TCA/Citric Acid (Krebs) Cycle

[@neilsherman2680]

All memorization, med school 1972-73, first year. Now retired fully. I never used most of the biochem. Still unconvinced of the need to force students to memorize this. What would happen if biochem exams were given open book format. My field was Radiation Oncology. Physics was really important, biochem less so.

[@neilsherman2680]

Note the 20 positive responses. The biochem reactions just happen unless toxic substances block key reactions. Still think this is worth testing, but open book format preferrred, not numbing memorization. In the toxicology portion of pharmacology(usually 2nd year), relevant, clinically useful biochem is presented, sometimes. Teaching of first year med school is in serious need of a curriculum overhaul, IMHO.

[@ingothitrust5248]

I am a prospective med student myself, but I have many colleagues who finished med school recently and most of them agree that with Biochem, there are only really 3 to 4 pathways you should know and the rest is just overkill......

[@GilbertCollado]

And another way to remember the NADH and FADH2 synthesis location on the cycle is to notice how the enzymes are all dehydrogenases, and if you just memorize succinate dehydrogenase is the one that makes FADH2, then the rest make NADH !! Over all great series though man.

[@Its_semio]

That how I'm remembering it. And if you keep forgetting which one is FADH2, just remember: "it succs to get a F" haha!

[@Rpere387]

lol

[@pedritatulica]

Very good, Gilbert Collado. One shoud have a minimum of knowledge even though it's "dirty". And this knowledge is going to be used in many other important cases.

[@sonya1500]

@@Its_semio Perfect now this is in my mind forever

[@sonya1500]

yeah 'dehydrogenase' come from the fact that the substrate is losing hydrogen to nad/fad+ , just to help the understanding a bit

[@garrettmorgan9926]

8:47 Another mnemonic for everyone: Remember that the word "dehydrogenase" means to rip off a hydrogen atom and put it on something else. For every dehydrogenase enzyme shown on the diagram, an NADH and an FADH2 molecule is formed. There are only 4 of them.

[@macduder2178]

Omg I love how he says Isocitrate like 48 times while emphasizing the importance of remembering that one part of the cycle and continues to repeat is over and over lol. I've honestly learned so much from this guy. Love the channel

[@maxbilo6191]

01:05 TCA Cycle Goal 03:37 TCA Cycle Overview 04:17 Rate Limiting Enzyme 05:11. Regulatory Mechanisms 07:55. TCA Cycle mneumonic 08:20 TCA Cycle Final Overview 08:26. NADH mneumonic 09:46 FADH mneumonic

[@jackt6110]

My own mnemonic: Obviously (Oxaloacetate) Citrate (Citrate) Is (Isocitrate) A (alpha-ketoglutarate) SillY (SuccinYl-CoA) Stupid (Succinate) Funny (Fumarate) Molecule (Malate) (Obviously) (Oxaloacetate) - depends on where you prefer to start describing the TCA cycle

[@Regreg347]

This was actually very helpful, thank you : )

[@cardiyansane1414]

Cool 👍🏾 thanks 😊

[@hudah6311]

Thank youuuu

[@Tarkamrutham]

Thank you so much 😊 !! The mnemonic helped me learn this very fast

[@alexandraobi2956]

Thank you

[@deziangel91]

Another mnemonic for this: Can (citrate) I (isocitrate) Keep (alpha-Ketoglutarate) Selling (Succinyl co A) Sex (succinate) For (Fumarate) Money (malate) officer (oxaloacetate)

[@JM-lh8rl]

Even better is the fact that it ties with the mnemonic for the rate-limiting enzyme beautifully!

[@daijahscott8642]

this is a good one!!

[@jessicapayne2211]

hahahahahahahaha!

[@sxli3340]

an (citrate) I (isocitrate) Keep (alpha-Ketoglutarate) Selling (Succinyl co A) Sex (succinate) For (Fumarate) Money (malate) officer

[@iamtatiana1]

😂😂😂 you are the best

[@dipumaurya8496]

omg thank you sm! this chapter used to give me nightmares, test is just a week later and now i have confidence that I'll top it, definitely one of the best channels out there

[@jacquelineagyeman6898]

Are at UF cos my exams is next week too.

[@dipumaurya8496]

@@jacquelineagyeman6898 what do you mean by UF?

[@jacquelineagyeman6898]

UF is university of Florida

[@dipumaurya8496]

@@jacquelineagyeman6898 ah, na I'm Indian, I live in India, this chapter was in our syllabus too, though a bit different but this video still did the job

[@77moral]

Amazing series!!! Not only the videos are made to the perfection, but also the comments (especially under this video) are very helpful. Thank you all for sharing! These videos are life-saving👍👍👍

[@2006evita]

You are a great teacher. You are so clear explaining concepts. I have seen lots of biochemistry videos online but others do not expone as good as you do.

[@Kercinogen]

Oh, just did a UWorld question showing the cycle and asking which step generates the GTP needed for gluconeogenesis. Answer is Succinyl CoA to Succinate.

[@eshaa8192]

Mnemonic to help remember which enzymes make stuff MINK FurS: M - Malate dehydrogenase I - Isocitrate Dehydrogenase N - The 3 enzymes in this word make NADH K - a-Ketoglutarate dehydrogenase FurS -Fadh2 made by Succinate dehydrogenase Also all of them end in dehydrogenase

[@farazbabar5068]

Man you're the best, Compressed complete 3 chapters in 20 minutes.

[@Jaysay7]

AMAZING VIDEO!! I knew this video would simplify TCA cycle but I had no idea it'd be this good. Thank you so much!

[@dnatortnator]

Thank you for this! If you ever revisit this topic, could you consider including the important cofactors/vitamins?

[@mahnoorkhurshid6431]

You are a life saver. Thank you for all your videos!

[@zshan4445]

2 plus 3 is 5 and 5 plus 2 is 7; these reactions in the pathway are the locations of NADH synthesis.

[@enjacy]

Really hated Biochemistry during my 1st year of mbbs...wished these videos were available in those days..

[@Mobambius]

instead of remembering they are in the middle of the alphabet, you can take note that the all start with letters that occur between N and H (I, K, M). So NadH producing dehydrogenases are between N and H, super easy!

[@aeizaashar8522]

a mnemonic could be Citrate- citrate Is- isocitrate A- alphaketoglutrate Special- succinyl coA Substrate- succinate For- fumerate Making- malate Oxaloacetate- oxaloacetate

[@dylanstevens4589]

Incredible video! So much better than the others on here for TCA.

[@xiuwenzhu87]

wow, you explained two entire lectures in 10 minutes!!!!

[@Baraa.K.Mohammad]

8:45 The best thing about the letter "O" is that it's "literally" not next to the letter "N", lol! Btw, you definitely are saving my ass when it comes to biochemistry! THANKS!

[@tane1038]

You sir, are a genius. Thank you for your time

[@Alchemist_171]

You're the best out there. Amazing compilation and presentation. Thank you, sir!

[@claudiaalonso5250]

If you're a spanish speaker and have trouble with the krebs cycle (even with these AMAZING videos) I highly suggest Ciclo de Krebs Rap Educativo by Rap de Medicina, absolute masterpiece and a fire song lol

[@margaretdente9519]

I AM NAD (not a doc) =Isocitrate, Alpha-ketoglutarate, Malate all use NAD.

[@SourLot]

Another Mnemonic: Can I Keep Seeling Seashells For Money Officer?

[@AsHiFa-2521]

Citrate is(isocitrate) krebs(alpha ketoglutarate) starting(succinyl coA) substrate(succinate) for( fumarate) making(malate) oxaloacetate

[@abdulrahmanansari7433]

Wow! wonderfully Explained.

[@dikshantjha]

I am NADH find me They are found right after those alphabets I : Isocitrate A: alpha KG M: Malate

[@jpvn2015]

Also succinyl-CoA to Succinate produces GTP which can be high yield!

[@michaelenorr]

Thank you sooooooo much. Now I understand all this. You'll be the only reason I pass microbio.

[@tamaranyirenda3405]

Amazing presentation and great explanation.

[@tahanaeem5886]

This channel is saving me rn 😭😍

[@cleugenecabanillas7382]

"This should be fairly obvious." Im sorry im so simple minded that its not obvious for me HUHUHU But thank you, this was highly educational and understandable. This was very much needed.

[@blackyrocky7438]

Aconitase enzyme is also important. Rat poison, fluoroacetate inhibit that enzyme

[@renoleevans]

Can (citrate) I (isocitrate) Keep (alpha-Ketoglutarate) successfully (Succinyl co A) stealing(succinate) From (Fumarate) my (malate) office (oxaloacetate)?

[@DorynAtekaniza]

Wooww🙏🏼🙏🏼

[@friedrichjung7268]

Id say that the letter O is definitely in the middle since it’s part of the great letter ELEMENO

[@mcalistair82]

You are amazing. This just made my life so much easier. I thank you

[@shadrackbrentuo3665]

When he mentions Oxaloacetate as classically being the end of the alphabet hence does not produce NADH2, the first thing that came to mind is O - Omega being the end of the Greek (classical) alphabet. If that helps.

[@AnasKhan-qo4pz]

nice way of explaining

[@mohamedhegazy2338]

you are the best the NADH or FADH will go with where DH, that is the way that remember them

[@stevenmelek7661]

I CAN'T THANK YOU ENOUGH

[@Tarkamrutham]

This video helped me a lot during my exam🙏 Thank you !!!

[@Kercinogen]

Hey love, just wanted to point out that NADH &FADH are generated wherever there is a dehydrogenase. Hope it helps.

[@SabigyaR]

NaDH Every alphabet alternate before N M-K-I

[@Backinschoolgranny]

My first time taking Biochem Thank you so much 🙏🏽 After your review today , this pneumonic for NADH came to my mind I AM NADH Isocitrate ,alpha- ketoglutarate, Malate

[@guinerveregunness3609]

This is my way of remembering it: Can (Citrate) I (Isocitrate) Keep (alpha-Ketoglutarate) Sucking (Succinyl- CoA) Salt (Succinate) From (Fumarate) My (Malate) Office (oxaloacetate)

[@beckysam3913]

Thank you, I will never forget this again! 😁

[@yana-marisaedwards1765]

HEY EVERYONE! LET THE ADS RUN FOR THIS CHANNEL! IT'S THE LEAST WE CAN DO!

[@gideonoderinde923]

Thank you so much for this video

[@shraddhachandratre9718]

COULD YOU PLEASE TELL WHERE IS THE ATP PRODUCED IN HERE??

[@pedritatulica]

Chandratte, look at my commentary! It is not ATP that is produced directly in the Krebs cycle. It's GTP! It occurs at the rx catalysed by succinateDH! The ATPs will be formed through the oxidations of NADH and FADH2 in the electron transport chain.

[@joekenorer]

I immediately felt like I had been trolled when you got the point. How tf did I even end up here?

[@manudattaraavi4700]

Kim as Nadh K- keto glutarate, I iso citrate m malate

[@iqra4397]

U deserve more subscribers

[@kingbobbie5196]

Thanks so much don✊

[@ChrisBranleh]

Where is the gluconeogenesis video? Cant find it

[@baboylove]

Must remember not to shout these mnemonics out loud at home though I live with my grandma

[@ogmexicanleaf]

I love you and your videos!! ❤️ 😭🙏

[@danalee5279]

I wish this video was around the first time I took microbiology

[@michaelsrowland]

How long does this take in the body?

[@cillbobsy8236]

A CIA Supervisor Should Find their Modus Operandi

[@georgeklucsarjr1988]

Mead acid synthesis? - haven't found cycle anywhere.

[@1412Z]

Thank you!

[@shaadowone]

Pease upload gluconeogenesis video

[@aayushirajani8088]

where did the mnemonic go?

[@rosstaylor7743]

yeah i dont see any dirty mnemonic here that everybody is talking about

[@rushnah3684]

how are 10 ATPS generated in TCA?

[@condescendingsmile9116]

amazing

[@khushiekiduniya]

bro this helped me a lot I mean seriously thhanksssssssss a lottttttttt

[@ramonaconstantinescu8414]

AMAZING!

[@lichh64]

Tricyclic Antidepressants

[@terrencegreen755]

Thank you so much

[@tayyabpirzada6344]

if i could only get a dollar for every time he says isocitrate

[@norshahilaismail1688]

U save for exam. Thank uu

[@drswetaruparel]

Thanks a lot for such helpful videos !!! 👍

[@wicterwterr4245]

Very helpful !

[@quacky69]

Our teacher showed this video in class and when the mnemonic was shown he was like what the hell, do not see this video it has dirty language

[@amorestperpe]

You should tell my teacher it's not important to memorize the enzymes... We have to memorize enzymes, chemical structures, byproducts, etc. for this, gluconeogenesis, fatty acid catabolism, and ox phos.... For one test..

[@elladoiron6441]

Same I feel you

[@ckying29]

This is the dirtiest mnemonic yet. Well done!

[@messiahnchinda9220]

Thumbs up sir kreb's cycle made easier

[@acceptableinformation]

thanks

[@drmutungatv]

Thanks so much. I appreciate the effort to make me understand

[@dianarodriguez6804]

Thank you :)

[@collegeofchemistry5508]

وااااو ،جيد جدا

[@satyanarayanyadav6177]

Please sir download molecular biology

[@agh6452]

Thank you

[@josephinegoma7442]

Thanks so much doc

[@IGMFSH]

lol i like these videos but that alphabet mnemonic was wild.

[@missswatimahapatra]

lol wasn't wearing headphones and this blasted while my fam was eating lunch haha love the mnemonic for this one!

[@alejandracontreras3297]

I love you, officialy I can create a fan website for you

[@whatuceeiswhatuget4211]

AWESOME!

[@anonymous-kk8cr]

It's fumerasing😂😂😂🏌️

[@Mia-ki3jx]

thank u

[@ladydelgadoh7537]

Subtitulos spanish please

[@kimthvnh]

You can just remember I.K.M

[@aidreiyan9071]

KIM MAKES NADH

[@thehandlez]

My mnemonic is: "Cee, I kiss SSaFe MoOn" (the crypto coin lol)

[@thehandlez]

And "it Sucks to get an F" for FADH2

[@michaelgoldstein8516]

lol wait, I'm sorry. O is considered the back of the alphabet and isn't sufficiently close to N? It's literally the next letter. LMNOP are usually said in one breath haha. The rest of this video was awesome, but that was a huuuuuuuge suspension of disbelief.

[@DirtyMedicine]

mentally O is where the end of the alphabet starts for me. It's like rounding, 1-4.9999999999 is low but as soon as you hit 5, thats when you round up

[@JooAnnna]

But where's the lie in that mnemonic? lol

[@nghiphuong1512]

Haha. definitely a dirty mnemonic. thank you