How to control deshalo impurity in buchwald coupling?
@prakashkelgandre87882 жыл бұрын
Thanks a lot !!!
@yogiyt5478 Жыл бұрын
Sir can we form inter molecular carbon nitrogen bonds by using this method
@Dr.Mosharraf Жыл бұрын
You may but I think you need to search literature. I never did.
@AbhishekSharma-wm6ln2 жыл бұрын
Sir i have seen we add water in Suzuki coupling but not in Buchwald or stille etc. Is there any specific reason in case of suzuki?
@Dr.Mosharraf2 жыл бұрын
In case of Suzuki coupling reaction, normally people use inorganic base like K2CO3, Na2CO3, Cs2CO3 etc which requires to be soluble in solution. But in case of Buchwald reaction require base which are organic solvent soluble and stille coupling use organometallic compound which can be in many cases flammable with water. So those reactions don’t require water. But there might be some exceptions. But it was a good question. Still I will study more to give you answer if I found something more interesting fact.
@Dr.Mosharraf2 жыл бұрын
doi.org/10.1021/jo0500176 This paper shows, some buchwald reaction get facilitated by water.
@vinothboopathy2467Ай бұрын
Sir..during reaction we are facing challenges.. Sometime reaction is moving good ...Sometime not. If we extra catalyst, reaction is proceeding.. Can I know the reason behind