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In this article we will discuss the causes of high B-12 without supplementation. In a previous video we talked about What Does A High B-12 Level Mean and some things to think about with that. In this article we will explore this topic in a little bit more detail.
The basis of this article is to discuss some of the more serious or problematic things that could be causing your high vitamin B-12 and the information is based a research paper. If you are having persistent elevated B-12 levels, this information will b helpful. So keep watching we're gonna get into the detail.
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The causes of high B-12 levels without supplementation are numerous. Before we get into this, we have to take first things first. Even though the title is "cause of high B-12 without supplementation," my experience helping people figure this out, they are taking B-12 but they are not aware of it. It maybe in a multivitamin, a workout drink, a protein powder, or something like this. So double-check you are not getting B-12 from various sources that you're not aware.
Now in a previous video we talked about how liver disease and cell membrane issues can be implicated in elevated B-12 levels. This still can be the cause of high B-12 without supplementation but there could be other, more serious, reasons for this as well. Most of these more serious causes are altering the transportation of B-12 via the transcobalamin transport proteins (more on this below). Both the cell membrane and transcobalmin proteins can be a part of the issue and solution. As you will see below look at some of the problems that can come up with the trans cobalamin the various transcript a'lamin transport proteins and various diseases that can cause elevated B-12 when you're not supplementing with B-12
most often when there is elevated B-12 levels whether or not you're taking be extra B-12 it has nothing to do with alterations in these transport proteins called transcobalmin. This is why most often when you have an elevated B-12 level that shows up on your laps it's ignored, pushed to the side, or explained away. Essentially if you remain having persistently elevated B-12 levels in the absence of supplementation you should explore this further. High B-12 levels could be an epiphenomenon or related to a deeper issue with B-12 transportation.
Role of Transcobalmin in High B-12 Level Without Supplementation
So how is B-12 transported? The chemical name for B-12 is cobalmin and it has to be bound to a carrier protein to move through the blood and more importantly into the cell. B-12 uses three different carrier proteins to do this TCN 1, TCN 2, and TCN 3. However only one of these transporters is actually functionally useful in delivering B-12 into its target cells. It is the TCN 2 transporter that is the main transporter for B-12. Therefore, anything that raises TCN 1 and TCN 3 will lower the functional activity of B-12 by limiting the binding of B-12 to the TCM 2. In this case all the B-12 is getting bound up by these other transcobalmins that don't really work well for getting B12 into the cell. Now this doesn't necessarily explain the elevated B-12 levels but it does explain how one can be deficient in B-12 in the presence of higher serum B-12 levels. So what is actually causing the high B-12 levels? Let's look at that next.
In the case that you've ruled out excess consumption of B-12 makes sense to explore some of these other things. This does not necessarily mean you have these things but problems that could be going on to cause elevated B-12. First thing to consider is solid tumors can cause elevated B-12 levels. Most commonly it would be liver tumors, hepatocellular carcinoma in particular. This can lead to elevated B-12 levels due to poor uptake of B-12 in the liver cells. With liver cancer some of the liver cells are damaged as a result the liver cell are are not expressing as many B-12 receptors. The same thing happens with liver disease whether it is acute or chronic hepatitis.
Hepatitis and Hepatocellular Carcinoma can also lead to increase release of B-12 from the cells being damaged. B-12 can be released from the cells because basically it is where most of the B-12 is stored. B12 is stored in the body. So solid tumors are a cause of high B12 and there are probably other cases of solid tumors outside of Hepatocellular carcinoma but this was the focus of the research paper.Blood cancers in general can lead to an increase in B-12 levels due to an increased production of these TCN 1 and TCN 3 trans cobalamin proteins. These particular transport proteins are made more commonly in certain cell lines like the granulocytes in the white blood cells. High B12 levels are found in many myloproliferative disease. These are disease of the bone marrow where the white blood cells come from. These disease states result in an increased production of white blood cells including Granulocytes.