Can We Use Antibodies to Treat Covid-19?

[@Liberator2142]

Why isn't this channel have more than a million subs... I'm getting sick of seeing misinformation everywhere. Thanks for the info sir. 👍🙂

[@teevannel3468]

I received this treatment and recovered nicely at home.

[@rosemaryklauscher9389]

I first read antibodies as antibiotics, and was very puzzled. This makes much more sense.

[@Trisstunes]

wouldn't natural antibodies also be man-made? 👀

[@SiirEgg]

Yeah I also had some issue with that statement

[@HercadosP]

Oh, that's true...

[@SpeakShibboleth]

Only around half of them

[@kevinclass2010]

"natural" means cloned directly from an existing antibody produced by an infected patient without modifications.

[@freedeliveryprinting3100]

Much of the work behind production of monoclonal antibodies is rooted in the production of hybridomas, which involves identifying antigen-specific plasma/plasmablast cells (ASPC) that produce antibodies specific to an antigen of interest and fusing these cells with myeloma cells. Myeloma is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. Often, no symptoms are notice initially. As it progresses, bone pain, anemia, kidney dysfunctions, and infections may occur. SOURCE: Wiki en.wikipedia.org/wiki/Monoclonal_antibody

[@christophermackerley4217]

These antibodies saved my life

[@Unsensitive]

Not from a factory, but i donated convalescent plasma 3 times for covid. Supposedly saving up to 15 people. Not donating again though. I need to resume blood donations to reduce my iron level. They won't let you do both, nor take a lil extra blood when doing the plasma donation. Gotta think of my own long term health.

[@seriousbuissness8061]

Amazing. Im assuming you had covid19 previously?

[@Unsensitive]

@@seriousbuissness8061 SAR-COV-2 back in March. Tested positive for antibodies. Never donated plasma before either. Not the most comfortable, but tolerable. I'd probably continue a bit longer if i hadn't an incidental finding during some research, of very early stage hemochromatosis, agenetic disorder of excessive iron absorbtion. I confirmed by genetic testing on ancestry dna, which i had done previously, and analysis by a separate online company. Just barely outside normal liver levels, and plan to keep that way by regular blood donations.

[@mikemartin8495]

You all should consider looking into Agenus (Agen). The company has been around since 1994. They’ve had a rocky road in the past but they now have gotten it together. They’re an immuno-therapy company but they also produce cell therapy (INKT’S), through their subsidiary company Agentus and they also produce vaccines. They also have the most powerful adjuvant (QS-21) on the market. Their main product and near future revenue generators are their PD-1 and CTLA-4 CPMS. Both are currently fast tracked for second line cervical cancer and have currently initiated a rolling BLA submission. The data is compelling and suggests that their PD-1 is as good if not, better than Merck’s Pembro (Keytruda) in CC. And in combination, it’s definitely superior to Keytruda in CC. Projected revenue for the drugs will be around ~165M domestically only. They have also partnered with a chinese pharma company called Betta pharmaceuticals for international rights in greater China. Agenus will be receiving milestone and royalty payments accordingly. Expansion of these two drugs will yield higher revenue. They’re also looking into partnering in Europe. Projected domestic and international revenue could be significantly higher than the ~165m I quoted for domestic sales. However, the biggest product they may have could be a potential multi blockbuster which is their next generation CTLA-4 1181. This is what most investors are banking on. They’re already seeing CR’s (complete responses) in Phase 1. It’s showing more than 70 percent clinical benefit (not to be confused with ORR.) Ctla-4 is notorious for being toxic but agenus has manufacturing a very tolerable version that has low toxicity levels. This is huge. I believe they have 10 CPMS in the clinic and somewhere around 10 in preclinical. They have partnerships with GILEAD, MERCK, GLAXOSMITHKLINE, INCYTE AND BETTA PHARMACEUTICALS. I’ve mentioned most of the pros on the company. The only con is, they need capital to market the product once approved and for label expansion. They may need to dilute or continue to do what they’ve been doing successfully which is partnering up with someone for a cash injection. But dilution at this stage may be looked at in a positive light considering their active pipeline. I hope you all enjoyed my synopsis. GLTA!!

[@am2schmarvelous]

Testing! I feel like a it's a terrible weak point in our response. I went to a pop up testing site after exposure and it took 13 days to get results. I went to a doctor referral test when I got a sore throat and had results the following day. We need to focus resources on processing tests.

[@therabbithat]

interacting with content to impress algorithm and spread video

thanks for share

[@truthseekerjen6254]

I got this antibody infusion yesterday in the er. It saved my life!

[@beetrue2ufirst]

How many days after a positive COVID test did you get the infusion?

[@MrRatherino]

it's all must a mess

[@mathiasniemeier4359]

I took Rituxen for 2 years weekly. Doing great! Can I use this for travel?

[@splashmt99]

What about nanobodies ?

[@sthelenskungfu]

Strange question: if we are aware of antibodies that effectively disable a virus, is there any reason we couldn't engineer a bacteria to produce that antibody and then spread that bacteria all over to release antibodies everywhere and get rid of the virus?

[@tylerphuoc2653]

You would need to have the immune system not attack that bacteria, hope that it doesn't mutate to become pathogenic, and hope that it doesn't produce a previously unobserved toxin where its colonies grow. Just my guesses.

[@onthecover5042]

Fun fact: If we heal people, they will, indeed, be healed

[@HercadosP]

The more you know

[@skywalker3760]

Hercados P. 😂😂😂

[@SRR-rh7id]

I have a question. When you say influenza vaccine different from measels vaccine, in what way do you mean it? Is it that influenza is given every year unlike measels, or that influenza has less efficacy than measels?

[@rockoutloud2me]

It seems like he meant that it would need to be given every year. Measles is kind of a one and done type virus, you're set for life. But because of how the influenza virus operates, it mutates very quickly and we are just trying to keep up with how it changes, hence the yearly vaccines. I've seen somewhere that there are already slight variations in covid-19 infections across the US, and it could get more extreme meaning one vaccine wouldn't cut it.

[@specialtramp]

It also means that the covid vaccine will not be highly effective - more like the flu vaccine, which doesn't prevent every infection, though those would do still get the flu tend to have a milder bout of illness.

[@SRR-rh7id]

@@rockoutloud2me Thank you! Can I have some further reading on Coronavirus mutating in such short period of time?

[@rockoutloud2me]

@@SRR-rh7id Yes! Here are a couple of links to articles. As of late September 2020, it seems there are 6 different strains of Covid-19. www.sciencedaily.com/releases/2020/08/200803105246.htm www.nature.com/articles/d41586-020-02544-6

[@kevinhackbarth9617]

Actually I was worried people would misinterpret his comment about flu va measles vaccines. He really shouldn't have said that without explaining it. We need vaccines against flu every year because there are many different strains of influenza and in different years, different strains are more or less common. While there are variants of SARS-CoV-2, none of them have been shown to functionally different in terms of infection or antibody generation (as far as I've heard). Also, influenza evolves more rapidly than coronaviruses, both because flu is sloppier at copying its genome and because those various strains recombine with each other to make evolutionary leaps. It's also true that antibody levels against influenza fall over time. In contrast, measles immunity is quite long lasting. Based off of immunity to other coronaviruses, many suspect immunity to SARS-CoV-2 will fade fairly quickly after immunization or infection. I believe this is what Dr. Carroll was referencing, not anything about viral evolution. However, it still remains to be seen how long lived immunity is. Indeed, the answer will probably depend on how someone is immunized and many personal factors.

[@1000jdg]

Just wondering. Is Sam the Surgeon Admiral an inside joke playing on the fact that the US Surgeon General is actually an admiral?

[@blackbox4214]

Good question all I know is that they have to pay like 500 dollars something a month to be named surgeon admiral

[@SaucerJess]

💙💙💙

[@mikeroni]

PLEASE DISCUSS THE BRADYKININ THEORY

[@beaudavis3808]

Just give me the vaccine and I will be fine.

[@CeeJMantis]

While I too hope for a safe/effective vaccine, and will happily get one when becomes available, having that doesn't also stop us from coming up with other means of treatment/prevention. Having an effective treatment that reduces severe symptoms, and/or the effects of long-lasting symptoms will be extremely beneficial to fighting the virus.

[@HercadosP]

The more variety, the better