Cell Cycle and Mitosis

The cell cycle, or cell-division cycle, is the series of events that take place in a cell leading to duplication of its DNA (DNA replication) and division of cytoplasm and organelles to produce two daughter cells.
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In cells with a nucleus, as in eukaryotes, the cell cycle is also divided into two main stages: interphase and the mitotic (M) phase (including mitosis and cytokinesis. During interphase, the cell grows, accumulating nutrients needed for mitosis, and undergoes DNA replication preparing it for cell division. During the mitotic phase, the replicated chromosomes and cytoplasm separate into two new daughter cells. To ensure the proper division of the cell, there are control mechanisms known as cell cycle checkpoints.
The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism, as well as the process by which hair, skin, blood cells, and some internal organs are renewed. After cell division, each of the daughter cells begin the interphase of a new cycle. Although the various stages of interphase are not usually morphologically distinguishable, each phase of the cell cycle has a distinct set of specialized biochemical processes that prepare the cell for initiation of cell division.

[@MEDSimplified]

Sorry for the Mistake guys. Its "DNA REPLICATION" not "TRANSCRIPTION". 😁

[@shilpamistry1669]

Please make video in protoplast isolation, culture and fusion

[@MMABeijing]

ok thank you for the correction, you could add it as a popping message on the video if you want to help people who have not seen your comment. I also have a question: in the S phase the DNA is replicated, and on your illustration you use chromosomes , but later on in the mitotic phase you explain that the genetic material within the cell goes from random string to chromosome-shape, which comfuses me: could you clarify at which point of the cell cycle the genetic material is shaped as a chromosome? thank you

[@fawadlashari638]

also mention where. thank u

[@MuhammadUmer-jg2gj]

4:43

[@sabarishsncs6011]

And also you mentioned that chromosome number double during S phase which is wrong

[@tiredcat6653]

Glad to find this channel!

[@thowheedshaik7157]

Hey man! where were you these many months..

[@MEDSimplified]

Was busy with residency exam brother. Thanks for asking

[@thowheedshaik7157]

@@MEDSimplified missed your explaination.

[@TonyTigerTonyTiger]

4:30 The number of chromosomes does not double in S phase. The number of chromosomes remains the same (46 for humans), but each chromosome goes from having one chromatid (having a single DNA molecule) to having 2 sister chromatids (having 2 DNA molecules, with the old and new chromatid attached to each other).

[@rashmidhuriya8454]

I am glad I found your page. Thank you for your efforts to make such videos.

[@roginik.3252]

Hey.!!I am happy that you are back☺️☺️.....gonna enjoy learning again .....thanks..

[@MEDSimplified]

Very glad to hear that. 😁

[@imgucciano]

If I would have found this channel earlier I would have scored 100% in Anatomy and Physiology 2. I couldn't understand Mitosis and meiosis but now I do. Thanks so much for this video. Now we need meiosis!

[@ramyashankar2182]

Understandable....Hope this will help me in my exams

[@rishavmukherjee6818]

Sir.. If u can please make a video on how the regulations done by the Cyclins and CDK in the checkpoints of cell cycle.

[@Tastyy_Bitesss]

Your voice is so relaxing 😴

[@Khanira199]

I don't have words to appreciate you ... mind blowing..you make it very crystal clear ❤❤❤❤HATS of ❤❤❤❤❤❤

[@uzma9476]

@ protein synthesis occur in G2 phase where as many organelles get double in G1 phase . *I guess the content of chromatin material gets double not the chromosomes i.e the number of chromosomes remain same

[@Ggyyygg5000]

Oh my god maine ye vdo 2yrars pehle dkhi the 2month se doond rhe the aj mili 😊

[@harshandhetpatel2078]

hello sir , nice video of course .please help me understand haploid and diploid cells

[@peerzadaabrar1800]

Very helpful. Thanks to Med simplified

[@MEDSimplified]

THANKS ABRAR

[@peerzadaabrar1800]

No thanks. U r worth appreciating. It is our pleasure to have u on youtube

[@mosaicheart2232]

Could you please tell how you make these educational videos? I mean the editing, drawing, voice/sound modification everything... This video is awesome.

[@kannigas6720]

Even I too wanted to know so

[@balasubramaniana3146]

Very long time waiting . Keep going on

[@MEDSimplified]

Thanks

[@Lee-so4ub]

Now this right here was so helpful. It was exactly what I needed thank you!

[@aloevera1269]

Thank God for this ! I was looking for this

[@MEDSimplified]

Thanks for the patience and support

[@NabiryeJoanita-qr2yz]

Thanks May you please make a video on nutrition in plants

[@kannigas6720]

I like Ur channel veryyyy... Much. Tq. U know Ur language is very good to understand without any struck. Keep it up good luck sir. Keep on posting videos on lessons. My concepts r clear when I listen to u. Tq for Ur efforts.

[@khushboorathore2940]

Great teacher Of biology I ever see.

[@abhishekshashipatil958]

really today i understood cell cycle and its divisions ur channel is best,loved it.

[@yawnzzZn_com]

mas naintindihan ko pa to kesa sa teacher namin😀 thank you!

[@zmohammed4972]

Thank God that I found your channel I was lost.

[@annenivethikapatrick9307]

I got understood cell cycle clearly and my doubts vanished Thank u so much for this awesome video YOU explained very clearly thank u thank so much

[@afshidaafs2370]

Ur teaching is really superb n understandable

[@ratheradil9297]

good to see u back

[@sandeepkumarsingh8566]

In S phase Replication no transcription

[@MEDSimplified]

Sorry for the Mistake

[@hunterbapu8812]

Vah good attention

[@slatty7393]

⚠️Plzz keep regular updates your teaching is awesome 😌♥️♥️♥️♥️♥️🔥

[@bradhilton2283]

I got say bud you are really good at what you do .

[@zeelpatel8210]

thank you!!

[@GurmeetKaur-jw4ld]

Really awesome

[@slatty7393]

I know you are MD doctor but you are really awesome perfect teacher i have ever seen plzz explains us like this only, love your explanation .♥️😘

[@legendsnisa2376]

these are seriously very helpful ...........thanks a lot ............continue processing whatever the matter is ..........live long and stay bless

[@TonyTigerTonyTiger]

6:54 Pro-metaphase is actually part of prophase. Some sources call it pro-metaphase and others call it late prophase, but it is the same events for either term. Both types of sources have for metaphase only the events related to the chromosomes lining up at the metaphase plate (which by the way is equatorial, not equitorial).

[@suhaniray3109]

There might be a slight error at 4: 35....in S phase, DNA is duplicated but no. Of chromosomes remains unchanged...you said no. Of chromosomes is doubled

[@balasubramaniana3146]

Please make the video separately for mitosis. And also please do video for meiosis because lot of confusions on there. Plzzzzzz do the video

[@MEDSimplified]

Video on MITOSIS coming in a week. And on meiosis too

[@a_j_s8725]

yeah plzzz......,

[@alecxlipatan9206]

dear make one for meiosis too

[@ashkesh1551]

Sir ,plz make videos on biology topics ....like transport in plants,animals...cell membranes,immunity...yr videos helps me a lot ...the topics i don't understand while reading a book I understand them through yr videos ....plz sir,do make videos on the topics...

[@AnkitKumar-rk1rv]

After such a long time😊😊

[@MEDSimplified]

Thanks for the patience 😁

[@anjaliarya3720]

After ages you back..thanks for the vedio

[@ruchisachdeva3540]

Pls make for Meosis also

[@khursidalam6159]

In s phase replication occurs not transcription

[@binanda_engti_kathar]

Yeah it should be replication...

[@AbdullahAlMamun-ou3qg]

Very easy explanation...Thanks.

[@tasneemkhalid5574]

That's great! Too much thanks 💐🌷🌷🌷

[@MEDSimplified]

You are very welcome

[@cjain646]

Really good job, Very Helpful

[@bathulayuvanandini335]

Thank u so much for giving lot of information bro

[@mohnishbudhrani2166]

Very good video

[@ahmadsabi4023]

Sir please be regular....

[@MEDSimplified]

Was busy with my residency exam. Will upload now.

[@aailaqazi7075]

Best video ever♥️💯

[@IsabelRodriguez-nv2ue]

Amazing video!!! Thanks so very much!!!!

[@ojasviagrawal3180]

Outstanding!!

[@ninoskasmith6568]

Excellent!

[@saraadel6076]

It's very useful, thanks

[@asivakumar3731]

Hey you are back broo

[@MEDSimplified]

Thanks for the patience bro

[@maryamfatima8534]

U explain so well ❤️

[@btchhangte4680]

Good video

[@shishir757678]

at 4:42 min the process is Replication and not Transcription

[@iqraanasim]

Thnx sr ...fr ths help

[@jessybaiju6084]

very good

[@hiraasghar4607]

superb👌 thank you 😊

[@rmvaishnavi4935]

plz make video on meiosis

[@MEDSimplified]

Will do!

[@abhishikta4193]

Sir , what is the definition of the cell cycle checkpoints...?? Please answer this...I 'm very confused about this..... Thank you ... ☺☺

[@VAISHALISHARMA]

@3.04 you mean to say karyokinesis is mitosis

[@farhattayyaba2949]

Please can someone let me know where i can find this video notes? Like a pdf?

[@bikramchand2552]

Tnx sir........nvr understood this b4 ....

[@ekujanghel82]

U r such A Pro🔥🔥🔥🔥👍

[@s.abirami8394]

Hi medsimplified team can I have video on meiosis 🥺🙂

[@bathulayuvanandini335]

Bro make another vedio for meosis

[@alaamadbouly2946]

please Dr i want link of video for meiosis lecture and i your explain really very nice

[@padmanabhapattanayak471]

Make vedio on meosis.... Plssss

[@abhishikta4193]

Sir , is there any checkpoint between the G2 and S phase ??

[@sunitanaik3936]

Sir, pls make video on meiosis also

[@lopaangle8203]

Please make a video on meiosis sir

[@miscreantlml9480]

Thanks man!

[@autumnd.2990]

Thank you. God is good.

[@dazzlingstatus112]

Simply superb💯

[@MWAssi...]

love it thanks

[@ambershah7827]

great work. thanks for this and also other videos. I have one question that if there are checkpoint before "S" phase and 'M" , for any damage in DNA , then what about that genetic problems ?? why they are ? are these checkpoint do not catch these DNA damage which leads to genetic diseases ?? kindly guide me regarding this. thank you MEDSimplified

[@PanckajMGoswami]

Nice one

[@alexsavage6231]

POV u have finals tomorrow

[@afsanakhan6826]

Mind-blowing

[@PrakharGuptaLeo]

Ah! Long time no see

[@MEDSimplified]

Ahhh. Was busy with the residency exam😁 thank u for the support 😊

[@PrakharGuptaLeo]

@@MEDSimplified oh i see! But hey! U have a responsibility now young man!.. if im willing to crack neet with awesome scores.. i want you to be the reason. please cover everything. I love ur videos and the way you elaborate everything 😘

[@dreamer5411]

Sir in S phase only amount of DNA gets doubled number of chromosomes remain constant.isnt it

[@TonyTigerTonyTiger]

4:40 Duplication of chromosomes is not accomplished by transcription, but by DNA replication.

[@fatematuzzahra4039]

En activation inhibit cell division

[@taniakumari6452]

Excellent 🙌❣️

[@drsavirgupta]

I like your store ;)

[@MEDSimplified]

Khareed'te kyu nhi babua fir kuch😂

[@drsavirgupta]

Haha purane grahak hai. Discount lagega fir lenge

[@gwprince4387]

@@MEDSimplified 🤣🤣hehe

[@meghaverma5460]

simply amazing...... :)

[@yarookhosa9013]

How you make such type of videos. Please tell me about apps.

[@castor9564]

Perfect

[@marliklaus8728]

Hi! Where can I get the link for the worksheets? I upgraded to the highest level of member yesterday but it says "link will be added soon". Thanks! Amazing content.

[@MEDSimplified]

You can find the links to dropbox on our members feed page on youtube

[@dolma99]

Sir your voice 👌❤

[@tanmaykhamankar]

U got another subscribe

[@MEDSimplified]

You are most welcome on this channel buddy😁

[@AdityaKumar-sn8hd]

Your explanation is damn good!!!!!!!!!!!!!!!!!!!!! :) (:

[@iswamyyadav]

thank you for tolled about cell cycle

[@TonyTigerTonyTiger]

9:30 For G1, you show a duplicated chromosome, and then for S phase you show 2 duplicated chromosomes. But in G1 the chromosome would have only a single chromatid, and in S phase there would be only 1 chromosome, but now duplicated so having 2 chromatids.

[@doracake788]

Cell doesn’t double it’s number of chromosomes 😡 during this phase, the amount of DNA in the cell has doubled, though the number of chromosomes are unchanged.

[@ghoushavaliali4815]

Super