pray for you and your health what a blessing you are to us all.

[@pedroalvarescabral1489]

Este prêmio Nobel para mim é o divisor de águas para a Saúde humana, parabéns para o Senhor Yoshinori Ohsumi!!

[@vanithevoice6230]

Sir , Namste !! Thank you for many showing light in the dark. Sir, thanks for proving technically which is following by many many cultures from many many centuries

[@williamrivas7809]

Great presentation, thanks Doc!

[@buddyrevell511]

What a beautiful soul. Love this man.

[@samirgoswami6966]

This has been in practice from ages in our hindu culture...Proud to be a Hindu now

[@adamirfan6986]

buddha japan?

[@twisted_nether373]

Fasting has been in our genome since the very dawn of man, but no one's proud to be a cave man for some reason.

[@MrRathel]

Thanks for sharing with us this video. excellent presentation.

[@noureddineali6779]

Respect to this man .

[@byzancez1125]

Thank you for sharing!

[@rafaelgrinder5553]

Thank you to share it. that is really important stuff

[@colleenkaralee2280]

​ That small beginning sparked massive further research into autophagy in human bodies. The NCBI and PubMed websites have search functions where one can find numerous articles into autophagy. Also Professor Valter Longo is doing applied research, starting with mice and rats and applying to humans, and he has come out with his own version of fasting diet to induce autophagy. Prof. Longo also featured in the BBC program, "Eat, Fast, and Live Longer". It is an eye opener. Empirical data for humans is gathering.

[@AaronBosterMD]

outstanding presentation. thank you for sharing

[@thomastraynor9299]

I am learning even at age 68 yrs old. Autophagy! . A genius!

[@pawanbhardwaj519]

Blessing to mankind

[@jgbdickcleland]

What a lovely man

[@manojranjanmohanty8063]

Thanku Sir,Though Vedantic principles never needs anyone's recommendation. Still your "Autophasy" researches established the faith of world on Vedic declaration. Thanks& Regards.

[@vivianhouse7796]

Don't pay attention to his language, his knowledge and his Nobel achievement was very Amazing, anyway he is Japanese and can speak well English in his age is spectacular, APPRECIATED

[@vivianhouse7796]

@Tanvir Mecha Usually Autophagy time is begun after 14 hours fasting but it is powerful when you are fasting up to 36 hours, before go to next level if you are used to fasting then you can increase the hours if beginner may begin starting from 14 hrs 16 hrs 18 hrs then challenge yourself to next level Most people just do intermittent fasting because they don't want to bother about nutrients but if you go along with good & clean eating for sure lots of benefits you can achieve My suggestion, just slow down and after you enjoy it and ur body is adapted then you can feel by yourself and automatically you will behave on your food, cheers and good luck

[@cosmicflow2720]

Am I the only one noticing he looks amazing for someone over 70 years young?

[@hfjchan]

He is asian mate

[@MaximusUndecimus]

@@hfjchan Better you should commented: "he is black so he looks so good" or because he is yellow is better than white? ok mate ! at the end we all die . Don't we mate?

[@suecollins3246]

76 if I have my math right! _Lovely_ looking man! Not a question of whether he looks old or young for his age - quite simply he looks _timeless_ !

[@sachintamil9514]

This genius didn't waste his precious time in learning english instead he chose to learn science.

[@adamirfan6986]

not really

[@dipasarkar8808]

thank you for sharing

[@2710daisy]

Well deserved Nobel prize.

[@onepunchflan3071]

Thank you Yoshinori

[@Jerlbing]

A genius man.

[@ahmetkartal1396]

Saygıdeğer şahsınız karşısında bütün insanlık size teşekkür borçludur. Sizin gibi insanlar çok değerli. Saygılarımımla..

[@kennystarfighter9919]

Thank you Yoshinori Ohsumi for proving fasting in science. It seems like we knew the benefits of fasting way back in time. Both tthe bible and the quran speaks about fasting. Our body loves to have rest from food intake it seems.

[@TheKahim]

It is different, religion fasting is without water especially Muslim one.

[@ibuumar]

@@TheKahim yes...but you can prolonged the fasting with this kind of water fasting...i did that way...i start my water fasting on Sunday...and then continue with muslim.fasting(without food and water) on Monday...and break my fast with water only ....this give me 24hrs of fasting...

[@rajskop]

Even Jews,Hinduism Buddhism and Greeks promoted Fasting. Buddhism promotes One Meal a Day lifestyle and there are rules in Monastery to not eat after noon and if you don't get time to eat you ha e eat your one meal another Morning........some monks in Hindusim don't eat for 10 days in some festivals ...old wisdom that was discarded by Western scientist in the early 1900's

[@davidterrell1242]

Because our ancient ancestors went long periods of time little to no food and our bodies, like many mammals, adapted to it. It is only recently in history that the average human would eat 3 meals of day (carbs/sugar) a day everyday of the year. Our bodies haven't adapted to the very frequent and high daily intake of carbs.

[@cinzialbm]

Thank you Dr Oshinori! We need more like you! We also need to understand that we are destroying our planet in order to have all this food available to us, that at the end, we don’t need.

[@rainmaker8655]

Facts!!! I'm all for the food shortage, we may begin to heal the people, if they can't eat all day and need to ration.

[@fahmasheratthirukkovelluru5483]

Outstanding discovery

[@dplsurve]

When the listener is ready understanding will come.

[@Brad-il9mw]

Monty Henry You forgot Confucius say... I know he is Japanese.

[@avicennawater]

Great scientist with focus mind, hard working, humble he brings memories to me when I was young I worked under great Japanese scientist Professor Fusao Hirata at then pharmaceutical sciences Wayne state university I was working on Apoptosis

[@jojivarghese3494]

Thanks for the video

[@nehemiahs2127]

elegant,good content.

[@drdurgaprasan]

Amazing thinking.

[@GodGotMe762]

Finally found this one

[@makhansinghjohal1979]

Amazing discovery 👍

[@aizenreeve9435]

I’m really fascinated with this study. And decided to embark my self on 7 a day fast. 2 days of dry fast and 5 days of water fast. I’ll be back in a week to share my results. Wish me luck.

[@aizenreeve9435]

On my 4th day, and I feel like shit. So weak and insomniatic. My breathe smells terrible and I feel so hungry. Hahaha will be keeping updates.

[@bozdoganfatih35]

Been there! Dry fast makes you terrible. Drink water whenever you feel bad. Add some salt into your water once or twice a day. You'll see the difference.

[@aizenreeve9435]

Thanks for the advice it helped a lot.

[@bozdoganfatih35]

Good luck 👍

[@Andrii87]

Are you alive ? :)

[@durranay]

Ramadan fasting comprises all the above stated. Time restricted eating and 1 month fasting. Interesting. This was practiced 1400 years ago. Good science discovered this finally. Im delighted

[@H33t3Speaks]

This is kinda like listening to Newton talk guys... this discovery is so profound.

[@sirlean-beautysubliminals-5515]

really inspiring

[@cassandrahawes8970]

I respect him just for surviving. But he is a humble and smart man as well.

[@goranoreskovic1497]

Great man!

[@artofmeditationwellness4486]

We are live right now

[@monsieurgremlin8033]

Thank you sir 🙌

[@danabartlett8581]

Thank you🙏🏼

[@eliasgouvelis69]

thank you!

[@filipinaislander7417]

Brilliant man 👋👋👋

[@alessandrafarias6906]

amazing

[@ociniguez]

Dam, I was thinking about this the other day, why I'm 40 and look like 18, it's bcuz I've been doing this since I was 16, till today. Explains alot why I still look young and healthy.

[@joanasheehan780]

I love you!!! Thank you for your Contribution to life! I praise God for your dedication to health and healing. God Bless You Abundantly. 🌹🌹🌹🌹❤️🌹❤️🌹❤️🌹🌹🌹🌹