T cell Development

[@Maxolotl124]

"you will have time to digest this" Me looking at this video 2 days before the test, having not studied at all: "ha, no"

[@danimari516]

My dental school immunology professor could learn a thing or 200 from you. Thank you for clarifying this concept (and B cell development) for me after hours of rewatching my professor's lectures!!

[@sanjib_75]

You really are an amazing teacher. Thank you for making these videos.

[@delilahjones6496]

I do believe in regards to positive selection that it is not the affinity of self-MHC recognition that determines cell fate, but whether or not the peptide bound to MHC is recognized with better affinity by the TCR and it's co-receptor CD4 or CD8. So, if a peptide is presented by MHC II and the developing thymocyte TCR and CD4 co-receptor recognize this peptide with the right affinity, then it becomes a CD4+ T cell. Correct me if I'm wrong, that's just what I read recently that it's a combination of all these factors and the co-receptor affinity is important in positive selection.

[@angmiller314]

love ur channel! made me genuinely interested in the immune system. (instead of just learning it for class!)

[@Weejee456]

why do i pay 1000$ for a teacher that don't teach and you're free

[@victoranosike2621]

Exactly

[@panyuanlim1116]

Thanks You made my microbiology exam

[@maureenrichardsimmunologym9632]

It's my pleasure

[@rufaromapuranga9249]

Amazing. Thank you

[@WhyNot-si4pj]

20:00 "Positive selection" takes place through the interaction between DP lymphocytes & self MHC molecules ! I've 2 questions : first , Is it dendritic cells that present both MHC I & MHC II self molecules ? second , Why does CD8 WEAKLY recognizes MHC molecules in +ve selections & self antigens in -ve selection ?

[@JacobSchomer]

Because you want the immune response to the mhc molecule and antigen combination and not too strongly to the MHC itself

[@latifahahmad5348]

you're saving my grade!

[@mariammusri5640]

Thank you SO SO much, you really helped me understand this, you're amazing!!!

[@sn-7754]

Nice video mam,I have 1 doubut allelic exclusion occur during t-cell development like B cell?

[@maureenrichardsimmunologym9632]

Hi Darshit, thanks for watching! This is something that has been the focus of study for a number of years. When I last looked, it appears that both T cells and B cells engage in allelic exclusion. This is how the "unsuccessful" chromosome avoids expressing an antigen receptor that is different from the "successful chromosome. This way we can be sure that T cells and B cells only have 1 antigen specificity. If you have data that says otherwise I would be very interested in it!

[@WhyNot-si4pj]

In B cells allelic exclusion takes place AFTER (DJ) gene segment rearrangement of the Ig heavy chain in the EARLY progenitor B cell line i.e : starting from the LATE progenitor B cell line ! In T cells the (DJ) gene segment rearrangement of the beta chain - corresponding to the Ig heavy chain - takes place during the DN2 cell line ! Do we have evidence of allelic exclusion starting from the DN3 cell line ??????

[@rumesahashmi2775]

very helpful

[@novaduh]

Can I switch my professor with you lol? Seriously though I learned more from her.

[@antoniomele436]

Thank you! This was very helpful

[@saraha.3860]

Thank u so much

[@fitrasalam2823]

sorry, is this from janeway? what edition?

[@jayshreedas8002]

Yeah it's Janeway. Get the latest edition

[@Zakariah1971]

Never even said what b stands for. Fail.

[@sarahconner9433]

It stands for "baby".....or "bitch" like your mom....😅😅😂 not really