Fasting - What does it do to your body?

[@jonjay9991]

I've been using Ketosis for weight loss off and on for the past 6-7 years now. So I've done a lot of reading and research on insulin resistance, glucose, etc. This video is PURE GOLD! This is only the second video I've watched of yours Doc, and I'm now a subscriber for life. Well done sir, you do a fantastic job of illustrating complex biological processes that even an uneducated simpleton like myself can understand. Keep up the great work!

[@achintsingh4552]

I'm here for the same reasons. To study the effect of fasting which triggers the production of ketones(that means fats turning into energy). So i wanna ask you, how has the keto-diet effected your weight so far and how is the experience? Thank you

[@mwasie]

Dr. Mike, this is one of your best videos that I, as a student, find most informative in its detail and level of clarity. Thank you sir! More please!

[@PrinceAngelStar]

I absolutely respect and appreciate that you make these videos and present the topics in a clear, concise manner. Well done! :)

[@shayekhabedin4462]

Brother, my lecturers have spent over 3 hrs trying to explain this to me, and I still didn't get it. YOU explain it to me in 15min and I feel like a king in biochemistry.

[@alanbricker8420]

Dude! In 15' 34," you accomplished what it took my former A&P teacher one week to accomplish, and she was good. Case in point, I'm emailing this video to her. Final note; you're quickly climbing the charts as my favorite medical guy. THANK you!

[@catfurlong5377]

Well damn. Possibly the best explanation of this EVER. Thank you so much, I'm in my first year of medical school in the UK and this is amazing!

[@janessaw.9412]

I'm sure I am not the only person who thinks that Dr. Mike the handsome Australian doctor is nice to learn from and look at! Thanks for the good videos! Helps a lot when trying to really understand these processes of the body! Pretty amazing how we are made!

[@DrMattDrMike]

Thanks!

[@0anant0]

Excellent video! @ 8:00 very important point - even a small amount of glucose will inhibit proteolysis and lipolysis. So no frequent small meals if you want to stimulate lipolysis.

[@doug2993]

I've heard what you are saying, but I don't think it really holds as true as some might want us to believe.There still has to be times of hunger to get the body to tap into fat stores. It still really comes down to a calorie deficit at the end of the day. Bodybuilders in the 80's used frequent feedings of high carbs and lost fat and got in shape for a show. Yes they had their drugs too, but the body is still the body, the drugs just make it easier.

[@KatariaGujjar]

@@doug2993 Calorie deficit model is outdated. It's the hormones. Insulin is a strong inhibitor of lipolysis. Even 1g of sugar entering the body will spike insulin for several hours, even though the 1g of sugar doesn't have enough energy for several hours of work.

[@redgoat8447]

Really impressed about ur presentation. This is what i want after reasearching tons of vids about fasting practicing. Thank you

[@haroonmirza1286]

This is pure gold !!! EVERY (I MEAN EVERY) bodybuilding enthusiast should watch this video at least 10 times to remove misconceptions about Gluconeogenesis Drs can you please make a video on what happens to "excess" protein? There is a very common (I believe) misconception that all the excess protein that one consumes is converted into Glucose (and subsequently into TG) ! It would be great to have things explained as you do. Thanks for great great resources.

[@MariaFerreira-hg8bc]

That is the best explanation I have ever watched in YT! I could be watching your vídeos for hours.... TKS!!! and congratulations

[@gregsLyrics]

Somewhere in here are the seeds of explanation for insulin resistance and the development of type 2 diabetes (T2DM). My brain is salivating to learn more on this topic. Thank you for educating me (and the world at large) on our health.

[@dailydoseofmedicinee]

Fasting can help decrease insulin levels and boost blood levels of human growth hormone and norepinephrine. These changes can help you burn fat more easily and help you lose weight.

[@suzhang628]

Thank you so much for this great vedio.It is useful knowledge not only for medical students but for anyone also🙂

[@ernestorodriguez7397]

Brilliant! Thank you so much Dr. Mike. I really appreciated your awesome video!

[@laurafmartinss]

Far out!!! You are an absolutely amazing teacher! I cannot thank you enough for this!

[@Pesh_w]

Thank you so much. You served my life. The way you teach this stuff is amazing ❤💗

[@tiffanycmm]

YOU'RE THE BEST!!! THANK YOU FOR THIS VIDEOOOO❤

[@oldcat3439]

Awesome video Dr Mike. Somehow just bumped into your channel and definitely subscribed. How do you find time for this ?? Keep up the excellent work ! :-)

[@bathtime21]

Best explanation

[@lemonj4772]

Very informative. You deserve more views. Thanks for the great content.

[@nashwakrisht3960]

Amazing information!! Wish I subscribed a long time ago!! Thanks Dr. Mike!!

[@nemonemo6285]

Another great video, thank you.

[@BetelihemMeresie]

Thanks 🙏 alot . I watch alot of Ur videos. It is very helpful. Keep it up

[@ausmiku]

I've seen research scans of the brain showing that only very specific parts require glucose for proper brain functioning. We can utilize gluconeogenesis very easily to make the approximate 5 grams of glucose needed. The brain is very happy to also use ketones for energy, our ancestors went days without any carb intake and their brains did not suddenly stop working.

[@robz.3225]

Can you point me to that research please. Very interesting!

[@EnglischLernen123]

Great video. Thank you so much. Quick question: isn't the major part of glycogen stored in the muscles. how do they enter the equation? Forgive me if this is a stupid question.

[@nicole1983ism]

Another great video. Have you done any content on steroids used for medicine. I’m struggling to understand the pathophysiology. I can only find info on bodybuilders. 👩‍🎓

[@BigZ_27]

This is a great video but i imagine its a bit hard to understand for non-med or bio students

[@Reyes6523]

Fantastic video.

[@Martin-xh4wk]

Thank you for the helpful video! Could you clarify when gluconeogenesis kicks in? Does it only kick in when our glycogen storage in the liver runs out or would it be similiar to a hybrid car where our body uses both, glycogen from the liver and gluconeogenesis simultaneously, depending what time of exercise we are doing ? Thanks In advance 🙏

[@GofishingandloveGod]

Great diabetic question.

[@Sardy540]

Phenomenal vid. Thanks so much!

[@0anant0]

Very good info! I have a question: what is the proportion of energy produced by proteolysis vs that by lipolysis after 12 hours? Does this proportion stay the same or proteolysis tapers off to save valuable muscles? If so, after how many hours? Can you provide a graph describing amounts of glucose, fatty acids, glycerol, broken-down proteins (alanine), ketones, etc, from 12 hours, to say 7 days of fasting? Thanks!

[@ivanovsamuraj3095]

Good question. Was wondering too. Do you now know the answer?

[@0anant0]

@@ivanovsamuraj3095 Not yet! I have asked similar questions on other videos, but the authors have not yet replied. In think if Dr Sten Ekberg decides to make a video on this topic, then he may provide the answers (because he does a thorough research on what he is talking about).

[@ivanovsamuraj3095]

@@0anant0 Okay. Thank you.

[@KatariaGujjar]

I don't know the exact numbers but fasting massively spikes HGH which strongly inhibits proteolysis (HGH promotes muscle building and conservation).

[@puneetsingh5312]

Thanks a lot Very good information.

[@Skepticalstudent45]

So how does one prevent proteolysis / preserve muscle mass during this process? Is there a way to remain fasted while ingesting doses of the necessary amino acids?

[@dhillonamarsingh5033]

Great explanation 👌

[@gtcih]

Your videos are the best!!!

[@OurGoodFarm]

Thank you for making this video.

[@jacobfeldman8724]

Bro i am willing to learn every language on earth just to thank you in all of them, You guys are just the best sick c*!s ever

[@misslawlesss]

i've heard that there is stored glycogen in the muscles also, and that the glucagon stimulates that and empties those stores before proteo- and lipo-breakdown into glucose. Ive heard that the muscles can contain upto 800-1000 grams.. Is this wrong?

[@ashdgee]

You are right.Muscles also store glycogen

[@florcampos725]

Hi Dr.Mike, how does fasting 12 hours at least 3 days a week increase HDL levels? What is the biochemical mechanism?

[@jordankuhar4797]

does lypolysis predominate? how much is lypolysis utilized vs proteolysis?

[@xgeneproteinx2889]

Informative. Thanks

[@dhillonamarsingh5033]

Superbly explained 👌

[@beatblocker2297]

Mike you are to good In our language ... I said only one word Ktharnaak 🔥🔥🔥

[@t1relaxation]

Do you know if the body's fat storage is mainly composed of either omega-3 or omega-6 fatty acids or another type of fatty acid?

[@AlR-db2mm]

Nice!

[@KatariaGujjar]

You said insulin inhibits proteolysis. Then what about diabetics who have perpetually high insulin but suffer unusually high proteolysis? How does that work? Thanks for the video!

[@hschaufeld]

you're my hero

[@phsal5182]

great video. thank you!

[@nightnurse49]

Great video, wish you were my teacher in nursing school, lol! 🤓🤓

[@lucianothomas3875]

Thanks!

[@GofishingandloveGod]

How long can a diabetic fast to reset homeostasis for insulin resistance.?

[@chaosawaits]

That was one glorious mustache. RIP mustache

[@stevanallen2824]

What's your opinion on men over 50 who's testosterone levels are low to normal. Is TRT a good option?

[@RotterdammerInMiami]

Hi Dr Mike, Thanks for this video. When we fast for 18 hours, what should our blood glucose level meseaure? I got 4.1 mmol/L, isn't that too high after 16 hours fasting?

[@Rbrp]

Perfect 🤩

[@MuskanKumari-gi7jn]

Sir, I want to know that the conversion of pyruvate into OAA can only occur in mitochondria? Does this conversion not proceed in cytoplasm?!! Like why do pyruvate goes into the mitochondria?

[@michaelrowland-us3he]

Is atp more importanty than glucose

[@hasudungansimanjuntak6122]

How long we need to fast in order to promote glucagon?

[@GofishingandloveGod]

Great diabetic question.

[@beatrizlamas5162]

Glucagon cannot act on adipocytes, lypolisis is stimulated by adreneline instead

[@martam518]

My friend went on fasting for 21 days . Did not eat 12 hours for every day. i noticed she was easily irritable, more nervous talking very very loud almost i would say screaming. Is it healthy to do sth like that. ?

[@TheSpecialJ11]

It really depends how she was fasting. If she ate when she woke up and then ate before bed, she was probably really messing up her body's rhythm. There are some really important reasons why intermittent fasting has your eating window during the day either with only eating in the morning to early evening or only eating in the afternoon until evening, not at night and not when you first wake up.

[@KatariaGujjar]

Maybe it interfered with her period.

[@marioscharalambous6455]

I thought the proteins/muscles are spared from breaking down when fasting? I thought that first is glucose stores, then lipid stores and lastly muscles/protein? According to the video, fat and muscles are burned simultaneously Isn't this true?

[@doug2993]

I remember learning what you said. I'm not so convinced that it's just that simple step by step process. Obviously the leaner you get and the longer you've been fasting, the more likely for muscle catabolism. I've experienced that first hand, even with PED's to help spare.

[@KatariaGujjar]

Muscles aren't spared initially. But HGH spiking after prolonged fasting conserves muscle and inhibits proteolysis. You will still lose muscle daily, if you are fasting everyday for more than a week and not getting sufficient dietary protein, but it is quite negligible + HGH will create more muscle than what is lost for OAA.

[@sonalnik3475]

Sir I am 40yrs obese women , does 16 hrs fasting helps me loose wght

[@samboriboun2213]

I learn this and explain to people.I feel educated lol

[@1millionmillionaires542]

This demonstrates GOD'S intelligence.

[@ivangohome]

👍 the source

[@md244-w6v]

this demonstrates your lack of intelligence

[@konnerspears7964]

​@luvtasteGod recommended fasting at a time when these benefits were unknown. Either he got really lucky or he's intelligent

[@davidlightskin7374]

Which one? 🤔

[@konnerspears7964]

@@davidlightskin7374 Jesus

[@tamanaaswal5316]

Love lrcture

[@alaa_alhaj_eid]

Thanks man 💚

[@gianlucafas9668]

what a f...k amazing lesson did u do??? TOPPPP

[@beyondthehoneymoon3999]

Am literary crying..😢😢

[@nightquest52]

Why does Liver generate ATP ? Or rather who consumes ATP generated in Liver ? As I understand it, if I want to transport energy, I do it in form of glucose.

[@KatariaGujjar]

The liver is the most metabolically active organ of the body and with one of the highest energy expenditure. It uses the ATP itself. The ATP can exist in blood from other means (i.e. cell break down) but from the liver it's not transported to other organs. Each cell makes it's own.

[@tq1990zhu]

Dr. Mike you look like the boy I had crush on 2 years ago and his name is Matt and I always thought you were Dr. Matt.. too bad lost chances but well he is probably better off without me. And wish you all the best during this pandemic. BTW are you irish as well?

[@iamlethibe]

😂

[@deekircher21]

What part of the body is ‘adipocyte’? Adipose tissue?

[@madhusbio-globe8219]

Adipose tissue is present in , 1st skin , then superficial fasia then deep fasia afterthat we have adipose tissue..

[@yvesmorales6623]

So fasting reduce adipose fat and muscle mass.. I don't like the later part

[@petrichor100]

yes it does. Unfortunately, I am saying this from experience. The los of muscle mass makes one look skinny fat even with the fat loss. Trying to rebuild the lost muscle mass as of now. I think fasting and cutting glucose is a deadly combo especially for those that are metabolically flexible to begin with and just looking for ways to stay healthy. What most people including myself think is "well, I feel great and energetic, so i must be fine." The reality is the drivers of this energy and "feeling good" are the stress hormones: adrenaline and cortisol. Hypothyroidism and adrenal fatigue are two possible outcomes if one does not interrupt this process early enough.

[@Truthseeking]

Next.... Rogan!!

[@Justin.Martyr]

*Growth Hormone after 12-Oras!!!!* *HOW DO I Know!!!!???* *Soo, If I Eat One Meal Every 12-Oras, then I Get ZERO Growth Hormone???*

[@DrewAlexandros]

0:37 "Our brain only wants carbs for energy" Doesn't it also use ketone bodies?

[@DrMattDrMike]

Ketones turn back to acetyl coA, the same end product as glucose.

[@DrewAlexandros]

@@DrMattDrMike Thankyou sir! When uni is finally open again i'll come express my gratitude personally!

[@chinmaykh2300]

@@DrMattDrMike sorry sir but I'm lost here. Isn't acetyl CoA the common pathway for Carbs, ketogenic aminoacids and lipids to enter the TCA cycle I'm not seeing your point actually:)

[@chinmaykh2300]

It does,but from what I've learnt even at the stage of prolonged fasting( 2-5 days of complete fasting a.k.a starvation) 80 percent of its energy requirement is still met by glucose and only 20percent by ketone bodies . I could be wrong of course:)

[@AlR-db2mm]

This video is about fasting, not starvation. There’s difference. Brain will preferentially (“only”) use glucose for energy as long as there’s glycogen and gluconeogenesis. When an organism enters starvation, brain is forced to use ketone bodies. I’d love to see a video about metabolic processes during severe starvation.

[@michaelsrowland]

I thought atp was more important

[@yashkotadia7677]

Why is no one talking about how difficult it is to focus on the biochemistry with this Greek god talking. And I’m a straight guy 😅

[@HamzaMizar]

Muslims’ fasting is the better one

[@dombarton2483]

Just proves that carbohydrates are not needed at all by any human to survive! The human brain doesnt prefer glucose...in fact glucose will always be used first because glucose is toxic in excess amounts. 4g to 5g of glucose is required at any given point..which is all the human body requires. Ketones is a much more fuel efficient energy source as the end result is more ATP bang for your buck so to speak. So remember this. Carbs are not necessary..and your brain will always use excess glucose first as it needs to remove it from the circulation as quickly as possible. Ketones are not toxic and is the most fuel efficient source of fuel for the human body!!

[@HamzaMizar]

One

[@srijandey87]

Ur lecture is fabulous but you are too handsome and I am getting distracted again and again

[@virgowrld9331]

Scientist just be making up these names for fun

[@negarakrami673]

👍🏼👍🏼👍🏼

[@qaisar.sulaiman]

bro is yolked

[@jasminejones9937]

I prefer Dr Jason Fung's explanation on Fasting rather than this long winded (& very boring one 🙄)Dr Fung makes it easier to understand without blinding us with science 🤒

[@robz.3225]

Well Fung really dumbs it down, so I understand why you like his explanation .

[@KatariaGujjar]

Dr. Fung is an excellent orator but his lectures won't always help you pass your biochemistry exam. His audience is the general public, not the academic students.