Central B cell Tolerance : Receptor Editing, Clonal Deletion and Anergy (FL-Immuno/79)

In this video lecture we will discuss mechanisms of central B cell tolerance
Receptor Editing
Clonal Deletion
Anergy

[@sannahshah1115]

My lecturer had taught us this over the course of 3 hours - you gave me exactly the same information in small mini-clips. Please continue to do what you do, we appreciate you :)

[@dyanmercado2624]

what causes the failure of central tolerance?

[@khannagma7553]

Helpful

[@mahmudahoque5543]

lecture begins from 2:04

[@user-mf1we7cc3g]

Thank you ❤️

[@subinbyclema]

Source of self antigens in the bone marrow blood plasma molecule strength BCR-Ag multivalent effective cross-linking BCR glycolipids Ag

[@PancakeEnthusiast342]

narration/video pace could be sped up a bit. great info, tho. i listen to these at 2x speed

[@FrankLectures]

Thank you for your feedback.

[@arnobashtar6707]

Does anyone know what the exact fate of an immature B cell in anergy is as it leaves into the periphery? Why doesn't that autoreactive B cell activate itself (T-cell independent B cell activation) and start to proliferate?

[@chandinighanta5505]

T-cell independent B cell activation requires 2 signals 1. Clustering of BCR on multivalent Ag 2. Recognition of danger signals The 2nd signal is absent in case of self Ag and thus leading to Anergy of the B cell

[@subinbyclema]

No interaction weak cross linking B cell development in the bone marrow Central B cell tolerance 1. receptor editing 2. anergy 3.clonal deletion VJC receptor editing light chain loci immunoglobuline gene non self reactive migrates to periphery

[@abduqodirovagulnoza5712]

Бир кунда нечта ичиш керак катталар

[@alishahzehra8306]

You just made me pass my module. Thankyou. Everything is perfect.

[@FrankLectures]

Thanks

[@subinbyclema]

Clonal deletion unresponsive anergy apoptosis

[@ramchandrasuthar2848]

Vert nice & unique

[@FrankLectures]

Thanks

[@hayasy6232]

Every thing is perfect 👍,Thank you soo much 😘❤...

[@Af5aL]

Video is great 👍🏻but audio are of poor quality!!!👎🏻

[@ibrahimlawan8056]

Good job, keep it up.

[@FrankLectures]

Thank you for your feedback.

[@princechandawatchingfromza9844]

It's a good video but the audio is bad

[@Arab1fy]

perfect videos but needs much more improvements I think it's very important to enhance the voice over and it will be much greater hope you the best in shaa' allah ^^

[@Arab1fy]

and I offer any help that can help you become better and better

[@FrankLectures]

Thank you for your feedback and suggestions. We will work on them. Thank you.

[@maram5102]

The content is very rich in info , but the voice is so distracting :(

[@FrankLectures]

Thank you for your feedback

[@raktimmukherjee278]

Can you please send me the Power Point that you have used in this VIDEO in my E-Mail ID? Also please mention the reference book that you have used for the figures......It's really a wonderful video and your power of explanation is simply amazing - Dr Raktim Mukherjee (Head of the Department, Shree PM Patel Institute of PG Studies and Research in Science, Sardar Patel University, Anand, Gujarat, India)

[@mehmoonabutt2661]

Very informative video✌