Krebs Cycle | Made Easy!

In this video, Dr Mike explains all the steps, enzymes, and cofactors of the Krebs cycle! He even explains how the B-Vitamins fit into the picture!

[@justineacheson208]

This explanation is so clear and a great level of detail for students - not too little, not too much.

[@idasharon9628]

im from india and it's so crazy how students from all over theh world r relying on yt videos😭😭

[@chextabexta4425]

Reading is nice and all, but visual diagrams coupled with verbal explanation is nice

[@jacieritchie588]

I was burnt out and your video helped me feel passionate about the sciences again. Thank you.

[@nataliefades]

Your arms did it for me.

[@maureenreagan9544]

Are you kidding?

[@Kingy_56]

ur the most jacked biology teacher I love it

[@Bea_Strong]

Aaaaaaand I FINALLY freaking understand it now!!!! Your videos should be required lectures for our A&P/ biology/ science classes. Better than any other “teaching” method in my classes. Thank you! 🙏

[@NombusoTinyNzuza]

Wow thank you Dr Mike, thank you so much. I was just about to tear my hair out because yoh!!!!

[@DrMattDrMike]

You are so welcome 🤗

[@strongerthandarkness613]

Studying for MCAT and this video was more helpful than the explanation during my biochem class. Much appreciated.

[@judymaria6223]

me too

[@tamunosubai6119]

Bro said everyone's favourite

[@Lakadat-m5s]

😂😂

[@pabita07]

Just what i needed back to back! glycolysis and kreb cycle💪🏼🙌🏼 subscribed

[@jonathansachikumba9657]

I'll come back again 👏👏👏

[@maureenreagan9544]

All I get is that it’s good to eat eggs. Right? (B vits).

[@reedschrichte800]

How in the world did the scientists figure all this stuff out? It's truly marvelous. Thanks for the B-complex heads-up! Maybe I'm missing something here, but are the phosphates lost or depleted in this process?

[@saharrifai7011]

This explanation was so comprehensive and easy to understand that i want to be asked about it in the exam now Thank you so much Doctor Mike

[@anusckebotha4654]

My mind is completely blown. This is the best explanation of the krebs cycle I've seen. Thank you!

[@mindatempleton1503]

Super helpful video (as are the others you've done about cellular respiration). Thanks! One question, though. My textbook says that "*after* moving into the mitochondrial matrix, the pyruvic acid (or pyruvate) is converted into a 2-carbon compound called Acetyl coenzyme A (Acetyl CoA)." Most other sources I'm finding say the same. However, if I understand correctly, this video is saying that this happens *before* moving into the mitochondria, and that the pyruvate molecule actually needs CoA to be able to cross the mitochondria membrane. I'm curious about this difference. Thanks.

[@LilyGraceySa]

“ Everyone’s favourite “ I’d strongly disagree.😂😂😂

[@GekaSouljah]

I am just watching to comprehend everything because today's lecture I was if I am watching news

[@isabelaalvarenga8862]

I am from brazil. I love tô study about boddy because i was gradued on phisical educacion. Wich City you live in usa ?

[@vanessaamber3086]

I understood this 18 min video compared to the hour lecture my Professor tried explaining it, you are a life saver

[@HudsonBryant08]

Either im a drooling idiot or this video wasn't explained well at all. Im a 10th grader and only understood the first 30 seconds

[@limitd.1921]

Coming back to this video for the 1000th time cause i always forget and watch it again

[@johnsavage4786]

What about the Candle cycle and the use of fat rather than glucose on a Carnivore diet

[@colenusbaum242]

How much this guy benching?

[@coolatma]

Great lecture Mike👍Any thoughts on reverse Krebs cycle that takes place in cancer cells ? thanks

[@SemisiSemisi-px5ou]

Bro I pay 50 for tutorial and I still dont understand. BUT here its for free and now I feel like Im ready for the test tomorrow

[@Charda_Lehnda_in_Canada]

I think my school is a living in a big complication 😢!!!!!!

[@99centfacts82]

Let me tell you the actual Krebs cycle. Learn the Krebs cycle-> pass the exam ->forget the Krebs cycle. -> move to next class -> relearn the Krebs cycle. ->pass the exam --> forget the Krebs cycle

[@99centfacts82]

Let me tell you the actual Krebs cycle. Learn the Krebs cycle-> pass the exam ->forget the Krebs cycle. -> move to next class -> relearn the Krebs cycle. ->pass the exam --> forget the Krebs cycle

[@christinedickson5723]

Hi Dr. Mike, Question, If the CoA is used for move carbon molecules around, why is it needed when the Alpha Ketogluterate moves to being a 4 carbon molecule ( Succinyl CoA)? It seems like it is snapped on, and then snapped off again? I don't see it being needed anywhere else in the Kreb Cycle ( other than at the begining when AcetylCoA enters mitochondria)?

[@Jishie_58]

Hello Dr Mike., I'm your new subscriber... I'm doing bsc nursing 1st year., Pls help me to get distinction mark in nursing...

[@skills-vlogs_infomations_tech]

Amazing

[@khalidafiaz7536]

really helpful Ask them ''Who is it that rescues you from the dangers in deep darknesses of the land and the sea , and whom do you call in humility and secrecy of your hearts saying if He saves us ffrom this we will be surely grateful say ;it is Allah alone that saves you from this and every other distress , yet you asssociate others with Him in His divinity [quran chapter 6;verse 63,64]

[@languageandmana9255]

I wish you have had a free online MCAT prep course which covers improtant topics

[@lishamq]

lol its 1:44am and my exam is today 🤣

[@ariellenashanatomyandyogas9574]

I have read various texts and articles on pyruvate's entrance to the mitochondria.... some say the conversion to acetyl-CoA happens in the mitochondial matrix (i think in one of your other videos - either glycolysis or kreb's you mention it "jumping" into the mitochondria), others say it needs to happen in the cytoplasm before (like you do in this video) - do you have any research you can point me towards that supports the need for Acetyl-CoA formation before entering the mitochondria?

[@Clevemac]

Adding in the carbon diagram changes my understanding of the cycle completely. How simple yet effective!

[@nelliefulton5958]

Thank you so much for being such amazing teachers on here as well as your podcast! Would you consider doing a whole video on the PDH complex?

[@laizadeocampo3657]

ain't our favorite topic but we have an oral discussion individually of this topic 😢

[@KimiyaAlizadeh-ds3oe]

I got a question! In the link reaction we used to take pyruvate into the matrix, so the link reaction actually happens inside thi mitochondria, however you said that acetyl CoA enters to the mitochondria after the link reaction!!which got me confused, I'll appreciate it if someone explains it to me

[@pallavipal3949]

Sir I have book in which Isocitrate converts into oxalosuccinate then after into alpha ketoglutarate( both in the presence of Isocitrate dehydrogenase )

[@switchbladefriends2637]

Physiology this is. Doctors talk of "stealing", but chemists talk of "donors and acceptors". You lost me at 4:22 when you started gesticulating a hydrogen ion transfer like as if one of us is a moron. Only that's not at all what happens, is it? There's a humongous machine within the cell burping out these tiny molecules, passing them on to other humongous machines to twist and crunch further. Those enzymes are the biochemistry magic.

[@KatelynBraniff]

the MOST helpful explanation of the the kreb's cycle! The explanation using the carbon atoms made this finally make sense for me! Thank you :)

[@casinicho]

Your video definitely helped! I have an exam next week, so hopefully I can ace it now lol

[@bretts6861]

Seems like all of these explanations involve glucose, but doesn’t your body burn fat most of the time?

[@meebly4769]

does the anaerobic glycolysis need B vitamins as well to turn Pyruvate into Lactate?

[@LoveLushASMR]

Thank you for explaining the kreb cycle. I have mercury poisoning and figured out because I had no more citric acid in me my body goes into a metabolic acidosis and citric acid reversed this but now I am needing a lot of sugar to function which explains the glucose process in the krebs cycle.

[@lindsayosborne597]

THANK YOU SO MUCH FOR MAKING THESE!!!

[@Ianarinda]

Thank you very much! Very detailed and informative video, God Bless You

[@gjl7022]

is ionic aluminum and arsenic a required trace element in the Krebs cycle?

[@Chris-mi1tt]

Your drawing is wrong. Pyruvate Dehydrogenase is on the inner side of the mitochondria, not in the cell cytoplasm. Pyruvate does not convert to Acetyl-CoA in the cytoplasm and then cross into the mitochondria. Thanks for screwing with my head. I had to go to 6 different web sites to triple check.

[@jonathanseyram2968]

Pyruvate converts to Acetyl CoA😒

[@jonathanseyram2968]

Everything he said is correct, do your research properly😒

[@judymaria6223]

only God can reward you Dr. The best explanation ❤

[@mstg412]

I didn't attend my class last time, this is so helpful😭

[@chris_ea]

❤ Thanks, can you explain how to retain all needed elements and how to add them to the body

[@arsonaleleth4877]

swear you need to come teach oat my school because idk why they make it so difficult when they could have just said what you said

[@SaliyaNkhoswe]

Thanks as always you make difficult thing sound easy all the way from Zambia Africa salute you Dr mike🎉🎉

[@DrMattDrMike]

Thank you! 😊

[@muzahidansari8458]

You skipped some steps 😅

[@tabahop581]

What steps😢

[@soopremo]

I hope you guys will have more videos about biochemistry!

[@johnlawrenceaspden2995]

This is great. Now I can whistle glycolysis (632) and the Krebs cycle (66544444). If I use sharps for CoA then it's (63#2) and (665#44444). You can even interleave them so it's (63#2) (665#44444) (665#44444) and repeat to represent a glycolysis causing two turns of the TCA cycle. The Music of Life!

[@mahaelhag6892]

The Krebs Cycle is a topic that is loved 😍😍😍😍 by students from St Finians College Secondary School Mullingar Co Westmeath Ireland who do/did LC Biology as a one Science Subject or BOTH LC Biology LC Chemistry A teacher who teaches JC Mathematics JC Science L Mathematics LC Biology LC Chemistry will come and get a PERMANENT JOB in St Finians College Secondary School Mullingar Co Westmeath Ireland

[@jasonlove8733]

Well done on the explanation 😊😊😊

[@tonbaraporbeni1473]

1. First reaction of the citric acid cycle is the condensation of acetyl-CoA with oxaloacetate to yield citrate, catalvzed by citrate synthase. 2. Citrate is converted to isocitrate by an enzyme aconitase. This conversion takes place in two steps: - Dehvdration to cis-aconitate - Rehydration to isocitrate. 3. Isocitrate undergoes dehydrogenation and decarboxy-lation in the presence of isocitrate dehydrogenase to form a-ketoglutarate. The formation of NADH and liberation of CO, occurs at this stage. 4. Next a-ketoglutarate undergoes oxidative decarboxy-lation, catalyzed by a multi-enzyme complex, a-ketoglutarate dehydrogenase, an a-ketoglutarate dehydrogenase complex requires thiamine pyro-phosphate (TPP), Lipoate, NAD, FAD and coenzyme-A and results in the formation of succinyl-CoA, a high energy compound, this reaction is physiologically irreversible. At this stage, second NADH is produced along with liberation of second CO, molecule. 5. Succinyl-CoA is converted to succinate by the enzyme succinate thiokinase. This reaction is coupled with the phosphorylation of GDP to GTP. This is a substrate level phosphorylation. This GTP is converted to ATP. 6. Succinate is oxidized further by succinate dehydrogenase to fumarate with the production of FADH,. 7. Next, fumarase catalyzes the addition of water to fumarate to give malate. 8. Malate is converted to oxaloacetate by malate dehydro-genase, and requires NAD*. The synthesis of third NADH occurs at this stage. The oxaloacetate is regenerated which can combine with another molecule of acetyl-CoA and continue the cycle.

[@eden7517]

Your videos are such a big help🥺❤

[@gitongaMorriz]

wonderful i love your lectures

[@margaritabaranova3880]

Thank you! I enjoyed the video very much! ✨

[@daz4627]

Fucking brilliant... I wish I had this 40-odd years ago when I did my biochem degree.... PS. I've forgotten almost EVERYTHING talked about in this video :-(

[@ARTICULTURE151]

Amazing video just made the topic so easy to understand thank you somuch ❤❤😊 God bless you always

[@sahilkhawaja_313]

I am obliged to thank you from the core of my heart for your teaching and efforts. I can't thank you enough but still... Thanks a lot my dearest sir. ❤️🥰

[@sanjaymadke9874]

Man I like your videos. They are great

[@elsamarks8477]

Fantastic work!!!! It helped a ton!

[@hassanhassanoo]

Thank you u real made biochem easy for me 🙏

[@muhammadaminkhan2249]

Great lecture 4 NADH = 24. ( 2X4)= 8×3=24+ 4(2FADH)+ 2ATP...total 30 + 8 glycolysis = 38

[@naveoli4930]

I love the video! I just have one question. What about reducing power? When NAD+ turns into NADH shouldn't a hydrogen atom be oxidized so that the NAD+ takes an electron and a neutral hydrogen atom attaches to the NAD+ to make NADH? I was just double-checking to get your response on the subject.

[@JMYaden]

Fantastic! Thank you for sharing this complex process is detail. I will return to it later for reference. Subscribed!

[@IndraniMukherjee-b5j]

This video helped me a lot thank u

[@Dankschon]

7:17

[@austingeog]

As a fat adapted human for 10 years (low carb not keto) I’m most interested in free fatty acids and the kreb cycle. Found this on internet. @Fatty acids are oxidized through fatty acid or β-oxidation into two-carbon acetyl CoA molecules, which can then enter the Krebs cycle to generate ATP. If excess acetyl CoA is created and overloads the capacity of the Krebs cycle, the acetyl CoA can be used to synthesize ketone bodies.” Two acetyl COA….. let’s go!

[@teddycholwe5163]

What would be the clinical consequences of inhibiting the enzyme iso-citrate Dehydrogenase?

[@lifehackswithadina1380]

"Everyone's favorite...." It wasn't until after I watched this video. Thank You, Dr. Mike! I am inspired to be like you someday

[@randomaf2848]

very nice! thank you

[@Eb5il]

Your lectures make me so happy, because I am sure that will understand the topic , thank you sir

[@maximlevytsky]

Дякую! Найкраще пояснення Циклу Кребса. Я не лікар, але все зрозуміло. Особливо як кетони використовують клитини мозку...

[@mohammedsalahadin1680]

❤

[@meeromeer8812]

Like a piece of cake. Thanks.

[@cephas9507]

I'm having an exam tomorrow and I must say this has raised my confidence to a new level

[@PianoProphetess]

Thank you

[@alwaysright7548]

This is a cycle So OAA turns into Citrate. That step is not explained. Yet great video

[@cianbatahi2356]

NVM I GET IT NOWW TYSM!!!

[@ElizabethRoseUNE]

Love that you also included info about how B vitamins fit in and fatty acids/ketones! Thank you!

[@jessicamajors7694]

I learned this better in less than 18 minutes than I have in several semesters of college level bio. Ferris Bueller, you're my hero.

[@svpam12345]

I would like to suggest a small correction in the 3rd reaction where iso-citrate should convert into oxalo succinate before alpha-ketoglutarate dehydrogenase

[@frejakjjaer]

your videos are the best on yt for medical study. kind regards!

[@НуркелдиТагайбаев]

👍👍👍👍👍

[@sunahangrai3601]

i tried to understand this process felt boring so left i will try it later again

[@skuller976]

I’m cooked

[@yenzhenghua3001]

Thanks sir, ur videos didn't just helped me a lot academically ,it also makes my day!! You're voice just sounds so cheerful & relaxing

[@rdaasad9970]

Thank you

[@EmmanuelAina-ih7yx]

Interesting 💖💖💖

[@loganrao353]

i am so cooked

[@alexserrano2599]

Quick question: isn’t the glucose to pyruvate conversion process an ATP-taker instead of an ATP-producer? If it’s not ATP, what facilitates this conversion? Thank you!

[@aarthikondra]

It needs two atp invested but produces four atp so two net atp are produced!!

[@vrindamohan91]

Most handsome Biology tutor to ever exist 🍁🌷

[@anilazahid]

Not mine fav 🥲

[@satyajiitdhaygude-jb1mc]

Where are you from