Cancer Drugs/Pharmacology

[@johnhancock2920]

I have never loved someone that I have never met so much

[@nyembidee1]

Totally agree 💯% love you @Dirty Medicine!!

[@foodiesworldUSA]

Love you @Dirty Medicine

[@rr.studios]

Not even your Dad? 😢

[@itzBarto]

Mnemo I use for Doxorubicin /Daunorubicin: They both end in -rubicin -> ruby (= red) -> the heart is red -> cardiotoxicity Dilated cardiomyopathy because it starts with D like Doxorubicin Dexrazoxane used to prevent it -> also starts with D and sounds like Roxane ('Roxane, you don't have to put on the red light', song by the police) -> again red for RUBYcin and heart Hope it helps someone :D

[@alih6953]

ty

[@yaraelhefnawi7632]

Funny things is doxorubicin is actually a red solution and is known as ‘the red devil’

[@mirbear72]

That's a good one

[@crystallemmon2830]

This is perfect!!! Thank you 🙏🏾

[@Seniors11]

Thank you! I sing the song Roxanne every time I see the drug name now lol!

[@ayshasarmad1240]

You have no idea how much I pray for you each night you are an angel, I was praying to GOD that you make a video on cancer drugs and the video came ,May God always always always keep you happy and blessed

[@alih6953]

May GOD bless you as well well wisher

[@shayguthrie7098]

I just passed STEP 1 so I am coming to reply to my most favorite Dirty mnemonic ever!! Vincristine and Chris Christie Bridgegate. I remember this one soooo well! Thank you for all you do. As soon as I am making money I am totally joining the channel.

[@2468ayesha2468]

Where is the ad. I want a few ads in your videos you deserve them👍🏼

[@mukulgupta1495]

For learning neuropathy for Paclitaxel: the "pathway"(neuropathy) of the bridge was blocked so you called a TAXI (paclitaxel)

[@ajabisong]

That took a new pathway (neuropathy)

[@stacymoroz4709]

10/10 - Taking step 1 in a few weeks and pharm has always been my weakest subject. Thank you so much, your videos are so helpful!

[@hamadrashid2285]

Just a tip, for side effects the human image with corresponding drugs to organs is a great visual mnemonic in the First aid book.

[@melissa90ify]

I’ve seen the “Chemo Man” image used for this

[@djmaamis3167]

You are goat in everything of medical school. I will come here after years when i pass my step 1 inshaallah, now I'm preparing my medical school pharmacology exam Thank you ❤

[@stephaniefabara2520]

Just to share my mnemonic for Topoisomerases I can 2 (to the) side so, "I can" is topoisomerase 1, which ends in CAN "2 (to the) side" is topoisomerase 2, which ends in SIDE

[@jab376]

You got it ha ha

[@muzamilmehmood3195]

Same here👍

[@alexisguadarrama3447]

THANK YOU!

[@alih6953]

Thank you for sharing sister

[@davidrios1492]

I have a test on Tuesday and I went from feeling I was going to flunk to feeling good in just 30 mins. THANK YOU!

[@recht181]

I was procrastinating studying and then got your alert, so I'm gonna watch and start studying now. Thanks!

[@umerhayat6857]

THIS WAS AMAZING!!!!!. Please do a video on anti tumor monoclonal antibodies!!!!!!!. They have started to come in questions a lot!!!!!

[@tuqa2798]

i miss your old way of explaining, you were very funny and energetic . please be your old you!! with my regards from iraq.

[@stablack3564]

You can remember which drugs block topoisomerase 1 and 2 by pronouncing irinotecONE and topotecONE (instead of -an).

[@alexbenitez2575]

Hi, Dirty I’ve come across two different questions about the Alkylating Agents and they have had G1 and Cell-Cycle Non-specific as answer choices and both times it’s been CCNS. Resources checked were Becker, Boards and Beyond 2018 and Uworld. I have to say that I use your mnemonics all the time for memorization and on test day and have benefitted tremendously, but for this one specific thing I thought I’d give a heads up. Thank you for your content it’s been very helpful.

[@Sammy.a1287]

You're right. Alkylating agents are cell cycle non-specific

[@rikis7086]

I made a different dumb mnemonic for Cladribine/Cytarabine: Tara likes pie, but Chad is a purist and won't eat anything unhealthy. Thus CyTARAbine is a PIErimidine analog, and CHADribine is a purine analog. Kinda silly but hope it helps someone!

[@Capsmetro27]

Where's the old cancer drug video where you had the "it's time for the percolator dance" part, I remembered that video better

[@dotri8099]

yeah i like that one better too

[@omega3pictures]

AGREED. "Piss-platin" for cisplatin is also much easier to memorize

[@anita26069]

@@omega3pictures oh yould you share this old one?

[@ricardodias3541]

Thank you, Dirty! You are my hero!

[@muskaninmed5860]

YOU ARE LITERALLY A GOD-SENT ANGEL

[@Mgggg500]

Thankyou dirty !!!!!! You are an angel

[@MehF00L]

I have a final today on cancer. Oh my god, I'M SAVED!

[@DanielzeGreat]

Can you upload the old video? It was shorter and easier to digest. I know this one is more complete, but it would be nice to have both versions. Thanks!

[@ayushi3392]

Irinotecan, topotecan - 'I can' …topoisomerase-1 Etoposide- '2 sides'…topoisomerase-2

[@DrBuntonDO]

I don't know if this helps anyone but the way I remember the M-phases as well is by remembering that a bridge can sometimes fold up, separating them in the middle, kind of like what happens in a cell right after metaphase.

[@argumentumadbaculum]

I will never forget 5FU adverse effect, ever again.

[@shanthisenthilkumar3831]

Very useful to study a tough topic. Thank u

[@sadianusrat1237]

Etoposide: E"two"poside. I don't know if anyone else shared that already but that's how I remember it.

[@bookbites101quotes]

Please make a video on immuno modulators and recent drugs

[@mubashirjaleel6255]

Very informative video

[@DrAbdullahJadran]

Excellent video, what an amazing explanation, thank you so much.

[@raydavalosrd]

"What the hell are they asking me?" Me at every question

[@hasansarhan9296]

This guy did made them super easy much easier to study than study them alone from a book

[@rehabali6968]

Thank u soo much I truly hope that u know the insane amount of help all of your content do , nothing in the wide world can express my gratitude ❤❤❤

[@NLKEquestrian]

this is probably the best video anyone can make for the driest topic in the universe. well done!

[@zaranajam4231]

Superb👍

[@sherazyousafwains]

TAXES are always increased so they polymerise microtubules.

[@akinwaleakinlade76]

M phase Duplicate phase( m phase inhibitors). Inhibition of microtubules. Vincristine, vinblastine( prevent polymerisation, stops microtubules). Neurotoxicity, paclitaxel,( hyperstabilise M phase, makes it superstable) Neuropathy eribulin causes arthalgia. Gi ( cell duplication) phase inhibitors cisplatin,( nephrotoxicity)bulsulfan( pulmonary fibrosis) cytotoxicity, cyclosphamide( hemorrhagic cystitis), camustine,(cns toxicity). S phase. ( DnA phase)! Azathiapine : purine synthesis 6 mecapurinol: purine synthesis xanthan oxidase Methotrexate myelosupression.

[@anukiran3]

God bless

[@pramodthapa2517]

I was praying for this! thank you so much

[@dr.mitchellbradyd.o.7071]

In the TAXI they had to take a different PATH.

[@dookieshoes861]

Or sitting on the taxi for to long can make your legs numb!

[@yasinyildirim4686]

This video is made by a beautiful and amazing human being!

[@JustFe03]

amazing!! better than sketchy for sure!

[@drswetaruparel]

Very very very helpful !!! 👍

[@ko5737]

Seriously ur such a saviour…👍🏻

[@_maaal_husseinshakir2993]

thank you so much , from iraq

[@sweetfate80]

you are so helpful thank you

[@abhisheksharma07]

You might wanna update this video as alkylating agents and platins are cell cycle non specific.

[@studywithramprasathrp3093]

Hey sir, you are the best senior out there 😍

[@tafwolf]

Please do some videos on high yield bacteria, fungi, virus and parasites. Like agars, virulence factors etc etc

[@johnheshbon]

A clear explanation.

[@arlybrutus1198]

Love the politics mnemonics you are a genius

[@sabafarrukh1795]

You say the cell cycle has been crammed into my brain since before medical school, but I, have sucked at understanding the cell cycle since I was 14 so hurrah.

[@muhammedsiddiqui1270]

Where's the percolator gone? It's time for the percolator , intercolating DNA !! Bring it back man!

[@chrizstele5922]

Paclitaxel starts with letter "P".. neuropathy has a "p" in the middle so...it can be memorized like that

[@jayl5734]

i thought he was gunna say paclitaxel / neuroPATHy. People would have to take another route, aka another PATH, to go through the bridge or whatever. but yours is pretty cool too!

[@namir1782]

great video but the main moa of antracyclins(doxo-daunorubicin) is also inhibitting the topoisomerase2

[@rainullah]

Thanks for Explaining in such a better way 🙏🙏

[@sharanjhaveri6324]

HEY , AMAZING VIDEO AS ALWAYS!! CAN yoU PLEASE DO ONE ON MONOCLONAL ANTIBODIES

[@ayshasarmad1240]

Please any one just help with monoclonal antibodies used for which receptor nemonics and tyrosine kinase inhibitors uses

[@xmega456]

youre amazing dude, thank you so much

[@M7mmad08]

Very helpful, you are fabulous

[@akshitakaushik6163]

the best way for the toxicities is the chemotherapy bear, the arms and legs are V vincristine and vinlblastine, add the extra E for joints.

[@MylaRayPereira]

tenipoSIDE/etopoSIDE (topo II) -- there are "TWO SIDES" to every story

[@Sorcerer1089]

Not sure if I'm the first to suggest it, (probably not) but Pclitaxel can be associated with neuropathy because the taxis were taking passengers on a different PATH.

[@muzamilmehmood3195]

Thanks 👍👍👍

[@devwarner6880]

Wow! Great ! Thanks!

[@arlybrutus1198]

so many funny moments the only thing is I cannot study around with you with my kids around lol

[@ammanovascotiaammanovascot5991]

lol

[@ua7632]

Isn’t carmustine also bioactivated in the liver? 9:01

[@tracey5301]

You are my hero

[@crystaldolly9498]

Can you make new video regarding hematology and oncology drugs added in first aid 2021?

[@jamspice25]

Amazing!

[@aryanneupane5673]

There are always two “ sides” to any thing. Etoposide and Teniposide = Topoisomerase 2

[@g.a.mylesii6677]

Please please please- this is good but I need the old video!

[@OthmanMatar]

thank you

[@ahmedelkheety3334]

for etoposide just remember eTWOposide

[@srana5049]

Thank you so much for this video!! You have actually made it super easy to learn.

[@bushraehsanullah2497]

Hey please post your old video with the percolator it's better . This is good too ;) but post both

[@ughsirius]

Thank you soooo much!!!

[@eminemfan8203]

Bleomycin and busulfan blow out the lungs. I like your mnemonic but this one helps me so I am hoping it helps others as well!

[@nathan9015cm9015cm]

Love you Dirty USMLE! Studying for step 1 now. Patreon for sure

[@ameterasu13]

I know did Plasma cell dyscrasias, MPNs, Myelodysplastic syndrome, Lymphoma, Leukemia but doe we have to do this ? Necessarily??

[@ramblingsofafutureMD]

a way I remembered topsides and pecans topsides have 2 Es so topisomerase 2 and pecans have one e so topoisomerase 1. hope it helps

[@everytimesummertime]

Vincristine - Crispy nerves Vinblastine - Blasts the bones :)

[@abigailfinkenauer4188]

so helpful!!!!!!!!!

[@sumayyahabib374]

I LOVE YOU DIRTY! you're Awesome❤

[@sonyalvi6266]

Thanks alot. This helps me alot 😭❤

[@048mahamuuthafahima8]

Please Make a video about men syndromes pleases

[@omniaabumiddain5783]

A genius! Thank you so much😍

[@ryanthomas5148]

Such a good review 💯

[@borancagatay]

My stupid reminder for topoisomerase 1 inhibitors topotecAn and irinotecAn they have A on their suffix and A is 1st letter of alphabet and that makes they inhibiting 1st topoisomerase lol.

[@amyma6463]

Thanks for making it so simple 😩❤

[@bookbites101quotes]

A great video , nicely divided , very high-yield . Thank you very much

[@Vunami]

Just want to let you know that Cisplatin arrests the G2/S phases.

[@sharliferramroop724]

omg thank you

[@osamaal-faqeh3462]

thanks

[@arvindkumarpt]

Awesome thank you so much 🙏🙏 especially the s phase drugs they were killing me 🥴 , not anymore 😁

[@akinwaleakinlade76]

5 fluorouracil Methotrexate Hydroxyurea 5 FU G2 Inhibitors. Topoisomerase inhibitor check if it wound correctly. Anti tumour antibiotics Doxorubicin( pulmonary fibrosis) Bleomycin: dilated cardiomyopathy.

[@JJ-cn2ud]

Doxo=Detailed cardiomyopathy Bleomycin=Pulmonary fibrosis

[@ryanhiggins3477]

Taxis find a PATH through the city

[@supriyakautish]

IrinotecAN,topotecAN AN=1 Inhibit topoisomerase 1

[@rogerwilcoshirley2270]

Mitosis and the cell cycle is covered in JHS and again in more detail in HS.