Blood 9, Hemolytic disease of the newborn

[@Bethannsbuddy]

Thank you, Dr. John Campbell, for explaining Rh factors so clearly. I appreciate the way you say things multiple times instead of assuming your viewers understood you the first time it was stated. I understand this concept so much better now!

[@PH-xw1ri]

Your videos are the best on KZbin.

[@trooper9005]

Thank you Dr. Campbell for explaining haemolytic disease In newborns i understand it better now

[@dannimason2708]

this was such an easy explanation to follow for something that can be very complicated, thanku!

[@haani2008]

Thanks Dr. John, this is the only video explained it clearly!!,

[@lilyrose1459]

Very explainative. Tnk you

[@playerlena4398]

Thank you doctor you always explain well ❤️

[@ewaseweryn7530]

Thank you so much, like always excellent explanation

[@advocatemuletwa8404]

This is well explained I was studying thud topic now as medical student but it was had for me understand now its all clear

[@exmuslimkhalid138]

Thank you very much for these great videos -

[@harithalawadi3105]

That was great explanation thank u

[@galaxysre]

Thank you so much for this clear explanation :)

[@julietantiaye5527]

Great video, thank you Dr.

[@geojor]

good one Dr Campbell...

[@syedi9839]

Thank you sir

[@tusharsapkale7]

Thanks you doctor

[@Gemzstone1]

Your videos are very good, I only wish you had one on how rh factor can change from e.g o negative to o positive.

[@NansLux]

Thank you for this great explanation Dr.! There is 1 issue that wasn’t addressed though, if you could please help me with an answer: what if, the mother had her first child, and all went well. She’s trying for a second child but was just told that she was positive for an antibody that could potentially affect any future pregnancy. Kell antibodies positive. She’s not pregnant yet, what should she do? Is in vitro her only option if her husband’s blood test results end up being + for that antigen, instead of negative? Thank you so much for any further explanation on this specific situation. That person is me; I was told by my Dr. That I am sensitized, I am 37yo and having fertility issues. What else could go wrong in 2020? Thank you in advance for helping me with an explanation. N

[@sarahhcoco]

Cool!

[@michaelkwabenaboakye3268]

thank you

[@wolfrahmphosphoros5808]

how come the injected antibodies don't enter the Foetus? regards and thank You for all your hard work.

[@wondawale2436]

first I would like to thank Dr.Campbell to their detail presentation about HDN duto Rh incompatibility when the mother is Rh negative , the father Rh positive and the fetus is Rh positive .Second I asked to you in my knowing concept and also your explanation the mother Rh antibody only produce for Rh positive fetus when the fetus blood inter to mothers circulation and also the amount of blood also have its effect to evoke the mother Rh antibody this is the time during birth so according to in our country the physician give anti -DIgG during the first pregnancy at 7th month what is this scientific reason ? and ABO blood grouping incompatibility reduce the chance of Rh incompatibility I know this concept by education time but I gate practically in working time at facility so what about you? the last their is Rh non responder mother by nature? ok thank I keep your answer.

[@hiteshvishwakarma6449]

Sir plz upload video on apoptosis and necrosis

[@enekucosmas5877]

How can I answer this question (describe the blood group according to the rhesus factor)

[@amielovee5540]

Hello Dr John cambell, would we be able to have a private chat in relation to this topic? I am an O rh negative woman who is super curious after conceiving a child born heamolitic.

[@TBassJaps]

Thank you 👏

[@sparklelight]

great sharing thank you

[@petrarurobert8781]

Hello Dr Campbell. My wife is pregnant and she is Rh -.We are a bit concerned about the Rhogam shot(as we don t know what is in it) and i wonder what is your opinion on this aspect now. Especially after covid period when there were so many lies.Thank you

[@NauticalStrings]

I think this is very strange, does this happen in the animal world too that a mother rejects his own offspring ?

[@tarotofthe9s]

What if the mother is hemolytic herself? Or the Bombay phenotype? Will the IgG antibodies attack the first born?

[@lastlight4252]

For Rh- females that were impregnated by an Rh+ man, and had an abortion in the older days, she will not have been given Rh antibodies, she will develop Rh antibodies, and future pregnancies are ill advised. An interesting consideration for abortions.

[@mokodin4295]

I understand about giving the antibodies to the mother at 28 weeks for the first baby but does it have to be given again for the second baby

[@pandimonium2260]

RhoGam anti-D IgG is given during the first pregnancy at 28 weeks to try and prevent the mother from producing a true Anti-D antibody. So if the mother was given RhoGam during the first pregnancy at 28 weeks and it's effective, then the mother didn't produce a true Anti-D antibody and will need RhoGam for the second pregnancy to prevent her from producing it during the second pregnancy. However, if the mother did make an Anti-D antibody even with the RhoGam, then giving her another RhoGam during her second pregnancy would be ineffective.

[@lindabloo1000]

if the mother is A posative and the baby is A posative R female then what blood group is the father

[@lindabloo1000]

So interested

[@asharafulalam6148]

Sir my mother blood group is o negative and my father blood group is o positive and my blood group is o positive.I am facing so many problem. Iwant to contact you.

[@Campbellteaching]

Why would these blood groupings cause you problems, the genetics are what you would expect?

[@gladysjoysolana1382]

what about in the case of ABO incompatibility of HDN?

[@trooper9005]

This is my 5th pregnancy and I never had that with haemolytic disease in my first 4 pregnancies so why would my 5 pregnancy have this ? Is it because my 4th child was a c-section??

[@sunnydhillon2809]

what do you mean there is chance fetal bood will get mixed with mothers blood during delivery. isnt mother supplying blood to fetus via umbilical vein and getting fetal blood back from umbilical arteries during the pregnancy anyways? that is blood is being mixed during the entire pregnancy i am confused.

[@carolineriegel]

There shouldn't be mixing of maternal and fetal blood, the placenta itself allows for oxygen, nutrient, and waste exchange through diffusion and active transport, but keeps each blood supply separate through membranes.

[@anveshtamboli9133]

Q.1For how much duration can the rh antibodies produced by the mother during her first delivery can survive? i mean the rh antibodies produced by mother survive till the 2nd delivery , right? Q.2 The type of rh antibody must be IgG, right? as it crosses the placental barrier?

[@Campbellteaching]

Once formed, we should assume the antibodies will be present for life. Yes, the antibodies are IgG, they can cross the placenta into fetal blood.

[@DarioAgx]

Wouldn't the external Anti-D IgG (RhoGam) we give, also have the ability to cross the placenta and cause a hemolytic reaction in the fetal circulation?

[@TimCampbell-cj4op]

+Dario Aguilar The anti-D is given after the delivery, so this will not be a problem.

[@asmaulliya]

Does the anti rh antibody of 1st pregnancy persist for 2nd pregnancy?isn't the antibody destroyed?

[@Campbellteaching]

It will persist, thats why its important to stop it developing in the first place, with anti D

[@wolfrahmphosphoros5808]

@@Campbellteaching how many Rhesus Factors are there? what other than D? regards.

[@ewaseweryn7530]

But what will happen if mother is Rh+ and baby is Rh-???

[@Campbellteaching]

Ewa Seweryn Nothing will happen to the baby as there are no naturally occurring antibodies to the Rh factor, so nothing to migrate through the placenta. Also, there are no antigens on the surface of the fetal red cells to interact with, so its doubly okay.

[@ewaseweryn7530]

Thank you

[@VondaInWonderland]

Is it true that a person with Rh- blood could have an extra vertebrae or rib, or is that poppycock?

[@sandydavidson8732]

by thank

[@VondaInWonderland]

Elainr Davidson ?¿?

[@Campbellteaching]

Its not true

[@jessicalaw1817]

@@Campbellteaching I have a extra vertabre in the back of my neck I'm rhOneg

[@Campbellteaching]

Have the doctors told you you have 8 cervical vertebrae Jessica?

[@donnasloane9031]

Thank you