Beta Blockers | Mechanism of Action, Indications, Adverse Reactions, Contraindications

[@ashleyprice2338]

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[@pennygodwin2962]

I just came from my cardiologist’s office and wanted some information on beta blockers, which he just prescribed. Your lecture was done so well that I watched it to the end and was surprised at how understandable you made it. Thank you! I’m sure you really ARE helping those commenting below get through medical courses with how well you teach the material.

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For some time (around Two years), I was maintaining my prescription medication to keep my high blood pressure not until this month I recently found about this t.co/GsO1JmyXtf therapy. A doctor has verified it too. Really dont require the drugs previously prescribed to me. .

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[@suefuller3014]

Thank you very much for taking the time to explain the three kinds of Beta blockers. For years I have taken atenolol for angina. Started in 1981. I am now 74 years old and have calcification in my heart. The doctor has taken me off atenolol and put me onCarvedilol. Your video is so good that I am going to watch it for the second time. I am very grateful to have found your video

[@paulbieber7103]

Best medical lectures on the web. Great content, great attitude. Keep it up.

[@bijoyt.thomas5518]

Nebivolol: A Novel Beta 1-Blocker with Nitric Oxide-Induced Vasodilatation very unique among other class . Good tolerability.Nebivolol is approved in Europe/Asia/Africa and Middle east countries widely used . ( particularly in asthma and COPD patients where other beta blockers are contraindicated)

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Hi dear thanks so much

[@taramorgan4142]

I absolutely love this channel. It's the only thing keeping me sane through FNP school. I may have listened to "double block that AV node" a few too many times but it helped me remember not to give beta blockers and calcium channel blockers together!

[@owenmomanyi8314]

14 mins in and I just know I have myself a new tutor. Excellent. Bravo. I'm speechless

[@SugarCube2003]

As someone who just started taking bisoprolol this video really helped understand what's actually supposed to be happening, what's going wrong and how the beta blockers will fix it as well as all potential risks! Big thanks! 😊

[@dkish4]

The best teacher ever I did learn this subject 40 years ago in Bucurest Romania ago, I remember all, you are amazing. Thank you

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idk if you'll ever read this comment but you my friend are a savior for all of us medical students.

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You made my studying a very comprehensive one! I cant thank you enough! I'm taking my NCLEX soon and you are a huge help!

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Starting my Pharmacy Degree next year and I can already see that your videos are going to extremely helpful.

[@amycoffin3841]

Love your content, it's saving me right now! Small point, but I learned that an indication for beta blockers in heart failure is to offset the ongoing effects of sympathetic activation in CHF. Obviously the sympathetic effects are good in acute settings, but in chronic settings the sympathetics are part of what leads to the pathophys of chronic CHF. I feel like that fills in a gap when you discuss indications! The ongoing compensation via autonomics can (paradoxically) lead to decompensation via physiologic/structural changes, but once the patient is decompensated you don't want to interfere with the autonomic compensation response because it is too little too late.

[@eirinimaggiorou8162]

You are the best tutor that I have ever had. Thank you so much, I presented β-blockers to my master program and I felt very confident after your video. Well done!!

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You explain it all so very well. You draw the map so completely between all the systems so when I making driving my car trying to decide which way to go I have your road map to make clinical decisions. You were great I love you

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You are the very best. Occasionally, when going over important concepts, it might be best to slow down a bit on the speed of your speech. Because you are so familiar and well versed in the subject, I can understand why you feel the need for speed in order to cover the subject completely in the short amount of time you have. Nonetheless, you are the VERY BEST lecturer I have ever encountered in my life.

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Some Ninja Nerds who have had issues with Zach's speed have reported setting the playback speed to x0.75 helps them! It's hard to contain his exuberance sometimes!

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this guy makes we want to study harder

[@robertpugsley6326]

I've just been diagnosed with SVT. I currently have DVT, PE, COPD-2, PAD and CAD. Checking what side effects Beta Blockers have. General, instead of being bedridden or close to it. I'm now going to be able to slow my tachycardia but now loose more quality of life due to diarrhea, increased edema, vision problems (had Glaucoma since 2000),... It seems the best move now is to purchase a 38' because I will never have any quality of life ever again. My entire family is gone, what friends I had are no more. I live in a van with the minimalist of life's aids with no Healthcare luxuries. From what I could understand and learn, the Second Generation might help...but again, too many negative side effects especially living alone. Praying doesn't work anymore.

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Hoping for your recovery and stay strong. Being alone can be tough especially with health problems but I pray you find the will to push through!

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Love you Sir...How much complex is the topic doesn't matter. .He makes it simple in so many ways. ..

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I am preparing for Nclex and studying here to make my concepts clear … thankyou for clearing concepts

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I am addicted to your videos Please upload more pharmacology lectures 💕

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Another amazing video, keep up the good work! You’re getting my whole class through pharmacy school. You deserve a shout out at our graduation. I couldn’t thank you enough.

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this man understanding of the topic is astounding

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I like the way you explained it, better then my professor 😂

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haha... agree

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I whish I had found you earlier than 1 day before my exam, thank you still. It's so much clearer now !

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Very very clear explanation from the start up to the last part Sir!!!

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Extremely nice and clear clarification. Tank you .

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thankyou for the beautiful explanation. please make videos on every topic of pharmacology, microbiology.

[@lourdesolvera6579]

Love how you explain things and it makes sense

[@reshmifrancisvadakkan8706]

This is just the perfect way of explaining beta blockers.

[@demasimarianofelix4405]

Great Job! I love watching your videos! They help me a lot at med school!! I would like to ask, if you’ve got your beta-adrenergic receptors blocked, and you want to raise your HR with atropine, which blocks the muscarinic receptors. Who’s gonna act? My point is, if your circulating catecholamines can’t bind to their receptors (because they are inhibited by the beta-blockers), why would you give an anti-cholinergic? I mean, you would be blocking the sympathetic and parasympathetic at the same time. I think that you should give something to displace the beta-blockers from their receptors, for example, isoprenaline. This is all my point of view, if I’m wrong, please let me know!! Because the best way of learning is through discussing knowledge. Anyways, I enjoy studying with your videos! You are extremely great, and you explain thousand times better than all of my med school teachers! Hugs from Argentina 🇦🇷! Sorry for my horrible English!!!

[@beshertabbara3674]

Thank you for the awesome overview. The labeling of the funny Na++ channel inside the pacemaker cell is "Ca++" (should be Na++) - around minute 23, 24 in the video.

[@mjnavarro1252]

Great video - very informative! I am confused on the effect of sympathetic stimulation on beta cells of the blood vessels in the video (8:05). I think it causes vasoconstriction, but in the video you said it is vasodilation which supports increase in BP too. Am I missing something? 😬

[@mohammedjeouit6483]

blood vessels have different types of receptors (alpha 1 & beta 2...) which are localised as so: alpha 1 are localised in arterioles all over the body expect coronary arteries and vessels that supply the CNS ,which have beta 2 receptors...so that when you have an activation of sympathetic nervous system or you are on shock the vasoconstriction does not affect the vessels supplying the brain and the heart thus maintaining their function.... (I guess)

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Your are inspiration to teach and can integrated among draw and explain very cleary...

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Definitely the best pharmacology lecture

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This is one of your hardest videos ive seen so far.

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More pharma please dr zach we need videos of analgesics and Local Ansthesia and many moreeee also please continue the microbiology series general medicine General surgery topics will be appreciated Thank you for the explanation and the effort that you put in your videos

[@Peter-vn5jq]

I got prescribed propranolol for anxiety after alcohol withdrawal, and, true to form, taking them has started causing me anxiety, lol. They do work really well for reducing the sweats, shakes, tachypnea and tachycardia, but they don't directly impact the mental aspect- one could even say that they approach anxiety from the other direction that benzos do. Benzos calm the brain, which calms the body, Inderal calms the body, which allows the mind to calm down. So now I'm watching videos like this one, so I can calm my hypochondriac ass down further, lmao. It's helping, too, so thanks. I'll dazzle my doctor with my knowledge during our next visit.

[@shahiramohammadi7284]

Love this lecture

[@bijianto2745]

Hello Sir ,very useful video.Thank you .Why need to give bisoprolol and diltiazem together to the patient ?

[@yusranawal8455]

its the best cology video i have watched. want u to make more on other topics like antibiotics and CNS

[@paulastafford1642]

Learned a lot! I didn't know atenolol and metopolol were in the same generation. Great video. You explain things so well. Thank you.

[@sharfishaikhi8192]

Hi sir can u tell me which is better beta blockers or calcium channel blockers best for tachycardia without any side effects

[@kanhucharandas4540]

Hi Sir! I am wishing you a happy teachers' day in advance as you are doing a invaluable work for the mankind.God bless you Dr Zach

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Intriguing. My BP before propanol was high with migraines and anxiety. Now my BP is either still high or super low. My thinking is leaning to me to Pheochromocytoma.

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FANTASTIC LECTURING SKILL!!!

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YOU'RE MAKING MEDICINE FUN! THANK YOU

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Beautiful fact he enjoys teaching ......lots of love to him❤️

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YOU are awesome, the greatest Ninja Nerd in the world !

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amazing proffesor Dr consultant u are sir

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Ninja Nerd you are the best! At first I found the topic hard to connect in such systematic way, but you made my day a lot easier. Are you MD? Resident? What kind of qualification do you have?

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I want to say just a huge huge thank u ,how u prepare all the topic sooooooo welll 😊😊😊😊😊

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How the heck do you remember all those drug names, functions and side effects??

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Probably revies them before talking about them.

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[@educlinstand]

Zac, can labetalol and carvedalol be used for peripheral vascular insufficiency - if decreasing TPR and increasing capillary hydrostatic, can that not assist in oxygen delivery to peripheral tissues particularly in diabetics?

[@Blakebryan5158]

So the beta 2 adrenergic effect on the smooth muscle causes vasodilation but when you switched over to the blocking mechanism you said blocking it causes vasodilation? Is this an error?

[@criscook51]

I take carvedilol and have noticed a problem with my short term memory. Is memory impairment a side effect of beta blockers?

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Need more videos on alpha and beta agonist drugs 🙏🙏🙏

[@Merle1987]

Trying Propranolol for migraine prevention (day three so far). I also have extrne levels of generalized anxiety and slightly high blood pressure. Week long migraine gone as of yesterday. No negative side effects so far.

[@SariShares]

I take carvedilol and lisinopril for high blood pressure. I have mild diastolic dysfunction and mild aorta widening as well as long QT Syndrome. I love your videos and indepth explainations!

[@mylvalopes6045]

This is amazing! I love the breakdown and it helped me make sense of it all