COVID-19 | Pathophysiology

[@katelynnm9750]

“When you take a breath in...” *takes deep breath automatically, oddly proud of my lungs for doing such a great job*

[@anonvlogs281]

It's all because of grace of God.

[@qumi369]

@@anonvlogs281 i can’t tell if you’re sarcastic or not

[@jeffreyramos287]

Thank you Doc for the wonderful lecture. Well, that explains why we as healthcare professionals should not sedate heavily or paralyze these COVID pts. Because when you sedate a vented patient, the blood pressure drops. And the traditional response is give more fluids. And the result is a viscous cycle of sedate, bp drops, then more fluids given and those fluids will go to the lungs. Thus needing more peep and oxygen requirements. As a respiratory therapist, we need to find the happy medium of ventilator settings and some sedation just to keep them comfortable. Thank you.

[@NinjaCokeGaming]

this guy explained it so well. haven't been this interested in a science lesson in a long time

[@darrenrichards4840]

Thanks so much for taking the time to post this. I have a layman interest in virology which is to say I don't have a medical background but to have viral interaction with body cells explained so clearly is really interesting especially in explaining why fluid in the lungs is generated and the mechanics behind that. I had no idea it was breakdown of the blood vessels and leaking plasma. Thank you, especially as I grew up hearing old folks in my Welsh village speak about fluid on the lungs and too much coughing leading to scaring. Until your post I didn't understand what was behind this.

[@asokbiswas6833]

The simpler way you explain the pathophysiology is fantastic. Anybody can understand. Thank you.

[@brownsugar85]

One of the best COVID tutorials I've seen!

[@raeez4613]

The only one I’ve seen

[@nadapenny8592]

Ngl I originally clicked because I thought you were shirtless in the thumbnail and I was intrigued by the thought of chaotic science man, but then I stayed for the engaging and informative presentation and overall I was absolutely not disappointed

[@Veteran365]

What does your fitness routine look like? You get a gold star for health good sir!

[@Saltysteele]

Brilliant!!! I'm an RRT boning up on ARDS, and this is the most informative video i've found yet!

[@lemonsauce3078]

It would help plenty to have links to research articles in the description or in the comment section, as references or for further reading

[@truthseeker5642]

Would you be kind enough to review how the virus in its relation to Cytokine Storm causes issues with coagulopathy? Thank you!

[@MisaelB17]

It is unknown yet. They know there is a strong relationship between thrombosis and inflammation and that those two processes reinforce each other. But that's about it. I will leave you a link of an article of the COVID-19 and haemostasis: a position paper from Italian Society on Thrombosis and Haemostasis (SISET). www.sah.org.ar/pdf/covid-19/083-20_pre-publishing.pdf

[@elyay7203]

I love people like you sharing important information for free

[@justus525]

Hi Dr. Mike! Thank you, this is the best coronavirus video so far. I’ve been watching your videos for my A&P class, you make it so easy to understand. You helped me a lot 😀

[@howtomedicate]

Amazing video. The audio could have been louder though😅

[@Daniel-zb5lm]

amazing video really good explanation but the only thing I could focus on was his biceps and triceps :) XD

[@stevepowsinger733]

Pathophysiology: I learned a new word.

[@Tanvir_Mahmood]

Excellent explanation as usual, but somehow you are very underrated

[@urbanprojectz]

Needs to have better sound, seems to be a youtube thing.

[@sokmkim5057]

Adam Webb sound is too low

[@einsteinzvice517]

#agreed

[@valentinaleeharrellcardona9076]

Your accent inhibits your pronunciation rendering misunderstandings of your explanation. Try losing the accent. God bless you and your house.

[@valentinaleeharrellcardona9076]

@@sokmkim5057 Einstein was an extremelly high educated man he never spoke that bad. Listen to Zack he will lead you to better pronunciation.

[@nayeemanusrat1015]

sir, that was mind-blowing. tomorrow i have an exam, and this helped me much♥️

[@eeeesss1217]

A Big THANK YOU for making this video, it was asked in my VIVA examination.

[@Cardiologist89]

Superb presentation... well done

[@maryamtebib7276]

you explained it amazingly, thank you so much for all the effort, you are helping a lot of students.

[@eleanormystim1641]

saving me minutes before my pathology exam

[@mondayrassone9528]

Excellent. Thank you. Clear and concise.

[@pouyahosseinzadeh985]

I was waiting for macrophages to come in earlier but the scenario didn’t go as I planned in my head! You’re explaining in such a great way that I remember the joy of studying when I was studying biology in university. Thank you :)

[@petalbobo]

he's so quirky and cute. like the awkward moment at the start and end where he just smiles lol

[@my-3j-3k-ot7]

Thanks Doc Mike.. wonderful lecture..Now I understand the concepts very well..You are a great teacher ☺️👍🏻

[@conuropsis]

This is excellent information, not too technical for the lay-person (me), and very clearly explained. One thing I've not seen discussed, probably because no one knows, is the infectious dose necessary to start an an infection. My understanding is that different viruses vary widely in that regard. With HIV, for instance, I'm told that a huge dose is necessary, and that with norovirus, as few as a dozen individual viruses can be enough to start an infection and make you sick.

[@asadzulfiqar7911]

You are correct that viral infection is not a binary thing as a certain threshold has to be met. Data on this virus is not clear yet; however, healthcare practitioners who are exposed more often have been found to have higher viral loads and worse outcomes, but a study out of China found asymptomatic and symptomatic people to have similar viral loads, so overall the the data is not clear on specifics with this virus. Also there are other confounding variables in regards to who becomes symptomatic and who does not, lots questions still left.

[@gurleenkaur126]

nice information but can you make a concept map of virus that how it links to varioussymptoms , risk factors , diagnosis and treatment please. waiting for this video

[@francesrebolledo]

Hey! Just wanted to say I was watching your videos when I was reviewing for the licensure exams, and now i’m a registered medical lab scientist! So great to have watched this, as always, so easy to follow 😊

[@johnmichealreinante3278]

Thanks for the explanation. Its very helpful.

[@josephmusumbu8310]

You may experience difficulties in handling your nursing assignments please check on me for help. [e-mail] Thank you.

[@ryanh.nguyenmd5357]

Realistically video, thank you so much, Doc

[@kirklazarus3493]

Thanks for explaining it the way you did! Great video

[@christopherhennelly7486]

Thank you Doc, I t gave me a good understanding. I really appreciate you having done. I buried so many during the AIDS crisis and feeling like were are in the medical storm of a lifetime once again.

[@MehediHasan-gz8dp]

Nicely explained. but audio shoulde be more loud and clear!🎉

[@madamebrunhilda5105]

Very good, clear explanation.

[@yanglee789]

Thanks a lot, you make it so easy to understand. I don't even know much about medicine.

[@786shahidmd]

It was very good presentation. Thanks for explaining so nicely. But you didn't explain the fecal oral transmission.

[@nicksonhyeladendu8085]

this is excellent. Great job

[@shireen9323]

well done doctor💜

[@dhillonamarsingh5033]

Great Information Thanks

[@dawnmcnamaramdpharmd5662]

Great teaching!

[@chikazulu102]

You're amazing please make a video about dialysis hemo and peritoneal

[@sharongeorge3622]

Brilliant explanation Mike

[@nicksonsebastiananthony7861]

Awesome description, great understanding about pathophysiology of COVID 19

[@paulstich3150]

Thanks doc! I just lost my step dad to covid on the 17th. It happened very suddenly. He started out delirious with a fever then two days later it went into his lungs and they inserted a ventilator. A day later they took it out and he died immediately. He was also a heavy drinker and had kidney failure and heart failure. We are heartbroken. He was only 61.

[@Nadasistschoen]

Great explanation! Thanks from NZ

[@FatimaAli-o7v]

Great job dr mike🎉

[@RA6162]

Thanks for the video ! Ur a genius for simplifyiing medicine in sucha manner !

[@liv6050]

wow, your explanation on what surfactant does was really helpful, finally get it now thank you heaps

[@小Q-x9o]

Very great video ! easily to understand and memorize!

[@karunanagaraj2778]

Please make vedio about bone disorders like cervical spondylitis etc

[@rcarnes1988]

Can you do a video on the microvascular thrombotic properties of COVID-19

[@ragegamervideos]

Awesome video, been trying to get my head around the whole coronavirus thing and watching this video really helped clear the gaps and understand it so much better. Great explanation cheers!

[@Thanh_Thien]

Thank you. Your video is very helpful and it's also easy to understand.

[@harnakreal7394]

I really understand the pathogenesis of the virus. Thanks very much.

[@ayeshaarshad9702]

Thank you so much for your such elaborated video. It helps to clear my concepts.

[@varshiniiyer4255]

Beautifully explained!

[@benjaminfox7105]

Hey Dr. Mike and Dr Matt - Thanks ever so much for this detailed explanation of the pathophysiology of SARS-CoV-2 - My wife and I really enjoyed it! Nice one! In other news, my placement in ED was unfortunately cancelled (no more students in ED) - Totally makes sense from a risk mitigation perspective. I've been redeployed to the renal ward - Which of course is, AWESOME. The renal system is grouse! Your previous videos are helping heaps in this placement. Thanks mate. Take care!

[@DrMattDrMike]

Nice! Best of luck in your Renal placement!! Have fun and keep us updated!

[@ThomasRohde]

Thanks a lot from me in Germany! Very clear information.

[@anshusinha1203]

Oh god , you are amazing 🤩 Keep uploading such lectures

[@starritaelovesbts]

this is sooo good! pls keep making videos 😊

[@josephmusumbu8310]

You may experience difficulties in handling your nursing assignments please check on me for help. [e-mail] Thank you.

[@oswaldotorres5525]

Incredible! Thank you for this explanation. You inspired me

[@MrMinister77]

Thanks Dr. Mike this video was really helpful. One thing that I didn't quite understand is, how does the virus inhibit the anti-inflammatory effects of AT 1-7? Does it use up the ACE2 proteins on the type 2 cells thereby reducing their availability or is their another mechanism I'm not understanding?

[@reiayanamnam5444]

This really helped clarify the difference between the SARS-CoV-2 and the mRNA vaccines. So the mRNA vaccine doesn’t make polypeptide protein to make the rest of the corona virus. Is this correct?

[@lisanatale2377]

Great lecture! Thank you!

[@dontrax2353]

Great info. So this is mainly droplet and not airborne? I work in a hospital and I feel like I can't get a straight answer.

[@DrMattDrMike]

DontraX23 droplet.

[@dontrax2353]

@@DrMattDrMike thank you. I just watched Dr. Fauci's interview with Trevor Noah. He explained that it can be transmitted through droplet and aerosol. Is that still considered airborne?

[@OneMamaToAnother]

Thank you for this very clear yet scary description. How much of what you described occurs when people are said to have a 'mild case'? And is there lasting damage to the lungs or other organs?

[@Saravostoo888]

Great explanation. Cheers!

[@jonathansanchez8802]

Amazing video. Appreciate the time and effort!

[@adetokunboakinseye3666]

Outstanding presentation!

[@IK_59]

Very nice lecture

[@jonjiecasenas4218]

Very helpful.. Thank you so much!

[@anuruthiya]

very thorough !!

[@jessicasymonds2910]

Loved this video - made it all very easy to understand!

[@424io]

Pulmonary interstitial space captures these debris and Lymphatic system eradicates, disposes, and removes.

[@websterlee7708]

Excellent info! Very clear. Well done and thank you.

[@urbanprojectz]

It would be good to know how a proposed vaccine would work. Would it prevent the ACE2 from occurring by preventing the bonding?

[@asadzulfiqar7911]

Vaccines work via adaptive immunity. Regardless of vaccine type, primary goal of a vaccine is to have B-cells (immune cells) create antibodies against pathogenic antigens (in this case, antigens on SARS-Cov-2). Antibodies can do many things, but most importantly here is that they are able to tag pathogens (virus here) for other immune cells to quickly neutralize the threat. This is important as when your normally (in the real world, not via Vaccine) encounter any pathogen (Virus in this case), your innate immunity fights the infection first while your adaptive immunity lags behind in creating antibodies (4 to 7 days), this is important time lost in fighting an infection. Side note: Innate immunity is your body's generalized attack mechanism and adaptive immunity is more like guided missiles (better at attacking true cause). Vaccines help because they allow you to have antibodies circulating and now if in the real world you encounter the pathogen (SARS-CoV-2 in this case) your immune system will be better prepared to deal with it from the get go. That is pretty much the basis of any vaccine. What your talking about is an antagonist or inhibitor, unfortunately blocking the ACE2 receptor would not work in this case, this is more complicated, so I will not expand further. Hope that helps.

[@samihasharminshahadat121]

@@asadzulfiqar7911 Thank you so so much for summarising the entire thing of immunity. Helped me in my immunity notes. Another query I have is that would Angiotensin inhibitor drugs work?

[@asadzulfiqar7911]

@@samihasharminshahadat121 No problem, sorry for late reply just saw this. The short answer to your question is no, but answer is not really known and not straight forward. Some research has shown reduction in risk of pneumonia of individuals taking these drugs. However, to answer your question, pharmacologically angiotensin-converting enzyme (ACE) inhibitor drugs are blocking the ACE receptor which is different then the ACEII receptor utilized by the covid-19 spike protein for entry. In short the drug is acting on a different receptor and would not block covid-19 entry. However, the concern with these drugs was if they would upregulate homolog ACEII receptor expression and thereby theoretically increase covid-19 susceptibility. This was shown not to be the case in animal models, where the administration of ACE and ARB inhibitor drugs did not upregulate lung ACEII receptor expression. Hope this helps.

[@samihasharminshahadat121]

@@asadzulfiqar7911 Thanks a ton for clearing this out..helped me a lot in knowing about this.Hope you are healthy and fine.Stay safe xx Cheers.

[@tamaldeb1565]

Nicely explained. Thank you.

[@FiveandCook]

Thanks doc...great explanations

[@shivanandanmathan7998]

Excellent and very clear Dr

[@anonvlogs281]

Good explanation, thank you.

[@hrushicatey]

Excellent as usual sir.. I have learned so much from you....

[@quincymongare2289]

Great summary!

[@hosannautube]

good and clear , easy to understand. thanks

[@ItzShaynacanvas]

Amazing expansion 😊

[@azeemsiddiqui3853]

Hey I have a question. During when the Spike proteins of the virus inhibit the ACE2 receptors, what will happen to Angiotensin I? Is it correct they are converted to Angiotensin II by ACE1 receptor. Since ACE1 has more activity it will cause more binding of Angiotensin II to type 1 Angiotensin II receptor and thus creating more pulmonary vascular permeability?

[@poonamkhairnar6479]

Nicely explained..thanks

[@PeacefulWarrior1720]

i took good notes and learned more about sars-cov-2 virus.thanks #stayhome #alertnotanxious

[@aumayaprado7535]

Is it different between pediatric and adult?

[@jigyasabhasin4182]

Nice explaination 👍

[@activitychannels3167]

Please make more videos..

[@jjn3533]

Thank you very much👍👍👍

[@amrapalikyatham8858]

Thanx.. Very good

[@chinomun2516]

Woow Nice vid. Good job. I clearly and easily understand the whole thing by viewing it once. I really want to be a doctor like u someday. Can you make a vid on how available drugs or treatments do its action in treating the patient effetively and ineffectively?

[@kodiaghaegbuna272]

You really helped me through school last year and I see you are still doing amazing videos. Thank you..🙌🙌

[@ashutoshkholia3439]

Thanku for this.....👏👏👏

[@activitychannels3167]

Very very informative

[@davidyohanna2229]

Wonderful lecture

[@dennismbau]

Great presentation.

[@sscc587]

Sign..I love learning from you doctor, I can learn from you all day....