Cancer Immunotherapy 101 with Dr. E. John Wherry

The basics of the immune system, immunotherapy, and cancer with Dr. E. John Wherry at the 2020 CRI Virtual Immunotherapy Patient Summit. #CRIsummit #immunotherapy #immunology
www.cancerresearch.org/virtua...
Immunotherapy continues to transform cancer treatment across several cancer types and shows incredible promise for the future of all cancer care. But what is immunotherapy and how does it work? How is immunotherapy different from other types of cancer treatment? www.cancerresearch.org/immuno...
Dr. E John Wherry, director of the UPenn Institute for Immunology, explains how our immune system works, breaks down the complex science underlying immunotherapy into basic concepts, describes the different types of immunotherapy, and discusses potential side effects and benefits that patients can anticipate. The presentation is followed by a Q&A moderated by Tamron Hall.
In this video, Dr. E John Wherry addresses:
- Components of the innate and adaptive immune system
- Current immunotherapies, including checkpoint blockade and CAR T cell therapy
- New immunotherapies in development, including new targets, neoantigen vaccines, and new combination treatments
- Genetic and genomic testing for cancer
- Common side effects of immunotherapy
- Cancer immunotherapy clinical trials
- Tumor biomarkers such as MSI-H and TMB-H
- Immunotherapy treatment regimen decisions, such as length of treatment or infusion timing
- Microbiome and immunotherapy
- Diet and nutrition with cancer immunotherapy
- Differences between immunotherapy and chemotherapy
- Autoimmune diseases and cancer immunotherapy
- Flu vaccine and cancer immunotherapy
E. John Wherry is the Barbara and Richard Schiffrin President’s Distinguished Professor, chair of the Department of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine and director of the UPenn Institute for Immunology. Dr. Wherry’s expertise lies mainly in T cell exhaustion, which can hamper anti-tumor immune responses. He has published over 200 papers, many of which have helped advance our understanding of how gene expression changes affect this exhaustion, which has led to strategies to improve the effectiveness of T cell-targeting immunotherapies. In recognition of his achievements, Dr. Wherry received the Distinguished Alumni award from Thomas Jefferson University, the Stand Up To Cancer Phillip A. Sharp Award, the Cancer Research Institute 2016 Frederick W. Alt Award for New Discoveries in Immunology. He is an associate director of CRI’s Scientific Advisory Council and member of CRI’s Clinical Leadership Committee. www.cancerresearch.org/about-...
The 2020 CRI Virtual Immunotherapy Patient Summit is part of the Cancer Research Institute's Answer to Cancer Patient Education Program. Established in 1953, the Cancer Research Institute (CRI) is a 501(c)(3) nonprofit organization dedicated to harnessing our immune system’s power to control and potentially cure all cancers. Our mission: Save more lives by fueling the discovery and development of powerful immunotherapies for all types of cancer. To accomplish this, we rely on donor support and collaborative partnerships to fund and carry out the most innovative clinical and laboratory research around the world, support the next generation of the field’s leaders, and serve as the trusted source of information on immunotherapy for cancer patients and their caregivers. www.cancerresearch.org
Cancer Research Institute is a registered 501(c)(3) nonprofit under EIN 13-1837442. Donations are tax-deductible to the fullest extent allowable under the law.

[@NazirAhmed-wh3kd]

Thanks Dr John best awareness about immunotherapy and fighting against cancer cell

[@wind7888]

Dr. E John Wherry explained it perfectly, easy to understand yet detailed enough. Clear and concise.

[@CancerResearchInstitute]

Glad you enjoyed this video- thank you for watching!

[@bencyber8595]

thank you😊 Dr. E. John Wherry, Ph.D. .

[@rohitsaxena22]

This talk was very informative. Thanks Dr John for his time.

[@CancerResearchInstitute]

Thanks for the feedback, Rohit. We are glad you found it insightful.

[@shadrackasamota1179]

Thanks, Dr. Wherry. Your presentation is detailed and easy to understand.

[@CancerResearchInstitute]

Thanks for watching! We are glad you found value in Dr. E. John Wherry's presentation!

[@ZeldaRosenthal]

I have recently seen Dr. Langer. I have Stage 4 NSCLC which is probably from radon. (My husband had the same cancer in August.) My PDL1 is 70% and I have no mutations. I am not a candidate for surgery (am missing upper and middle R lobes for the same cancer in 1997.), and radiation isn’t possible. I had my first infusion of Keytruda on Wednesday. Within 6 hours, I had a fever of 99.4 and was having trouble breathing. It took me hours to fall asleep. The next day, I was diagnosed with Atelectasis and am on antibiotics. They will not give me Pred because of the Keytruda. You have given me hope for other treatments if this doesn’t work or I cannot tolerate the Keytruda. Thank you!

[@CancerResearchInstitute]

We are wishing you all the best with your treatment!

[@Lovely99990]

Excellent presentation!!!

[@terrywilding8580]

Thank you for your info. Will be doing extensive research on Bladder cancer. Live in Ontario, and had 6 BCG treatments. Results tomorrow. Your info was definitely calming with the results of BCG treatments. I am 74 and considerably healthy. Willing to experiment to prevent any reoccurrence of bladder cancer

[@terrywilding8580]

Test was inconclusive. Two red marks inside bladder, uncertain cause. Scheduled for biopsy to see the cause.

[@CancerResearchInstitute]

Hi Terry. Learn more about immunotherapy for bladder cancer with Dr. Terence Friedlander here: kzbin.info/www/bejne/gIPRdHSMqMmrbZo

[@PaulBeiser]

Thanks, Dr. Wherry (and CRI). Excellent talk and info for us non-medical types. Very clear and informative!

[@CancerResearchInstitute]

Hi Paul, thank you for tuning and the positive feedback. 😊

[@niki6399]

Wonderfully explained, thanks!

[@tsakatozhimo3470]

God bless 🙏🏼

[@sandraredmond4812]

What do you think of keytruda as an adjunct therapy with nano knife IRE for prostate cancer ?

[@rohitsaxena22]

So what happens to the already deactivated T-cells. Does immunotherapy only prevent new T-cell to attach to tumour cells? If yes, then can starting immunotherapy early give better results (considering the patient has PDL-1 inhibitor )??

[@artjag1]

Many thanks for the information, I am suffering from secondary liver cancer that spread from my colon apparently... I have had a colon resection, followed by chemo till I had liver resection, and then more chemo followed by radiation treatment on the Linnac machine for two tumors about 1 1/4 inches in dimension.... I now have new appearing tumors , six so I have been told, fairly small at this time... Is immunotherapy an available treatment for me... My health is otherwise very good, I am not a drinker and have never smoked... I am also a pretty young 74 year onld male... I reside in BC Canada...

[@CancerResearchInstitute]

Hi Edmund- we are not a medical facility and are unable to provide medical advice. For information on immunotherapy, please visit our website at www.cancerresearch.org and discuss your options with your medical team.

[@hararedeclare3839]

Wow! Thanks.This kind of reminds me of Star Trek.Going into another world ,like Cells Trek.My genome test from prostate cancer biopsy,said my gene expression displays dividing cells or derangement(I think my doctor said).So would this mean cancer cells could be more recognized by T-cells ,with immunotherapy? I planned to call Decipher, to asked if MSI a factor in the test,because that would determine if I qualify for immunotherapy right? Thanks

[@dan020350]

💚

[@monikarajbhandari5678]

Thank you for all this information sir . Is immunotherapy is also painful as chemo therapy?

[@CancerResearchInstitute]

Hi Monika! Everyone's experience with immunotherapy is different. You can learn more about the different types of treatment options and their side effects by visiting our website: www.cancerresearch.org/en-us/immunotherapy/treatment-types

[@priyankachaudhary6905]

Sir my father has lung adenocarcina 4stage his pdl 1expression is negative.. Will immunotherapy work for it...

[@vijaypathania2788]

My mother is stage 4 metastisis cancer ...

[@CancerResearchInstitute]

Hi Priyanka. That depends on several factors. Learn about the PD-L1 biomarker here: www.cancerresearch.org/en-us/immunotherapy/what-is-immunotherapy/biomarkers-in-cancer-immunotherapy Learn about immunotherapy for lung cancer here: www.cancerresearch.org/immunotherapy/cancer-types/lung-cancer

[@rosiorojo4458]

Hola tengo cáncer de colon con metástasis vivo en Denver en este momento ,hay algo que pueda hacer?

[@CancerResearchInstitute]

Obtenga más información sobre la inmunoterapia para el cáncer colorrectal aquí.www.cancerresearch.org/es/immunotherapy/cancer-types/colorectal-cancer

[@sujitsankhla2585]

What is the cost of this treatment

[@CancerResearchInstitute]

Hi Sujit. The cost of immunotherapy varies according to several factors, including which drug and the treatment plan. For financial resources, please visit www.cancerresearch.org/patients/free-resources-support-answers/helpful-links

[@wendyfield7708]

Interesting but sounds very complicated.

[@aidaserrano9524]

I have a sister with bone cancer metastasis 1years with quimioterapia and other things nothing works

[@josphatlombe]

Let Dr answer some of the side effects .let him mention them

[@johnharland2336]

I agree totally! I've done a lot of research on this drug as I have Clear Cell Renal Carcinoma and am recovering from a radical left kidney nephrectomy. I'm not trying to be negative just realistic: My oncologist was pushing Keytruda as the only course of action without giving me options. Such as CAR-T or Oncolytic Virus Immunotherapy. It was almost like he was trying to sell me a used car or getting paid to push Keytruda. Subsequently, I am getting a second opinion today. Some of the side effects of Keytruda can be devastating and on occasion irreversible. I saw one doctor (on YT) laugh as he was saying some people with trade getting lifelong diabetes for the hope of Keytruda curing their cancer. The side effects are no joke when considering the clinical trials, of my particular disease of only 994 participants of 2 years, have only resulted in barley a 7-10% disease free survival rate with Keytruda compared to people that did nothing. Every doctor, all of them, say if you experience side effects call them immediately. So, if I'm on a plane and experience breathing problems or uncontrollable diarrhea are they going to meet me at the airport and administer corticosteroids? Nope! The bottom line is it's a gamble. I'm not interested that the FDA approved this drug giving how quickly they approved all the covid vaccines with no clinical trials or the many other drugs that failed cancer patients in the past. Do your research and make educated decisions. For me, I will do what the most educated and experienced doctors i can find tell to do. In the end, Jesus is watching, and it is by his will every atom in this universe and me moves. God bless your journey...