What Do Vitamins Actually Do? (Vitamin Lore)

Thanks to Bespoke Post for sponsoring this video! New subscribers get 20% off their first box of awesome - go to bespokepost.com/thatchemist20 and enter code THATCHEMIST20 at checkout.
This is the Vitamin Tierlist - vitamins play many important roles in our bodies and the biochemistry that vitamins do is pretty neat!
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0:00 Intro
2:45 sponsor
4:43 A
11:34 B1
17:24 B2
19:56 B3
22:45 B5
24:30 B6
27:09 B7
28:24 B9
30:29 B12
31:47 C
35:48 D
38:09 E
41:38 K
Team
Writer/Producer - That Chemist (Joey)
Editor/Animator - ReformLabs
Research/Production Assistant - Exergonick
Technical Lead - Polygorg (Georg)
3D Systems Engineer - Robot Chicken
Acknowledgements
This video was made possible with help from several members of the TC Discord Community, especially Gocker (protein modelling expertise) & Ballerene (biochemistry expertise). Also @ExplosionsAndFire !
_________
References
Neurotoxin Tierlist • Which Neurotoxin is th...
Medicosis (corn tortillas) • Pellagra (Vitamin B3 D...
Vitamin B12 part 1 • R.B. Woodward Total Sy...
Vitamin B12 part 2 • R.B. Woodward Total Sy...
@MedicosisPerfectionalis • Biochemistry (New)
General nutrient information www.ncbi.nlm.nih.gov/books/NB...
First vitamins doi.org/10.4066/AMJ.2013.1588.
Essential Nutrient an overview www.sciencedirect.com/topics/...
Early vitamin paper doi.org/10.1246/NIKKASHI1880.....
Fat Soluble Vitamins www.ncbi.nlm.nih.gov/books/NB...
Water Soluble Vitamins www.ncbi.nlm.nih.gov/books/NB...
Vitamin K ods.od.nih.gov/factsheets/Vit...
Vitamin A and Carotenoids ods.od.nih.gov/factsheets/Vit...
Vitamin A and retinoid signaling www.ncbi.nlm.nih.gov/pmc/arti...
Consequences of Vitamin A Deficiency doi.org/10.3390/IJMS21155570
Vitamin A Toxicity www.ncbi.nlm.nih.gov/books/NB...
The Golden Rice Project www.goldenrice.org/
Thiamine ods.od.nih.gov/factsheets/Thi...
Dry Beriberi in a Man doi.org/10.1186/1752-1947-4-409
Beriberi. doi.org/10.1016/0306-9877(95)...
Relevance of N-Heterocyclic Carbenes pubs.acs.org/doi/10.1021/jo30...
Thiamine Pyrophosphate an overview www.sciencedirect.com/topics/...
Riboflavin ods.od.nih.gov/factsheets/Rib...
Niacin ods.od.nih.gov/factsheets/Nia...
Nixtamalization www.sciencedirect.com/topics/...
Nicotinic Acid Deficiency an overview www.sciencedirect.com/topics/...
Pantothenic Acid ods.od.nih.gov/factsheets/Pan...
Vitamin B6 ods.od.nih.gov/factsheets/Vit...
Biotin ods.od.nih.gov/factsheets/Bio...
Folate ods.od.nih.gov/factsheets/Fol...
Vitamin B12 ods.od.nih.gov/factsheets/Vit...
Vitamin C ods.od.nih.gov/factsheets/Vit...
Vitamin D ods.od.nih.gov/factsheets/Vit...
Vitamin E ods.od.nih.gov/factsheets/Vit...
Vitamin K ods.od.nih.gov/factsheets/vit...
Vitamin digestion and absorption - www.kegg.jp/pathway/map04977
Biosynthesis of cofactors - www.kegg.jp/pathway/map0124
Pathway information:
Vitamin A Retinol www.kegg.jp/pathway/map00830
Vitamin B1 Thiamine www.kegg.jp/pathway/map00730
Vitamin B2 Riboflavin www.kegg.jp/pathway/map00740
Vitamin B3 Niacin www.kegg.jp/pathway/map00760+...
Vitamin B5 Pantothenic Acid Beta alanine metabolism www.kegg.jp/pathway/map00410
CoA synthesis www.kegg.jp/pathway/map00770
Vitamin B6 Pyridoxine www.kegg.jp/pathway/map00750
Vitamin B7 Biotin www.kegg.jp/pathway/map00780
Vitamin B9 Folate/folic acid www.kegg.jp/pathway/map00790
Vitamin B12 Cobalamin www.kegg.jp/pathway/map00860+...
Vitamin C Ascorbic acid www.kegg.jp/pathway/map0005
Glutathione www.kegg.jp/pathway/map00480
Vitamin D steroid biosynthesis www.kegg.jp/pathway/map0010
Vitamin E Tocopherol www.kegg.jp/pathway/map00130+...
www.kegg.jp/pathway/map01110+...
Vitamin K Phytonadione www.kegg.jp/pathway/map00130+...
Relevant human Proteins found in RCSB PDB RCSB.org 10.1093/nar/28.1.235
And predicted proteins found at www.uniprot.org/

[@That_Chemist]

New Bespoke Post subscribers get 20% off their first ”box of awesome” - go to bespokepost.com/thatchemist20 and enter code THATCHEMIST20 at checkout. Thanks to Bespoke Post for sponsoring!

[@topcatcoast2coast579]

Loved watching you nerd out with Hamilton Morris on his channel. I love how visibly excited yous all get👍📌

[@sebastianmaier5328]

Thanks alot

[@theulfhednar3915]

You are Amazing, keep the amazing work

[@That_Chemist]

@@sebastianmaier5328 thanks! that's actually a decent idea - I will share it with the team :)

[@delquandrecolter3477]

Pyruvate t9 goucatonatw 😊

[@tristanlaurent5785]

I'm starting to like biology... and it scares me

[@That_Chemist]

same tbh

[@testingtesting421]

Biochemistry is a wonderful middle ground. Enzymes catalyze some amazing reactions through interesting mechanisms. Biomolecules also have very interesting characteristics and structural motifs.

[@Crustaceous]

Just wait until you find sacred geometry. Pretty patterns got me enjoying MATH 😂

[@jtgd]

What if I told you, biology is a great field parallel to computer science?

[@szxnv]

one of us.. one of us...

[@memaimu]

Spoilers: Vitamin B1 Thiamine, Vitamin B3 Nicotinamide, Vitamin B6 Pyrodoxine, and Vitamin B12 Cyanocobalamin are the GOAT according to this guy.

[@That_Chemist]

Yes they are - very cool chemistry 😎

[@freigeist777]

Cyanocobalamin is a kind of useless form of B12 for our body, the orther 3 isomeres work though

[@Verinius]

Dude I love how science content creators are using trendy KZbin stuff to teach science. I am easily baited into science videos with titles like "Vitamin tier list" "Are giraffes OP?" "Scientific theory iceberg"

[@rilmar2137]

I have no background in chemistry. I know very little about chemistry. However, your videos are a joy to watch

[@That_Chemist]

I hope you learn something useful from the videos :)

[@othman3049]

​@@That_Chemist good evening sir, can you recommend a chemistry fundamentals textbook? especially organic chemistry

[@That_Chemist]

@@othman3049 Clayden is pretty good, especially if you find mechanisms to be helpful - chemlibre texts is another free online resource

[@Rileydog53]

you’re putting out some of the best chemistry content on youtube right now. thank you.

[@That_Chemist]

I will share your kind words with the team :)

[@Exergonick]

😳🥰

[@sm00gzbear]

The best of course being Nile green.

[@ayo9057]

@@That_Chemist imagine if we could absorb vitimins.

[@charismauniversity9626]

You are welcome 😊

[@estellagrace7276]

Fun fact about Vit K - it is given routinely to babies right after they are born (usually via IM injection or occasionally oral supplementation) because they are naturally low in it and don't yet have the gut bacteria that produce it which as explained in the video can affect blood clotting. It reduces the rate of intracranial haemorrhage which can cause brain damage - particularly important for babies who have had more traumatic births (i.e. vacuum or forceps assisted births).

[@mauz791]

Interesting fact, thanks for sharing!

[@roddydykes7053]

Oh yeah I got vacuumed out of my mom’s cnut. Hardly ever hear anyone bring that method up

[@SoulDelSol]

​@@roddydykes7053that's terrible. Sounds like they screwed that up. I don't think you're supposed to suck a baby's skull on a vacuum to point you can pull him around even when stuck! Or wrap bbq tongs or forceps or whatever around its face and yank him out. I bet it feels like being constipated except there are no farts to help push it out

[@jopainting1668]

These comments are.. awful.

[@dmonburner8791]

on the 8th day the baby begins producing its own, hence why jewish people wait until the 8th day for circumcision

[@deliriouscookie3107]

Now we need a sequel by Ex&F on how to make explosive vitamins :D

[@ExplosionsAndFire]

"what's the healthiest explosive"

[@Sniperboy5551]

@Explosions&Fire I love you, Tom. No homo. Nice collab with Cold Ones, it reminded me just how much I miss new uploads from you.

[@danielhonetschlager8508]

​@@ExplosionsAndFirewe need an answer

[@MandrakeFernflower]

​@@ExplosionsAndFire nitroglycerin is used as a medicine so maybe its that one

[@benjaminmiller3620]

*Ascorbic acid* is actually used to make a rocketry propellant! It's called crimson powder and I believe it's primarily used in ejection charges as a more potent, cooler burning, alternative to black powder.

[@hydrogenbond7303]

There's funny way to memorize the vitamins soluble in fats in Czech language - the word for butt (which contains fat) is "ZADEK" and If you take out the "Z" you get the vitamins soluble in fat - "ADEK" :D

[@jenda386]

The really important thing is to remember that the fat-soluble vitamins are not R, D, E and L.

[@timkurz6086]

In German too we memorize them by EDEKA a common grocery store here

[@awli8861]

"Zadek" is also a word for butt in Polish language

[@viktordelac5294]

In croatian DEKA means blanket so it works

[@Nov1cegg]

In Brazilian Portuguese, "keda" sounds exactly like "queda", which means falling. So I memorized it as "if you slip on it (cause fat is slipper), KEDA"

[@ArkonArchive]

So basically: Eggs have everything you need.

[@ananthropomorphictalkinggo6641]

Of course they do, that's literally their sole reason for existing.

[@wyltedleaves]

eggs based fr

[@xenoblad]

They have a lot of stuff, but no fiber or vitamin c. Depending on if you think excess cholesterol is bad, eggs can be an issue in that area.

[@illegal.anglo88]

@@xenobladfiber is not a nutrient and is bullshit. Cut out fiber and you actually poop better. In terms of vitamin C it’s actually only necessary if you eat carbs. It’s too complicated to explain why through text but you can google why. In terms of cholesterol our liver produces more cholesterol than we can possibly consume so why is it bad for us? So really eggs do have everything we need.

[@anthonysoprano7066]

@@xenobladthe cholesterol worries with regards to eggs is bullshit.

[@jackal7905]

Speak more biochemistry, please. This video is so satisfying.

[@jreelite7149]

The colored functional group atoms makes my brain feel good. You did an amazing job with this. Excited for the one.

[@That_Chemist]

I can't take all the credit - it is only possible thanks to the whole team!

[@peggedyourdad9560]

@@That_Chemist Then you have an amazing team.

[@inhisname8395]

Carnivore diet is the best

[@maxr1104]

As someone who’s just getting off of accutane myself, I think understanding the chemical processes behind why my skin excessively dried out and my dozens of nose bleeds would be interesting to see! As always thank you for the effort you put into these videos!

[@zachsuarez1830]

Same

[@dinglesplat3281]

Same

[@davidhagersten8447]

@Max R Read any of Grant Genereux's three free ebooks on vitamin A. Grant Genereux has been on a low vitamin A diet for +8 years. Too bad you have been damaged by a high dose retinoic acid in accutane.

[@pabloescobar4029]

Don’t take that shi

[@Gairith]

Whoa they still make accutane? I thought it was lawsuit'd out of existence Fun story: out of shameful habit, I went to pop a zit while on my first month of accutane. The dry skin under my fingertips just slid off instead

[@TehLiquid]

You can also get Vitamin-E from Eggs, just like Vitamin-B1, B2, B5, B6, B12, Biotin, Choline, Folate, Vitamin-A, D, E and K2. Along with (And I know these aren't Vitamins, but still..) Iodine, Iron, Phosphoprus, Selenium, Sodium and Zinc. They're literally a perfect food.

[@perad1895]

from a organic, actual free range, good diet having chicken you may yes. not from just any eggs.

[@ssgoko88]

​@@perad1895 could you explain how an egg could even be made without these essential materials I'm pretty sure it's any egg.

[@perad1895]

@@ssgoko88 quality of and egg....depends on the quality of the chicken....the quality of the chicken depends on the quality of its lifestyle. simple borskie....not sure what you asked me to be honest.

[@HousemaidMomoSakura]

​@Pera 'D i think they were confused about "not just any eggs" and might have assumed you implied eggs from other animals lacked some of the qualities of chicken eggs, since you specified "chicken eggs" earlier in the comment, so they asked you to elaborate on that. I might be wrong tho.

[@perad1895]

@@HousemaidMomoSakura gotcha..talking about chicken only here....but regardless my point of the animal and its living condition = quality of the egg. don't change. but thats the same for any good food tbh.

[@jamham69]

"this is the more complicated part" is THE funniest shit. you lost me immeditaly the moment you started talking and, 5 minutes into an endless string of chemical names, you say "now it gets complicated" Perfect. i love this channel so much

[@balazsbelavari7556]

so in hungary (where I live) there is a big thing about vitamin c, because one hungarian scientist got the idea of extracting it from peppers and he did so succesfully. So apart from citrus fruits, peppers (as in paprika) should be good too. (go look it up if you want it’s Albert Szentgyörgyi and it’s a whole thing, there aren’t a lot of hungarian contributions to science so the ones we did make are super hyped up in every school)

[@Yarmox]

There are MANY Hungarian scientific contributions. Ignaz Semmelweis is the reason many many babies have survived being born. Just one significant example. Szeresed magad, koszonom.

[@chayaropsrirattanawong203]

This some of the best-summarized versions of biochemistry that we (basic medical science ie. doctors, dentists, medical science, etc.) have to learn in my country for this particular topic. We just basically remember all the B vitamins as (1-PPP, 2-FAD, 3-NAD, 5-CoA, 6-transaminase, 7-CO2 transporter, 9-nucleotide synt, 12-Cobalt version of heme). Usually, we only got the text with some pictures but not the whole pathway (only the significant one) to study not to mention that every vitamin plays a role in understanding how our body works (you need to understand the basic pathway of metabolism first + heme synthesis). It is a fascinating topic and I admire how you presented it in an easy-understandable way for a topic that is mostly oversimplified to good-bad benefit.

[@That_Chemist]

Thank you! It really helps when people share it so that it can reach as many people who would benefit as possible :)

[@PitBullSerbian]

Vitamin D deserves S tier, you undersold it's effects so hard. Maybe it's boring from a chemical standpoint, but from biochemical and endocrine it's not.

[@sealpiercing8476]

I'm starting to wonder if part of the historical success of wheat-based diets might have been due to growing yeast in it. Not just a little bit to raise the bread, but a lot of it so the yeast can synthesize some vitamins.

[@That_Chemist]

Honestly I’ve thought about this as well

[@JotaC]

Beer and wine were literally more drunk than water back in ancient civilizations, not only because it was safer, since it was less likely to get infectious disease from alcoholic beverages than it was to get from contaminated water, but also because those beverages were found to have an effect on reducing the amount of "diseases" (aka deficiencies) that people had.

[@That_Chemist]

most wines in ancient times tended to be drugged wines too - The Immortality Key discusses this at greater length

[@Yuhyuhmuhmuh]

​@@JotaC sorry Jota, but that's a myth. People have always drank more water than anything else until recently when canned beverages became cheap than bottled water

[@madboycal7859]

Your production in videos has gotten a lot better over time (not saying your prior videos are bad). This is S tier content.

[@alexd4102]

Poggers

[@sashboo1370]

I have said before how your videos are really improving, but this one is like none other before. The visual support is clean, the memes are funny and the information is easy to comprehend. Amazing job!

[@barefootalien]

Regarding finding local edible plants with needed vitamins... I would assume that in most places humans have lived for an appreciable length of time, people have pretty much figured out what plants are edible pretty effectively. Finding an edible plant that's also palatable and cultivatable and fills a gap in human needs in an area, that nobody knows about should be exceedingly rare.

[@quinnlintott406]

Hands down the best chemistry content on youtube. I really like that you touch on adjacent topics like psychopharmacology as well. Thanks for all your hard work!

[@da3m0nic_79]

Amazing production on this one. Your team is amazing

[@That_Chemist]

They are indeed :)

[@nolanhanson5743]

@@That_Chemist What program is used to make the structures (and can I also make color coded letters with it?)

[@medman4309]

​@@That_Chemist yes! Whoever makes your graphics is doing an incredible job. Loved the TCA cycle one

[@squeezter]

Maybe even his best vid so far

[@Exergonick]

@@nolanhanson5743 it's a mix of blender, wavefronts from RCSB pdb's, and chemdraw. Those usually are consistent but honest we would use anything as long as it shows what we would like to show effectively.

[@hevis6638]

One cool thing about biotin is its interaction with avidin. More specifically, the binding affinity of avidin to biotin is among the strongest non-covalent bonds. It's pretty much non-reversible without denaturing the avidin.

[@KittenRaptor]

I've been dealing with nutrition in a macro sense for many years, and until today I had no idea Vitamin B12 was a Cobalt complex.

[@randompillow5146]

Just wanted to say these videos are amazing to watch for me as an undergraduate chemistry student. It introduces me to aspects of chemistry I haven’t learned about yet and helps me be somewhat familiar with some things before I even learn about them in classes.

[@That_Chemist]

Great to hear!

[@ken198100]

Niacin was originally called nicotinic acid because it can be created by the oxidation of nicotine with nitric acid. However, people knew nicotine as the addictive chemical in tobacco, so the name niacin was used instead. Niacin comes from the words NIcotinic ACid vitamIN.

[@iskander07]

Thank you

[@diablominero]

Vitamin K2 supplementation has been found to be effective in preventing osteoporosis and some heart problems.

[@MedicosisPerfectionalis]

🤩 Thank you so much for mentioning my video! I appreciate you!

[@That_Chemist]

I appreciate your videos a lot - keep up the incredible work!

[@MedicosisPerfectionalis]

@@That_Chemist Thank you 🙏

[@vitamincds735]

I like how you've updated your visual presentation! Your slides are colorful and fun to look at.

[@dhawthorne1634]

Nixtamalization of corn was also explained in Tasting History: Unwrapping Aztec Tamales as well as SciShow: Corn Shouldn't Be Food, But It Is. A walk-through of the full process can be found on Rose Red Homestead: How to Nixtamalize Dent Corn.

[@drowzy_rick2718]

Please please please please make a detailed video on Acutane! I've read countless articles and research about how to works on a cellular level and I still can not connect all the pieces, however from what i did understand the drug is genuinely miraculous! I just got off two cycles and the symptoms were extremely wacky but I was left with perfectly clear skin at the end and my acne has not returned since. I had extreme dryness in my eyes, lips, skin, hair as well as joint pain in my knees and hips, tightness in my hips and pain in my lower back. I noticed i was far more injury prone and I even took longer to heal from injuries while I was on it. Really hope you take this suggestion into consideration as I think its near impossible detailed information on the drug even though its so widely used and talked about amongst teenagers struggling with acne. Love the videos and thank you so much!

[@GerinoMorn]

Also, wasn't Golden Rice also better yielding in other nutrients? And I think it was thwarted by anti-GMO scare-tactics in developing countries...

[@peggedyourdad9560]

I think is was also super hardy and able to grow in a variety of conditions, including during periods of less water.

[@RepChris]

Absolutely, greenpeace destroyed a lot of crops due to their purist views that put "not GMOs" over stopping preventable loss of human life

[@josephkanowitz6875]

ב''ה, the full story is that apparently business reasons killed it

[@akramisalah8189]

@@josephkanowitz6875 ב"ה?

[@Exergonick]

Its definitely not thwarted its still supported by private investment, but it does stand that nutritionally it wasn't better than normal rice it was evaluated twice by the FDA. But new generations of it will likely be introduced eventually and reevaluated. But at the time it was brand new and didn't deliver on promises at least in America. In Asia it was political resistance maybe somewhat anti GMO but more anti western influence.

[@VinsCool]

I really like that new style of presentation going with the classic That Chemist voiceover

[@ShockedCaucasian]

Ooo Im excited! I love the production quality on these and ive been super curious about vitamins, Perfect combo!

[@TigasCraft42]

This is amazing. Would love to see more biochemistry content here!

[@applechocolate4U]

Man I'm liking all the chemistry details in the editing. I'm a huge fan, and someone who really likes the videos you put out

[@That_Chemist]

I appreciate the kind words!

[@jeremiquirus1958]

Something that fascinates me is how essential amino acids like phenylalanine and tryptophan have cyclic carbon rings that arent formed in animals bodies. We are reliant on plants and microorganisms for the building blocks of our bodies.

[@deltalima6703]

??? No they dont.

[@user-jr3zr2mp9c]

Yes thats how omnivores work

[@jercos]

Your animation and overlay work is getting amazing, really adding the the draw of the content. The visible complexity of the spinning enzymes involved in the Krebs cycle drives home how amazing that machinery is as a whole without saying a word. When looking at inputs and outputs it seems all too simple, but it's a ladder of the same complexity as the mitochondrial electron transport chain.

[@That_Chemist]

Thanks! We have some more cool changes coming in the next tierlist we will be posting (hopefully in the next few days, definitely before the end of May)!

[@That_Chemist]

I don’t make these by myself anymore, but rather we have a team of people who are dedicated to working on it :)

[@hhvhhvcz]

i loved every second of this video, could you pretty please do also follow up with periodic elements and include simple compounds e.g. Li, Fe, Mg, NaCl etc

[@totallynotagecko3866]

Hey, I know I’m a little late to the video but if you see this by any chance could you start adding the IUPAC names under the graphics of molecules? Especially the hydrocarbons. I’m in grade 12 chemistry right now on the organic chemistry unit and it would be a massive help in reinforcing what I’m learning

[@aleksandrskidan9262]

This is definitely the best video about vitamins I have ever seen, it was really detailed and I loved every second of it, have you thought about doing similar video about minerals?

[@That_Chemist]

I haven't thought a ton about minerals (rocks), but in terms of biominerals we could definitely do something like this in the future

[@PaulSteMarie]

@@That_Chemist Geology Hub frequently refers to the chemical composition of lava, typically silica vs alkali metals, but geologists in general have their own rather odd way of categorizing minerals (felsic vs mafic). Toss in the the weirdness of clay minerals and you've got lots to talk about.

[@stanlevox2291]

Would totally like a video on astaxanthin been reading all the NIH and pubmed studies. Trying even to ask chatgpt3 how to achieve that orange colored skin that can happen with astaxanthin as well. I did 100mg daily for a few months from 2 different brands and didn't achieve that orange result. My eyesight improved along with taking Sulbutiamine and Astaxanthin from negative 1.25 to 0.75 (fR sighted) along with (convuluted with rather) eye exercises daily. Over the course of 1 year, going to try and add NMN to get back to not needing to wear contact lenses. Also added bacopa and lions mane extract to the mix, 2 grams and 5-10 grams respectively. (Also increased potassium (Kiwi, greens) and magnesium glycibate due to sulbutiamine utilizing more uptake).

[@sunbear2340]

I really appreciate the conciseness and precision of the script, some of the best ive seen in youtube educational content.

[@That_Chemist]

thank you!

[@Demoralized88]

And he speaks so clearly and quickly. Tons of information in an interesting format even if I'm only able to comprehend some of it.

[@carolinewhite9678]

I would really appreciate the video on Vit A, specifically accutane. As I think about starting a course but I'm terrified of nose bleeds more than anything else.

[@amentrison2794]

As someone in a biochem program, your stock exchange analogy actually confused me for a brief moment lol. I had to use my knowledge of coenzymes to understand the analogy rather than the other way around. This was a fun video. More bio stuff please!

[@deltalima6703]

Lol

[@trulyinfamous]

I haven't watched this channel in a while and so far I'm liking the changes to the format. The glow effect on some of the text makes it look like my vision is blurry though.

[@GerinoMorn]

Oh, and I'm so up for a video about various retinoids, especially how newer generations like adapalene are causing less/none photosensitivity in skin!

[@zachsuarez1830]

I would love one about all the skin stuff like even comparing the different chemicals and stuff or whatever in each retinitoid also that’s cool they don’t cause photosensitivity is there a way maybe to make acutane do that? I though photosensitivity was becasuw it made skin cycle faster so it was new skin which is easy to burn

[@emyyyxx]

i’m on accutane and there’s so much misinformation out there but it still kinda scares me. would love a video on it (:

[@yahia9481]

What s that ?

[@Vacced]

​@@yahia9481 gets ride of acne, has many side effects

[@feelinghealingfrequences7179]

or consider not being on a poison moreplatesmoredates and leo and longevity covers accutane

[@bellenesatan]

​@@feelinghealingfrequences7179 your name is "feeling healing frequencies" you probably think 5G is deadly sit the poison talk out

[@MRgun202]

Adding one thing, Umetaro Suzuki was working on vitamins but originally term "vita-aminy" was created by Casimir Funk in 1912 who created concept of vitamins

[@icycrusader1947]

And then Funk was credited with the discovery of B1...despite likely discovering B2.

[@user-dg3ug7ny5d]

I wish I had waltzed upon this video before submitting my multi-vitamins literature review! Trying to academically put that there is no standardised, regulated definition was a task and a half. This video definitely cemented how much I enjoy biochemistry, but the stress of studying higher-level chem past the required foundational level has me hesitating on it. It also means I need to study a level 200 chem unit before I reach the level 300 biochem units, so I at least have a year and a half, two years max before then if I want to get serious about it. Thanks again to you and your wonderful team! My brain has been most satisfied! :)

[@maximusnickila4440]

This was my favorite tier list video, thank you Mr. That. Cordially, Maximus.

[@afeathereddinosaur]

Hrngh. These biologists, misnomering chemicals ánd these nutritionists claiming that food is good or bad. Did you see how the egg went from being healthy to being unhealthy to being healthy again to being unhealthy to being healthy now in a span of 40 years? Crazy stuff.

[@That_Chemist]

imo it's because most people don't understand the complexity of biology - hopefully they will after some more of these biochem videos 😎

[@jamersbazuka8055]

BuT cHoLeStErOl

[@MikeIsCannonFodder]

Based on what you said about B12 maybe this changed, but folic acid was usually recommended to pregnant women in part to help prevent neural tube defects.

[@Exergonick]

Its both, folic acid has been known for a while, but "recently" b12 was also shown to independently reduce the risk. Nature Reviews Endocrinology volume 5, page 354 (2009)

[@MySuperhappyfuntime]

I really love the colour scheme and the editing on this video. Well done.

[@JOJO-yd7qs]

i really appreciate this. I think it’s interesting to hear about vitamins with out a huge health hype and miss information.

[@diablominero]

There've been some exciting results in aging reversal in lab mice using niacin derivatives.

[@rubyblindheim4572]

I would absolutely love a video on carotenoids, beta carotenes, acutane, etc. Thank you for such educational and informative content!😊❤

[@johns1625]

Very curious about acutane. I took that when I was a teenager and although it was the only thing that actually cured my acne it had some marvelously horrible effects on my skin, like a desiccated piece of flaky jerky covered in cold sores. Like my entire lips were just one big cold sore. Never had one after that nor before.

[@leafykille]

Wow this is awesome! So much chemistry:) I would love you to slightly extend the informative flash graphics so it's easier to pause on them to examine them in more detail.

[@blackout6179]

Recommendation: Tier list of amino acids / supplements, like: Citicoline, GDP, NAND, NAN+, N-Acetyl-L-Tyrosine etc..

[@creamydistortion]

Your channel is amazing. Even for amateur viewers who will probably never be in a lab (like myself), it's still just so interesting to learn about this stuff.

[@That_Chemist]

Thank you :)

[@evanixiast]

"Fat soluble vitamins are less likely to cause deficiency" me having a severe vitamin D deficiency last year and having to take a lot daily because I'm allergic to sunlight ☺

[@deeznuts4551]

I have Coeliac disease, this video is really interesting!! It helps to explain why I need to get a B1 infusion. I’ve also struggled with iron(I had borderline anaemia), vitamin D etc due to my intestines being unable to absorb the vitamins after being destroyed from eating gluten.

[@markparker5585]

Apologies if someone has already pointed this out, but there is a graphics error at 37:05, where it should show D2 for the plant based form, not D3.

[@6alecapristrudel]

Biotin/B7 is S tier! Not because of sulf*r, but because Shiny! I use B7 as brightener in my "buy it at the pharmacy" shiny copper plating bath formula. Vitamin C is S tier because it's the reducing agent of choice for my electroless/chemical Silver bath. Niacin seems interesting for silver too but I haven't played around with it yet.

[@multiarray2320]

i dont actively watch your videos because i dont have to do a lot with chemistry, but this video was really enjoyable. was the quality of your videos always that good? i remember it a bit different (not meant to be insulting).

[@GerinoMorn]

This is my favourite type of videos: chemistry in biomedical context

[@catoverlords9560]

I have a lot of health anxiety and thus, have a hard time appreciating my body. This video helped me change my attitude - if my body can do all these crazy biochemical reactions and conversions, it deserves some respect. Thank you for your content. I appreciate it and the team a lot.

[@Zoominguy007]

Putting them all in a tier list really helped me differentiate and remember them and their roles in the body. Absolutely genius video formatting thank you!!

[@FreakySteph]

As an undergraduate biologist I can say that Vitamin B7 is actually useful for detection experimental procedures in biology, since it forms complexes with avidin and maybe for that reason it should have been higher on the list (maybe D tier). But sulfur does suck and it does stink indeed. Anyway, I love how far your channel has come and the quality of your content has improved dramatically. Your videos are always extensively detailed and I thoroughly enjoy them. Even though I chose biology as my major, I do love chemistry and your videos remind me of how fun chemistry is while also enhancing my current knowledge.

[@That_Chemist]

Thank you for your kind words :)

[@siemkamsteeg4536]

I like how you describe everything in such details it helps me understand and remember it way better, is there an Accutane video also?

[@Jackieception]

love that touch of humor. "i just wanna express myself bro" .. A vitamin: "NO" . these kinds of teachers is what the world needs

[@DrobisPR]

A year out from my BS in biochem , and I'm glad you brought up how yellow flavins are! Was the first quality my professor mentioned in intermediary metabolism and I was thinking, "wonder if E&F knows". Thank you for the great content!

[@nirodper]

It gives a nice color to your pee after eating liver :D

[@jarnodavidson3432]

I really like the new new format like a bit of info and I also like the new colours

[@karlhibell278]

Learnt more about biochemistry in 2:04 minutes then I have for the past 5 years. You sir deserve wayyy more subscribers so to help with that you just gained mine :)

[@virupannamedikinal]

This is the video that I wanted to watch. So much information,thank you so much.

[@That_Chemist]

Thank you for watching :)

[@Ksweetpea]

My winter depression was largely a crippling vitamin D deficiency spiced up with ADHD and general anxiety disorder 😂

[@qybe6330]

Same

[@tremarley9648]

Most people are deficient in vitamin D today

[@AcousticTelevisions]

Eyyy SAD-ADHD-anxiety gang

[@NeutronMicrowave]

les goooo

[@kyuofcosmic]

B12 is so cool, it’s also an antidote for cyanide poisoning!

[@Dave2713]

I like your channel, good blend of humor sprinkled into very digestible information.

[@DeathMetalDerf]

I have been waiting for you to cover this topic! Thanks very much for an excellent video with some great information. Very well done indeed! I hope everyone is doing well, and having a great day!

[@That_Chemist]

My pleasure!

[@MrTimebomb12]

Even though I don't understand half of this stuff I do generally get the idea. I just love these kinds of videos because I get to appreciate how beautifully complex nature is.

[@ikosaheadrom]

I have to put the video in x0.75

[@sydhenderson6753]

Riboflavin has given me quite a scare because if you consume an excess it come out in your urine and Riboflavin is astrobright yellow. (I don't think it's underrated in the tier list). I think he was entirely too clever with vitamin C and think he may have been influenced to put it into C tier because it was Vitamin C. It obviously is S tier given its important role in history.

[@dirtpounder]

Vit c is tasty, should be up top on that alone.

[@TSteffi]

It may be rare, but in my 20s I actually had mild scurvy for some time. It caused my gums to bleed whenever I brushed my teeth. It got to the point where I just had to make a partial vacuum in my mouth, and it would start bleeding. It stopped when I took Vitamin C supplements for a while.

[@hummusslurp_8335]

As soon as I read the words "vitamin lore" I knew this was gonna be good, maybe I would've actually chosen that biology course if it was taught like this

[@Jonas_Fox]

I read an entire book on Vitamin K2 and the surrounding studies. Something about it as a coenzyme for proteins that transport calcium from and to tissues in the body, apparently really important in preventing atherosclerosis and reshaping bone during pregnancy and childhood growth. Book is called Vitamin K2 and the Calcium Paradox. They also cover some interactions between all the fat soluble vitamins. I'd love to see you tackle the chemistry behind these studies. Thanks for all you're doing here. 🤜🤛

[@psychedelaholic]

Vitamin C isn't only found in fruits and vegetables, it's also found in some meats specifically organ meats like raw chicken liver.

[@McSlobo]

Yeah, probably found, but would you eat raw chicken liver? Whale skin on the other hand...

[@psychedelaholic]

@@McSlobo As long as it's pastured and organic, preferably local yes. I've been eating it every day for years.

[@beep8131]

i started on accutane relatively recently, id love to see a whole video about the vitamin a-esque (retinoids? im in the first year of my undergrad in chem lol, i dont know ANYTHING) even if i am a bit late to the party. the packaging alone on accutane is no joke, every surface reminds you about the birth defects. its interesting that compounds so similar can be used topically and ingested orally for acne

[@lehiawombat]

As someone who had two courses of Acutane, I'd be curious to have a video on that! :D

[@thunderlordd4]

can you do a video on vitamins and minerals best for testosterone tierlist?

[@iskander07]

Vitamin D, Calcium, Zinc and Iron.

[@thunderlordd4]

@@iskander07 could you explain why iron? i can only think of promoting healthy blood flow that can help testosterone circulate

[@Darthcater450]

This video is so well made. Even though I am a finance student and have no relation with chemistry, here I am watching a 45 minute video 😀

[@That_Chemist]

Glad to hear it :)

[@noobood]

May I reference your video content to provide our members with a better understanding? Your content is fantastic!

[@That_Chemist]

Yes! Of course

[@Sandvichman.]

yo, nice video this can be one of the more difficult things to search for on the internet, so thanks "what does vitamin A do" "help your eye" "how does vitamin A help your eye" "help your eye"

[@Ophiuchus97]

Mineral tier list?

[@ireallylikehuskies9472]

i love the new glow-y theme! it helps make my favorite subject even more mesmerizing, thank you!

[@That_Chemist]

I will let David know :)

[@EpicDeception]

This is amazing. It's all I've ever wanted. Thank you.

[@jannikgluckert8501]

I am unable to look at the spinning protein models without immediately thinking about the spinning rat meme. Very insightful video!

[@multiarray2320]

can you also do a video about all the other micronutritions (i hope thats the english name). it would perfectly fit to this video. but it would be less chemistry and more biology.

[@protondonor3808]

Can confirm, I'm watching this and deficient in most B vitamins, due to malabsorption related to Crohn's disease. :P Great vid, would love one on retinoids if only so that I can hear about how developmental toxicity from retinoids actually works.

[@feelinghealingfrequences7179]

consider buying sub lingual B vitamins KAL brand is good quality

[@manniemintea9098]

Thank you! I love Bio and chem and everything in between, Definitely going to watch again!