Chapter 20.3: Demo: Creating e-PRF and Injecting the Bio-Filler presented by Dr. Richard Miron

[@cutiepie-726]

What would you do in the case of a vascular occlusion?

[@ktrose886]

This is fascinating. Do you have any recommendations on solving an issue with blockages or necrosis here since there is no dissolver like Hyaluronidase?

[@prfedu]

A blockage has never happened before using the Alb-PRF and clinicians have been used for several years in thousands of patients. There's a reason for this... One of the downsides to HA is that once injected, HA attracts water and so it actually expands which is the primary reason blockage or necrosis may occur post-injection. The Alb-PRF actually shrinks because its usually mixed in a 2:1 ratio (2 part heated albumin gel (Filler component) and 1 part liquid PRF (growth factor component)). The liquid PRF dissipates into the tissue rapidly causing the Bio-Filler to shrink following injection (in our courses at www.prfedu.com/facial you'll learn more about this and how to inject slightly greater volumes to compensate for this if you want more info later). That being said, it's always good to have a backup in the event something does happen. The plastic surgeons that collaborate with our research team advise using 2 solutions in the event blockage would ever occur. 1) Use nitroglycerin ointment application which is common for angina attacks but opens vessels. This alone can sometimes resolve even HA complications. In the even this doesn't solve the problem, the clinician should 2) inject TPA (tissue plasminogen activator) which will rapidly break down a blood clot. Hope this helps :-)

[@maxmustermann4772]

@@prfedu Thanks for this detailed information. I wanted to ask if there is a risk of vascular occlusion/blindness with pure prf (liquid prf), but since the thicker alb-prf mix doesn't seem to cause problems, I assume that liquid prf is even more harmless? It would be great if you could confirm this, because I am thinking about gettin prf injections and I am a bit concerned.

[@spopparty]

can it be used in lips?

[@SABRINA-qo9wv]

Plasma filler can u use 27g to inject or is it to thick

[@aristeidis1988]

Do we have any experience how long it last? I have read some articles that report extension from 3 weeks (I-PRF) to 4-6 months (alb-PRF). Do you have a personal experience? For example chicks augmentation or nasolabial folds, how long will last before bio-filler looses it volume? Last do you have any experience if you make a different kind of bio filler (alb-prp) how long will it last? Denaturated albumin and prp ( alb- prp. Tubes with with anticoagulant of sodium citrate are used and then you cook ppp and you mix with prp) I think the key question is how long it takes for denaturated Albumine to break down inside dermis and if by mixing it with either PRF of PRP you can extend this time.. Thank you.

[@btsarianagrande1956]

do u have an answer please